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Changes in astrocyte function induced by stress-induced glucocorticoid exacerbate major depressive disorder

Progress in neurobiology 2025年 251卷 102786页

作者： Beomjo Park Gee Euhn Choi College of Veterinary Medicine Jeju National University Jeju 63243 South Korea. Laboratory of Veterinary Biochemistry College of Veterinary Medicine and Veterinary Medical Research Institute Jeju National University Jeju 63243 South Korea Interdisciplinary Graduate Program in Advanced Convergence Technology & Science Jeju National University Jeju 63243 South Korea. Electronic address: choige@jejunu.ac.kr.

Major depressive disorder (MDD) is a prevalent psychiatric condition that affects millions of people worldwide and is a leading cause of disability. Chronic stress is a key factor in the development of MDD, leading to hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis and elevated glucocorticoid levels, which in turn affect brain function and structure. Astrocytes, crucial for maintaining central nervous system (CNS) homeostasis, play a significant role in the pathophysiology of MDD. Dysregulation of glucocorticoid signaling in astrocytes contributes to changes in astrocyte survival, reactivity, metabolism, neurotrophic support, gliotransmitter release, and neuroinflammation, exacerbating depressive symptoms. This review explains the necessity for exploring the effects of glucocorticoid in astrocytes and subsequent MDD progression. Firstly, we briefly explore the glucocorticoid signaling and the multifaceted function of astrocytes. Then, this study discusses the mechanisms by which chronic stress and glucocorticoid exposure induce astrocyte-mediated neurodegenerative changes, highlighting the importance of targeting glucocorticoid-related signaling of astrocytes in developing therapeutic interventions for MDD. Understanding these mechanisms could lead to the development of more effective treatments aimed at restoring astrocyte function and alleviating MDD.

关键词： Astrocyte Glucocorticoid Major depressive disorder Stress

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Author Correction: SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs

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EXPERIMENTAL AND MOLECULAR MEDICINE 2023年第12期55卷 2609-2609页

作者： Kim, Junsoo Youn, Daehwa Choi, Seunghoon Lee, Youn Woo Sumberzul, Dulguun Yoon, Jeongeun Lee, Hanju Bae, Jong Woo Noh, Hyuna On, Dain Hong, Seung-Min An, Se-Hee Jang, Hui Jeong Kim, Seo Yeon Kim, Young Been Hwang, Ji-Yeon Lee, Hyo-Jung Kim, Hong Bin Park, Jun Won Yun, Jun-Won Shin, Jeon-Soo Seo, Jun-Young Nam, Ki Taek Choi, Kang-Seuk Lee, Ho-Young Chang, Hyeshik Seong, Je Kyung Cho, Jun Center for RNA Research Institute for Basic Science (IBS) Seoul National University Seoul Republic of Korea Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju Republic of Korea Korea Mouse Phenotyping Center (KMPC) Seoul National University Seoul Republic of Korea Laboratory of Developmental Biology and Genomics Research Institute for Veterinary Science and BK 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul Republic of Korea Department of Nuclear Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea School of Biological Sciences Seoul National University Seoul Republic of Korea Laboratory of Avian Diseases Research Institute for Veterinary Science and BK 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul Republic of Korea Preclinical Research Center Seoul National University Bundang Hospital Seongnam Republic of Korea Department of Periodontology Section of Dentistry Seoul National University Bundang Hospital Seongnam Republic of Korea Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Republic of Korea Division of Biomedical Convergence College of Biomedical Science Kangwon National University ChunCheon Republic of Korea Laboratory of Veterinary Toxicology College of Veterinary Medicine Seoul National University Seoul Republic of Korea Severance Biomedical Science Institute Graduate School of Medical Science Brain Korea 21 Project Yonsei University College of Medicine Seoul Republic of Korea Department of Nuclear Medicine Seoul National University College of Medicine Seoul Republic of Korea Interdisciplinary Program and BIO MAX Institute Seoul National University

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ARSENIC HASTENS THE ONSET OF OSTEOARTHRITIS BY TRIGGERING THE NF-κB-HIF-2α/ZIP8 SIGNALING PATHWAY VIA REACTIVE OXYGEN SPECIES

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Osteoarthritis and Cartilage 2024年 32卷 S430-S430页

作者： Gamaarachchige, Dinesh Suminda Godagama Min, Yunhui Heo, Yunji Lee, Juyeon Jung, Man-Young GHOSH, MRINMOY Son, Young-Ok Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University Jeju Korea (the Republic of) Department of Animal Biotechnology Faculty of Biotechnology Jeju National University Jeju Korea (the Republic of) Department of Biology Education Jeju National University Jeju Korea (the Republic of) Department of Biotechnology School of Bio Chemical and Processing Engineering (SBCE) Kalasalin-gam Academy of Research and Educational Krishnankoil Tamil Nadu India

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Generating function for projected entangled-pair states

arXiv

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arXiv 2023年

作者： Tu, Wei-Lin Vanderstraeten, Laurens Schuch, Norbert Lee, Hyun-Yong Kawashima, Naoki Chen, Ji-Yao Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama223-8522 Japan Center for Nonlinear Phenomena and Complex Systems Université Libre de Bruxelles Belgium University of Vienna Faculty of Physics Boltzmanngasse 5 Wien1090 Austria University of Vienna Faculty of Mathematics Oskar-Morgenstern-Platz 1 Wien1090 Austria Division of Display and Semiconductor Physics Korea University Sejong30019 Korea Republic of Department of Applied Physics Graduate School Korea University Sejong30019 Korea Republic of Interdisciplinary Program in E·ICT-Culture-Sports Convergence Korea University Sejong30019 Korea Republic of Institute for Solid State Physics The University of Tokyo Chiba Kashiwa277-8581 Japan Trans-scale Quantum Science Institute The University of Tokyo Bunkyo Tokyo113-0033 Japan Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices School of Physics Sun Yat-sen University Guangzhou510275 China

Diagrammatic summation is a common bottleneck in modern applications of projected entangled-pair states, especially in computing low-energy excitations of a two-dimensional quantum many-body system. To solve this problem, here we extend the generating function approach for tensor network diagrammatic summation, a scheme previously proposed in the context of matrix product states. Taking the form of a one-particle excitation, we show that the excited state can be computed efficiently in the generating function formalism, which can further be used in evaluating the dynamical structure factor of the system. Our benchmark results for the spin-1/2 transverse-field Ising model and Heisenberg model on the square lattice provide a desirable accuracy, showing good agreement with known results. We then study the spin-1/2 J1-J2 model on the same lattice and investigate the dynamical properties of the putative gapless spin liquid phase. We conclude with a discussion on generalizations to multi-particle excitations. © 2023, CC BY.

关键词： Excited states

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Dynamics of one-dimensional spin models via complex-time evolution of tensor networks

arXiv

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arXiv 2025年

作者： Cha, Jeong Hyeok Lee, Hyun-Yong Kim, Heung-Sik Department of Semiconductor Physics Kangwon National University Chuncheon24341 Korea Republic of Interdisciplinary Program in Earth Environmental System Science and Engineering Kangwon National University Chuncheon24341 Korea Republic of Division of Semiconductor Physics Korea University Sejong30019 Korea Republic of Department of Applied Physics Graduate School Korea University Sejong30019 Korea Republic of Institute of Quantum Convergence Technology Kangwon National University Chuncheon24341 Korea Republic of

Studying the real-time dynamics of strongly correlated systems poses significant challenges, which have recently become more manageable thanks to advances in density matrix renormalization group (DMRG) and tensor network methods. A notable development in this area is the introduction of a complex-time evolution scheme for tensor network states, originally suggested for solving Anderson impurity model and designed to suppress the growth of entanglement under time evolution. In this study, we employ the complex-time evolution scheme to investigate the dynamics of one-dimensional spin systems, specifically the transverse-field Ising model (TFIM) and the XXZ model. Our analysis revisits the dynamic critical exponent z of the TFIM and explores the dynamical structure factor in both gapped and gapless states of the XXZ model. Importantly, the complex-time evolution reproduces the results of real-time evolution while mitigating the rapid growth of quantum entanglement typically associated with the latter. These results demonstrate that the combination of complex-time evolution and extrapolation provides a robust and efficient framework for studying the dynamics of complex quantum systems, enabling more comprehensive insights into their behavior. © 2025, CC BY.

关键词： Quantum entanglement

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Cubic ferromagnet and emergent U(1) symmetry on its phase boundary

arXiv

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arXiv 2022年

作者： Tu, Wei-Lin Lyu, Xinliang Ghazanfari, S.R. Wu, Huan-Kuang Lee, Hyun-Yong Kawashima, Naoki Division of Display and Semiconductor Physics Korea University Sejong30019 Korea Republic of Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama223-8522 Japan Institute for Solid State Physics University of Tokyo Chiba Kashiwa277-8581 Japan Department of Physics Condensed Matter Theory Center Joint Quantum Institute University of Maryland College ParkMD20742 United States Department of Applied Physics Graduate School Korea University Sejong30019 Korea Republic of Interdisciplinary Program in E·ICT-Culture-Sports Convergence Korea University Sejong30019 Korea Republic of Trans-scale Quantum Science Institute The University of Tokyo Bunkyo Tokyo113-0033 Japan

We study the simplest quantum lattice spin model for the two-dimensional (2D) cubic ferromagnet by means of mean-field analysis and tensor network calculation. While both methods give rise to similar results in detecting related phases, the 2D infinite projected entangled-pair state (iPEPS) calculation provides more accurate values of transition points. Near the phase boundary, moreover, our iPEPS results indicate that it is more difficult to pin down the orientation of magnetic easy axes, and we interpret it as the easy-axis softening. This phenomenon implies an emergence of continuous U(1) symmetry, which is indicated by the low-energy effective model and has been analytically shown by the field theory. Our model and study provide a concrete example for utilizing iPEPS near the critical region, showing that the emergent phenomenon living on the critical points can already be captured by iPEPS with a rather small bond dimension. © 2022, CC BY.

关键词： Quantum entanglement

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XERICO as a target for engineering stress-resilient crops: Mechanisms, applications, and future directions

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Plant Physiology and Biochemistry 2025年 225卷 110013页

作者： Im, Jong Hee Kim, Won-Chan Han, Kyung-Hwan Ko, Jae-Heung Department of Horticulture Michigan State University East Lansing 48824 MI United States Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University Jeju 63243 South Korea DOE Great Lakes Bioenergy Research Center Michigan State University East Lansing 48824 MI United States School of Applied Biosciences Kyungpook National University Daegu 41566 South Korea Department of Forestry Michigan State University East Lansing 48824 MI United States of Green-Bio Science Kyung Hee University Yongin 17104 South Korea

XERICO's capacity to enhance ABA-driven stress responses across diverse crops, its regulatory crosstalk with other hormonal pathways, and its compatibility with advanced genetic engineering tools highlight its central role in sustainable agriculture. Leveraging XERICO in crop improvement programs aligns with the urgent need to mitigate the impacts of climate-induced stress in agriculture, offering a pathway toward resilient and high-yielding crops. By enabling crops to withstand drought and other environmental stresses, XERICO-based biotechnological approaches hold transformative potential for global food security and environmental sustainability. © 2025 Elsevier Masson SAS

关键词： ABA regulation Climate resilience Drought tolerance Environmental stress Genetic engineering Sustainable agriculture XERICO

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Correction to: Role of NADPH oxidase and its therapeutic intervention in TGF-β-mediated EMT progression: an in vitro analysis on HeLa cervical cancer cells

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Applied Biological Chemistry 2021年第1期64卷 1-1页

作者： Muthuramalingam, Karthika Cho, Moonjae Kim, Youngmee Department of Biochemistry School of Medicine Jeju National University Jeju Republic of Korea Institute of Medical Science Jeju National University Jeju Republic of Korea Interdisciplinary Graduate Program in Advanced Convergence Technology & Science Jeju National University Jeju Republic of Korea

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Harnessing microalgae to mitigate the environmental impact of the cement industry: Emission reduction and bio-cement production

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Carbon Capture science & technology 2025年 16卷

作者： Ve Van Le Maranda Esterhuizen Quynh-Giao Tran Jin-Ho Yun Man-Young Jung Sang-Ah Lee Faculty of Biotechnology College of Applied Life Sciences Jeju National University 102 Jejudaehak-Ro Jeju 63243 South Korea University of Helsinki Ecosystems and Environment Research Programme Faculty of Biological and Environmental Sciences Niemenkatu 73 Lahti 15140 Finland Cell factory Research Centre Korea Research Institute of Bioscience & Biotechnology 125 Gwahak-ro Yuseong-gu Daejeon 34141 South Korea Department of Environmental Biotechnology KRIBB School of Biotechnology University of Science & Technology Daejeon 34113 South Korea Department of Integrative Biotechnology Sungkyunkwan University Suwon 16419 South Korea Interdisciplinary Graduate Program in Advance Convergence Technology and Science Jeju National University 102 Jejudaehak-ro Jeju 63243 South Korea Bio-Health Materials Core-Facility Center Jeju National University 102 Jejudaehak-ro Jeju 63243 South Korea Department of Biology Education Jeju National University Jeju 63243 South Korea

The cement industry has been the cornerstone of economic development since the Industrial Revolution. However, the calcination process used to produce cement raw materials releases various pollutants, such as carbon dioxide, nitrogen oxides, and sulfur oxides, which are key contributors to global warming. Therefore, innovative technologies are urgently needed to minimize the environmental impact of the cement industry. In recent years, microalgae have gained attention because of their advantages in recovering resources and reducing the impacts of industrial pollutants. The use of microalgae to address the environmental challenges associated with cement production remains largely overlooked in current reviews. This review summarizes the recent advances in the utilization of microalgae to address the environmental challenges posed by the cement industry. Microalgae offer two main pathways for environmental mitigation: the (i) production of bio-cement as an eco-friendly alternative for construction and (ii) conversion of cement flue gases into biomass feedstock with high-value downstream applications. We also identify existing challenges and propose an integrative “Microalgae–Bacteria Consortium” system as a sustainable strategy for the significant reduction of the environmental footprint of cement production. This approach has the potential to transform the cement industry into a more sustainable and eco-friendlier sector. Overall, microalgae provide an innovative and sustainable platform to revolutionize the cement industry into a greener sector, supporting the global shift toward a low-carbon, circular economy.

关键词： Microalgae–bacteria consortium Microalgae Cement calcination Bio-cement Flue gas Sustainable construction Greenhouse gas

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Thermal Hall Effects of Spins and Phonons in Kagome Antiferromagnet Cd-Kapellasite

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Physical Review X 2020年第4期10卷 041059-041059页

作者： Masatoshi Akazawa Masaaki Shimozawa Shunichiro Kittaka Toshiro Sakakibara Ryutaro Okuma Zenji Hiroi Hyun-Yong Lee Naoki Kawashima Jung Hoon Han Minoru Yamashita The Institute for Solid State Physics The University of Tokyo Kashiwa 277-8581 Japan Graduate School of Engineering Science Osaka University Toyonaka 560-8531 Japan Department of Physics Chuo University Kasuga Bunkyo-ku Tokyo 112-8551 Japan Okinawa Institute of Science and Technology Graduate University Kunigami-gun 904-0495 Japan Department of Applied Physics Graduate School Korea University Sejong 30019 Korea Division of Display and Semiconductor Physics Korea University Sejong 30019 Korea Interdisciplinary Program in E·ICT-Culture-Sports Convergence Korea University Sejong 30019 Korea Department of Physics Sungkyunkwan University Suwon 16419 Korea

We investigate the thermal-transport properties of the kagome antiferromagnet Cd-kapellasite (Cd-K). We find that a field-suppression effect on the longitudinal thermal conductivity κxx sets in below approximately 25 K. This field-suppression effect at 15 T becomes as large as 80% at low temperatures, suggesting a large spin contribution κxxsp in κxx. We also find clear thermal Hall signals in the spin liquid phase in all Cd-K samples. The magnitude of the thermal Hall conductivity κxy shows a significant dependence on the sample’s scattering time, as seen in the rise of the peak κxy value in almost linear fashion with the magnitude of κxx. On the other hand, the temperature dependence of κxy is similar in all Cd-K samples; κxy shows a peak at almost the same temperature of the peak of the phonon thermal conductivity κxxph which is estimated by κxx at 15 T. These results indicate the presence of a dominant phonon thermal Hall κxyph at 15 T. In addition to κxyph, we find that the field dependence of κxy at low fields turns out to be nonlinear at low temperatures, concomitantly with the appearance of the field suppression of κxx, indicating the presence of a spin thermal Hall κxysp at low fields. Remarkably, by assembling the κxx dependence of κxysp data of other kagome antiferromagnets, we find that, whereas κxysp stays a constant in the low-κxx region, κxysp starts to increase as κxx does in the high-κxx region. This κxx dependence of κxysp indicates the presence of both intrinsic and extrinsic mechanisms in the spin thermal Hall effect in kagome antiferromagnets. Furthermore, both κxyph and κxysp disappear in the antiferromagnetic ordered phase at low fields, showing that phonons alone do not exhibit the thermal Hall effect. A high field above approximately 7 T induces κxyph, concomitantly with a field-induced increase of κxx and the specific heat, suggesting a coupling of the phonons to the field-induced spin excitations as the origin of κxyph.

关键词： Frustrated magnetism Spin liquid Thermal Hall effect Thermal conductivity

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