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Exploring the mechanistic role of epidermal growth factor receptor activation in non-cancer kidney disease

BIOCELL 2025年第1期49卷 79-92页

作者： JU-YEON LEE DAEUN MOON JINU KIM Medical Course College of MedicineCatholic Kwandong UniversityGangneung25601Republic of Kore Department of Anatomy College of MedicineJeju National UniversityJeju63243Republic of Korea Interdisciplinary Graduate Program in Advanced Convergence Technology&Science Jeju National UniversityJeju63243Republic of Korea

The epidermal growth factor receptor(EGFR)is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular *** review explores the function of EGFR in kidney physiology and its implications for various kidney *** signaling is essential for kidney function and repair mechanisms,and its dysregulation significantly impacts both acute and chronic kidney *** review discusses the normal distribution of EGFR in kidney tubular segments,the mechanism of its activation and inhibition,and the therapeutic potential of EGFR-targeting antagonists and ***,it explores the pathophysiological characteristics observed in rodent models of kidney diseases through pharmacological and genetic inhibition of EGFR,highlighting therapeutic challenges and limitations such as species differences,variability in disease models,and potential adverse ***,the findings underscore the multifaceted role of EGFR in kidney diseases,influencing inflammation,fibrosis,and tissue *** complex involvement suggests that targeting EGFR may be a beneficial therapeutic strategy for managing these conditions,potentially mitigating inflammation and fibrosis while promoting tissue repair.

关键词： Epidermal growth factor receptor Chronic kidney disease Acute kidney injury Tubulointerstitial fibrosis

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Surface engineering of ZnO electrocatalyst by N doping towards electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2024年第1期88卷 71-81,I0002页

作者： Rohini Subhash Kanase Getasew Mulualem Zewdie Maheswari Arunachalam Jyoti Badiger Suzan Abdelfattah Sayed Kwang-Soon Ahn Jun-Seok Ha Uk Sim Hyeyoung Shin Soon Hyung Kang Department of Interdisciplinary Program for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Graduate School of Energy Science and Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Department of Chemistry Education and Optoelectronic Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea Department of Advanced Chemicals and Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GDE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrothermal method,and nitridation was performed at different times to control the N-doping *** an increase in the N-doping content,the morphological properties of the nanosheet changed significantly,namely,the 2D nanosheets transformed into irregularly shaped ***,the ECR performance of Zn O electrocatalysts with different N-doping content was assessed in 1.0 M KHCO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a small amount of N doping,it decreased for higher N doping *** them,the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 mA cm^(-2).This improvement of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,demonstrating that this improvement of N:ZnO-1 h electrocatalyst comes from(ⅰ)the optimized active sites lowering the free energy barrier for the rate-determining step(RDS),and(ⅱ)the modification of electronic structure enhancing the electron transfer rate by N doping.

关键词： ZnO N-doped ZnO Gas-diffusion electrode CO Selectivity Electrochemical CO_(2)reduction

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MERNet: Multimodal Emotion Recognition in Conversation Network via Cross-Modal Knowledge Distillation and Contrastive Learning

MERNet: Multimodal Emotion Recognition in Conversation Netwo...

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International Conference on Big Data and Smart Computing (BIGCOMP)

作者： Sooyeon Hwang Gahgene Gweon Eunseong Kwon Interdisciplinary Program in Artificial Intelligence Seoul National University South Korea Graduate School of Convergence Science and Technology Seoul National University South Korea Dept. of Computer Science and Engineering POSTECH South Korea

ISBN: (数字)9798331529024

ISBN: (纸本)9798331529031

Multimodal Emotion Recognition in Conversation (ERC) is a task of predicting the emotion of each utterance in a conversation by utilizing both verbal and non-verbal modalities. However, existing approaches often struggle to bridge cross-modal gaps, resulting in misaligned features and frequent misclassification of minority emotions into semantically similar majority emotions. To address these challenges, we propose MERNet, a framework that employs cross-modal knowledge distillation and contrastive learning to align multimodal features and effectively distinguish subtle emotions in conversations. Our framework consists of two stages: 1) guiding non-verbal modalities with the text modality to transfer knowledge and align their features, and 2) applying contrastive learning with emotion labels as anchors to distinguish subtle differences between similar emotions and address the class imbalance problem. Experiments conducted on two benchmark datasets, IEMOCAP and MELD, demonstrate that our MERNet outperforms existing state-of-the-art models.

关键词： Knowledge engineering Bridges Emotion recognition Visualization Computational modeling Contrastive learning Benchmark testing Linguistics Big Data

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Examining the Impact of Expression Fragmentation and Number Redundancy on Financial QA task

Examining the Impact of Expression Fragmentation and Number ...

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International Conference on Big Data and Smart Computing (BIGCOMP)

作者： Yoonjae Lee Kyung Seo Ki Gahgene Gweon Bugeun Kim Graduate School of Convergence Science and Technology Seoul National University South Korea Interdisciplinary Program in Artificial Intelligence Seoul National University South Korea Department of AI Chung-Ang University South Korea

ISBN: (数字)9798331529024

ISBN: (纸本)9798331529031

The goal of financial QA is to generate solution equations by solving problems about financial reports. Current financial QA models can suffer from two issues: expression fragmentation and number redundancy. We conduct experiments to examine the impact of the two issues. The experimental results show that addressing the expression fragmentation issue in financial QA using EPT improves the execution accuracy by 0.09, and alleviating the number redundancy issue by removing redundant numbers in the input of the FinQANet generator improves the execution accuracy by 0.07.

关键词： Accuracy Computational modeling Redundancy Big Data Mathematical models Generators

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HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis

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Plant Communications 2023年第4期4卷 225-239页

作者： Gyeongik Ahn Hee Jin Park Song Yi Jeong Gyeong-Im Shin Myung Geun Ji Joon-Yung Cha Jeongsik Kim Min Gab Kim Dae-Jin Yun Woe-Yeon Kim Research Institute of Life Science Institute of Agricultural and Life ScienceGyeongsang National UniversityJinju 52828Republic of Korea Division of Applied Life Science(BK21 Four) Plant Biological Rhythm Research CenterPlant Molecular Biology and Biotechnology Research CenterGraduate School of Gyeongsang National UniversityJinju 52828Republic of Korea Department of Biological Sciences College of Natural SciencesChonnam National UniversityGwangju 61186Republic of Korea Faculty of Science Education and Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National UniversityJeju 63243Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Science PMBBRCGyeongsang National UniversityJinju 52828Republic of Korea Institute of Glocal Disease Control Konkuk UniversitySeoul 05029Republic of Korea Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE) Northeast Normal UniversityChangchun 130024China

Flowering is the primary stage of the plant developmental transition and is tightly regulated by environmental factors such as light and ***,the mechanisms by which temperature signals are integrated into the photoperiodic flowering pathway are still poorly ***,we demonstrate that HOS15,which is known as a GI transcriptional repressor in the photoperiodic flowering pathway,controls flowering time in response to low ambient *** 16℃,the hos15 mutant exhibits an early flowering phenotype,and HOS15 acts upstream of photoperiodic flowering genes(GI,CO,and FT).GI protein abundance is increased in the hos15 mutant and is insensitive to the proteasome inhibitor ***,the hos15 mutant has a defect in low ambient temperature-mediated GI degradation,and HOS15 interacts with COP1,an E3 ubiquitin ligase for GI *** analyses of the hos15 cop1 double mutant revealed that repression of flowering by HOS15 is dependent on COP1 at 16℃.However,the HOS15-COP1 interaction was attenuated at 16℃,and GI protein abundance was additively increased in the hos15 cop1 double mutant,indicating that HOS15 acts independently of COP1 in GI turnover at low ambient *** study proposes that HOS15 controls GI abundance through multiple modes as an E3 ubiquitin ligase and transcriptional repressor to coordinate appropriate flowering time in response to ambient environmental conditions such as temperature and day length.

关键词： Arabidopsis flowering response low ambient temperature HOS15 GIGANTEA

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Thermoluminescence Studies of Pakistani Limestone Pellets for X-Rays: Comparison with Commercial Tld-100 Dosimeter

SSRN

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SSRN 2023年

作者： Mahmood, M. Masood Kakakhel, M. Basim Lee, Junyoung Mirza, Jamal Ahmed Millers, Rodrigo Hernandez Ye, Sung-Joon Islamabad45650 Pakistan Health Physics Division PINSTECH Nilore Islamabad Pakistan Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul08826 Korea Republic of Isotope Production Division Pakistan Institute of Nuclear Science and Technology Nilore Islamabad44000 Pakistan Research Institute for Convergence Science Graduate School of Convergence Science and Technology Seoul National University Seoul08826 Korea Republic of Advance Institutes of Convergence Technology Seoul National University Suwon16229 Korea Republic of

With the increased use of ionizing radiations across a spectrum of applications, the quest for identifying low-cost thermoluminescence (TL) materials to be used for radiation dosimetry is of vital importance. Therefore, identification and confirmation of natural materials suitable for radiation dosimetry is an active area of research. Such potential materials must have features like rigidity, insolubility, and chemical inertness etc. besides having additional dosimetric characteristics. One such promising low-cost material can be a limestone having vast deposits in Pakistan. So far, the TL and dosimetric characterization of pellets fabricated with Pakistani limestone and irradiated with X-rays has not been previously reported. All the studied literature has reported powdered form of limestone. The present study reports pelletized limestone and its intercomparison with *** quarried crystalline samples of limestone were hand crushed, sieved and compressed to fabricate pellets of size comparable to standard TLD chips. TL response, kinetic parameters, dose linearity, batch homogeneity, individual sensitivity correction factor (i.e., elemental correction coefficient ECC), lowest detectable dose limit (LDDL), coefficient of variation (COV), energy dependency (for X-ray energy range from 50 kV to 6 MV), and response fading (for a month) were determined and compared with TLD-100. For TL analysis, pellets were irradiated to 250 kV X-rays with a dose of 8 Gy. The pellets exhibited complex TL glow curve showing four peaks (P1, P2, P3 and P4) with a peak temperature of around P1 (90–110°C), P2 (130–170°C), P3 (240–280°C) and P4 (320–350°C) respectively. A dose linearity (with 250 kV X-rays) for 1–10 Gy, was observed while comparing with TLD-100. The pellets showed a linearity while TLD-100 showed supra-linearity in the studied dose range. Tm-Tstop method was applied initially for TL analysis to identify the overlapping peaks of the glow curve followed by Computerized gl

关键词： Thermoluminescence

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Diel and seasonal activity pattern of alien sika deer with sympatric mammalian species from Muljangori-oreum wetland of Hallasan National Park, South Korean

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Journal of Ecology and Environment 2021年第1期45卷 88-96页

作者： Banjade, Maniram Han, Sang-Hyun Jeong, Young-Hun Oh, Hong-Shik Faculty of Science Education Jeju National University Jeju 63243 South Korea Korean National Park Institute of Biodiversity Conservation Korean National Park Service Gurye 57616 South Korea Interdisciplinary Graduate Programme in Advance Convergence Technology and Science Faculty of Science Education Jeju National University Jeju 63243 South Korea

Background: Sika deer, Cervus nippon, were originally introduced to South Korea from Japan and Taiwan for commercial farming purposes. Unfortunately, they were released into the wild during religious events and have since begun to impact the native ecosystem and species endemic to South Korea. The study of activity patterns can improve our understanding of the environmental impact of non-native species and their association with sympatric species. Using camera traps, we studied the diel and seasonal activity patterns of non-native sika deer and quantified the temporal overlap with sympatric mammalian species in the Muljangori-oreum wetlands of Hallasan National Park, South Korea. Results: A total of 970 trap events were recorded for five mammalian species from nine locations during the camera-trap survey. Siberian roe deer (Capreoluspygargus tianschanicus) had the highest number of recorded events (72.0%), followed by sika deer (Cervus nippon) (16.2%), wild boar (Sus scrofa) (5.0%), Asian badger (Meles leucurus) (4.5%), and the Jeju weasel (Mustela sibirica quelpartis) (2.0%). Sika deer had bimodal activity patterns throughout the year, with peaks throughout the spring-autumn twilight, and day and night time throughout the winter. Relating the daily activity of sika deer with other mammalian species, roe deer expressed the highest degree of overlap (∆₄ = 0.80) while the Asian badger demonstrated the lowest overlap (∆₄ = 0.37). Conclusions: Our data show that sika deer are a crepuscular species with seasonal variations in daily activity patterns. Additionally, we identified the temporal differences in activity peaks between different mammals in the Muljangori-oreum wetlands and found higher degree of overlap between sika deer and roe deer during twilight hours. © 2021, The Author(s).

关键词： Camera traps Diel activity Management Sika deer Sympatric species

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Investigating the Dependence of X-Ray Dose Enhancement by Gold Nanoparticles on Two Bromine-Based Presage® Formulas

SSRN

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SSRN 2022年

作者： Alghadhban, Shama Kim, Dongwoo Koo, ChangUk Lee, Kangwon Ye, Sung-Joon Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Republic of Department of Applied Bioengineering Research Institute of Convergence Science Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Republic of Biomedical Research institute Seoul National University Hospital Seoul Korea Republic of Advance Institutes of Convergence Technology Seoul National University Suwon Korea Republic of

Two tissue-equivalent bromine-based PRESAGE ® dosimeters were fabricated in-house with and without gold nanoparticles (GNPs). The radical initiators used in the two formulas, F1 and F2, were 1,1,1,2-tetrabromoethane and tetrabromomethane, respectively. The aim of this study is to investigate the dependence of radiosensitization on PRESAGE ® formula, GNP concentrations and size, and irradiation energy. Their optical density changes pre- and post-irradiation of 150 kVp and 6 MV X-rays were measured with and without GNPs using a spectrophotometer. Dose enhancement factors of 150 kVp for 0.125, 0.25 and 0.5 mM of 50 nm-GNPs were 1.23, 1.26 and 1.27, respectively, measured by F1. The same factors were 1.20, 1.33 and 1.45 measured by F2. About 4% and 2% dose enhancement of 6 MV at 0.25 mM of 50 nm-GNPs were measured by F1 and F2, respectively. The dose enhancement of 150 kVp at 0.25 mM of 5 nm-GNP was 1.6 measured by F1. The dependencies observed in the two formulas were confirmed by Monte Carlo simulations. The tissue-equivalent bromine-based PRESAGE ® dosimeters can be used to estimate dose enhancement of X-rays which was shown to be dependent on PRESAGE ® formula, radiation energy, GNPs concentration and size. © 2022, The Authors. All rights reserved.

关键词： Gold nanoparticles

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Advancing hybrid quantum-classical algorithms via mean operators

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Physical Review A 2023年第1期108卷 L010401-L010401页

作者： Donggyu Kim Pureum Noh Hyun-Yong Lee Eun-Gook Moon Department of Physics Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Korea Department of Applied Physics Graduate School Korea University Sejong 30019 Korea Division of Display and Semiconductor Physics Korea University Sejong 30019 Korea Interdisciplinary Program in E·ICT-Culture-Sports Convergence Korea University Sejong 30019 Korea

Hybrid quantum-classical algorithms have been suggested to control the quantum entanglement of many-body systems in noisy intermediate-scale quantum technology, and yet their applicability is limited by the numbers of qubits and quantum operations. Here, we propose a mean-operator theory which overcomes limitations by combining the advantages of hybrid algorithms and standard mean-field theory. We demonstrate that an introduction of a mean operator prepares an entangled target many-body state with a significantly reduced number of quantum operations. We also show that a class of mean operators is expressed as time-evolution operators, which indicates that our theory is directly applicable to quantum simulations with Rydberg atoms and trapped ions.

关键词： Atom & ion trapping & guiding Quantum algorithms Quantum phase transitions Quantum simulation Strongly correlated systems Ultracold gases Symmetries in condensed matter Tensor network methods Variational wave functional methods

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Cultivation of Chlorella sp. HS2 using wastewater from soy sauce factory

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Chemosphere 2023年 342卷 140162页

作者： Kim, Minsik Lee, Sang-Ah Yun, Jin-Ho Ko, So-Ra Cho, Dae-Hyun Kim, Hee Su Oh, Hee-Mock Kim, Hee-Sik Ahn, Chi-Yong Daejeon34141 Korea Republic of Dept. of Biological Engineering Inha University Incheon22212 Korea Republic of Faculty of Biotechnology College of Applied Life Sciences Jeju National University Jeju63243 Korea Republic of Interdisciplinary Graduate Program in Advance Convergence Technology and Science Jeju National University Jeju63243 Korea Republic of Department of Integrative Biotechnology Sungkyunkwan University Gyeonggi-do Suwon16419 Korea Republic of FarmHannong Chungcheongnam-do Nonsan33010 Korea Republic of

Incorporation of wastewater from industrial sectors into the design of microalgal biorefineries has significant potential for advancing the practical application of this emerging industry. This study tested various food industrial wastewaters to assess their suitability for microalgal cultivation. Among these wastewaters, defective soy sauce (DSS) and soy sauce wastewater (SWW) were chosen but DSS exhibited the highest nutrient content with 13,500 ppm total nitrogen and 3051 ppm total phosphorus. After diluting DSS by a factor of 50, small-scale cultivation of microalgae was conducted to optimize culture conditions. SWW exhibited optimal growth at 25–30 °C and 300–500 μE m−2 s−1, while DSS showed optimal growth at 30–35 °C. Based on a 100-mL lab-scale and 3-L outdoor cultivation with an extended cultivation period, DSS outperformed SWW, exhibiting higher final biomass productivity. Additionally, nutrient-concentrated nature of DSS is advantageous for transportation at an industrial scale, leading us to select it as the most promising feedstock for microalgal cultivation. With further optimization, DSS has the potential to serve as an effective microalgal cultivation feedstock for large-scale biomass production. © 2023 The Authors

关键词： Microalgae

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