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IEEE Symposium on Bioinformatics and Bioengineering (BIBE)

作者： M. Gheiratmand H. Soltanian-Zadeh H. Khaloozadeh Electrical Engineering Department K.N. Toosi University of Technology Tehran Iran Radiology Department Henry Ford Health System Image Analysis and Communications Laboratory Detroit MI USA School of Cognitive Sciences Institute for Studies Theoretical Physics and Mathematics (IPM) Tehran Iran Control and Intelligent Processing Center of Excellence Electrical and Computer Engineering Department University of Tehran Tehran Iran

Understanding the primatespsila visual system has been one of the challenging problems of different groups of scientists for years. Though many studies, from physiology and neuroscience to computer vision, are done on different aspects of visual processing in the cortex, a comprehensive computational model of visual cortex is still missing. We have implemented a computational model of object recognition in ventral visual pathway in our previous work. This hierarchical model covers visual areas V1/V2, V4/PIT, and AIT sending inputs to the Prefrontal Cortex (PFC) for categorization. To extend our model, in this work, we have added a simple model of motion detection in neurons of areas V1 and MT of the dorsal stream to our previous model. This has enabled the model to perform another principal function of the visual cortex, i.e., motion perception.

关键词： Brain modeling Computational modeling Neurons Biological system modeling Object recognition Motion analysis Solid modeling Visual system Computer vision Motion detection

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Evaluation of BOLD Sensitivity Using a Realistic MRI Simulator

Evaluation of BOLD Sensitivity Using a Realistic MRI Simulat...

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Joint Meeting of the International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart and the International Conference on Functional Biomedical Imaging (NFSI-ICFBI)

作者： Ali-Reza Mohammadi-Nejad G.-Ali Hossein-Zadeh Hamid Soltanian-Zadeh Control and Intelligent Processing Center of Excellence School of ECE University of Tehran Tehran Iran Henry Ford Health System Medical Image Analysis Laboratory Detroit MI USA

MRl simulation is a suitable method to evaluate and acquire understanding of the complex blood oxygenation level dependent (BOLD) effect. To study the observability of BOLD signal, we extended a MRI simulator. This simulator is capable of complete modeling of object (tissue) and main field inhomogeneities. We made a digital phantom in which the magnitude of fractional oxygenation (Y), hematocrit (Hct) values in red blood cells, the diameter of vessels, and also the position of blood vessel within the voxel can be changed. Then we created echo planar imaging (EPI) images of the phantom under resting and activated states using the simulator. Resulting images were analyzed using cross-correlation and t-test analysis for activation detection. Then the effect of various parameters on the detection of BOLD is investigated. These parameters include fractional oxygenation, spatial extent of BOLD effect and the location of vessel inside voxel. This simulation study provides a basis for planning experiments aimed at BOLD contrast detection with EPI pulse sequence.

关键词： Magnetic resonance imaging Red blood cells Medical simulation Biomedical imaging image analysis Magnetic susceptibility Analytical models Imaging phantoms Blood vessels Magnetic properties

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A Hierarchical Clustering Based on Mutual Information Maximization

A Hierarchical Clustering Based on Mutual Information Maximi...

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IEEE International Conference on image processing

作者： M. Aghagolzadeh H. Soltanian-Zadeh B. Araabi A. Aghagolzadeh Control and Intelligent Processing Center of Excellence Department of Electrical and Computer Engineering University of Tehran Tehran Iran Radiology Image Analysis Laboratory Henry Ford Health System Detroit MI USA Faculty of Electrical and Computer Engineering University of Tabriz Tabriz Iran

Mutual information has been used in many clustering algorithms for measuring general dependencies between random data variables, but its difficulties in computing for small size datasets has limited its efficiency for clustering in many applications. A novel clustering method is proposed which estimates mutual information based on information potential computed pair-wise between data points and without any prior assumptions about cluster density function. The proposed algorithm increases the mutual information in each step in an agglomerative hierarchy scheme. We have shown experimentally that maximizing mutual information between data points and their class labels will lead to an efficient clustering. Experiments done on a variety of artificial and real datasets show the superiority of this algorithm, besides its low computational complexity, in comparison to other information based clustering methods and also some ordinary clustering algorithms.

关键词： Mutual information Clustering algorithms Clustering methods Data mining Data structures Density functional theory Computational complexity Entropy Higher order statistics Probability density function

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NONPARAMETRIC ENTROPY-BASED COUPLED MULTI-SHAPE MEDICAL image SEGMENTATION

NONPARAMETRIC ENTROPY-BASED COUPLED MULTI-SHAPE MEDICAL IMAG...

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IEEE International Symposium on Biomedical Imaging

作者： Alireza Akhoundi-Asl Hamid Soltanian-Zadeh School of Cognitive Sciences Institute of Studies in Theoretical Physics and Mathematics Tehran Iran Control and Intelligent Processing Center of Excellence (CIPCE) School of Electrical and Computer Engineering University of Tehran Tehran Iran Image Analysis Laboratory Radiology Department Henry Ford Health System Detroit MI USA

ISBN: (纸本)9781424406715;1424406714

We propose a 3D nonparametric, entropy-based, coupled, multishape approach for the segmentation of subcortical brain structures in magnetic resonance images (MRI). Our method uses PCA to capture structures variability. Because of complex relationships of pose and shape of the coupled structures, we only use their shape and size relation. To this end, we apply separate registrations of the structures. For each structure, we consider a similarity transform using seven parameters. In addition, to generate most accurate results, we estimate probability density functions (pdf) iteratively. The proposed method minimizes an entropy-based energy function using quasi-Newton algorithm. To improve the results, we use analytical derivatives. Sample results are given for the segmentation of putamen, thalamus and caudate illustrating the impact of coupling on the accuracy of the results.

关键词： Biomedical imaging image segmentation Shape Couplings Brain Magnetic resonance Magnetic resonance imaging Principal component analysis Probability density function Iterative algorithms

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AUTOMATIC BRAIN TUMOR SEGMENTATION USING TISSUE DIFFISIVITY CHARACTERISTICS

AUTOMATIC BRAIN TUMOR SEGMENTATION USING TISSUE DIFFISIVITY ...

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IEEE International Symposium on Biomedical Imaging

作者： Azadeh Yazdan-Shahmorad Hesamoddin Jahanian Suresh Patel Hamid Soltanian-Zadeh Radiology Department Henry Ford Health System Medical Image Analysis Laboratory Detroit MI USA Electrical and Computer Engineering Department Wayne State University Detroit MI USA Biomedical Engineering Department University of Michigan Ann Arbor MI USA Control and Intelligent Processing Center of Excellence Electrical and Computer Engineering Department Faculty of Engineering University of Tehran Tehran Iran

ISBN: (纸本)9781424406715;1424406714

Water diffusion measurements have been shown to be sensitive to tissue cellular size, extra cellular volume, and membrane permeability. Therefore, diffusion tensor imaging (DTI) by MRI can be used to characterize highly cellular regions of tumors versus acellular regions, distinguishing cystic regions from solid regions. An automatic segmentation method is proposed in this paper based on a multi-phase clustering algorithm to segment the brain tumors in a feature space extracted from DTI images. The algorithm is applied on images of a total of 20 patients with 4 different types of tumors. The tumor region segmentation was 92% accurate based on the segmentation results using anatomical images and 100% accurate based on biopsy results. In general, the segmentation results obtained by the proposed method revealed a strong agreement with the biopsy results and anatomical images, providing support for the accuracy and robustness of the proposed feature space and the segmentation procedure.

关键词： Neoplasms image segmentation Diffusion tensor imaging Clustering algorithms Biopsy Permeability measurement Volume measurement Size measurement Biomembranes Magnetic resonance imaging

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LANDING AN UNMANNED AIR VEHICLE: VISION BASED MOTION ESTIMATION AND NONLINEAR CONTROL

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Asian Journal of Control 2008年第3期1卷

作者： Omid Shakernia Yi Ma T. John Koo Shankar Sastry Dept. of Electrical Engineering & Computer Science University of California at Berkeley Berkeley CA94720-1774 U.S.A. Tak-Kuen John Koo received the B.Eng. degree in 1992 in Electronic Engineering and the M.Phil. in 1994 in Information Engineering both from the Chinese University of Hong Kong. From 1994 to 1995 he was a graduate student in Signal and Image Processing Institute at the University of Southern California. He is currently a Ph.D. Candidate in Electrical Engineering and Computer Sciences at the University of California at Berkeley. His research interests include nonlinear control theory hybrid systems inertial navigation systems with applications to unmanned aerial vehicles. He received the Distinguished M.Phil. Thesis Award of the Faculty of Engineering The Chinese University of Hong Kong in 1994. He was a consultant of SRI International in 1998. Currently he is the team leader of the Berkeley AeRobot Team and a delegate of The Graduate Assembly University of California at Berkeley. He is a student member of IEEE and SIAM. S. Shankar Sastry received his Ph.D. degree in 1981 from the University of California Berkeley. He was on the faculty of MIT from 1980-82 and Harvard University as a Gordon McKay professor in 1994. He is currently a Professor of Electrical Engineering and Computer Sciences and Bioengineering and Director of the Electronics Research Laboratory at Berkeley. He has held visiting appointments at the Australian National University Canberra the University of Rome Scuola Normale and University of Pisa the CNRS laboratory LAAS in Toulouse (poste rouge) and as a Vinton Hayes Visiting fellow at the Center for Intelligent Control Systems at MIT. His areas of research are nonlinear and adaptive control robotic telesurgery control of hybrid systems and biological motor control. He is a coauthor (with M. Bodson) of “Adaptive Control: Stability Convergence and Robustness Prentice Hall 1989.” and (with R. Murray and Z. Li) of “A Mathematical Introduction to Robotic Manipulati

In this paper, we use computer vision as a feedback sensor in a control loop for landing an unmanned air vehicle (UAV) on a landing pad. The vision problem we address here is then a special case of the classic ego-motion estimation problem since all feature points lie on a planar surface (the landing pad). We study together the discrete and differential versions of the ego-motion estimation, in order to obtain both position and velocity of the UAV relative to the landing pad. After briefly reviewing existing algorithm for the discrete case, we present, in a unified geometric framework, a new estimation scheme for solving the differential case. We further show how the obtained algorithms enable the vision sensor to be placed in the feedback loop as a state observer for landing control. These algorithms are linear, numerically robust, and computationally inexpensive hence suitable for real-time implementation. We present a thorough performance evaluation of the motion estimation algorithms under varying levels of image measurement noise, altitudes of the camera above the landing pad, and different camera motions relative to the landing pad. A landing controller is then designed for a full dynamic model of the UAV. Using geometric nonlinear control theory, the dynamics of the UAV are decoupled into an inner system and outer system. The proposed control scheme is then based on the differential flatness of the outer system. For the overall closed-loop system, conditions are provided under which exponential stability can be guaranteed. In the closed-loop system, the controller is tightly coupled with the vision based state estimation and the only auxiliary sensor are accelerometers for measuring acceleration of the UAV. Finally, we show through simulation results that the designed vision-in-the-loop controller generates stable landing maneuvers even for large levels of image measurement noise. Experiments on a real UAV will be presented in future work.

关键词： Motion estimation computer vision based control unmanned air vehicle differential flatness

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Spatially Adaptive Kernels for Adaptive Spatial Filtering of fMRI Data

Spatially Adaptive Kernels for Adaptive Spatial Filtering of...

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International Joint Conference on Neural Networks (IJCNN)

作者： V. Taimouri G.-A. Hossein-Zadeh H. Soltanian-Zadeh Control and Intelligent Processing Centre of Excellence ECE Department Faculty of Engineering University of Tehran Tehran Iran School of Cognitive Sciences Institute of Studies in Theoretical Physics and Mathematics and Medical Image Analysis Laboratory Henry Ford Health System Detroit MI USA

Making use of neighborhood time series is an effective way of noise reduction in fMRI data. However the conventional averaging methods blur activated areas. In this paper, a filter with adaptive kernel is designed such that its kernel size and direction are defined at each voxel. First, for finding the optimum size of kernel, a linear combination of some isotropic Gaussian filters with different variances is used, and optimum value of variance is specified. Then, the appropriate kernel direction is determined by a linear combination of some anisotropic basic filters with various directions. The weights of these linear combinations can be calculated by using the restricted canonical correlation method. The proposed method is compared with a similar method based on the steerable filters and the results show that the proposed method improves the ROC curve and prohibits false spread of the activation areas.

关键词： Kernel Adaptive filters Filtering Nonlinear filters Anisotropic magnetoresistance Magnetic separation Process control intelligent control Correlation Magnetic resonance imaging

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Rule-based decision-making framework for knowledge-based anatomical landmark localization (K-BALL)

Rule-based decision-making framework for knowledge-based ana...

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IEEE International Symposium on Biomedical Imaging

作者： M.-R. Siadat H. Soltanian-Zadeh K. Elisevich Henry Ford Health System Radiology Image Analysis Laboratory Detroit MI USA Control and Intelligent Processing Center of Excellence Department of Electrical and Computer Engineering University of Tehran Tehran Iran Department of Neurosurgery Henry Ford Health System Detroit MI USA

K-BALL is a general method for localization of anatomical phenomena of the same origin with natural discrepancies distributed over a reference space, e.g., human brain anatomical structures. In this paper, we focus on information analysis step (2nd step) of K-BALL during which landmarks extracted in its first step are evaluated. We provide a framework in which rules are automatically generated based on estimated and derived models. We show that the rules based on the derived models can improve the overall success rate of K-BALL. Each rule evaluates the extracted points by producing an intermediate confidence factor (ICNF). A total confidence factor is calculated using ICNF's to facilitate the acceptance or rejection of a set of points as landmarks of interest. Using the rules merely based on the estimated models, simulation study produced an overall success rate of 91.8%. Using the rules based on both of the estimated and derived models, this rate increased to 92.5%

关键词： Decision making Hippocampus Information analysis Data mining Humans Radiology image analysis Radio control Process control Control systems

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High SNR flexible top hat monopole probe for 1.5 T MRI

High SNR flexible top hat monopole probe for 1.5 T MRI

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作者： Mohammadzadeh, M. Shahabadi, M. Soltanian-Zadeh, H. Tavakoli, A. Rafiei, B. Javidnia, D. Oghabian, M.A. Department of Physics Amir-Kabir University of Technology Tehran Iran School of Electrical and Computer Engineering University of Tehran Tehran Iran Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran Image Analysis Laboratory Department of Radiology Henry Ford Health System Detroit MI United States Department of Electrical Engineering Amir-Kabir University of Technology Tehran Iran Medical Imaging Center Imam Khomeyni Hospital Tehran Iran Research Center for Science and Technology in Medicine Tehran University of Medical Sciences Tehran Iran

In this paper, design principles and application of a thin and flexible intravascular top hat monopole probe with increased signal-to-noise ratio (SNR) and improved longitudinal and radial coverage are described and compared with the conventional monopole probe. The top hat probe is constructed by removing a segment of the shield of a coaxial cable. A flexible thin copper foil in contact with the inner conductor of the cable is added to the end section of the cable. The copper foil acts as an antenna top hat load increasing the uniformity of the current distribution on the probe and establishes a uniform region of SNR distribution around the probe. Improvement of the SNR distribution of the top hat probe relative to the conventional monopole probe is evaluated using quantitative indices. Experimental results show that for the top hat probe, the ratio of the maximum image SNR to its relative standard deviation (SR) is 2.73 times higher than that of a conventional probe. © 2006 IOP Publishing Ltd.

关键词： Medical imaging

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Hippocampus Volume and Texture analysis for Temporal Lobe Epilepsy

Hippocampus Volume and Texture Analysis for Temporal Lobe Ep...

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IEEE International Conference on Electro-Information Technology

作者： Kourosh Jafari-Khouzani Hamid Soltanian-Zadeh Kost Elisevich Henry Ford Health System Radiology Image Analysis Laboratory Detroit MI USA Department of Computer Science Wayne State University Detroit MI USA Control and Intelligent Processing Center of Excellence ECE Department University of Tehran Tehran Iran Neurosurgery Department Henry Ford Health System Detroit MI USA

It has been previously shown that intensity and volume features of the hippocampus from MR images of the brain are useful in detecting the abnormality and consequently candidacy of the hippocampus for temporal lobe epilepsy (TLE) surgery. In this paper, we have studied and compared volume and texture features of hippocampus for TLE lateralization. Volume and some features describing the intensity non-uniformities are used. We use manual segmentation of the hippocampi from T1 weighted images and map them to the FLAIR images. Wavelet features as well as mean and variance of the hippocampus intensities of the FLAIR slices are used as texture features. A dataset of 55 patients with 28 right and 27 left abnormal sides was used in the experiments. Experimental results show that the volume and intensity features are useful in determining the abnormal side

关键词： Hippocampus Temporal lobe Epilepsy image texture analysis image segmentation image analysis Shape Surgery Wavelet packets Radiology

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