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Multi-omics graph convolutional networks for digestive system tumour classification and early-late stage diagnosis

CAAI Transactions on Intelligence Technology 2024年第6期9卷 1572-1586页

作者： Lin Zhou Zhengzhi Zhu Hongbo Gao Chunyu Wang Muhammad Attique Khan Mati Ullah Siffat Ullah Khan School of Information Science and Technology University of Science and Technology of ChinaHefeiAnhuiChina Anhui Engineering Research Center on Information Fusion and Control of Intelligent Robot WuhuAnhuiChina Department of Breast Center West District of The Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina Institute of Advanced Technology University of Science and Technology of ChinaHefeiAnhuiChina School of Electrical and Electronic Engineering Nanyang Technological UniversitySingaporeSingapore School of Biological and Environmental Engineering Chaohu UniversityChaohu Regional Collaborative Technology Service Center for Rural RevitalizationHefeiChina Department of Artificial Intelligence College of Computer Engineering and SciencePrince Mohammad Bin Fahd UniversityAl-KhobarSaudi Arabia School of Automation Northwestern Polytechnical UniversityXi'anShaanxiChina Institute of Engineering and Computing Science University of Science and Technology of BannuKPKBannuPakistan

The prevalence of digestive system tumours(DST)poses a significant challenge in the global crusade against *** neoplasms constitute 20%of all documented cancer diagnoses and contribute to 22.5%of cancer-related *** accurate diagnosis of DST is paramount for vigilant patient monitoring and the judicious selection of optimal *** this challenge,the authors introduce a novel methodology,denominated as the Multi-omics Graph Transformer Convolutional Network(MGTCN).This innovative approach aims to discern various DST tumour types and proficiently discern between early-late stage tumours,ensuring a high degree of *** MGTCN model incorporates the Graph Transformer Layer framework to meticulously transform the multi-omics adjacency matrix,thereby illuminating potential associations among diverse samples.A rigorous experimental evaluation was undertaken on the DST dataset from The Cancer Genome Atlas to scrutinise the efficacy of the MGTCN *** outcomes unequivocally underscore the efficiency and precision of MGTCN in diagnosing diverse DST tumour types and successfully discriminating between early-late stage DST *** source code for this groundbreaking study is readily accessible for download at https://***/bigone1/MGTCN.

关键词： digestive system tumors early-late stage multi-omics tumor types

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Anomaly-Resistant Decentralized State Estimation Under Minimum Error Entropy With Fiducial Points for Wide-Area Power Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 74-87页

作者： Bogang Qu Zidong Wang Bo Shen Hongli Dong Hongjian Liu the College of Automation Engineering Shanghai University of Electric PowerShanghai 200090China IEEE the Department of Computer Science Brunel University LondonUxbridgeMiddiesex UB83PHUK the College of Information Science and Technology Donghua UniversityShanghai 200051 the Engineering Research Center of Digitalized Textile and Fashion Technology Ministry of EducationShanghai 201620China the Artificial Intelligence Energy Research Institute Northeast Petroleum UniversityDaqing 163318 the Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Northeast PetroleumDaqing 163318 the Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572024China the Key Laboratory of Advanced Perception and Intelligent Control of High-End Equipment Ministry of EducationAnhui Polytechnic UniversityWuhu 2410000 the School of Mathematics and Physics Anhui Polytechnic UniversityWuhu 241000China

This paper investigates the anomaly-resistant decentralized state estimation(SE) problem for a class of wide-area power systems which are divided into several non-overlapping areas connected through transmission lines. Two classes of measurements(i.e., local measurements and edge measurements) are obtained, respectively, from the individual area and the transmission lines. A decentralized state estimator, whose performance is resistant against measurement with anomalies, is designed based on the minimum error entropy with fiducial points(MEEF) criterion. Specifically, 1) An augmented model, which incorporates the local prediction and local measurement, is developed by resorting to the unscented transformation approach and the statistical linearization approach;2) Using the augmented model, an MEEF-based cost function is designed that reflects the local prediction errors of the state and the measurement;and 3) The local estimate is first obtained by minimizing the MEEF-based cost function through a fixed-point iteration and then updated by using the edge measuring information. Finally, simulation experiments with three scenarios are carried out on the IEEE 14-bus system to illustrate the validity of the proposed anomaly-resistant decentralized SE scheme.

关键词： Decentralized state estimation(SE) measurements with anomalies minimum error entropy unscented Kalman filter wide-area power systems

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MEFA-Net: A mask enhanced feature aggregation network for polyp segmentation

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computers in Biology and Medicine 2025年 186卷 109601-109601页

作者： Ke, Xiao Chen, Guanhong Liu, Hao Guo, Wenzhong Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing College of Computer and Data Science Fuzhou University Fuzhou350116 China Engineering Research Center of Big Data Intelligence Ministry of Education Fuzhou350116 China

Accurate polyp segmentation is crucial for early diagnosis and treatment of colorectal cancer. This is a challenging task for three main reasons: (i) the problem of model overfitting and weak generalization due to the multi-center distribution of data;(ii) the problem of interclass ambiguity caused by motion blur and overexposure to endoscopic light;and (iii) the problem of intraclass inconsistency caused by the variety of morphologies and sizes of the same type of polyps. To address these challenges, we propose a new high-precision polyp segmentation framework, MEFA-Net, which consists of three modules, including the plug-and-play Mask Enhancement Module (MEG), Separable Path Attention Enhancement Module (SPAE), and Dynamic Global Attention Pool Module (DGAP). Specifically, firstly, the MEG module regionally masks the high-energy regions of the environment and polyps through a mask, which guides the model to rely on only a small amount of information to distinguish between polyps and background features, avoiding the model from overfitting the environmental information, and improving the robustness of the model. At the same time, this module can effectively counteract the "dark corner phenomenon" in the dataset and further improve the generalization performance of the model. Next, the SPAE module can effectively alleviate the inter-class fuzzy problem by strengthening the feature expression. Then, the DGAP module solves the intra-class inconsistency problem by extracting the invariance of scale, shape and position. Finally, we propose a new evaluation metric, MultiColoScore, for comprehensively evaluating the segmentation performance of the model on five datasets with different domains. We evaluated the new method quantitatively and qualitatively on five datasets using four metrics. Experimental results show that MEFA-Net significantly improves the accuracy of polyp segmentation and outperforms current state-of-the-art algorithms. Code posted on https://***/

关键词： Endoscopy

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Identification of Key Genes as Potential Drug Targets for Gastric Cancer

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Tsinghua science and Technology 2023年第4期28卷 649-664页

作者： Md.Tofazzal Hossain Md.Selim Reza Yin Peng Shengzhong Feng Yanjie Wei Center for High Performance Computing Joint Engineering Research Center for Health Big Data Intelligent Analysis TechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Computer Science and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Statistics Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityGopalganj 8100Bangladesh Guangdong Provincial Key Laboratory for Genome Stability and Disease Prevention and Regional Immunity and Diseases Department of PathologyShenzhen UniversityShenzhen 518060China

Gastric cancer(GC)is one of the most common cancers and ranks the third in cancer mortality all over the *** goal of this study was to identify potential hub-genes,highlighting their functions,signaling pathways,and candidate drugs for the treatment of GC *** used publicly available next generation sequencing(NGS)data to identify differentially expressed(DE)*** top DE genes were mapped to STRING database to construct the protein-protein interaction(PPI)network and top hub genes were selected for further *** found a total of 1555 DE genes with 870 upregulated and 685 downregulated genes in *** selected the top 400(200 upregulated and 200 downregulated)genes to construct a PPI network and extracted the top 15 hub *** gene ontology(GO)term and kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analyses of the 15 hub genes exposed some important functions and signaling pathways that were significantly associated with GC *** survival analysis of the hub genes disclosed that the lower expressions of the three hub genes CDH2,COL4A1,and COL5A2 were associated with better survival of GC *** three genes might be the candidate biomarkers for the diagnosis and treatment of ***,we considered 3 key proteins(genomic biomarkers)(COL4A1,CDH2,and CO5A2)as the drug target proteins(receptors),performed their docking analysis with the 102 meta-drug agents,and found Everolimus,Docetaxel,Lanreotide,Venetoclax,Temsirolimus,and Nilotinib as the top ranked 6 candidate drugs with respect to our proposed target proteins for the treatment against GC ***,the proposed drugs might play vital role for the treatment against GC patients.

关键词： gastric cancer hub genes candidate genes molecular docking candidate drugs

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Medical CT Image Super-resolution Algorithm based on GAN

Medical CT Image Super-resolution Algorithm based on GAN

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computer, Vision and intelligent Technology (ICCVIT), International Conference on

作者： Saihu Tian Taile Peng Zhongan Wang Zhengfeng Li School of Computer Science and Technology Anhui Engineering Research Center for Intelligent Computing and Application on Cognitive Behavior Huaibei Normal University Huaibei China

ISBN: (数字)9798331540043

ISBN: (纸本)9798331540050

Computed Tomography (CT) images are essential for visualizing the internal structures of the human body and are widely applied in the diagnosis of various diseases. However, during the processes of generating, storing, and transmitting medical CT images, the clarity of these images can be degraded by non-human factors, resulting in issues such as reduced resolution and blurred texture details, thereby compromising image fidelity. In this study, we present an approach utilizing Generative Adversarial Networks (GANs). that incorporates a grayscale value loss as an additional constraint while maintaining the original loss function constraints. We conduct experiments for 4x super-resolution reconstruction. To evaluate the reconstruction performance, we compare the Peak Signal-to-Noise Ratio (PSNR) and the Structural Similarity Index (SSIM) of the reconstructed images. The experimental results demonstrate ,which the proposed method exhibits promising performance in both quantitative metrics and visual quality.

关键词： Visualization PSNR Computed tomography Computational modeling Superresolution Noise Gray-scale Generative adversarial networks Image reconstruction Medical diagnostic imaging

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Digital Twin Ancient Architecture: The Exploration of the Digital Protection of Ancient Architecture

Digital Twin Ancient Architecture: The Exploration of the Di...

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作者： Li, Shanglin Lin, Anping School of Computer Science and Artificial Intelligence Xiangnan University Hunan Chenzhou423000 China Hunan Engineering Research Center of Advanced Embedded Computing and Intelligent Medical Systems Hunan Chenzhou China School of Physics and Electronic Electrical Engineering Xiangnan University Hunan Chenzhou China

The digital protection of ancient architectures has achieved important achievements. However, technology development has encountered a bottleneck. The main problem is that the digitization of ancient buildings is limited to building static and isolated three-dimensional models, which cannot meet the increasing professional requirements of digital protection. To solve the above problems, the concept of digital twin ancient architecture (DTAA) is proposed, focusing on the high-dimensional data integration method of the DTAA, as well as the construction method and technical route. Finally, the development and application of digital twin ancient architecture are discussed. The proposed method can bring new ideas to the field of digital protection of ancient architectures. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： 3D modeling

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Analysis of Labanotation generation based on motion capture data 5

Analysis of Labanotation generation based on motion capture ...

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5th International Conference on Artificial Intelligence and computer science, AICS 2023

作者： Chen, Boran Wang, Jiaji Miao, Zhenjiang Li, Jianpo Yang, Shengchun Jilin Electric Power Big Data Intelligent Processing Engineering Technology Research Center School of Computing Northeast Electric Power University Jilin Jilin132012 China Institute of Information Science School of Computer and Information Technology Beijing Jiaotong University Beijing100044 China

ISBN: (纸本)9781510668621

Labanotation is an approach to record human movement with different distributions in space that have different representations of symbols. Motion capture is a technique that records the trajectory of an object in the time domain by tracking the motion of key points, observed using different sensors, and recorded in files. This paper is to manually mark the Labanotation based on 3D human motion capture data, to divide the 3D human motion into gaits and poses, and to record and represent different human movements and positions in space in the notation. This is an exploration of motion capture data to generate Labanotation, while also contributing to the preservation of folk-art forms. © 2023 SPIE.

关键词： Time domain analysis

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GTMGC: USING GRAPH TRANSFORMER TO PREDICT MOLECULE'S GROUND-STATE CONFORMATION 12

GTMGC: USING GRAPH TRANSFORMER TO PREDICT MOLECULE'S GROUND-...

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12th International Conference on Learning Representations, ICLR 2024

作者： Xu, Guikun Jiang, Yongquan Lei, Pengchuan Yang, Yan Chen, Jim X. School of Computing and Aritifical Intelligence Southwest Jiaotong University Chengdu China Institute of Aritifical Intelligence Southwest Jiaotong University Chengdu China Engineering Research Center of Sustainable Urban Intelligent Transportation Ministry of Education China Department of Computer Science George Mason University FairfaxVA United States

The ground-state conformation of a molecule is often decisive for its properties. However, experimental or computational methods, such as density functional theory (DFT), are time-consuming and labor-intensive for obtaining this conformation. Deep learning (DL) based molecular representation learning (MRL) has made significant advancements in molecular modeling and has achieved remarkable results in various tasks. Consequently, it has emerged as a promising approach for directly predicting the ground-state conformation of molecules. In this regard, we introduce GTMGC, a novel network based on Graph-Transformer (GT) that seamlessly predicts the spatial configuration of molecules in a 3D space from their 2D topological architecture in an end-to-end manner. Moreover, we propose a novel self-attention mechanism called Molecule Structural Residual Self-Attention (MSRSA) for molecular structure modeling. This mechanism not only guarantees high model performance and easy implementation but also lends itself well to other molecular modeling tasks. Our method has been evaluated on the Molecule3D benchmark dataset and the QM9 dataset. Experimental results demonstrate that our approach achieves remarkable performance and outperforms current state-of-the-art methods as well as the widely used open-source software RDkit. © 2024 12th International Conference on Learning Representations, ICLR 2024. All rights reserved.

关键词： Molecules

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A Distributed Framework for Large-scale Protein-protein Interaction Data Analysis and Prediction Using MapReduce

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IEEE/CAA Journal of Automatica Sinica 2022年第1期9卷 160-172页

作者： Lun Hu Shicheng Yang Xin Luo Huaqiang Yuan Khaled Sedraoui MengChu Zhou School of Computer Science and Technology Dongguan University of TechnologyDongguan 523808China School of Computer Science and Technology Wuhan University of TechnologyWuhan 430070China Chongqing Engineering Research Center of Big Data Application for Smart Cities and Chongqing Key Laboratory of Big Data and Intelligent ComputingChongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of SciencesUrumqi 830000China Center of Research Excellence in Renewable Energy and Power Systems and the Department of Electrical and Computer EngineeringFaculty of EngineeringKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Electrical and Computer Engineering New Jersey Institute of TechnologyNewarkNJ 07102 USA

Protein-protein interactions are of great significance for human to understand the functional mechanisms of *** the rapid development of high-throughput genomic technologies,massive protein-protein interaction(PPI)data have been generated,making it very difficult to analyze them *** address this problem,this paper presents a distributed framework by reimplementing one of state-of-the-art algorithms,i.e.,CoFex,using *** do so,an in-depth analysis of its limitations is conducted from the perspectives of efficiency and memory consumption when applying it for large-scale PPI data analysis and *** solutions are then devised to overcome these *** particular,we adopt a novel tree-based data structure to reduce the heavy memory consumption caused by the huge sequence information of *** that,its procedure is modified by following the MapReduce framework to take the prediction task distributively.A series of extensive experiments have been conducted to evaluate the performance of our framework in terms of both efficiency and *** results well demonstrate that the proposed framework can considerably improve its computational efficiency by more than two orders of magnitude while retaining the same high accuracy.

关键词： Distributed computing large-scale prediction machine learning MapReduce protein-protein interaction(PPI)

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A Provably Secure and Lightweight Access Control Protocol for EI-Based Vehicle to Grid Environment

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IEEE Internet of Things Journal 2023年第18期10卷 16650-16657页

作者： Shamshad, Salman Mahmood, Khalid Shamshad, Usman Hussain, Ibrar Hussain, Shafiq Das, Ashok Kumar The University of Lahore Department of Software Engineering Lahore54590 Pakistan National Yunlin University of Science and Technology Graduate School of Intelligent Data Science Douliu64002 Taiwan Riphah International University Riphah School of Computing and Innovation Lahore54000 Pakistan University of Sahiwal Department of Computer Science Sahiwal57000 Pakistan International Institute of Information Technology Hyderabad Center for Security Theory and Algorithmic Research Hyderabad500032 India Old Dominion University Virginia Modeling Analysis and Simulation Center SuffolkVA23435 United States

The energy Internet (EI) presents a novel paradigm for renewable energy distribution that utilizes communication and computing technologies to revolutionize the conventional intelligent transportation systems (ITSs) and power grid into a structure that provides assistance to open innovation. The EI offers sustainable and bidirectional transmission for the improvement and analysis of energy convention among electric vehicles (EVs) and service providers. To ensure efficient, reliable, and secure operation, EI must be safe from security attacks. Therefore, efficient and secure key negotiation is a significant issue for the EI-based Vehicle-to-Grid (V2G) architecture. Thus, to ensure the system's security, we have devised a robust scheme to facilitate a secure key agreement between the entities involved for the secure and efficient renewable energy distribution for the EI-based energy vehicles in V2G. The devised scheme's robustness is solicited through the widely accepted formal random or real (RoR) model. In addition, the informal security analysis is conducted on the devised scheme, which is evident that the designed scheme achieves all the required security features of EI-based ITS. Moreover, the performance evaluation results endorse that the designed scheme achieves the desired security and minimizes the communication, computation, and energy overhead by 29.33%, 27.94%, and 28.08% in comparison to the existing competitive schemes. © 2014 IEEE.

关键词： Vehicle-to-grid

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