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BioBankWarden: A web-based system to support translational cancer research by managing clinical and biomaterial data

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COMPUTERS IN BIOLOGY AND MEDICINE 2017年 84卷 254-261页

作者： Ferretti, Yuri Brandao Miyoshi, Newton Shydeo Silva, Wilson Araujo, Jr. Felipe, Joaquim Cezar [a] Inter-institutional Post-graduation Program on Bioinformatics University of São Paulo Brazil[b] Department of Computing and Mathematics Faculty of Philosophy Sciences and Languages of Ribeirão Preto University of São Paulo Brazil[c] Center for Integrative Systems Biology - CISBi NAP/USP University of São Paulo Brazil[d] Department of Genetics School of Medicine of Ribeirão Preto University of São Paulo Brazil

Background: Researchers of translational medicine face numerous challenges in attempting to bring research results to the bedside. This field of research covers a wide range of resources, including blood and tissue samples, which are processed for isolation of RNA and DNA to study cancer omics data (genomics, proteomics and metabolomics). Clinical information about patients' habits, family history, physical examinations, remissions, etc., is also important to underpin studies aimed at identifying patterns that lead to the development of cancer and to its successful treatment. Purpose: Development of a web-based computer system-BioBankWarden-to manage, consolidate and integrate these diversified data, enabling cancer research groups to retrieve and analyze clinical and biomolecular data within an integrative environment. The system has a three-tier architecture comprising database, logic and user-interface layers. Results: The system's integrated database and user-friendly interface allow for the control of patient records, biomaterial storage, research groups, research projects, users and biomaterial exchange. Conclusions: BioBankWarden can be used to store and retrieve specific information from different clinical fields linked to biomaterials collected from patients, providing the functionalities required to support translational research in the field of cancer. (C) 2015 Elsevier Ltd. All rights reserved.

关键词： Translational medicine Biological databases Oncogenomics Biomaterial management Clinical data management

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