Based on nonlinear finite element method (FEM), the effect of back berm has been systematically studied. It is found that the lateral displacement of embankment could be reduced by back berm effectively, and the stabi...
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Based on nonlinear finite element method, the deformation and stability of embankment influenced by surcharge preloading is analyzed. It is shown that the location of the maximal lateral displacement of embankment is ...
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Introduction: With the range of educational tools available it is now realistic for learner models to take account of broader information, and there are strong arguments for placing open learner models in the centre o...
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A particle swarm optimization (PSO)-based automatic system to determine the number of optimal band sets and corresponding bands is proposed. A simple searching criterion function, called minimum estimated abundance co...
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On-line portfolio selection has been attracting increasing interests from artificial intelligence community in recent decades. Mean reversion, as one most frequent pattern in financial markets, plays an important role...
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ISBN:
(纸本)9781577356332
On-line portfolio selection has been attracting increasing interests from artificial intelligence community in recent decades. Mean reversion, as one most frequent pattern in financial markets, plays an important role in some state-of-the-art strategies. Though successful in certain datasets, existing mean reversion strategies do not fully consider noises and outliers in the data, leading to estimation error and thus non-optimal portfolios, which results in poor performance in practice. To overcome the limitation, we propose to exploit the reversion phenomenon by robust L1-median estimator, and design a novel on-line portfolio selection strategy named "Robust Median Reversion" (RMR), which makes optimal portfolios based on the improved reversion estimation. Empirical results on various real markets show that RMR can overcome the drawbacks of existing mean reversion algorithms and achieve significantly better results. Finally, RMR runs in linear time, and thus is suitable for large-scale trading applications.
Neural network language models, or continuous-space language models (CSLMs), have been shown to improve the performance of statistical machine translation (SMT) when they are used for reranking n-best translations. Ho...
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Random walks constitute a fundamental mechanism for a large set of dynamics taking place on networks. In this article, we study random walks on weighted networks with an arbitrary degree distribution, where the weight...
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Random walks constitute a fundamental mechanism for a large set of dynamics taking place on networks. In this article, we study random walks on weighted networks with an arbitrary degree distribution, where the weight of an edge between two nodes has a tunable parameter. By using the spectral graph theory, we derive analytical expressions for the stationary distribution, mean first-passage time (MFPT), average trapping time (ATT), and lower bound of the ATT, which is defined as the average MFPT to a given node over every starting point chosen from the stationary distribution. All these results depend on the weight parameter, indicating a significant role of network weights on random walks. For the case of uncorrelated networks, we provide explicit formulas for the stationary distribution as well as ATT. Particularly, for uncorrelated scale-free networks, when the target is placed on a node with the highest degree, we show that ATT can display various scalings of network size, depending also on the same parameter. Our findings could pave a way to delicately controlling random-walk dynamics on complex networks.
Aim:φC31 integrase mediates site-specific recombination between two short sequences, attP and attB, in phage and bacterial genomes, which is a promising tool in gene regulation-based therapy since the zinc finger str...
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Aim:φC31 integrase mediates site-specific recombination between two short sequences, attP and attB, in phage and bacterial genomes, which is a promising tool in gene regulation-based therapy since the zinc finger structure is probably the DNA recognizing domain that can further be engineered. The aim of this study was to screen potential pseudo att sites of (I)C31 integrase in the human genome, and evaluate the risks of its application in human gene therapy. Methods: TFBS (transcription factor binding sites) were found on the basis of reported pseudo att sites using multiple motif-finding tools, including AlignACE, BioProspector, Consensus, MEME, and Weeder. The human genome with the proposed motif was scanned to find the potential pseudo att sites ofφC31 integrase. Results: The possible recognition motif ofφC31 integrase was identified, which was composed of two co-occurrence conserved elements that were reverse complement to each other flanking the core sequence TTG. In the human genome, a total of 27924 potential pseudo att sites ofφC31 integrase were found, which were distributed in each human chromosome with high-risk specificity values in the chromosomes 16, 17, and 19. When the risks of the sites were evaluate more rigorously, 53hits were discovered, and some of them were just the vital functional genes or regulatory regions, such as ACYP2, AKR1B1, DUSP4, etc. Conclusion: The results provide clues for more comprehensive evaluation of the risks of usingφC31 integrase in human gene therapy and for drug discovery.
Existing information retrieval approaches provide only limited capabilities to capture the query ***,a complete understanding of search requirements is essential for improving the effectiveness of retrieval in the eme...
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Existing information retrieval approaches provide only limited capabilities to capture the query ***,a complete understanding of search requirements is essential for improving the effectiveness of retrieval in the emergency management *** achieve this goal,we proposed a novel emergency cross-media information retrieval model,which includes four parts: information collection,information indexing,information retrieval and intelligent mobile *** proposed model has two *** is to use ontology technique to identify appropriate semantic information according to query words. The other is to use image semantic analysis based on SIFT to achieve the task of emergency image *** experiments show that our model obtained encouraging performance results.
Rocchio's relevance feedback model is a classic query expansion method and it has been shown to be effective in boosting information retrieval performance. The selection of expansion terms in this method, however,...
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