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Relationship between pulmonary nodule malignancy and surrounding pleurae, airways and vessels: a quantitative study using the public LIDC-IDRI dataset

arXiv

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arXiv 2021年

作者： Qin, Yulei Gu, Yun Zhang, Hanxiao Yang, Jie Wang, Lihui Wang, Zhexin Yao, Feng Zhu, Yue-Min Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University Shanghai200240 China Institute of Medical Robotics Shanghai Jiao Tong University Shanghai200240 China CREATIS INSA Lyon CNRS UMR 5220 INSERM U1206 Université de Lyon Villeurbanne69621 France Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province School of Computer Science and Technology Guizhou University Guiyang550025 China Department of Thoracic Surgery Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai200025 China

Objectives: To investigate whether the pleurae, airways and vessels surrounding a nodule on non-contrast computed tomography (CT) can discriminate benign and malignant pulmonary nodules. Materials and Methods: The LIDC-IDRI dataset, one of the largest publicly available CT database, was exploited for study. A total of 1556 nodules from 694 patients were involved in statistical analysis, where nodules with average scorings 3 were respectively denoted as benign and malignant. Besides, 339 nodules from 113 patients with diagnosis ground-truth were independently evaluated. Computer algorithms were developed to segment pulmonary structures and quantify the distances to pleural surface, airways and vessels, as well as the counting number and normalized volume of airways and vessels near a nodule. Odds ratio (OR) and Chi-square (χ2) testing were performed to assess the correlation between features of surrounding structures and nodule malignancy. A non-parametric receiver operating characteristic (ROC) analysis was conducted in logistic regression to evaluate discrimination ability of each structure. Results: For the benign and malignant groups, the average distances from nodules to pleural surface, airways and vessels are respectively (6.56, 5.19), (37.08, 26.43) and (1.42, 1.07) mm. The correlation between nodules and the counting number of airways and vessels that contact or project towards nodules are respectively (OR=22.96, χ2=105.04) and (OR=7.06, χ2=290.11). The correlation between nodules and the volume of airways and vessels are (OR=9.19, χ2=159.02) and (OR=2.29, χ2=55.89). The areas-under-curves (AUCs) for pleurae, airways and vessels are respectively 0.5202, 0.6943 and 0.6529. Conclusion: Our results show that malignant nodules are often surrounded by more pulmonary structures compared with benign ones, suggesting that features of these structures could be viewed as lung cancer biomarkers. © 2021, CC BY.

关键词： Computerized tomography

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Multi-Adapter RGBT Tracking

Multi-Adapter RGBT Tracking

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International Conference on Computer Vision Workshops (ICCV Workshops)

作者： Cheng Long Li Andong Lu Ai Hua Zheng Zhengzheng Tu Jin Tang Anhui University Hefei China Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and Technology Anhui University Hefei China Key Laboratory of Industrial Image Processing and Analysis of Anhui Province Hefei China

ISBN: (数字)9781728150239

ISBN: (纸本)9781728150246

The task of RGBT tracking aims to take the complementary advantages from visible spectrum and thermal infrared data to achieve robust visual tracking, and receives more and more attention in recent years. Existing works focus on modality-specific information integration by introducing modality weights to achieve adaptive fusion or learning robust feature representations of different modalities. Although these methods could effectively deploy the modality-specific properties, they ignore the potential values of modality-shared cues as well as instance-aware information, which are crucial for effective fusion of different modalities in RGBT tracking. In this paper, we propose a novel Multi-Adapter convolutional Network (MANet) to jointly perform modality-shared, modality-specific and instance-aware feature learning in an end-to-end trained deep framework for RGBT tracking. We design three kinds of adapters within our network. In a specific, the generality adapter is to extract shared object representations, the modality adapter aims at encoding modality-specific information to deploy their complementary advantages, and the instance adapter is to model the appearance properties and temporal variations of a certain object. Moreover, to reduce computational complexity for real-time demand of visual tracking, we design a parallel structure of generic adapter and modality adapter. Extensive experiments on two RGBT tracking benchmark datasets demonstrate the outstanding performance of the proposed tracker against other state-of-the-art RGB and RGBT tracking algorithms.

关键词： Adaptation models Robustness Target tracking Feature extraction Visualization Task analysis

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dense feature aggregation and pruning for RGBT tracking

arXiv

引用

arXiv 2019年

作者： Zhu, Yabin Li, Chenglong Luo, Bin Tang, Jin Wang, Xiao Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and Technology Anhui University Hefei Anhui China Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and Technology Anhui University Institute of Physical Science and Information Technology Anhui University Hefei Anhui China Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and Technology Anhui University Key Laboratory of Industrial Image Processing and Analysis of Anhui Province Hefei Anhui China

How to perform effective information fusion of different modalities is a core factor in boosting the performance of RGBT tracking. This paper presents a novel deep fusion algorithm based on the representations from an end-to-end trained convolutional neural network. To deploy the complementarity of features of all layers, we propose a recursive strategy to densely aggregate these features that yield robust representations of target objects in each modality. In different modalities, we propose to prune the densely aggregated features of all modalities in a collaborative way. In a specific, we employ the operations of global average pooling and weighted random selection to perform channel scoring and selection, which could remove redundant and noisy features to achieve more robust feature representation. Experimental results on two RGBT tracking benchmark datasets suggest that our tracker achieves clear state-of-the-art against other RGB and RGBT tracking methods. Copyright © 2019, The Authors. All rights reserved.

关键词： Machine learning

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Learning tubule-sensitive CNNs for pulmonary airway and artery-vein segmentation in CT

arXiv

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arXiv 2020年

作者： Qin, Yulei Zheng, Hao Gu, Yun Huang, Xiaolin Yang, Jie Wang, Lihui Yao, Feng Zhu, Yue-Min Yang, Guang-Zhong Institute of Image Processing and Pattern Recognition Institute of Medical Robotics Shanghai Jiao Tong University Shanghai China Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province School of Computer Science and Technology Guizhou University Guiyang China Department of Thoracic Surgery Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai China Université de Lyon INSA Lyon CREATIS CNRS INSERM UMR 5220 VilleurbanneU1206 France Institute of Medical Robotics School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China

Training convolutional neural networks (CNNs) for segmentation of pulmonary airway, artery, and vein is challenging due to sparse supervisory signals caused by the severe class imbalance between tubular targets and background. We present a CNNs-based method for accurate airway and artery-vein segmentation in non-contrast computed tomography. It enjoys superior sensitivity to tenuous peripheral bronchioles, arterioles, and venules. The method first uses a feature recalibration module to make the best use of features learned from the neural networks. Spatial information of features is properly integrated to retain relative priority of activated regions, which benefits the subsequent channel-wise recalibration. Then, attention distillation module is introduced to reinforce representation learning of tubular objects. Fine-grained details in high-resolution attention maps are passing down from one layer to its previous layer recursively to enrich context. Anatomy prior of lung context map and distance transform map is designed and incorporated for better artery-vein differentiation capacity. Extensive experiments demonstrated considerable performance gains brought by these components. Compared with state-of-the-art methods, our method extracted much more branches while maintaining competitive overall segmentation performance. Codes and models are available at http://***/News/56. © 2020, CC BY.

关键词： Computerized tomography

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Deep Adaptive Fusion Network for High Performance RGBT Tracking

Deep Adaptive Fusion Network for High Performance RGBT Track...

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International Conference on Computer Vision Workshops (ICCV Workshops)

作者： Yuan Gao Chenglong Li Yabin Zhu Jin Tang Tao He Futian Wang Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and Technology Anhui University Hefei China Institute of Physical Science and Information Technology Anhui University Hefei China Key Laboratory of Industrial Image Processing and Analysis of Anhui Province Hefei China Anhui COWAROBOT CO. Ltd Wuhu China

ISBN: (数字)9781728150239

ISBN: (纸本)9781728150246

Due to the complementarity of RGB and thermal data, RGBT tracking has received more and more attention in recent years because it can effectively solve the degradation of tracking performance in dark environments and bad weather conditions. How to effectively fuse the information from RGB and thermal modality is the key to give full play to their complementarities for effective RGBT tracking. In this paper, we propose a high performance RGBT tracking framework based on a novel deep adaptive fusion network, named DAFNet. Our DAFNet consists of a recursive fusion chain that could adaptively integrate all layer features in an end-to-end manner. Due to simple yet effective operations in DAFNet, our tracker is able to reach the near-real-time speed. Comparing with the state-of-the-art trackers on two public datasets, our DAFNet tracker achieves the outstanding performance and yields a new state-of-the-art in RGBT tracking.

关键词： Feature extraction Target tracking Robustness Fuses Convolution Adaptive systems

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Understanding metric-related pitfalls in image analysis validation

arXiv

引用

arXiv 2023年

作者： Reinke, Annika Tizabi, Minu D. Baumgartner, Michael Eisenmann, Matthias Heckmann-Nötzel, Doreen Kavur, A. Emre Rädsch, Tim Sudre, Carole H. Acion, Laura Antonelli, Michela Arbel, Tal Bakas, Spyridon Benis, Arriel Blaschko, Matthew B. Buettner, Florian Cardoso, M. Jorge Cheplygina, Veronika Chen, Jianxu Christodoulou, Evangelia Cimini, Beth A. Collins, Gary S. Farahani, Keyvan Ferrer, Luciana Galdran, Adrian van Ginneken, Bram Glocker, Ben Godau, Patrick Haase, Robert Hashimoto, Daniel A. Hoffman, Michael M. Huisman, Merel Isensee, Fabian Jannin, Pierre Kahn, Charles E. Kainmueller, Dagmar Kainz, Bernhard Karargyris, Alexandros Karthikesalingam, Alan Kenngott, Hannes Kleesiek, Jens Kofler, Florian Kooi, Thijs Kopp-Schneider, Annette Kozubek, Michal Kreshuk, Anna Kurc, Tahsin Landman, Bennett A. Litjens, Geert Madani, Amin Maier-Hein, Klaus Martel, Anne L. Mattson, Peter Meijering, Erik Menze, Bjoern Moons, Karel G.M. Müller, Henning Nichyporuk, Brennan Nickel, Felix Petersen, Jens Rafelski, Susanne M. Rajpoot, Nasir Reyes, Mauricio Riegler, Michael A. Rieke, Nicola Saez-Rodriguez, Julio Sánchez, Clara I. Shetty, Shravya Summers, Ronald M. Taha, Abdel A. Tiulpin, Aleksei Tsaftaris, Sotirios A. van Calster, Ben Varoquaux, Gaël Yaniv, Ziv R. Jäger, Paul F. Maier-Hein, Lena Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Heidelberg Division of Intelligent Medical Systems Germany NCT Heidelberg A Partnership Between DKFZ University Medical Center Heidelberg Germany Heidelberg Division of Medical Image Computing Germany Heidelberg Division of Intelligent Medical Systems Germany MRC Unit for Lifelong Health and Ageing UCL Centre for Medical Image Computing Department of Computer Science University College London London United Kingdom School of Biomedical Engineering and Imaging Science King’s College London London United Kingdom Instituto de Cálculo CONICET – Universidad de Buenos Aires Buenos Aires Argentina Centre for Medical Image Computing University College London London United Kingdom McGill University Montreal Canada Division of Computational Pathology Dept of Pathology & Laboratory Medicine Indiana University School of Medicine IU Health Information and Translational Sciences Building Indianapolis United States University of Pennsylvania Richards Medical Research Laboratories FL7 PhiladelphiaPA United States Department of Digital Medical Technologies Holon Institute of Technology Holon Israel European Federation for Medical Informatics Le Mont-sur-Lausanne Switzerland Center for Processing Speech and Images Department of Electrical Engineering KU Leuven Leuven Belgium partner site Frankfurt/Mainz a partnership between DKFZ and UCT Frankfurt Marburg Germany Heidelberg Germany Goethe University Frankfurt Department of Medicine Germany Goethe University Frankfurt Department of Informatics Germany and Frankfurt Cancer Insititute Germany Department of Computer Science IT University of Copenhagen Copenhagen Denmark Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. Dortmund Germany Imaging Platform Broad Institute of MIT and Harvard CambridgeMA United States Centre for Statistics in Medicine University of Oxford Oxford United Kingdom Center for Biomedical In

Validation metrics are key for tracking scientific progress and bridging the current chasm between artificial intelligence (AI) research and its translation into practice. However, increasing evidence shows that particularly in image analysis, metrics are often chosen inadequately. While taking into account the individual strengths, weaknesses, and limitations of validation metrics is a critical prerequisite to making educated choices, the relevant knowledge is currently scattered and poorly accessible to individual researchers. Based on a multi-stage Delphi process conducted by a multidisciplinary expert consortium as well as extensive community feedback, the present work provides the first reliable and comprehensive common point of access to information on pitfalls related to validation metrics in image analysis. While focused on biomedical image analysis, the addressed pitfalls generalize across application domains and are categorized according to a newly created, domain-agnostic taxonomy. The work serves to enhance global comprehension of a key topic in image analysis validation. © 2023, CC BY.

关键词： Computer vision

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A Reliable Data Hiding Scheme Using Jigsaw Sudoku

A Reliable Data Hiding Scheme Using Jigsaw Sudoku

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2018 International Conference on Network, Communication, Computer Engineering (NCCE 2018)

作者： Wanli Lyu Dongshuo Yin Yu Zhang Jiahao Deng Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and TechnologyAnhui UniversityKey Lab of Industrial Image Processing and Analysis of Anhui Province

ISBN: (纸本)9781510871076

A distinctive data hiding method based on Jigsaw Sudoku is proposed in this *** from other methods,the proposed method is based on Jigsaw Sudoku which is a kind of irregularly shaped *** to the novelty of Jigsaw Sudoku,the proposed method can provide a safer scheme for data hiding than that with pure *** proposed method can hide a certain number of 9-ary numbers in a steganographic image which has a corresponding *** a 256*256 key matrix stretched from a size 9*9 Jigsaw Sudoku,secret message can be hidden in a vector image byte by byte in the form of *** results show that,the proposed method has a better peaksignal-to-noise-ratio(PSNR) compared with some other data hiding methods.

关键词： Sudoku PSNR hiding methods irregularly shaped steganographic image corresponding specification

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Tangram Algorithm:High image Quality Secret Sharing Scheme Using Two Steganographic images

Tangram Algorithm:High Image Quality Secret Sharing Scheme U...

引用

2018 International Conference on Network, Communication, Computer Engineering (NCCE 2018)

作者： Wanli Lyu Jiahao Deng Yu Zhang Dongshuo Yin Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and TechnologyAnhui UniversityKey Lab of Industrial Image Processing and Analysis of Anhui Province

ISBN: (纸本)9781510871076

In this paper,our proposed scheme using two steganography *** other data hiding schemes,this scheme studies the characteristics of the Tangram puzzle model and the secret message bytes that make up the eight binary bits that are hidden into the two *** matrix M *,horizontal and vertical coordinate range from 0 to 255,and the pixel pairs in the cover image are used to help hide the secret message bytes in our *** paired pixel points into single and double number hidden in two *** show that the program can hide relatively more pixels in a cover image with less losing image quality.

关键词： steganography images Tangram puzzle matrix M hide relatively scenario

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Metrics Reloaded: Recommendations for image analysis validation

arXiv

引用

arXiv 2022年

作者： Maier-Hein, Lena Reinke, Annika Godau, Patrick Tizabi, Minu D. Buettner, Florian Christodoulou, Evangelia Glocker, Ben Isensee, Fabian Kleesiek, Jens Kozubek, Michal Reyes, Mauricio Riegler, Michael A. Wiesenfarth, Manuel Emre Kavur, A. Sudre, Carole H. Baumgartner, Michael Eisenmann, Matthias Heckmann-Nötzel, Doreen Rädsch, Tim Acion, Laura Antonelli, Michela Arbel, Tal Bakas, Spyridon Benis, Arriel Blaschko, Matthew B. Jorge Cardoso, M. Cheplygina, Veronika Cimini, Beth A. Collins, Gary S. Farahani, Keyvan Ferrer, Luciana Galdran, Adrian Ginneken, Bram Van Haase, Robert Hashimoto, Daniel A. Hoffman, Michael M. Huisman, Merel Jannin, Pierre Kahn, Charles E. Kainmueller, Dagmar Kainz, Bernhard Karargyris, Alexandros Karthikesalingam, Alan Kenngott, Hannes Kofler, Florian Kopp-Schneider, Annette Kreshuk, Anna Kurc, Tahsin Landman, Bennett A. Litjens, Geert Madani, Amin Maier-Hein, Klaus Martel, Anne L. Mattson, Peter Meijering, Erik Menze, Bjoern Moons, Karel G.M. Müller, Henning Nichyporuk, Brennan Nickel, Felix Petersen, Jens Rajpoot, Nasir Rieke, Nicola Saez-Rodriguez, Julio Sánchez, Clara I. Shetty, Shravya Smeden, Maarten Van Summers, Ronald M. Taha, Abdel A. Tiulpin, Aleksei Tsaftaris, Sotirios A. Calster, Ben Van Varoquaux, Gaël Jäger, Paul F. Heidelberg Division of Intelligent Medical Systems and HI Helmholtz Imaging Germany Faculty of Mathematics and Computer Science and Medical Faculty Heidelberg University Heidelberg Germany NCT Heidelberg a partnership between DKFZ University Medical Center Heidelberg Germany Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Heidelberg Division of Intelligent Medical Systems Germany partner site Frankfurt/Mainz a partnership between DKFZ and UCT Frankfurt-Marburg Germany Heidelberg Goethe University Frankfurt Germany Department of Medicine Goethe University Frankfurt Germany Department of Informatics Frankfurt Cancer Insititute Germany Department of Computing Imperial College London London United Kingdom Heidelberg Division of Medical Image Computing and HI Applied Computer Vision Lab Germany Institute for AI in Medicine University Medicine Essen Essen Germany Centre for Biomedical Image Analysis Faculty of Informatics Masaryk University Brno Czech Republic ARTORG Center for Biomedical Engineering Research University of Bern Bern Switzerland Department of Radiation Oncology University Hospital Bern University of Bern Bern Switzerland Simula Metropolitan Center for Digital Engineering Oslo Norway UiT The Arctic University of Norway Romsø Norway Heidelberg Division of Biostatistics Germany Heidelberg Division of Intelligent Medical Systems Division of Medical Image Computing HI Applied Computer Vision Lab Germany MRC Unit for Lifelong Health and Ageing UCL Centre for Medical Image Computing Department of Computer Science University College London London United Kingdom School of Biomedical Engineering and Imaging Science King’s College London London United Kingdom Heidelberg Division of Medical Image Computing Germany Instituto de Cálculo CONICET – Universidad de Buenos Aires Buenos Aires Argentina Centre for Medical Image Computing University College London London United Kingdom McGill University Montréal

Increasing evidence shows that flaws in machine learning (ML) algorithm validation are an underestimated global problem. Particularly in automatic biomedical image analysis, chosen performance metrics often do not reflect the domain interest, thus failing to adequately measure scientific progress and hindering translation of ML techniques into practice. To overcome this, we created Metrics Reloaded, a comprehensive framework guiding researchers in the problem-aware selection of metrics. It was developed by a large international consortium in a multi-stage Delphi process and is based on the novel concept of a problem fingerprint – a structured representation of the given problem that captures all aspects that are relevant for metric selection, from the domain interest to the properties of the target structure(s), data set and algorithm output. Based on the problem fingerprint, users are guided through the process of choosing and applying appropriate validation metrics while being made aware of potential pitfalls. Metrics Reloaded targets image analysis problems that can be interpreted as a classification task at image, object or pixel level, namely image-level classification, object detection, semantic segmentation, and instance segmentation tasks. To improve the user experience, we implemented the framework in the Metrics Reloaded online tool. Following the convergence of ML methodology across application domains, Metrics Reloaded fosters the convergence of validation methodology. Its applicability is demonstrated for various biomedical use cases. © 2022, CC BY.

关键词： Semantic Segmentation

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Rapid Artificial Intelligence Solutions in a Pandemic - The COVID-19-20 Lung CT Lesion Segmentation Challenge

Research Square

引用

Research Square 2021年 rs3rs-571332页

作者： Roth, Holger R. Xu, Ziyue Diez, Carlos Tor Jacob, Ramon Sanchez Zember, Jonathan Molto, Jose Li, Wenqi Xu, Sheng Turkbey, Baris Turkbey, Evrim Yang, Dong Harouni, Ahmed Rieke, Nicola Hu, Shishuai Isensee, Fabian Tang, Claire Yu, Qinji Sölter, Jan Zheng, Tong Liauchuk, Vitali Zhou, Ziqi Moltz, Jan Hendrik Oliveira, Bruno Xia, Yong Maier-Hein, Klaus H. Li, Qikai Husch, Andreas Zhang, Luyang Kovalev, Vassili Kang, Li Hering, Alessa Vilaça, João L. Flores, Mona Xu, Daguang Wood, Bradford Linguraru, Marius George NVIDIA BethesdaMD United States Sheikh Zayed Institute for Pediatric Surgical Innovation Children’s National Hospital WashingtonDC United States Division of Diagnostic Imaging and Radiology Children’s National Hospital WashingtonDC United States Radiology and Imaging Sciences National Institutes of Health Clinical Center BethesdaMD United States School of Computer Science and Engineering Northwestern Polytechnical University China Heidelberg Germany Lynbrook High School San JoseCA United States Shanghai Jiao Tong University China Luxembourg Centre for Systems Biomedicine University of Luxembourg Luxembourg School of Informatics Nagoya University Japan Biomedical Image Analysis Department United Institute of Informatics Problems Belarus Guangdong Key Laboratory of Intelligent Information Processing Shenzhen University China Fraunhofer Institute for Digital Medicine MEVIS Bremen Germany School of Medicine University of Minho Braga Portugal ICVS/3B’s - PT Government Associate Laboratory Braga/Guimarães Portugal Algoritmi Center School of Engineering University of Minho Guimarães Portugal Heidelberg Germany Fraunhofer Institute for Digital Medicine MEVIS Lübeck Germany 2Ai – Polytechnic Institute of Cávado and Ave Barcelos Portugal School of Medicine and Health Sciences George Washington University WashingtonDC United States

Artificial intelligence (AI) methods for the automatic detection and quantification of COVID-19 lesions in chest computed tomography (CT) might play an important role in the monitoring and management of the disease. We organized an international challenge and competition for the development and comparison of AI algorithms for this task, which we supported with public data and state-of-the-art benchmark methods. Board Certified Radiologists annotated 295 public images from two sources (A and B) for algorithms training (n=199, source A), validation (n=50, source A) and testing (n=23, source A;n=23, source B). There were 1,096 registered teams of which 225 and 98 completed the validation and testing phases, respectively. The challenge showed that AI models could be rapidly designed by diverse teams with the potential to measure disease or facilitate timely and patient-specific interventions. This paper provides an overview and the major outcomes of the COVID-19 Lung CT Lesion Segmentation Challenge - 2020. © 2021, CC BY.

关键词： COVID-19

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