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EXCESSIVE SUCROSE EXACERBATES HIGH FAT DIET-INDUCED HEPATIC INFLAMMATION AND FIBROSIS PROMOTING OSTEOARTHRITIS IN MICE MODEL

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Osteoarthritis and Cartilage 2025年 33卷 S139-S140页

作者： Yunhui Min Yunji Heo Dinesh Suminda Godagama Gamaarachchige minhye Kim myeongyeon shin Md. M. Ansari Young-Ok Son Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University Jeju Korea (the Republic of) Department of Animal Biotechnology Faculty of Biotechnology College of Applied Life Sciences Jeju National University Jeju-si Jeju-do Korea (the Republic of) Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju national University Jeju-si Jeju-do Korea (the Republic of)

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Multi-class Segmentation of Anatomical Structures Using Deep Learning in CBCT Images Containing Metal Artifacts

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Transactions of the Korean Institute of Electrical Engineers 2022年第1期71卷 253-260页

作者： Yang, Su Chun, Soyoung Kim, Dael Jeoun, Bo Soung Yoo, Jiyong Kang, Se-Ryong Choi, Min-Hyuk Kim, Jo-Eun Huh, Kyung-Hoe Lee, Sam-Sun Heo, Min-Suk Yi, Won-Jin Dept. of Applied Bioengineering Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Republic of Interdisciplinary Program of Bioengineering Seoul National University Seoul Korea Republic of Dept. of Biomedical Radiation Sciences Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Republic of Dept. of Oral and Maxillofacial Radiology Seoul National University Dental Hospital Seoul Korea Republic of Dept. of Oral and Maxillofacial Radiology School of Dentistry and Dental Research Institute Seoul National University Seoul Korea Republic of

In order to perform preoperative surgical planning, accurate segmentation of anatomical structures in cone-beam computed tomography (CBCT) images is required. However, this image segmentation is often impeded by metal artifacts, and it takes a lot of time due to morphological variability in patients. In this paper, we proposed a deep learning based automatic multi-calss segmentation method for anatomical structures in CBCT images containing metal artifacts. Four U-Net based deep learning models were used for anatomical structure segmentation. Each deep learning model was constructed by changing the encoder of U-Net architecture to the backbones (DenseNet121, VGGNet16, ResNet101, and EfficienNetB4). For training and testing our method, we used 20744 CBCT images containing metal artifacts from 30 patient datasets. Experimental results show that the segmentation performances of the mandible, midfacial bone, mandibular canal, and maxillary sinus were achieved F1 scores of , , , and using DenseNet121 with Tversky loss, respectively. Furthermore, our method was able to perform robust and accurate segmentation of anatomical structures in CBCT images containing metal artifacts. © 2022 Korean Institute of Electrical Engineers. All rights reserved.

关键词： Image segmentation

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Glucocorticoid Enhances Presenilin1-Dependent Aβ Production at Er's Mitochondrial-Associated Membrane by Downregulating Rer1 in Neuronal Cells

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SSRN 2023年

作者： Choi, Gee Euhn Park, Ji Yong Park, Mo Ran Yoon, Jee Hyeon Han, Ho Jae Laboratory of Veterinary Biochemistry College of Veterinary Medicine Veterinary Medical Research Institute Jeju National University Jeju63243 Korea Republic of Interdisciplinary Graduate Program in Advanced Convergence Technology & Science Jeju National University Jeju63243 Korea Republic of Department of Veterinary Physiology College of Veterinary Medicine Research Institute for Veterinary Science BK21 Four Future Veterinary Medicine Leading Education & Research Center Seoul National University Seoul08826 Korea Republic of

Stress-induced release of glucocorticoid is an important amyloidogenic factor that upregulates amyloid precursor protein (APP) and β secretase 1 (BACE1) levels. Glucocorticoid also contributes to the pathogenesis of Alzheimer’s disease (AD) by increasing ER-mitochondria connectivity, in which amyloid β (Aβ) processing occurs rigorously because of its lipid raft-rich characteristics. However, the mechanism by which glucocorticoid enhances γ-secretase activity in the mitochondrial-associated membrane of ER (MAM) and subsequent accumulation of mitochondrial Aβ is unclear. In this study, we determined how glucocorticoid enhances Aβ production in MAM using SH-SY5Y cells and ICR mice. First, we observed that cortisol-induced Aβ accumulation in mitochondria preceded its extracellular apposition by enhancing γ-secretase activity, which was the result of increased presenilin 1 (PSEN1) localization in MAM. Screening data revealed that cortisol selectively downregulated the ER retrieval protein Rer1, which triggered its maturation and subsequent entry into the endocytic secretory pathway of PSEN1. Accordingly, overexpression of RER1 reversed the deleterious effects of mitochondrial Aβ on mitochondrial respiratory function and neuronal cell viability. Notably, we found that cortisol guided the glucocorticoid receptor (GR) to bind directly to the RER1 promoter, thus trans-repressing its expression. Inhibiting GR function reduced Aβ accumulation at mitochondria and improved the outcome of a spatial memory task in mice exposed to corticosterone. Taken together, glucocorticoid enhances PSEN1-mediated Aβ generation at MAM by downregulating Rer1, which is a potential target at early stages of AD pathogenesis. © 2023, The Authors. All rights reserved.

关键词： Mitochondria

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Structure-Based Optimization of Tead Inhibitors: Exploring a Novel Subpocket Near Glu347 for the Treatment of Nf2-Mutant Cancer

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SSRN 2024年

作者： Kim, Jin Kwan Kim, Jinhyuk Kim, Hadong Jin, Haiyan Yoo, Youngki Fei, Xiang Maeng, Han-Joo Seo, Seung-Yong Han, Gyoonhee No, Kyoung Tai Baobab AiBIO Co. Ltd. Incheon21983 Korea Republic of Gachon Institute of Pharmaceutical Sciences College of Pharmacy Gachon University Incheon21936 Korea Republic of Department of Integrative Biotechnology Yonsei University Incheon21983 Korea Republic of Incheon21983 Korea Republic of Department of Pharmacy College of Pharmacy Yonsei University Incheon21983 Korea Republic of Institute of Convergence Science and Technology Yonsei University Incheon21983 Korea Republic of Interdisciplinary Graduate Program in Integrative Biotechnology and Translational Medicine Korea Republic of

The Hippo pathway is a signaling pathway implicated in various diseases, including cancer, that regulates the levels of yes-associated protein (YAP) and PDZ-binding motif (TAZ) proteins. These proteins bind to transcriptional enhanced associate domain (TEAD) proteins and function as transcription factors in the nucleus, producing oncogenic target genes such as CTGF and CYR61. TEAD proteins require palmitoylation via a covalent bond with cysteine in the central pocket to bind YAP/TAZ. Therefore, competitive inhibition that prevents palmitoylation could serve as an effective anticancer strategy. In this study, we analyzed the crystal structures of known inhibitors to identify new binding spots that were previously unexplored, with the aim of discovering more potent compounds using structure-based drug design. Consequently, we identified a novel hydrogen-bonding site and discovered Compound 2, which effectively binds to this site, as confirmed by X-ray crystallography. Furthermore, Compound 2 exhibited stable pharmacokinetic properties and demonstrated impressive efficacy in a mouse xenograft model. © 2024, The Authors. All rights reserved.

关键词： Transcription

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First report on the reproduction of captive Chinese many-toothed snake (Sibynophis chinensis) in Jeju Island, South Korea

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Journal of Ecology and Environment 2020年第1期44卷 1页

作者： Banjade, Maniram Jeong, Young-Hun Han, Sang-Hyun Kim, Yoo-Kyung Kim, Byung Soo Oh, Hong-Shik Faculty of Science Education Jeju National University Jeju 6324 South Korea Korean National Park Institute of Biodiversity Conservation Korean National Park Service Wonju South Korea Shinseong Girls Middle School Jeju City Jeju Island South Korea Interdisciplinary Graduate Programme in Advance Convergence Technology and Science Faculty of Science Education Jeju National University Jeju 6324 South Korea

The Chinese many-toothed snake (Sibynophis chinensis) is an endangered species in South Korea. To determine its reproductive activity, here we captured a gravid S. chinensis from Mulyeongari Oreum Wetland Conservation Area, Jeju Island, on May 27, 2018, and reared it at Animal Taxonomy and Morphology Laboratory, Jeju National University, South Korea. The snake oviposited a clutch of six eggs between June 12 and 20, 2018, with an average size of 24.86 ± 1.36 mm in length and 9.86 ± 0.49 mm in width, which were artificially incubated at a constant temperature of 27 °C. After incubating for 34-41 days, five of these six eggs successfully hatched. Average snout-vent length (SVL), tail length (TL), and body weight (BW) of hatchlings were 136.5 ± 5.17 mm, 47.76 ± 2.80 mm, and 1.66 ± 0.12 g, respectively. This study observed the reproductive activity of S. chinensis and characterized its eggs and hatchlings for the first time, providing valuable information for the long-term conservation plan of S. chinensis in South Korea. © 2020 The Author(s).

关键词： Clutch size Egg characteristics Egg-laying Hatchling Sibynophis chinensis

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XERICO as a target for engineering stress-resilient crops: Mechanisms, applications, and future directions

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Plant Physiology and Biochemistry 2025年 225卷 110013页

作者： Im, Jong Hee Kim, Won-Chan Han, Kyung-Hwan Ko, Jae-Heung Department of Horticulture Michigan State University East Lansing 48824 MI United States Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University Jeju 63243 South Korea DOE Great Lakes Bioenergy Research Center Michigan State University East Lansing 48824 MI United States School of Applied Biosciences Kyungpook National University Daegu 41566 South Korea Department of Forestry Michigan State University East Lansing 48824 MI United States of Green-Bio Science Kyung Hee University Yongin 17104 South Korea

XERICO's capacity to enhance ABA-driven stress responses across diverse crops, its regulatory crosstalk with other hormonal pathways, and its compatibility with advanced genetic engineering tools highlight its central role in sustainable agriculture. Leveraging XERICO in crop improvement programs aligns with the urgent need to mitigate the impacts of climate-induced stress in agriculture, offering a pathway toward resilient and high-yielding crops. By enabling crops to withstand drought and other environmental stresses, XERICO-based biotechnological approaches hold transformative potential for global food security and environmental sustainability. © 2025 Elsevier Masson SAS

关键词： ABA regulation Climate resilience Drought tolerance Environmental stress Genetic engineering Sustainable agriculture XERICO

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Quantifying Outdoor Cooling Effects of Vertical Green System on Mean Radiant Temperature

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SSRN 2023年

作者： Kim, Eun Sub Yun, Seok Hwan Lee, Dong Kun Kim, Na Youn Piao, Zheng Gang Kim, Sang Hyuck Park, Seunghwan Interdisciplinary Program in Landscape Architecture Seoul National University Seoul08826 Korea Republic of Integrated Major in Smart City Global Convergence Program Seoul National University Seoul08826 Korea Republic of Specialized Graduate School of Intelligent Eco-Science 4 Dept. of Landscape Architecture Seoul National University Seoul08826 Korea Republic of Department of Landscape Architecture and Rural System Engineering Seoul National University Seoul08826 Korea Republic of Department of Building Energy Research Korea Institute of Civil Engineering and Building Technology Goyang10223 Korea Republic of

Vertical green systems (VGS) are expected to mitigate outdoor heat stress through a transpiration cooling effect. There is a lack of knowledge on how VGS influence outdoor thermal comfort, particularly focusing on energy flux. This study quantifies the outdoor cooling effects of VGS, and distinguishes the energy flux between them and outdoor urban spaces. In addition, we discuss their cooling efficiency. Outdoor experiments were conducted during the hot summer period on building facades in city. Our study on VGS focused on the measurement of climatic variables, surface temperatures of plant leaves (Fatsia japonica), net radiation, and estimating transpiration and evaporation. The surface temperature of VGS were up to 4.3 °C higher than those of high albedo walls, while the reflected radiations (short and long-wave radiation) were 120 w/m2 lower than albedo walls during the day. The mean radiant temperature (MRT) of VGS was 3.02 °C lower than the high albedo wall during daytime, except in the case of shaded areas (0.45 °C). We confirmed that the cooling efficiency of transpiration was 7.38 times more effective than evaporation from soil without plants. Therefore, VGS is efficient in terms of long-term heat reduction and can be an effective strategy to mitigate outdoor heat stress. © 2023, The Authors. All rights reserved.

关键词： Transpiration

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Cubic ferromagnet and emergent U(1) symmetry on its phase boundary

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Physical Review B 2023年第22期107卷 224406-224406页

作者： Wei-Lin Tu Xinliang Lyu S. R. Ghazanfari Huan-Kuang Wu Hyun-Yong Lee Naoki Kawashima Division of Display and Semiconductor Physics Korea University Sejong 30019 Korea Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama 223-8522 Japan Institute for Solid State Physics University of Tokyo Kashiwa Chiba 277-8581 Japan Department of Physics Condensed Matter Theory Center and Joint Quantum Institute University of Maryland College Park Maryland 20742 USA Department of Applied Physics Graduate School Korea University Sejong 30019 Korea Interdisciplinary Program in E.ICT-Culture-Sports Convergence Korea University Sejong 30019 Korea Trans-scale Quantum Science Institute The University of Tokyo Bunkyo Tokyo 113-0033 Japan

We study the simplest quantum lattice spin model for the two-dimensional (2D) cubic ferromagnet by means of mean-field analysis and tensor network calculation. While both methods give rise to similar results in detecting related phases, the 2D infinite projected entangled-pair state (iPEPS) calculation provides more accurate values of transition points. Near the phase boundary, moreover, our iPEPS results indicate that it is more difficult to pin down the orientation of magnetic easy axes, and we interpret it as the easy-axis softening. This phenomenon implies an emergence of continuous U(1) symmetry, which is indicated by the low-energy effective model and has been analytically shown by the field theory. Our model and study provide a concrete example for utilizing iPEPS near the critical region, showing that the emergent phenomenon living on the critical points can already be captured by iPEPS with a rather small bond dimension.

关键词： Magnetic anisotropy Magnetism Quantum criticality Projected entangled pair states Tensor network methods

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Environmental Chromium Exposure Drives Osteoarthritis Pathogenesis via NF-κB–Hif-2α/Zip8 Signaling in Articular Cartilage

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Osteoarthritis and Cartilage 2025年 33卷 S376-S377页

作者： Dinesh Suminda Godagama Gamaarachchige Yunhui Min Yunji Heo minhye Kim myeongyeon shin Md. M. Ansari Young-Ok Son Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University Jeju Korea(the Republic of) Animal biothchnology jeju national university Jeju-si Korea(the Republic of) Next Generation Convergence Science and Technology Cooperative Course Jeju National University Jeju Korea (the Democratic People's Republic of) Department of Animal Biotechnology Jeju National University Jeju Jeju self-governing Province Korea (the Republic of)

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Generating Function for Projected Entangled-Pair States

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PRX Quantum 2024年第1期5卷 010335-010335页

作者： Wei-Lin Tu Laurens Vanderstraeten Norbert Schuch Hyun-Yong Lee Naoki Kawashima Ji-Yao Chen Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama 223-8522 Japan Center for Nonlinear Phenomena and Complex Systems Université Libre de Bruxelles B-1050 Bruxelles Belgium University of Vienna Faculty of Physics Boltzmanngasse 5 Wien 1090 Austria University of Vienna Faculty of Mathematics Oskar-Morgenstern-Platz 1 Wien 1090 Austria Division of Display and Semiconductor Physics Korea University Sejong 30019 Korea Department of Applied Physics Graduate School Korea University Sejong 30019 Korea Interdisciplinary Program in E·ICT-Culture-Sports Convergence Korea University Sejong 30019 Korea Institute for Solid State Physics The University of Tokyo Kashiwa Chiba 277-8581 Japan Trans-scale Quantum Science Institute The University of Tokyo Bunkyo Tokyo 113-0033 Japan Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices School of Physics Sun Yat-sen University Guangzhou 510275 China

Diagrammatic summation is a common bottleneck in modern applications of projected entangled-pair states, especially in computing low-energy excitations of a two-dimensional quantum many-body system. To solve this problem, here we extend the generating-function approach for tensor-network diagrammatic summation, a scheme previously proposed in the context of matrix product states. Taking the form of a one-particle excitation, we show that the excited state can be computed efficiently in the generating-function formalism, which can further be used in evaluating the dynamical structure factor of the system. Our benchmark results for the spin-1/2 transverse-field Ising model and Heisenberg model on the square lattice provide a desirable accuracy, showing good agreement with known results. We then study the spin-1/2J1-J2 model on the same lattice and investigate the dynamical properties of the putative gapless spin liquid phase. We conclude with a discussion on generalizations to multiparticle excitations.

关键词： Quasiparticles & collective excitations Quantum many-body systems Quantum spin models Strongly correlated systems Many-body techniques Projected entangled pair states Tensor network methods

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