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检索条件"机构=Interdepartmental Graduate Program in Bioinformatics and Computational Biology"
176 条 记 录,以下是41-50 订阅
排序:
Virtual Flavonoids Screening Identifies Potent Compounds Against Enterovirus A71 and Coxsackievirus A16
SSRN
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SSRN 2023年
作者: Sripattarphan, Amita Sanachai, Kamonpan Chavasiri, Warinthorn Wolschann, Peter Langer, Thierry Boonyasuppayakorn, Siwaporn Rungrotmongkol, Thanyada Center of Excellence in Structural and Computational Biology Department of Biochemistry Faculty of Science Chulalongkorn University Bangkok10330 Thailand Department of Biochemistry Faculty of Science Khon Kaen University Khon Kaen40002 Thailand Center of Excellence in Natural Products Chemistry Department of Chemistry Faculty of Science Chulalongkorn University Bangkok10330 Thailand Department of Pharmaceutical Chemistry Faculty of Life Sciences University of Vienna Althanstraße 14 ViennaA-1090 Austria Institute of Theoretical Chemistry University of Vienna Vienna1090 Austria Center of Excellence in Applied Medical Virology Department of Microbiology Faculty of Medicine Chulalongkorn University Bangkok10330 Thailand Program in Bioinformatics and Computational Biology Graduate School Chulalongkorn University Bangkok10330 Thailand
Worldwide outbreaks of hand, foot, and mouth disease (HFMD) are caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Since no anti-HFMD drugs are currently available, it is interesting to study potentia... 详细信息
来源: 评论
AI solutions for drafting in Magic: The gathering
arXiv
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arXiv 2020年
作者: Ward, Henry N. Brooks, Daniel J. Troha, Dan Mills, Bobby Khakhalin, Arseny S. Bioinformatics and Computational Biology Graduate Program University of Minnesota MinneapolisMN United States *** San DiegoCA United States Biology Program Bard College Annandale-on-HudsonNY United States
Drafting in Magic the Gathering is a sub-game within a larger trading card game, where several players progressively build decks by picking cards from a common pool. Drafting poses an interesting problem for game and ... 详细信息
来源: 评论
Tessellated granular metamaterials with tunable elastic moduli
arXiv
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arXiv 2023年
作者: Pashine, Nidhi Wang, Dong Zhang, Jerry Patiballa, Sree Kalyan Witthaus, Sven Shattuck, Mark D. O’Hern, Corey S. Kramer-Bottiglio, Rebecca Department of Mechanical Engineering & Materials Science Yale University New HavenCT06520 United States Department of Physics Yale University New HavenCT06520 United States Department of Applied Physics Yale University New HavenCT06520 United States Graduate Program in Computational Biology & Bioinformatics Yale University New HavenCT06520 United States Benjamin Levich Institute Physics Department The City College of the City University of New York New YorkNY10031 United States
Most granular packings possess shear moduli (G) that increase with the applied external pressure, and bulk moduli (B) that increase or remain constant with pressure. This paper presents "tessellated" granula... 详细信息
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Local two-sample testing over graphs and point-clouds by random-walk distributions
arXiv
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arXiv 2020年
作者: Landa, Boris Qu, Rihao Chang, Joseph Kluger, Yuval Program in Applied Mathematics Yale University Department of Pathology Yale University School of Medicine Department of Statistics and Data Science Yale University Interdepartmental Program in Computational Biology and Bioinformatics Yale University Department of Immunology Yale School of Medicine
Rejecting the null hypothesis in two-sample testing is a fundamental tool for scientific discovery. Yet, aside from concluding that two samples do not come from the same probability distribution, it is often of intere... 详细信息
来源: 评论
Spectral Top-Down Recovery of Latent Tree Models
arXiv
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arXiv 2021年
作者: Aizenbud, Yariv Jaffe, Ariel Wang, Meng Hu, Amber Amsel, Noah Nadler, Boaz Chang, Joseph T. Kluger, Yuval Program in Applied Mathematics Yale University New HavenCT06511 United States Department of Computer Science Weizmann Institute of Science Rehovot76100 Israel Department of Statistics Yale University New HavenCT06520 United States Interdepartmental Program in Computational Biology and Bioinformatics Yale University New HavenCT06511 United States Department of Pathology Yale University New HavenCT06511 United States
Modeling the distribution of high dimensional data by a latent tree graphical model is a prevalent approach in multiple scientific domains. A common task is to infer the underlying tree structure, given only observati... 详细信息
来源: 评论
Local and global measures of the shear moduli of jammed disk packings
arXiv
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arXiv 2023年
作者: Zhang, Shiyun Jin, Weiwei Wang, Dong Xu, Ding Zhang, Jerry Shattuck, Mark D. O’Hern, Corey S. Department of Physics University of Science and Technology of China Anhui Hefei230026 China Department of Mechanical Engineering and Materials Science Yale University New HavenCT06520 United States Benjamin Levich Institute and Physics Department The City College of New York New YorkNY10031 United States Department of Physics Yale University New HavenCT06520 United States Department of Applied Physics Yale University New HavenCT06520 United States Graduate Program in Computational Biology and Bioinformatics Yale University New HavenCT06520 United States
Strain-controlled isotropic compression gives rise to jammed packings of repulsive, frictionless disks with either positive or negative global shear moduli. We carry out computational studies to understand the contrib... 详细信息
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Buparlisib and ponatinib inhibit aggressiveness of cholangiocarcinoma cells via suppression of IRS1-related pathway by targeting oxidative stress resistance
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Biomedicine and Pharmacotherapy 2024年 180卷 117569-117569页
作者: Kaewlert, Waleeporn Sakonsinsiri, Chadamas Lert-itthiporn, Worachart Mahalapbutr, Panupong Ali, Saba Rungrotmongkol, Thanyada Jusakul, Apinya Armartmuntree, Napat Pairojkul, Chawalit Feng, Guofei Ma, Ning Pinlaor, Somchai Murata, Mariko Thanan, Raynoo Department of Biochemistry Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Cholangiocarcinoma Research Institute Khon Kaen University Khon Kaen 40002 Thailand Center of Excellence in Structural and Computational Biology Department of Biochemistry Faculty of Science Chulalongkorn University Bangkok 10330 Thailand Program in Bioinformatics and Computational Biology Graduated School Chulalongkorn University Bangkok 10330 Thailand The Center for Research and Development of Medical Diagnostic Laboratories Faculty of Associated Medical Sciences Khon Kaen University Khon Kaen 40002 Thailand Department of Medical Science Amnatcharoen Campus Mahidol University Amnat Charoen 37000 Thailand Department of Pathology Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Department of Environmental and Molecular Medicine Mie University Graduate School of Medicine Mie 514-8507 Japan Graduate School of Health Science Suzuka University of Medical Science Suzuka Mie 510-0226 Japan Department of Parasitology Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand
Cholangiocarcinoma (CCA) is an oxidative stress-driven liver cancer with bile duct epithelial cell phenotypes and currently lacks effective treatments, making targeted drug therapy urgently needed. Oxidative stress pl... 详细信息
来源: 评论
Biomedical data and AI
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Science China Life Sciences 2025年 第5期68卷 1536-1540页
作者: Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I
The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integratin...
来源: 评论
A general kernel boosting framework integrating pathways for predictive modeling based on genomic data
arXiv
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arXiv 2020年
作者: Zeng, Li Yu, Zhaolong Zhang, Yiliang Zhao, Hongyu Department of Biostatistics Yale University New HavenCT06511 United States Interdepartmental Program in Computational Biology and Bioinformatics Yale University New HavenCT06511 United States Department of Genetics Yale School of Medicine New HavenCT06510 United States
Predictive modeling based on genomic data has gained popularity in biomedical research and clinical practice by allowing researchers and clinicians to identify biomarkers and tailor treatment decisions more efficientl... 详细信息
来源: 评论
Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma
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Biomedicine and Pharmacotherapy 2023年 第1期166卷 115429-115429页
作者: Hsieh, Chiao-Hui Huang, Chen-Tsung Cheng, Yi-Sheng Hsu, Chun-Hua Hsu, Wen-Ming Chung, Yun-Hsien Liu, Yen-Lin Yang, Tsai-Shan Chien, Chia-Yu Lee, Yu-Hsuan Huang, Hsuan-Cheng Juan, Hsueh-Fen Department of Life Science National Taiwan University Taipei Taiwan Center for Computational and Systems Biology National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Institute of Plant Biology National Taiwan University Taipei Taiwan Genome and Systems Biology Degree Program National Taiwan University and Academia Sinica Taipei Taiwan Department of Agricultural Chemistry National Taiwan University Taipei Taiwan Department of Surgery National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan Department of Pediatrics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung University Taipei Taiwan Center for Advanced Computing and Imaging in Biomedicine Taipei Taiwan
Neuroblastoma, a childhood cancer affecting the sympathetic nervous system, continues to challenge the development of potent treatments due to the limited availability of druggable targets for this aggressive illness.... 详细信息
来源: 评论