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Correction to: Dietary intervention using (1,3)/(1,6)-β-glucan, a fungus-derived soluble prebiotic ameliorates high-fat diet-induced metabolic distress and alters beneficially the gut microbiota in mice model

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European journal of nutrition 2021年第4期60卷 2273页

作者： Karthika Muthuramalingam Vineet Singh Changmin Choi Seung In Choi Young Mee Kim Tatsuya Unno Moonjae Cho Department of Biochemistry School of Medicine Jeju National University Jeju 63243 Republic of Korea. Faculty of Biotechnology School of Life Sciences SARI Jeju National University Jeju 63243 Republic of Korea. Department of Pharmaceutical Research Institute Quegen Biotech Co. Ltd Seoul 429931 Republic of Korea. Faculty of Biotechnology School of Life Sciences SARI Jeju National University Jeju 63243 Republic of Korea. tatsu@jejunu.ac.kr. Subtropical/Tropical Organism Gene Bank Jeju National University Jeju 63243 Republic of Korea. tatsu@jejunu.ac.kr. Department of Biochemistry School of Medicine Jeju National University Jeju 63243 Republic of Korea. moonjcho@jejunu.ac.kr. Institute of Medical Science Jeju National University Jeju 63241 Republic of Korea. moonjcho@jejunu.ac.kr. Interdisciplinary Graduate Program in Advanced Convergence Technology & Science Jeju National University Jeju 63241 Republic of Korea. moonjcho@jejunu.ac.kr.

A correction to this paper has been published: https://***/10.1007/s00394-021-02537-9

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Volume entropy and generalized Markov system for modelling information flow in a brain graph

arXiv

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arXiv 2018年

作者： Lee, Hyekyoung Kim, Eunkyung Kang, Hyejin Huh, Youngmin Lee, Youngjo Lim, Seonhee Lee, Dong Soo Biomedical Research Institute Seoul National University Hospital Seoul National University Department of Nuclear Medicine Seoul National University Department of Rehabilitation Medicine Seoul National University College of Medicine Seoul National University Data Science for Knowledge Creation Research Center Seoul National University Interdisciplinary Program in Cognitive Science Seoul National University Department of Statistics College of Natural Sciences Seoul National University Department of Molecular Medicine and Biopharmaceutical Sciences College of Medicine or College of Pharmacy Seoul National University Graduate School of Convergence Science and Technology Department of Mathematical Sciences Seoul National University Seoul Korea Republic of Korea Brain Research Institute Daegu Korea Republic of

Entropy is a classical measure to quantify the amount of information or complexity of a system. Various entropy-based measures such as functional and spectral entropies have been proposed in brain network analysis. However, they are less widely used than traditional graph theoretic measures such as global and local efficiencies because either they are not well-defined on a graph or difficult to interpret its biological meaning. In this paper, we propose a new entropy-based graph invariant, called volume entropy. It measures the exponential growth rate of the number of paths in a graph, which is a relevant measure if information flows through the graph forever. We model the information propagation on a graph by the generalized Markov system associated to the weighted edge-transition matrix. We estimate the volume entropy using the stationary equation of the generalized Markov system. A prominent advantage of using the stationary equation is that it assigns certain distribution of weights on the edges of the brain graph, which we call the stationary distribution. The stationary distribution shows the information capacity of edges and the direction of information flow on a brain graph. The simulation results show that the volume entropy distinguishes the underlying graph topology and geometry better than the existing graph measures. In brain imaging data application, the volume entropy of brain graphs was significantly related to healthy normal aging from 20s to 60s. In addition, the stationary distribution of information propagation gives a new insight into the information flow of functional brain graph. Copyright © 2018, The Authors. All rights reserved.

关键词： Entropy

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2-[(Hydroxymethyl)amino]ethanol in water as a preservative: Study of formaldehyde released by Taguchi's method 5

2-[(Hydroxymethyl)amino]ethanol in water as a preservative: ...

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5th International Conference on Chemical and Bioprocess Engineering, ICCBPE 2015

作者： Wisessirikul, W. Loykulnant, S. Montha, S. Fhulua, T. Prapainainar, P. Interdisciplinary Graduate Program in Advanced and Sustainable Environmental Engineering Thailand Advanced Institute of Science and Technology Tokyo Institute of Technology Kasetsart University Bangkok10900 Thailand Natural Rubber Focus Unit National Metal and Materials Technology Center NSTDA 111 Paholyothin Rd. Klong 1 Klong Luang Pathumthani12120 Thailand Environment Research Unit National Metal and Materials Technology Center NSTDA 111 Paholyothin Rd. Klong 1 Klong Luang Pathumthani12120 Thailand National Center of Excellence for Petroleum Petrochemicals and Advance Materials Department of Chemical Engineering Faculty of Engineering Kasetsart University Thailand Center of Excellence of Nanotechnology Kasetsart University Thailand

This research studied the quantity of free formaldehyde released from 2- [(hydroxymethyl)amino]ethanol (HAE) in DI water and natural rubber latex mixture using high-performance liquid chromatography (HPLC) technique. The quantity of formaldehyde retained in the solution was cross-checked by using titration technique. The investigated factors were the concentration of preservative (HAE), pH, and temperature. Taguchi's method was used to design the experiments. The number of experiments was reduced to 16 experiments from all possible experiments by orthogonal arrays (3 factors and 4 levels in each factor). Minitab program was used as a tool for statistical calculation and for finding the suitable condition for the preservative system. HPLC studies showed that higher temperature and higher concentration of the preservative influence the amount of formaldehyde released. It was found that conditions at which formaldehyde was released in the lowest amount were 1.6%w/v HAE, 4 to 40 °C, and the original pH. Nevertheless, the pH value of NR latex should be more than 10 (the suitable pH value was found to be 13). This preservative can be used to replace current preservative systems and can maintain the quality of latex for long-term storage. Use of the proposed preservative system was also shown to have reduced impact on the toxicity of the environment. © Published under licence by IOP Publishing Ltd.

关键词： Formaldehyde

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SU-G-JeP4-14: Assessment of Inter- and Intra-Fractional Motion for Extremity Soft Tissue Sarcoma Patients by Using In-House Real-Time Optical Image-Based Monitoring System

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Medical Physics 2016年第6PART28期43卷 3684-3684页

作者： H Kim I Kim S Ye Interdisciplinary Program in Radiation Applied Life Science College of Medicine Seoul National University Seoul Republic of Korea Dept. of Radiation Oncology Seoul National University Hospital Seoul Republic of Korea Program in Biomedical Radiation Sciences Graduate School of Convergence Science and Technology Seoul National University Seoul Republic of Korea

Purpose: This study aimed to assess inter- and intra-fractional motion for extremity Soft Tissue Sarcoma (STS) patients, by using in-house real-time optical image-based monitoring system (ROIMS) with infra-red (IR) external markers. Methods: Inter- and intra-fractional motions for five extremity (1 upper, 4 lower) STS patients received postoperative 3D conformal radiotherapy (3D-CRT) were measured by registering the image acquired by ROIMS with the planning CT image (REG_ROIMS). To compare with the X-ray image-based monitoring, pre- and post-treatment cone beam computed tomography (CBCT) scans were performed once per week and registered with planning CT image as well (REG_CBCT). If the CBCT scan is not feasible due to the large couch shift, AP and LR on-board imager (OBI) images were acquired. The comparison was done by calculating mutual information (MI) of those registered images. Results: The standard deviation (SD) of the inter-fractional motion was 2.6 mm LR, 2.8 mm SI, and 2.0 mm AP, and the SD of the intra-fractional motion was 1.4 mm, 2.1 mm, and 1.3 mm in each axis, respectively. The SD of rotational inter-fractional motion was 0.6° pitch, 0.9° yaw, and 0.8° roll and the SD of rotational intra-fractional motion was 0.4° pitch, 0.9° yaw, and 0.7° roll. The derived averaged MI values were 0.83, 0.92 for REG_CBCT without rotation and REG_ROIMS with rotation, respectively. Conclusion: The in-house real-time optical image-based monitoring system was implemented clinically and confirmed the feasibility to assess inter- and intra-fractional motion for extremity STS patients while the daily basis and real-time CBCT scan is not feasible in clinic.

关键词： Medical X-ray imaging Cone beam computed tomography Optical devices Three dimensional image processing Tissues Image registration Cancer Radiation therapy

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SU-C-BRB-06: Utilizing 3D Scanner and Printer for Dummy Eye-Shield: Artifact-Free CT Images of Tungsten Eye-Shield for Accurate Dose Calculation

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Medical Physics 2015年第6PART2期42卷 3194-3195页

作者： J Park J Lee H Kim I Kim S Ye Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Institute of Radiation Medicine Seoul National University Medical Research Center Seoul Korea Department of Radiation Oncology Seoul National University Hospital Seoul Korea Interdisciplinary Program in Radiation Applied Life Science Seoul National University College of Medicine Seoul Korea Advanced Institutes of Convergence Technology Seoul National University Suwon Korea

Purpose: To evaluate the effect of a tungsten eye-shield on the dose distribution of a patient. Methods: A 3D scanner was used to extract the dimension and shape of a tungsten eye-shield in the STL format. Scanned data was transferred into a 3D printer. A dummy eye shield was then produced using bio-resin (3D systems, VisiJet M3 Proplast). For a patient with mucinous carcinoma, the planning CT was obtained with the dummy eye-shield placed on the patient's right eye. Field shaping of 6 MeV was performed using a patient-specific cerrobend block on the 15 × 15 cm 2 applicator. The gantry angle was 330° to cover the planning target volume near by the lens. EGS4/BEAMnrc was commissioned from our measurement data from a Varian 21EX. For the CT-based dose calculation using EGS4/DOSXYZnrc, the CT images were converted to a phantom file through the ctcreate program. The phantom file had the same resolution as the planning CT images. By assigning the CT numbers of the dummy eye-shield region to 17000, the real dose distributions below the tungsten eye-shield were calculated in EGS4/DOSXYZnrc. In the TPS, the CT number of the dummy eye-shield region was assigned to the maximum allowable CT number (3000). Results: As compared to the maximum dose, the MC dose on the right lens or below the eye shield area was less than 2%, while the corresponding RTP calculated dose was an unrealistic value of approximately 50%. Conclusion: Utilizing a 3D scanner and a 3D printer, a dummy eye-shield for electron treatment can be easily produced. The artifact-free CT images were successfully incorporated into the CT-based Monte Carlo simulations. The developed method was useful in predicting the realistic dose distributions around the lens blocked with the tungsten shield.

关键词： Computed tomography Tungsten 3D printing Image scanners Three dimensional image processing Monte Carlo methods Medical image artifacts Cancer Field shaping

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SU-E-T-717: Surface Coating for Prevention of Metallic Seed Migration in Tissues

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Medical Physics 2015年第6PART23期42卷 3501-3502页

作者： H Lee W Lee J Park Y Choy S Ye Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Interdisciplinary Program in Bioengineering Seoul National University College of Engineering Seoul Korea Department of Biomedical Engineering Seoul National University College of Medicine Seoul Korea Department of Radiation Oncology Seoul National University Hospital Seoul Korea

Purpose: In radiotherapy, metallic implants often detach from their deposited sites and migrate to other locations. This undesirable migration could cause inadequate dose coverage for permanent brachytherapy and difficulties in image-guided radiation delivery for patients. To prevent migration of implanted seeds, we propose a potential strategy to use of a biocompatible and tissue-adhesive material called polydopamine. Methods: In this study, non-radioactive dummy seeds that have the same geometry and composition as commercial I-125 seeds were coated in polydopamine. Using scanning electron microscopy and X-ray photoelectron spectroscopy, the surface of the polydopamine-coated and non-coated seeds was characterized. The detachment stress between the two types of seeds and the tissue was measured. The efficacy of polydopamine-coated seed was investigated through in-vitro migration tests by tracing the seed location after tissue implantation and shaking for given times. The cytotoxicity of the polydopamine coating was also evaluated. Results: The results of the coating characterization have shown that polydopamine was successfully coated on the surface of the seeds. In the adhesion test, the polydopamine-coated seeds had 2.1-fold greater detachment stress than non-coated seeds. From the in-vitro test, it was determined that the polydopamine-coated seed migrated shorter distances than the non-coated seed. This difference was increased with a greater length of time after implantation. Conclusion: We suggest that polydopamine coating is an effective technique to prevent migration of implanted seeds, especially for permanent prostate brachytherapy.

关键词： Tissues Brachytherapy Dosimetry Metallic coatings Scanning electron microscopy Biocompatibility Image guided radiation therapy Medical imaging X-ray photoelectron spectroscopy

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2-[(Hydroxymethyl)amino]ethanol in water as a preservative: Study of formaldehyde released by Taguchi's method

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IOP Conference Series: Earth and Environmental science 2016年第1期36卷

作者： W Wisessirikul S Loykulnant S Montha T Fhulua P Prapainainar Interdisciplinary Graduate Program in Advanced and Sustainable Environmental Engineering Thailand Advanced Institute of Science and Technology and Tokyo Institute of Technology Kasetsart University Bangkok 10900 Thailand Natural Rubber Focus Unit National Metal and Materials Technology Center NSTDA 111 Paholyothin Rd. Klong 1 Klong Luang Pathumthani 12120 Thailand Environment Research Unit National Metal and Materials Technology Center NSTDA 111 Paholyothin Rd. Klong 1 Klong Luang Pathumthani 12120 Thailand National Center of Excellence for Petroleum Petrochemicals and Advance Materials Department of Chemical Engineering Faculty of Engineering Kasetsart University Thailand Center of Excellence of Nanotechnology Kasetsart University Thailand

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Corrigendum to "Target-specific near-IR induced drug release and photothermal therapy with accumulated Au/Ag hollow nanoshells on pulmonary cancer cell membranes" [Biomaterials 45 (2015) 81-92]

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Biomaterials 2015年 65卷 124-125页

作者： Mi Suk Noh Somin Lee Homan Kang Jin-Kyoung Yang Hyunmi Lee Doyk Hwang Jong Woo Lee Sinyoung Jeong Yoonjeong Jang Bong-Hyun Jun Dae Hong Jeong Seong Keun Kim Yoon-Sik Lee Myung-Haing Cho Laboratory of Toxicology College of Veterinary Medicine Seoul National University Seoul 151-742 Republic of Korea Program in Nano Science and Technology Graduate School of Convergence Science and Technology Seoul National University Seoul 151-742 Republic of Korea Medical Supplies Evaluation Center Korea Testing Certification Gunpo 435-862 Republic of Korea. Graduate Group of Tumor Biology Seoul National University Seoul 151-742 Republic of Korea. Interdisciplinary Program in Nano-Science and Technology Seoul National University Seoul 151-742 Republic of Korea School of Electrical Engineering and Computer Science Seoul National University Seoul 151-742 Republic of Korea. School of Chemical and Biological Engineering Seoul National University Seoul 151-742 Republic of Korea. Department of Biophysics and Chemical Biology and Department of Chemistry Seoul National University Seoul 151-742 Republic of Korea. Department of Chemistry Education Seoul National University Seoul 151-742 Republic of Korea. Laboratory of Toxicology College of Veterinary Medicine Seoul National University Seoul 151-742 Republic of Korea. Department of Bioscience and Biotechnology Konkuk University Seoul 143-701 Republic of Korea. Department of Chemistry Education Seoul National University Seoul 151-742 Republic of Korea. School of Chemical and Biological Engineering Seoul National University Seoul 151-742 Republic of Korea. Electronic address: yslee@snu.ac.kr. Graduate Group of Tumor Biology Seoul National University Seoul 151-742 Republic of Korea Advanced Institute of Convergence Technology Seoul National University Suwon 443-270 Republic of Korea. Electronic address: mchotox@snu.ac.kr.

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MO-FG-303-04: A Smartphone Application for Automated Mechanical Quality Assurance of Medical Accelerators

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Medical Physics 2015年第6PART29期42卷 3567-3567页

作者： H Kim H Lee K Choi S Ye Interdisciplinary Program in Radiation applied Life Science College of Medicine Seoul National University Seoul Republic of Korea Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Republic of Korea Department of Radiation Oncology Seoul National University Hospital Seoul Republic of Korea

Purpose: The mechanical quality assurance (QA) of medical accelerators consists of a time consuming series of procedures. Since most of the procedures are done manually – e.g., checking gantry rotation angle with the naked eye using a level attached to the gantry –, it is considered to be a process with high potential for human errors. To remove the possibilities of human errors and reduce the procedure duration, we developed a smartphone application for automated mechanical QA. Methods: The preparation for the automated process was done by attaching a smartphone to the gantry facing upward. For the assessments of gantry and collimator angle indications, motion sensors (gyroscope, accelerator, and magnetic field sensor) embedded in the smartphone were used. For the assessments of jaw position indicator, cross-hair centering, and optical distance indicator (ODI), an optical-image processing module using a picture taken by the high-resolution camera embedded in the smartphone was implemented. The application was developed with the Android software development kit (SDK) and OpenCV library. Results: The system accuracies in terms of angle detection error and length detection error were < 0.1° and < 1 mm, respectively. The mean absolute error for gantry and collimator rotation angles were 0.03° and 0.041°, respectively. The mean absolute error for the measured light field size was 0.067 cm. Conclusion: The automated system we developed can be used for the mechanical QA of medical accelerators with proven accuracy. For more convenient use of this application, the wireless communication module is under development. This system has a strong potential for the automation of the other QA procedures such as light/radiation field coincidence and couch translation/rotations.

关键词： Medical accelerators Quality assurance Kinematics Collimators Magnetic field sensors Gyroscope motion Cameras Field size Movement sensors

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Radiation dose reduction in CBCT imaging using K-edge filtering and energy weighting

Radiation dose reduction in CBCT imaging using K-edge filter...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Se-Ryong Kang Woo-Jin Lee Sang-Yoon Woo Dae-Seung Kim Won-Jin Yi Department of Biomedical Radiation Sciences Graduate School of Convergence Science and Technology Seoul National University Interdisciplinary Program in Radiation Applied Life Science College of Medicine Seoul National University Department of Oral and Maxillofacial Radiology School of Dentistry Seoul National University Department of Oral and Maxillofacial Radiology School of Dentistry and the Department of Biomedical Radiation Sciences Graduate School of Convergence Science and Technology Seoul National University

ISBN: (纸本)9781424479276

This paper presents K-edge filtering and energy weighting methods which enhance the contrast with less radiation does. Usually, energy weighting methods are used with photon-counting detector based CT for each energy bin data obtained to enhance the quality of image. However, we used these methods combine with K-edge filtering in energy-integrating detector. Using K-edge filtering, different energy bin data for energy weighting methods were obtained, and then energy weighting factors were calculated to enhance the contrast of image. We report an evaluation of the contrast-to-noise ratio (CNR) of reconstructed image with and without these two methods. This evaluation was proceeded with two phantoms;one is the phantom created personally, and the other is Sendentexct IQ dental CBCT (SENDENTEXCT, EU). As for the phantom created personally, the CNR of images reconstructed with these methods were increased than CNR of standard images. It was seen that 31% to 81% in each energy weighting method for optimizing each material (cortical bone, inner bone, soft tissue, iodine (18.5g/l), iodine (37g/l)). In conclusion, we can enhance the contrast of CT images with less radiation dose using K-edge filtering and energy weighting method.

关键词： Computed tomography Image reconstruction Materials Filtering Dentistry Bones

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