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Constructing Epidermal Rete Ridges Using Composite Hydrogel to Enhance Multiple Signaling Pathways for the Maintenance of Epidermal Stem Cell Niche

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SSRN 2023年

作者： Shen, Zhizhong Liu, Zixian Sun, Lei Li, Meng Han, Lu Wang, Jianming Wu, Xunwei Sang, Shengbo Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception College of Information and Computer Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System the Ministry of Education Taiyuan University of Technology Taiyuan030024 China Shanxi Research Institute of 6D Artificial Intelligence Biomedical Science Taiyuan030031 China General Hospital of TISCO North Street Xinghualing District Taiyuan030809 China Engineering Laboratory for Biomaterials and Tissue Regeneration Ningbo Stomatology Hospital Savaid Stomatology School Hangzhou Medical College Ningbo China Department of Tissue Engineering and Regeneration School and Hospital of Stomatology Cheeloo College of Medicine Shandong University Shandong Key Laboratory of Oral Tissue Regeneration Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Shandong Jinan China Cutaneous Biology Research Center Massachusetts General Hospital Harvard Medical School BostonMA United States

The undulating microstructure rete ridge (RR) located at the junction between the dermis and epidermis plays a crucial role in improving skin mechanical properties and maintaining skin homeostasis. However, the investigation of RR microstructures are usually neglected in current tissue engineering for skin regeneration. Here, to create an epidermal model with RR microstructures, keratinocytes were inoculated onto a patterned GelMA-PEGDA hydrogel constructed using molding technology. Furthermore, grafting acryloylated Arg-Gly-Asp (RGD) peptides on the hydrogel surface significantly improved cell adhesion, fusion, and development. RT-PCR, Western blot, and immunofluorescence staining confirmed that cells on RR microstructures exhibited higher gene and protein expression associated with epidermal stem cells. RNA sequencing analysis of cells on RR microstructure showed higher gene expression profiles related to stem cell maintenance, basement membrane formation, and epidermal development. Furthermore, RT-PCR analysis of epidermal models of various dimensions demonstrated that smaller microstructures were more conducive to epidermal stem cell marker gene expression, which is analogous to human skin. Overall, we have successfully developed a method for integrating RR microstructures into an epidermal model that mimics natural skin to maintain epidermal stem cell niche, providing a valuable reference for researching skin regeneration within the fields of tissue engineering and regenerative medicine. © 2023, The Authors. All rights reserved.

关键词： Microstructure

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An Efficiency Enhanced Graphene/n-Si Schottky Junction for Solar Cells

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Chinese Physics Letters 2018年第7期35卷 58-61页

作者：李刚程宏伟郭丽芳王开鹰程再军 MicroNano System Research Center College of Information and Computer & Key Lab of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of Technology Taiyuan 030024 School of Optoelectronic and Communication Engineering Xiamen University of Technology Xiamen 361024

A novel and facile oxidation-induced self-doping process of graphene-silicon Schottky junction by nitric acid（HNO3） vapor is reported. The HNO3 oxidation process makes graphene p-type self-doped, and leads to a higher built-in potential and conductivity to enhance charge transfer and to suppress charge carrier recombination at the graphene-silicon Schottky junction. After the HNO3 oxidation process, the open-circuit voltage is increased from the initial value of 0.36 V to the maximum value of 0.47 V, the short-circuit current is greatly increased from 0.80μA to 7.71μA, and the ideality factor is optimized from 4.4 to 1.0. The enhancement of the performance of graphene-Si solar cells may be due to oxidation-induced p-type self-doping of graphene-Si junctions.

关键词： Graphene

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Cerebrovascular Segmentation in MRA via Reverse Edge Attention Network 23rd

Cerebrovascular Segmentation in MRA via Reverse Edge Attenti...

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23rd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2020

作者： Zhang, Hao Xia, Likun Song, Ran Yang, Jianlong Hao, Huaying Liu, Jiang Zhao, Yitian College of Information Engineering Capital Normal University Beijing China Cixi Institute of Biomedical Engineering Ningbo Institute of Industrial Technology Chinese Academy of Sciences Ningbo China School of Control Science and Engineering Shandong University Jinan China Department of Computer Science and Engineering Southern University of Science and Technology Shenzhen China International Science and Technology Cooperation Base of Electronic System Reliability and Mathematical Interdisciplinary Capital Normal University Beijing China Laboratory of Neural Computing and Intelligent Perception Capital Normal University Beijing China Beijing Advanced Innovation Center for Imaging Theory and Technology Capital Normal University Beijing China

ISBN: (纸本)9783030597245

Automated extraction of cerebrovascular is of great importance in understanding the mechanism, diagnosis, and treatment of many cerebrovascular pathologies. However, segmentation of cerebrovascular networks from magnetic resonance angiography (MRA) imagery continues to be challenging because of relatively poor contrast and inhomogeneous backgrounds, and the anatomical variations, complex geometry and topology of the networks themselves. In this paper, we present a novel cerebrovascular segmentation framework that consists of image enhancement and segmentation phases. We aim to remove redundant features, while retaining edge information in shallow features when combining these with deep features. We first employ a Retinex model, which is able to model noise explicitly to aid removal of imaging noise, as well as reducing redundancy within an image and emphasizing the vessel regions, thereby simplifying the subsequent segmentation problem. Subsequently, a reverse edge attention module is employed to discover edge information by paying particular attention to the regions that are not salient in high-level semantic features. The experimental results show that the proposed framework enables the reverse edge attention network to deliver a reliable cerebrovascular segmentation. © 2020, Springer Nature Switzerland AG.

关键词： Image enhancement

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A decentralized social networking architecture enhanced by blockchain

A decentralized social networking architecture enhanced by b...

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2019 IEEE International Conference on Service Operations and Logistics, and Informatics, SOLI 2019

作者： Zeng, Shuai Yuan, Yong Wang, Fei-Yue State Key Laboratory for Management and Control of Complex Systems Institute of Automation Chinese Academy of Sciences Beijing China Qingdao Academy of Intelligent Industries Qingdao China Research Center of Military Computational Experiments and Parallel System National University of Defense Technology Changsha China Beijing Engineering Research Center of Intelligent Systems and Technology Institute of Automation Chinese Academy of Sciences Beijing China

ISBN: (纸本)9781728128535

The privacy issues become a major problem that should be resolved for the existing centralized online social networks, which have prompted researchers to consider the decentralization framework for online social networks. In this paper, we propose a novel decentralized social networking architecture enhanced by blockchain technology. We use a sharding framework to increase the system scalability, a blockchain system to ensure the data integrity and consistency, a reputation-based authority control method to improve the system security. © 2019 IEEE.

关键词： Blockchain

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Cooperative collision avoidance method for multi-UAV based on kalman filter and model predictive control

Cooperative collision avoidance method for multi-UAV based o...

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2019 IEEE International Conference on Unmanned systems and Artificial Intelligence, ICUSAI 2019

作者： Huang, Hanqiao Zhou, Huan Zheng, Meiyun Xu, Cheng Zhang, Xiaofeng Xiong, Wei Unmanned System Research Institute Northwest Polytechnical University Xi'an China Aeronautical Engineering College Air Force Engineering University Xi'an China School of Marine Science and Technology Northwest Polytechnical University Xi'an China Science and Technology on Complex System Control and Intelligent Agent Cooperation Laboratory Beijing China UAV Researc Center Army Aviation Institute Beijing China

ISBN: (纸本)9781728158594

Collision avoidance is the primary problem to be solved in formation flight of multiple Unmanned aerial vehicles(UAVs). Firstly, a cooperative collision avoidance architecture of multiple UAVs is designed according to the requirement of autonomous collision avoidance of single UAV. Then a new cooperative collision avoidance method of multiple UAVs based on Kalman filter and model predictive control(MPC) is proposed. In this method, extended Kalman filter(EKF) is used to estimate the state of obstacles and target points in uncertain environment space, and to predict the trajectory of obstacles and target points. At the same time, relevant performance index functions and constraints are set up. On the basis of sharing environmental information, model predictive control strategy is used to guide and make cooperative collision avoidance decisions for multiple UAVs. The simulation results show that the proposed method is effective in uncertain environment perception and UAV collision avoidance, and the cooperative mechanism has obvious advantages. © 2019 IEEE.

关键词： Model predictive control

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Numerical Simulation of Thermal Field in Czochralski Monocrystalline Silicon Shoulder

Numerical Simulation of Thermal Field in Czochralski Monocry...

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Asian control Conference

作者： Jing ZHANG YaNi PAN Ding LIU Crystal Growth Equipment and System Integration Engineering Research Center Labotatory for Compiex System Control and intelligent of Information Processing Xi’an University of Technoligy Xi’an China

ISBN: (纸本)9781728102634

The shoulder is a process of maintaining dislocation-free growth in a Czochralski grown monocrystalline silicon, which is the key to the smooth entry of the crystal into the body. It has been found in production practice that crystal-change often occurs in the middle section of the shoulder. In this paper, the dynamic distribution of the thermal field, flow field, thermal stress and crystal-melt interface shape of the shoulder process is analyzed by numerical simulation. Theoretically, the phenomenon of easy crystal-change in the process of shouldering is explained, and the heater power adjustment process of the shoulder process is proposed. The comparison between the simulation and the actual crystal pulling data shows the correctness of the analysis and provides guidance for the actual crystal pulling.

关键词： Crystal growth Thermal stresses Stress Silicon Heating systems Temperature distribution

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Intranasal hybrid vesicles delivering personalized in situ nano-vaccines induce glioblastoma remodeling to sensitize immunotherapy

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Nano Today 2025年 65卷

作者： Xue Wang Hanwen Zhang Mingzhi Han Fucai Chen Yingjie Zhang Kuanhan Feng Jinghuang Wang Yali Shi Peng Cao Liuqing Di Ruoning Wang State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture Nanjing University of Chinese Medicine Nanjing 210023 China School of Pharmacy Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery System (DDS) Nanjing University of Chinese Medicine Nanjing 210023 China Department of Neurosurgery Qilu Hospital Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science Shandong University Jinan 250012 China

Personalized in situ tumor vaccine (PISTV), an attractive type of cancer immunotherapy, promotes a potent T cell anti-cancer immune response in multiple malignancies. Nevertheless, the limited cancer elimination efficacy of PISTV was exhibited in glioblastoma (GBM). Herein, an intranasal hybrid vesicle is designed based on ginseng-derived nanoparticles (GDNPs) fusing with liposomes, encapsulating shikosin (SKN), muscone, and MAN-CpG ODN (mCpG) to enable personalized in situ tumor vaccination for amplifying anti-GBM immune response. Following intranasal administration, the hybrid vesicles penetrated the nasal mucosal barrier and circumvented the blood-brain-barrier via the olfactory bulbar pathway. Subsequently, these nano-vaccines reached the tumor site, attributed to ginsenoside Rg3 in GDNPs. SKN-mediated whole tumor cell lysis served as a tumor-antigen pool to combine with immune adjuvant mCpG, resulting in the personalized in situ tumor vaccination, then recruiting dendritic cells (DCs) and promoting DCs maturation. Afterwards, DCs antigen presentation was enhanced to mobilize T cells, differentiating into cytotoxic T lymphocytes, thus inducing adaptive anti-tumor immunity. Furthermore, the GDNPs-mediated tumor-associated macrophages repolarization combines with SKN-blocked glycolytic pathway to reverse the immunosuppressive TME from “cold” into “hot”, thereby inducing innate immunity. We developed a nanoplatform that can deliver immunogenic cell death activators and Toll-like receptor agonists to antigen-capturing cells, synchronously conveying glycolysis inhibitors and TAM repolarization inducers to TME. This work demonstrated its robust capacity to activate innate and adaptive immune responses in distal metastasis, rechallenge, and humanized patient-derived xenograft tumor-bearing mice, providing a promising pathway for immunotherapeutic sensitization of GBM.

关键词： Glioblastoma Glycolysis inhibition Hybrid vesicles Immunosuppressive microenvironment In situ vaccines Intranasal administration

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Research on Transforming Effect and Calculation Method of MMC Converter on AC / DC Harmonics

Research on Transforming Effect and Calculation Method of MM...

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Sustainable Power and Energy Conference (iSPEC)

作者： Liu Cui Guangqiang Peng Jingsong He Jiyang Wu Chizu Mao Ning Jiao State Key Laboratory of HVDC Electric Power Research Institute China Southern Power Grid GuangZhou China Guangdong Provincial Key Laboratory of Intelligent Operation and Control for New Energy Power System GuangZhou China CSG Key Laboratory for Power System Simulation Electric Power Research Institute China Southern Power Grid GuangZhou China Maintenance & Test Center EHV Power Transmission Company Guangzhou CSGKEY LABORATORY FOR DC TRANSMISSIONEQUIPMENT STATE EVALUATION AND FAULT DIAGNOSIS GuangZhou China College of Electrical Engineering and Information Technology Sichuan University Chengdu China

ISBN: (纸本)9781665414401

Modular multilevel converter (MMC) is currently the most concerned voltage source converter topology in the field of flexible direct current transmission (VSC-HVDC). Due to its non-linear characteristics, harmonic components will inevitably be generated in AC and DC systems, which may affect the operation of equipment and system, cause protection equipment to malfunction, and cause interference to neighboring communications. The MMC converter is a non-linear device, which can be considered as an amplifying modulator with voltage and current conversion functions. The AC and DC networks are coupled to each other through the MMC converter to generate dynamic harmonic interaction. In recent years, harmonic instability problems have appeared in many VSC-HVDC projects. Compared with other converter topologies, the transfer relationship of harmonics on the AC and DC sides of MMC converters has not been studied in depth. In this paper, by studying the AC/DC harmonic conversion characteristics of MMC converters, it reveals the conversion law of MMC converters between AC/DC harmonics; through theoretical derivation, the quantitative calculation method of MMC harmonic transmission process is given. PSCAD simulation results prove the correctness of the above results.

关键词： Network topology Simulation Bridge circuits Voltage Power system harmonics Harmonic analysis Frequency conversion

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Broadband Electromagnetic Wave Tunneling with Transmuted Material Singularity

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Physical Review Letters 2020年第20期125卷 207401-207401页

作者： Yichao Liu Fei Sun Yibiao Yang Zhihui Chen Jianzhong Zhang Sailing He Yungui Ma Key Lab of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi Province College of Physics and Optoelectronics Taiyuan University of Technology Taiyuan 030024 China State Key Lab of Modern Optical Instrumentation Centre for Optical and Electromagnetic Research College of Optical Science and Engineering International Research Center for Advanced Photonics Zhejiang University Hangzhou 310058 China Department of Electromagnetic Engineering School of Electrical Engineering Royal Institute of Technology (KTH) S-100 44 Stockholm Sweden

Subwavelength channels filled with near-zero-index (NZI) media can realize extraordinary optical functionalities, for example, tunneling electromagnetic wave without reflections, but usually confined in a narrow wavelength band due to the material singularity (refractive index n≈0), which seriously limits the practical potentials. In this Letter, we show this limit can be fundamentally overcome by an alternative, named near-zero-index-featured (NZIF) structure, with the singularity transmuted via a controlled optical conformal mapping, enabling the device implementation with nonmagnetic normal dielectrics (i.e., relative permittivity >1). Their equivalence is strictly examined through a subwavelength tunneling waveguide. Classic wave tunneling features in a broad frequency range are revealed in various confined geometries. These properties are robust against the disturbance of several kinds of structural defects benefited from the infinite effective local wavelength. The broadband and lossless NZIF medium proposed here provides a promising way to pursue the fascinating light controlling functionalities as initially enabled by singular NZI materials.

关键词： Transformation optics Waveguides

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Finite Element Analysis of Series Elastic Actuator for Exoskeleton Robot Joint

Finite Element Analysis of Series Elastic Actuator for Exosk...

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IEEE International Conference on Mechatronics and Automation

作者： Pengyu Xi Weimin Ge Sen Zhang Zhili Zhang Teresa Zielinska Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control School of Mechanical Engineering Tianjin University of Technology Tianjin China National Demonstration Center for Experimental Mechanical and Electrical Engineering Education Tianjin University of Technology Intelligent Manufacturing College Tianjin Sino-German University of Applied Science Tianjin China Institute of Aeronautics and Applied Mechanics Warsaw University of Technology Warsaw Poland

ISBN: (数字)9781728164168

ISBN: (纸本)9781728164175

The finite element simulation for the joints of an exoskeleton robot is conducted in this paper. Using software OpenSim to simulate the normal walking gait of the human body, the motion angle and moment of the human hip, knee and ankle joints are obtained. Using the obtained data as the input parameters in the finite element simulation of the simulation software Ls-dyna, the strain diagrams and contact force curves of the circular roller and cam disk were obtained. In this study, three commonly used materials are selected: alloy steel, ductile iron and hard aluminum alloy. Finally, the effects of different materials on the key components of the series elastic actuator are studied.

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