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检索条件"机构=Interdepartmental Program in Computational Biology and Bioinformatics"
43 条 记 录,以下是11-20 订阅
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Hyperbolic Diffusion Procrustes Analysis for Intrinsic Representation of Hierarchical Data Sets
Hyperbolic Diffusion Procrustes Analysis for Intrinsic Repre...
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International Conference on Acoustics, Speech, and Signal Processing (ICASSP)
作者: Ya-Wei Eileen Lin Yuval Kluger Ronen Talmon Viterbi Faculty of Electrical and Computer Engineering Technion Interdepartmental Program in Computational Biology and Bioinformatics Yale University Applied Math Program Yale University Department of Pathology School of Medicine Yale University
In this paper, we present Hyperbolic Diffusion Procrustes Analysis (HDPA), a new method for informative representation of hierarchical datasets based on hyperbolic geometry, diffusion geometry, and Procrustes analysis...
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A pathway-based kernel boosting method for sample classification using genomic data
arXiv
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arXiv 2018年
作者: Zeng, Li Yu, Zhaolong Zhao, Hongyu Department of Biostatistics Yale University New HavenCT06511 United States Interdepartmental Program in Computational Biology and Bioinformatics Yale University New HavenCT06511 United States
The analysis of cancer genomic data has long suffered "the curse of dimensionality". Sample sizes for most cancer genomic studies are a few hundreds at most while there are tens of thousands of genomic featu... 详细信息
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Characterization of the retinal proteome during rod photoreceptor genesis
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BMC Research Notes 2010年 第1期3卷 1-8页
作者: Barnhill, Alison E Hecker, Laura A Kohutyuk, Oksana Buss, Janice E Honavar, Vasant G Greenlee, Heather West Interdepartmental Neuroscience Program Iowa State University Ames IA United States Department of Biomedical Sciences Iowa State University Ames IA United States Bioinformatics and Computational Biology Program Iowa State University Ames IA United States Department of Biochemistry Biophysics and Molecular Biology Iowa State University Ames IA United States Department of Computer Science Iowa State University Ames IA United States National Animal Disease Center Ames IA 50010 United States Mayo Clinic Department of Ophthalmology Rochester MN 55905 United States
Background. The process of rod photoreceptor genesis, cell fate determination and differentiation is complex and multi-factorial. Previous studies have defined a model of photoreceptor differentiation that relies on i... 详细信息
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Local two-sample testing over graphs and point-clouds by random-walk distributions
arXiv
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arXiv 2020年
作者: Landa, Boris Qu, Rihao Chang, Joseph Kluger, Yuval Program in Applied Mathematics Yale University Department of Pathology Yale University School of Medicine Department of Statistics and Data Science Yale University Interdepartmental Program in Computational Biology and Bioinformatics Yale University Department of Immunology Yale School of Medicine
Rejecting the null hypothesis in two-sample testing is a fundamental tool for scientific discovery. Yet, aside from concluding that two samples do not come from the same probability distribution, it is often of intere... 详细信息
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Analysis of cancer omics data in a semantic web framework
Analysis of cancer omics data in a semantic web framework
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Workshop on Semantic Web Applications and Tools for Life Sciences 2010, SWAT4LS 2010
作者: Holford, Matthew E. McCusker, James P. Cheung, Kei-Hoi Krauthammer, Michael Interdepartmental Program in Computational Biology and Bioinformatics Yale University New Haven CT United States Department of Pathology Yale University New Haven CT United States Department of Computer Science Yale University New Haven CT United States Center for Medical Informatics Yale University New Haven CT United States Department of Genetics Yale University New Haven CT United States
Our work concerns the elucidation of the cancer (epi)genome, transcriptome and proteome to better understand the complex interplay between a cancer cell's molecular state and its response to anti-cancer therapy. T... 详细信息
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MetNetAPI: A flexible method to access and manipulate biological network data from MetNet
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BMC Research Notes 2010年 第1期3卷 312-312页
作者: Sucaet, Yves Wurtele, Eve Syrkin Department of Genetics Development and Cell Biology Iowa State University Ames IA 50011 United States Interdepartmental Program in Bioinformatics and Computational Biology Iowa State University Ames IA 50011 United States
Background. Convenient programmatic access to different biological databases allows automated integration of scientific knowledge. Many databases support a function to download files or data snapshots, or a webservice... 详细信息
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Formalizing the representation of immune exposures for human immunology studies  9
Formalizing the representation of immune exposures for human...
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9th International Conference on Biological Ontology, ICBO 2018
作者: Vita, Randi Overton, James A. Cheung, Kei-Hoi Kleinstein, Steven H. Peters, Bjoern Division for Vaccine Discovery San Diego Institute for Allergy and Immunology San DiegoCA United States Department of Emergency Medicine Yale Center for Medical Informatics Yale School of Medicine New HavenCT United States Department of Pathology Yale School of Medicine New HavenCT United States Interdepartmental Program in Computational Biology and Bioinformatics Yale University New HavenCT United States
Human immunology studies typically examine how immune exposures associated with vaccinations, infectious, allergic or autoimmune diseases, or transplantations perturb the immune system with the goal to develop diagnos... 详细信息
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Biwhitening reveals the rank of a count matrix
arXiv
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arXiv 2021年
作者: Landa, Boris Zhang, Thomas T.C.K. Kluger, Yuval Program in Applied Mathematics Yale University United States Department of Electrical and Systems Engineering University of Pennsylvania United States Interdepartmental Program in Computational Biology and Bioinformatics Yale University United States Department of Pathology Yale University School of Medicine United States
Estimating the rank of a corrupted data matrix is an important task in data analysis, most notably for choosing the number of components in PCA. Significant progress on this task was achieved using random matrix theor... 详细信息
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Distinct adipose progenitor cells emerging with age drive active adipogenesis
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Science (New York, N.Y.) 2025年 第6745期388卷 eadj0430页
作者: Wang, Guan Li, Gaoyan Song, Anying Zhao, Yutian Yu, Jiayu Wang, Yifan Dai, Wenting Salas, Martha Qin, Hanjun Medrano, Leonard Dow, Joan Li, Aimin Armstrong, Brian Fueger, Patrick T. Yu, Hua Zhu, Yi Shao, Mengle Wu, Xiwei Jiang, Lei Campisi, Judith Yang, Xia Wang, Qiong A. Department of Molecular and Cellular Endocrinology Arthur Riggs Diabetes and Metabolism Research Institute City of Hope Medical Center Duarte CA USA Department of Integrative Biology and Physiology University of California Los Angeles CA United States Light Microscopy Core City of Hope Medical Center Duarte CA USA The Integrative Genomics Core City of Hope Medical Center Duarte CA USA Division of Developmental and Translational Diabetes and Endocrinology Research City of Hope Medical Center Duarte CA USA Comprehensive Metabolic Phenotyping Core City of Hope Medical Center Duarte CA USA Pathology Core of Shared Resources City of Hope Medical Center Duarte CA USA Comprehensive Cancer Center Beckman Research Institute City of Hope Medical Center Duarte CA USA Children's Nutrition Research Center Department of Pediatrics Baylor College of Medicine Houston TX United States Key Laboratory of Immune Response and Immunotherapy Shanghai Institute of Immunity and Infection Chinese Academy of Sciences Shanghai China Buck Institute for Research on Aging Novato CA United States Bioinformatics Interdepartmental Program University of California Los Angeles CA United States Institute for Quantitative and Computational Biosciences University of California Los Angeles CA United States Molecular and Medical Pharmacology University of California Los Angeles CA United States
Starting at middle age, adults often suffer from visceral adiposity and associated adverse metabolic disorders. Lineage tracing in mice revealed that adipose progenitor cells (APCs) in visceral fat undergo extensive a...
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APIR:Aggregating Universal Proteomics Database Search Algorithms for Peptide Identification with FDR Control
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Genomics, Proteomics & bioinformatics 2024年 第2期22卷 171-187页
作者: Yiling Elaine Chen Xinzhou Ge Kyla Woyshner MeiLu McDermott Antigoni Manousopoulou Scott B.Ficarro Jarrod A.Marto Kexin Li Leo David Wang Jingyi Jessica Li Department of Statistics and Data Science University of CaliforniaLos AngelesCA 90095USA Department of Immuno-Oncology Beckman Research InstituteCity of Hope National Medical CenterDuarteCA 91010USA Department of Quantitative and Computational Biology University of Southern CaliforniaLos AngelesCA 90089USA Department of Cancer Biology and Blais Proteomics Center Dana-Farber Cancer InstituteDepartment of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02215USA Department of Pediatrics City of Hope National Medical CenterDuarteCA 91010USA Bioinformatics Interdepartmental Program University of CaliforniaLos AngelesCA 90095USA Department of Human Genetics University of CaliforniaLos AngelesCA 90095USA Department of Computational Medicine University of CaliforniaLos AngelesCA 90095USA Department of Biostatistics University of CaliforniaLos AngelesCA 90095USA
Advances in mass spectrometry(MS)have enabled high-throughput analysis of proteomes in biological *** state-of-the-art MS data analysis relies on database search algorithms to quantify proteins by identifying peptide... 详细信息
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