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SU-G-JeP4-14: Assessment of Inter- and Intra-Fractional Motion for Extremity Soft Tissue Sarcoma Patients by Using In-House Real-Time Optical Image-Based Monitoring System

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Medical Physics 2016年第6PART28期43卷 3684-3684页

作者： H Kim I Kim S Ye Interdisciplinary Program in Radiation Applied Life Science College of Medicine Seoul National University Seoul Republic of Korea Dept. of Radiation Oncology Seoul National University Hospital Seoul Republic of Korea Program in Biomedical Radiation Sciences Graduate School of Convergence Science and Technology Seoul National University Seoul Republic of Korea

Purpose: This study aimed to assess inter- and intra-fractional motion for extremity Soft Tissue Sarcoma (STS) patients, by using in-house real-time optical image-based monitoring system (ROIMS) with infra-red (IR) external markers. Methods: Inter- and intra-fractional motions for five extremity (1 upper, 4 lower) STS patients received postoperative 3D conformal radiotherapy (3D-CRT) were measured by registering the image acquired by ROIMS with the planning CT image (REG_ROIMS). To compare with the X-ray image-based monitoring, pre- and post-treatment cone beam computed tomography (CBCT) scans were performed once per week and registered with planning CT image as well (REG_CBCT). If the CBCT scan is not feasible due to the large couch shift, AP and LR on-board imager (OBI) images were acquired. The comparison was done by calculating mutual information (MI) of those registered images. Results: The standard deviation (SD) of the inter-fractional motion was 2.6 mm LR, 2.8 mm SI, and 2.0 mm AP, and the SD of the intra-fractional motion was 1.4 mm, 2.1 mm, and 1.3 mm in each axis, respectively. The SD of rotational inter-fractional motion was 0.6° pitch, 0.9° yaw, and 0.8° roll and the SD of rotational intra-fractional motion was 0.4° pitch, 0.9° yaw, and 0.7° roll. The derived averaged MI values were 0.83, 0.92 for REG_CBCT without rotation and REG_ROIMS with rotation, respectively. Conclusion: The in-house real-time optical image-based monitoring system was implemented clinically and confirmed the feasibility to assess inter- and intra-fractional motion for extremity STS patients while the daily basis and real-time CBCT scan is not feasible in clinic.

关键词： Medical X-ray imaging Cone beam computed tomography Optical devices Three dimensional image processing Tissues Image registration Cancer Radiation therapy

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Generating Function for Projected Entangled-Pair States

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PRX Quantum 2024年第1期5卷 010335-010335页

作者： Wei-Lin Tu Laurens Vanderstraeten Norbert Schuch Hyun-Yong Lee Naoki Kawashima Ji-Yao Chen Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama 223-8522 Japan Center for Nonlinear Phenomena and Complex Systems Université Libre de Bruxelles B-1050 Bruxelles Belgium University of Vienna Faculty of Physics Boltzmanngasse 5 Wien 1090 Austria University of Vienna Faculty of Mathematics Oskar-Morgenstern-Platz 1 Wien 1090 Austria Division of Display and Semiconductor Physics Korea University Sejong 30019 Korea Department of Applied Physics Graduate School Korea University Sejong 30019 Korea Interdisciplinary Program in E·ICT-Culture-Sports Convergence Korea University Sejong 30019 Korea Institute for Solid State Physics The University of Tokyo Kashiwa Chiba 277-8581 Japan Trans-scale Quantum Science Institute The University of Tokyo Bunkyo Tokyo 113-0033 Japan Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices School of Physics Sun Yat-sen University Guangzhou 510275 China

Diagrammatic summation is a common bottleneck in modern applications of projected entangled-pair states, especially in computing low-energy excitations of a two-dimensional quantum many-body system. To solve this problem, here we extend the generating-function approach for tensor-network diagrammatic summation, a scheme previously proposed in the context of matrix product states. Taking the form of a one-particle excitation, we show that the excited state can be computed efficiently in the generating-function formalism, which can further be used in evaluating the dynamical structure factor of the system. Our benchmark results for the spin-1/2 transverse-field Ising model and Heisenberg model on the square lattice provide a desirable accuracy, showing good agreement with known results. We then study the spin-1/2J1-J2 model on the same lattice and investigate the dynamical properties of the putative gapless spin liquid phase. We conclude with a discussion on generalizations to multiparticle excitations.

关键词： Quasiparticles & collective excitations Quantum many-body systems Quantum spin models Strongly correlated systems Many-body techniques Projected entangled pair states Tensor network methods

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Corrigendum to "Target-specific near-IR induced drug release and photothermal therapy with accumulated Au/Ag hollow nanoshells on pulmonary cancer cell membranes" [Biomaterials 45 (2015) 81-92]

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Biomaterials 2015年 65卷 124-125页

作者： Mi Suk Noh Somin Lee Homan Kang Jin-Kyoung Yang Hyunmi Lee Doyk Hwang Jong Woo Lee Sinyoung Jeong Yoonjeong Jang Bong-Hyun Jun Dae Hong Jeong Seong Keun Kim Yoon-Sik Lee Myung-Haing Cho Laboratory of Toxicology College of Veterinary Medicine Seoul National University Seoul 151-742 Republic of Korea Program in Nano Science and Technology Graduate School of Convergence Science and Technology Seoul National University Seoul 151-742 Republic of Korea Medical Supplies Evaluation Center Korea Testing Certification Gunpo 435-862 Republic of Korea. Graduate Group of Tumor Biology Seoul National University Seoul 151-742 Republic of Korea. Interdisciplinary Program in Nano-Science and Technology Seoul National University Seoul 151-742 Republic of Korea School of Electrical Engineering and Computer Science Seoul National University Seoul 151-742 Republic of Korea. School of Chemical and Biological Engineering Seoul National University Seoul 151-742 Republic of Korea. Department of Biophysics and Chemical Biology and Department of Chemistry Seoul National University Seoul 151-742 Republic of Korea. Department of Chemistry Education Seoul National University Seoul 151-742 Republic of Korea. Laboratory of Toxicology College of Veterinary Medicine Seoul National University Seoul 151-742 Republic of Korea. Department of Bioscience and Biotechnology Konkuk University Seoul 143-701 Republic of Korea. Department of Chemistry Education Seoul National University Seoul 151-742 Republic of Korea. School of Chemical and Biological Engineering Seoul National University Seoul 151-742 Republic of Korea. Electronic address: yslee@snu.ac.kr. Graduate Group of Tumor Biology Seoul National University Seoul 151-742 Republic of Korea Advanced Institute of Convergence Technology Seoul National University Suwon 443-270 Republic of Korea. Electronic address: mchotox@snu.ac.kr.

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MO-FG-303-04: A Smartphone Application for Automated Mechanical Quality Assurance of Medical Accelerators

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Medical Physics 2015年第6PART29期42卷 3567-3567页

作者： H Kim H Lee K Choi S Ye Interdisciplinary Program in Radiation applied Life Science College of Medicine Seoul National University Seoul Republic of Korea Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Republic of Korea Department of Radiation Oncology Seoul National University Hospital Seoul Republic of Korea

Purpose: The mechanical quality assurance (QA) of medical accelerators consists of a time consuming series of procedures. Since most of the procedures are done manually – e.g., checking gantry rotation angle with the naked eye using a level attached to the gantry –, it is considered to be a process with high potential for human errors. To remove the possibilities of human errors and reduce the procedure duration, we developed a smartphone application for automated mechanical QA. Methods: The preparation for the automated process was done by attaching a smartphone to the gantry facing upward. For the assessments of gantry and collimator angle indications, motion sensors (gyroscope, accelerator, and magnetic field sensor) embedded in the smartphone were used. For the assessments of jaw position indicator, cross-hair centering, and optical distance indicator (ODI), an optical-image processing module using a picture taken by the high-resolution camera embedded in the smartphone was implemented. The application was developed with the Android software development kit (SDK) and OpenCV library. Results: The system accuracies in terms of angle detection error and length detection error were < 0.1° and < 1 mm, respectively. The mean absolute error for gantry and collimator rotation angles were 0.03° and 0.041°, respectively. The mean absolute error for the measured light field size was 0.067 cm. Conclusion: The automated system we developed can be used for the mechanical QA of medical accelerators with proven accuracy. For more convenient use of this application, the wireless communication module is under development. This system has a strong potential for the automation of the other QA procedures such as light/radiation field coincidence and couch translation/rotations.

关键词： Medical accelerators Quality assurance Kinematics Collimators Magnetic field sensors Gyroscope motion Cameras Field size Movement sensors

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Cellucalst enzyme-assisted extraction of Sargassum horneri enhances the immunomodulation by regulating TLR4/MyD88/NF-kB pathway in murine splenocytes with or without Concanavalin A

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Biomedicine and Pharmacotherapy 2024年 181卷 117673-117673页

作者： Yang, Jiwon Kim, Hyo Jin Herath, Kalahe Hewage Iresha Nadeeka Madushani Jee, Youngheun Interdisciplinary Graduate Program in Advanced Convergence Technology & Science Jeju National University Jeju 63243 South Korea Department of Food Bioengineering Jeju National University Jeju 690-756 South Korea Department of Environmental Health Harvard T.H. Chan School of Public Health Harvard University Boston Massachusetts United States Department of Biosystems Engineering Faculty of Agriculture and Plantation Management Wayamba University Gonawila Makandura 60170 Sri Lanka Department of Veterinary Medicine and Veterinary Medical Research Institute Jeju National University Jeju 64243 South Korea

Sargassum horneri (S. horneri) is an edible species of large brown algae inhabiting along the coasts of northeastern Asia. The study focuses on the impact of celluclast enzyme extract of S. hoeneri (SHC) on various immune cell populations in splenocytes including granulocytes, macrophages, dendritic cells, and T lymphocytes. SHC alone increased the population of granulocytes and macrophages and the secretion of M1 macrophage-derived cytokines (TNF-α, IL-22), and M2 macrophage-derived cytokines (IL-4, IL-10). Interestingly, however, SHC suppressed the concanavalin A (Con A)-expanded populations of macrophages, dendritic cells, granulocytes, T and B cells, and Con A-promoted secretion of M1-macrophage derived cytokines (IFN-γ, IL-1β, TNF-α, IL-17, IL-22) and M2-macrophage derived cytokines (IL-4, IL-10, IL-13, TGF-β). SHC further restrained the Th1, Th2, and Th17 cell responses through attenuating the expression of respective transcription factors T-bet, Gata3, and Rorγt. The anti-inflammatory property of SHC is highlighted through its influence on cytokine production, particularly in the NF-κB pathway, and the attenuation of Toll-like receptor (TLR) signaling. The results reveal that SHC acts as both an immunostimulator and an inhibitor of hyperimmune reactions, showcasing its potential therapeutic applications in conditions involving dysregulated immune responses such as autoimmune diseases and inflammatory disorders. This positions SHC as a promising candidate for the development of functional ingredients with diverse applications encompassing the realms of food, pharmaceuticals, and cosmetics. © 2024

关键词： Celluclast Concanavalin A S. horneri Splenocytes

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Entanglement properties of disordered quantum spin chains with long-range antiferromagnetic interactions

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Physical Review B 2020年第21期102卷 214201-214201页

作者： Y. Mohdeb J. Vahedi N. Moure A. Roshani Hyun-Yong Lee R. N. Bhatt Stefan Kettemann Stephan Haas Department of Physics and Earth Sciences Jacobs University Bremen Bremen 28759 Germany Technische Universität Braunschweig Institut für Mathematische Physik Mendelssohnstr. 3 38106 Braunschweig Germany Department of Physics Sari Branch Islamic Azad University Sari 48164-194 Iran Department of Physics and Astronomy University of Southern California Los Angeles California 90089-0484 USA Department of Applied Physics Graduate School Korea University Sejong 30019 Korea Division of Display and Semiconductor Physics Korea University Sejong 30019 Korea Interdisciplinary Program in EċICT-Culture-Sports Convergence Korea University Sejong 30019 Korea Department of Electrical Engineering Princeton University Princeton New Jersey 08544 USA School of Natural Sciences Institute for Advanced Study Princeton New Jersey 08540 USA Division of Advanced Materials Science Pohang University of Science and Technology (POSTECH) Pohang 790-784 Korea

Entanglement measures are useful tools in characterizing otherwise unknown quantum phases and indicating transitions between them. Here we examine the concurrence and entanglement entropy in quantum spin chains with random long-range couplings, spatially decaying with a power-law exponent α. Using the strong disorder renormalization group (SDRG) technique, we find by analytical solution of the master equation a strong disorder fixed point, characterized by a fixed point distribution of the couplings with a finite dynamical exponent, which describes the system consistently in the regime α>12. A numerical implementation of the SDRG method yields a power-law spatial decay of the average concurrence, which is also confirmed by exact numerical diagonalization. However, we find that the lowest-order SDRG approach is not sufficient to obtain the typical value of the concurrence. We therefore implement a correction scheme which allows us to obtain the leading-order corrections to the random singlet state. This approach yields a power-law spatial decay of the typical value of the concurrence, which we derive both by a numerical implementation of the corrections and by analytics. Next, using numerical SDRG, the entanglement entropy (EE) is found to be logarithmically enhanced for all α, corresponding to a critical behavior with an effective central charge c=ln(2), independent of α. This is confirmed by an analytical derivation. Using numerical exact diagonalization (ED), we confirm the logarithmic enhancement of the EE and a weak dependence on α. For a wide range of partition size l, the EE fits a critical behavior with a central charge close to c=1, which is the same as for the clean Haldane-Shastry model with a power-law-decaying interaction with α=2. Only for small l≪L, in a range which increases with the number of spins N, we find deviations which are rather consistent with the strong disorder fixed point central charge c=ln(2). Furthermore, we find using ED that the conc

关键词： Magnetism Quantum entanglement Disordered systems Doped semiconductors Density matrix methods Exact diagonalization Renormalization group Tensor network methods

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Cubic ferromagnet and emergent U(1) symmetry on its phase boundary

arXiv

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arXiv 2022年

作者： Tu, Wei-Lin Lyu, Xinliang Ghazanfari, S.R. Wu, Huan-Kuang Lee, Hyun-Yong Kawashima, Naoki Division of Display and Semiconductor Physics Korea University Sejong30019 Korea Republic of Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama223-8522 Japan Institute for Solid State Physics University of Tokyo Chiba Kashiwa277-8581 Japan Department of Physics Condensed Matter Theory Center Joint Quantum Institute University of Maryland College ParkMD20742 United States Department of Applied Physics Graduate School Korea University Sejong30019 Korea Republic of Interdisciplinary Program in E·ICT-Culture-Sports Convergence Korea University Sejong30019 Korea Republic of Trans-scale Quantum Science Institute The University of Tokyo Bunkyo Tokyo113-0033 Japan

We study the simplest quantum lattice spin model for the two-dimensional (2D) cubic ferromagnet by means of mean-field analysis and tensor network calculation. While both methods give rise to similar results in detecting related phases, the 2D infinite projected entangled-pair state (iPEPS) calculation provides more accurate values of transition points. Near the phase boundary, moreover, our iPEPS results indicate that it is more difficult to pin down the orientation of magnetic easy axes, and we interpret it as the easy-axis softening. This phenomenon implies an emergence of continuous U(1) symmetry, which is indicated by the low-energy effective model and has been analytically shown by the field theory. Our model and study provide a concrete example for utilizing iPEPS near the critical region, showing that the emergent phenomenon living on the critical points can already be captured by iPEPS with a rather small bond dimension. © 2022, CC BY.

关键词： Quantum entanglement

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Comprehensive analysis of the chloroplast genome and phylogenetic relationships ofSasa quelpaertensisNakai

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Mitochondrial DNA Part B 2024年第1期9卷

作者： Jin Hee Kim Jeongsik Kim a Subtropical Horticulture Research Institute Jeju National University Jeju Republic of Korea a Subtropical Horticulture Research Institute Jeju National University Jeju Republic of Koreab Faculty of Science Education Jeju National University Jeju Republic of Koreac Interdisciplinary Graduate Program in Advanced Convergence Technology & Science Jeju National University Jeju Republic of Korea

Jeju-Joritdae (Sasa quelpaertensisNakai) is a broad-leaved bamboo grass endemic to Mount Halla, Jeju Island, South Korea. In this study, we report the complete chloroplast genome sequence ofS. quelpaertensis. Its chloroplast genome is 139,730 bp in size and consists of a large single-copy (LSC, 83,351 bp) region, one small single-copy (SSC, 12,788 bp) region, and two inverted repeats (IRs, 21,796 bp each). The chloroplast genome ofS. quelpaertensisencodes 131 genes, including 86 protein-coding, 37 tRNA, and 8 rRNA genes. The overall GC content of theS. quelpaertensischloroplast genome is 38.86%. Phylogenetic analysis using the chloroplast genome sequence showed thatS. quelpaertensisis closely related toSasa veitchiiandSasella kogasensis. These findings provide valuable genomic resources for future studies of theSasagenus in South Korea and other countries encompassing its distribution area.

关键词： Jeju-Joritdae bamboo grass Sasa palmata Poaceae plastome genome

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Author Correction: SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs

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EXPERIMENTAL AND MOLECULAR MEDICINE 2023年第12期55卷 2609-2609页

作者： Kim, Junsoo Youn, Daehwa Choi, Seunghoon Lee, Youn Woo Sumberzul, Dulguun Yoon, Jeongeun Lee, Hanju Bae, Jong Woo Noh, Hyuna On, Dain Hong, Seung-Min An, Se-Hee Jang, Hui Jeong Kim, Seo Yeon Kim, Young Been Hwang, Ji-Yeon Lee, Hyo-Jung Kim, Hong Bin Park, Jun Won Yun, Jun-Won Shin, Jeon-Soo Seo, Jun-Young Nam, Ki Taek Choi, Kang-Seuk Lee, Ho-Young Chang, Hyeshik Seong, Je Kyung Cho, Jun Center for RNA Research Institute for Basic Science (IBS) Seoul National University Seoul Republic of Korea Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju Republic of Korea Korea Mouse Phenotyping Center (KMPC) Seoul National University Seoul Republic of Korea Laboratory of Developmental Biology and Genomics Research Institute for Veterinary Science and BK 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul Republic of Korea Department of Nuclear Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea School of Biological Sciences Seoul National University Seoul Republic of Korea Laboratory of Avian Diseases Research Institute for Veterinary Science and BK 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul Republic of Korea Preclinical Research Center Seoul National University Bundang Hospital Seongnam Republic of Korea Department of Periodontology Section of Dentistry Seoul National University Bundang Hospital Seongnam Republic of Korea Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Republic of Korea Division of Biomedical Convergence College of Biomedical Science Kangwon National University ChunCheon Republic of Korea Laboratory of Veterinary Toxicology College of Veterinary Medicine Seoul National University Seoul Republic of Korea Severance Biomedical Science Institute Graduate School of Medical Science Brain Korea 21 Project Yonsei University College of Medicine Seoul Republic of Korea Department of Nuclear Medicine Seoul National University College of Medicine Seoul Republic of Korea Interdisciplinary Program and BIO MAX Institute Seoul National University

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Generating function for projected entangled-pair states

arXiv

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arXiv 2023年

作者： Tu, Wei-Lin Vanderstraeten, Laurens Schuch, Norbert Lee, Hyun-Yong Kawashima, Naoki Chen, Ji-Yao Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama223-8522 Japan Center for Nonlinear Phenomena and Complex Systems Université Libre de Bruxelles Belgium University of Vienna Faculty of Physics Boltzmanngasse 5 Wien1090 Austria University of Vienna Faculty of Mathematics Oskar-Morgenstern-Platz 1 Wien1090 Austria Division of Display and Semiconductor Physics Korea University Sejong30019 Korea Republic of Department of Applied Physics Graduate School Korea University Sejong30019 Korea Republic of Interdisciplinary Program in E·ICT-Culture-Sports Convergence Korea University Sejong30019 Korea Republic of Institute for Solid State Physics The University of Tokyo Chiba Kashiwa277-8581 Japan Trans-scale Quantum Science Institute The University of Tokyo Bunkyo Tokyo113-0033 Japan Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices School of Physics Sun Yat-sen University Guangzhou510275 China

Diagrammatic summation is a common bottleneck in modern applications of projected entangled-pair states, especially in computing low-energy excitations of a two-dimensional quantum many-body system. To solve this problem, here we extend the generating function approach for tensor network diagrammatic summation, a scheme previously proposed in the context of matrix product states. Taking the form of a one-particle excitation, we show that the excited state can be computed efficiently in the generating function formalism, which can further be used in evaluating the dynamical structure factor of the system. Our benchmark results for the spin-1/2 transverse-field Ising model and Heisenberg model on the square lattice provide a desirable accuracy, showing good agreement with known results. We then study the spin-1/2 J1-J2 model on the same lattice and investigate the dynamical properties of the putative gapless spin liquid phase. We conclude with a discussion on generalizations to multi-particle excitations. © 2023, CC BY.

关键词： Excited states

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