The epidermal growth factor receptor(EGFR)is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular *** review explores the function of EGFR in kidney physiology and its implication...
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The epidermal growth factor receptor(EGFR)is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular *** review explores the function of EGFR in kidney physiology and its implications for various kidney *** signaling is essential for kidney function and repair mechanisms,and its dysregulation significantly impacts both acute and chronic kidney *** review discusses the normal distribution of EGFR in kidney tubular segments,the mechanism of its activation and inhibition,and the therapeutic potential of EGFR-targeting antagonists and ***,it explores the pathophysiological characteristics observed in rodent models of kidney diseases through pharmacological and genetic inhibition of EGFR,highlighting therapeutic challenges and limitations such as species differences,variability in disease models,and potential adverse ***,the findings underscore the multifaceted role of EGFR in kidney diseases,influencing inflammation,fibrosis,and tissue *** complex involvement suggests that targeting EGFR may be a beneficial therapeutic strategy for managing these conditions,potentially mitigating inflammation and fibrosis while promoting tissue repair.
The endoplasmic reticulum(ER)is a cellular organelle responsible for protein synthesis and *** its protein folding capacity is exceeded,unfolded or misfolded proteins accumulate,causing ER stress and triggering the un...
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The endoplasmic reticulum(ER)is a cellular organelle responsible for protein synthesis and *** its protein folding capacity is exceeded,unfolded or misfolded proteins accumulate,causing ER stress and triggering the unfolded protein response(UPR)to restore ER *** UPR gene expression in plants follows a diel cycle,the mechanisms by which the circadian clock regulates these genes remain ***,we demonstrate that sensitivity to ER stress in root growth exhibits time-of-day phases and that the circadian clock regulates UPR target gene expression during ER ***,mutations in the core morning clock component CIRCADIAN CLOCK ASSOCIATED 1(CCA1)impair ER stress ***1 forms a complex with the UPR modulator basic leucine zipper 28(bZIP28)and acts as an upstream regulator of ER stress *** ER stress,CCA1 is stabilized and associates with bZIP28 at the ER stress response element within the BiP3 promoter,enhancing the ER stress ***,CCA1 and bZIP28 coordinate a time-dependent adaptive response to ER stress to maintain ER *** re-sults suggest that the circadian clock primes the timing and levels of ER chaperone expression to enhance ER stress tolerance.
The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-b...
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The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GDE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrothermal method,and nitridation was performed at different times to control the N-doping *** an increase in the N-doping content,the morphological properties of the nanosheet changed significantly,namely,the 2D nanosheets transformed into irregularly shaped ***,the ECR performance of Zn O electrocatalysts with different N-doping content was assessed in 1.0 M KHCO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a small amount of N doping,it decreased for higher N doping *** them,the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 mA cm^(-2).This improvement of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,demonstrating that this improvement of N:ZnO-1 h electrocatalyst comes from(ⅰ)the optimized active sites lowering the free energy barrier for the rate-determining step(RDS),and(ⅱ)the modification of electronic structure enhancing the electron transfer rate by N doping.
Various obstacles[poor tissue penetration,hypoxic tumor microenvironment,and reactive oxygen species(ROS)production quenching due to aggregation]obstruct imaging-guided high-efficiency phototherapy targeting ***,nanop...
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Various obstacles[poor tissue penetration,hypoxic tumor microenvironment,and reactive oxygen species(ROS)production quenching due to aggregation]obstruct imaging-guided high-efficiency phototherapy targeting ***,nanophthalocyanine(ZnPcN4-TF)is elaborately designed based on a synthetic phthalocyanine derivative(ZnPcN4)and nonimmunogenic transferrin(TF)through multiple noncovalent interactions for photoacoustic(PA)imaging-guided *** conjugating electron-rich amino groups effectively suppressed fluorescence and ROS generation due to the strong photoinduced electron transfer effect,ZnPcN4 became an ideal photothermal and PA imaging ***4-TF not only effectively targeted tumor sites and accumulated there,but also,surprisingly,facilitated the enhancement of ROS production via a type I process in an aggregate compared to ZnPcN4 itself,potentially due to accelerated electron ***,ZnPcN4-TF had a substantially more powerful photothermal effect than ZnPcN4 ***,this design effectively overcomes the obstacles to photodynamic therapy(aggregation-related ROS generation quenching in a hypoxic environment).Furthermore,PA imaging solves the tissue penetration challenge in optical *** study provides a broader base for designing novel photosensitizers to improve phototherapy under hypoxia.
Multimodal Emotion Recognition in Conversation (ERC) is a task of predicting the emotion of each utterance in a conversation by utilizing both verbal and non-verbal modalities. However, existing approaches often strug...
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Multimodal Emotion Recognition in Conversation (ERC) is a task of predicting the emotion of each utterance in a conversation by utilizing both verbal and non-verbal modalities. However, existing approaches often strug...
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ISBN:
(数字)9798331529024
ISBN:
(纸本)9798331529031
Multimodal Emotion Recognition in Conversation (ERC) is a task of predicting the emotion of each utterance in a conversation by utilizing both verbal and non-verbal modalities. However, existing approaches often struggle to bridge cross-modal gaps, resulting in misaligned features and frequent misclassification of minority emotions into semantically similar majority emotions. To address these challenges, we propose MERNet, a framework that employs cross-modal knowledge distillation and contrastive learning to align multimodal features and effectively distinguish subtle emotions in conversations. Our framework consists of two stages: 1) guiding non-verbal modalities with the text modality to transfer knowledge and align their features, and 2) applying contrastive learning with emotion labels as anchors to distinguish subtle differences between similar emotions and address the class imbalance problem. Experiments conducted on two benchmark datasets, IEMOCAP and MELD, demonstrate that our MERNet outperforms existing state-of-the-art models.
In order to perform preoperative surgical planning, accurate segmentation of anatomical structures in cone-beam computed tomography (CBCT) images is required. However, this image segmentation is often impeded by metal...
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The goal of financial QA is to generate solution equations by solving problems about financial reports. Current financial QA models can suffer from two issues: expression fragmentation and number redundancy. We conduc...
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ISBN:
(数字)9798331529024
ISBN:
(纸本)9798331529031
The goal of financial QA is to generate solution equations by solving problems about financial reports. Current financial QA models can suffer from two issues: expression fragmentation and number redundancy. We conduct experiments to examine the impact of the two issues. The experimental results show that addressing the expression fragmentation issue in financial QA using EPT improves the execution accuracy by 0.09, and alleviating the number redundancy issue by removing redundant numbers in the input of the FinQANet generator improves the execution accuracy by 0.07.
The goal of financial QA is to generate solution equations by solving problems about financial reports. Current financial QA models can suffer from two issues: expression fragmentation and number redundancy. We conduc...
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Flowering is the primary stage of the plant developmental transition and is tightly regulated by environmental factors such as light and ***,the mechanisms by which temperature signals are integrated into the photoper...
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Flowering is the primary stage of the plant developmental transition and is tightly regulated by environmental factors such as light and ***,the mechanisms by which temperature signals are integrated into the photoperiodic flowering pathway are still poorly ***,we demonstrate that HOS15,which is known as a GI transcriptional repressor in the photoperiodic flowering pathway,controls flowering time in response to low ambient *** 16℃,the hos15 mutant exhibits an early flowering phenotype,and HOS15 acts upstream of photoperiodic flowering genes(GI,CO,and FT).GI protein abundance is increased in the hos15 mutant and is insensitive to the proteasome inhibitor ***,the hos15 mutant has a defect in low ambient temperature-mediated GI degradation,and HOS15 interacts with COP1,an E3 ubiquitin ligase for GI *** analyses of the hos15 cop1 double mutant revealed that repression of flowering by HOS15 is dependent on COP1 at 16℃.However,the HOS15-COP1 interaction was attenuated at 16℃,and GI protein abundance was additively increased in the hos15 cop1 double mutant,indicating that HOS15 acts independently of COP1 in GI turnover at low ambient *** study proposes that HOS15 controls GI abundance through multiple modes as an E3 ubiquitin ligase and transcriptional repressor to coordinate appropriate flowering time in response to ambient environmental conditions such as temperature and day length.
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