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SU-E-J-140: Dual-Gated Radiotherapy with PTV Partition Technique: A Feasibility Study

Medical Physics 2013年第6PART8期40卷 183-183页

作者： H Kim K Choi S Ye Interdisciplinary Program in Radiation Applied Life Science Seoul National University College of Medicine Seoul Korea Biomedical Research Institute Seoul National University Hospital Seoul Korea Institute of Radiation Medicine Seoul National University Medical Research Center Seoul Korea Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Suwon Korea Department of Radiation Oncology Seoul National University Hospital Seoul Korea

Purpose: Dual-gated radiotherapy is a promising method to reduce overall treatment time in which a dose is delivered at inhale and exhale phases. However, problems still remain associated with the phase shift and the target motion artifact. Dual-gated method deals with both phases — inhale and exhale, hence the delivered dose uncertainties due to the residual motion may be doubled. In order to account for these uncertainties, we applied PTV partition technique to dual-gated radiotherapy method. Methods: An IMRT plan for a lung cancer patient was optimized in Eclipse TPS at exhale phase. The PTV on the exhale CT was partitioned into three regions along the superior-inferior axis; head, mid, and tail region. The dose distribution on PTV was reformed as follows: a) no dose is given to the head region, b) a gradient dose (zero to the prescription dose) is given to the mid region, and c) a hundred percent of prescription dose is given to the tail region. The reformed exhale phase dose distribution and structures were deformed to the inhale phase CT using MIM software. Thereafter the dose distribution on PTV at inhale phase was reformed in order that complement of the prescription dose is given to each region. Results: The dose-volume histogram for PTV in the dual-gated plan with partitioned PTV was comparable to that in the conventional gating plan while the presented technique gives robustness to the residual motion. Conclusion: The proposed method using the PTV partition technique is promising to assess dose uncertainties due to the phase shift and the target motion artifact. Further assessment of the robustness to the residual motion by experiments using thorax phantom is warranted in this regard.

关键词： Dosimetry Radiation therapy Cancer Intensity modulated radiation therapy Lungs

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SU-E-J-99: Utilizing CT Dual DFOV in Treatment Planning System

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Medical Physics 2013年第6PART8期40卷 173-173页

作者： HyunSeok Lee Jung-in Kim Wonmo Sung Jong In Park Sung-Joon Ye Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Biomedical Research Institute Seoul National University Hospital Seoul Korea Institute of Radiation Medicine Seoul National University Medical Research Center Seoul Korea Interdisciplinary Program in Radiation Applied Life Science Seoul National University College of Medicine Seoul Korea Department of Radiation Oncology Seoul National University Hospital Seoul Korea

Purpose: Typically, a Display Field of View (DFOV) parameter is set to accommodate the wide part of anatomy in the scan, which is the shoulder in head and neck (HN) cases. The dual DFOV can make use of two image resolutions in one CT set. However, the Eclipse™ treatment planning system (TPS) accepts only the larger DFOV when reconstructing the body volume and thus particularly reduces in-plane resolution of the head region. In this study, we developed a method to preserve the original resolution of head CT images. Methods: The anthromorphic phantom was scanned from head to shoulder using the GE LightSpeed RT16 CT by applying small and large DFOV to head and shoulder region, respectively. Our in-house software enables dual DFOV CT images to be entered into Eclipse™ TPS. Basically, the software converts the pixel size of head CT images from 512 × 512 to 1024 × 1024 by expanding the DFOV outside. Results: The original and processed CT sets were loaded by Eclipse™ TPS and the differences were analyzed. Processed CT images showed two times better resolution than original CT images in head region. Distinguishing target and OAR in processed CT images is also clearer than before. We also confirmed that the mean percentage difference of CT numbers before and after processing was negligible for total phantom volume of the head region except steep gradient region which CT number changes drastically. Conclusion: The advantage of dual DFOV images was fully taken in the Eclipse™ TPS. In treatment planning, defining target and organ at risk which is the most important part for accurate treatment can be improved using high resolution dual DFOV CT images.

关键词： Computed tomography Medical imaging Medical treatment planning Anatomy Germanium

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ARSENIC HASTENS THE ONSET OF OSTEOARTHRITIS BY TRIGGERING THE NF-κB-HIF-2α/ZIP8 SIGNALING PATHWAY VIA REACTIVE OXYGEN SPECIES

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Osteoarthritis and Cartilage 2024年 32卷 S430-S430页

作者： Gamaarachchige, Dinesh Suminda Godagama Min, Yunhui Heo, Yunji Lee, Juyeon Jung, Man-Young GHOSH, MRINMOY Son, Young-Ok Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University Jeju Korea (the Republic of) Department of Animal Biotechnology Faculty of Biotechnology Jeju National University Jeju Korea (the Republic of) Department of Biology Education Jeju National University Jeju Korea (the Republic of) Department of Biotechnology School of Bio Chemical and Processing Engineering (SBCE) Kalasalin-gam Academy of Research and Educational Krishnankoil Tamil Nadu India

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SU-D-105-05: Independent Evaluation of Respiratory-Gated Treatments Using In-House Quality Assurance Tool

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Medical Physics 2013年第6PART3期40卷 101-101页

作者： J Park Y Park J Lee H Kim Ye Interdisciplinary Program in Radiation Applied Life Science Seoul National University College of Medicine Seoul Korea Biomedical Research Institute Seoul National University Hospital Seoul Korea Institute of Radiation Medicine Seoul National University Medical Research Center Seoul Korea Department of Radiation Oncology Massachusetts General Hospital Boston MA Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Department of Radiation Oncology Seoul National University Hospital Seoul Korea

Purpose: To quantitatively evaluate the reproducibility of patient breathing between the calculated phase from respiratory signal and RPM (real-time position management system, Varian Medical Systems, Palo Alto, CA) within treatment. We developed an independent retrospective verification system (RVS) for gated-radiotherapy using full signal and gating window in RPM system. Methods: RVS was programmed by LabVIEW 2009 with wavelet-based multi-resolution analysis, which is a useful and accurate technique for identifying peaks and valleys of noisy signals. The respiratory signal and real-time calculated phase information from RPM was exported to RVS as a text file. Using this text file, several respiratory parameters were calculated by RVS, and were compared with the generated parameters from RPM. The evaluated parameters included phase-shift, total displacement, residual motion, baseline shift, and so forth. The analysis was conducted for both in-gate and full respiratory signal separately. The analysis report was automatically generated in Excel file format. Eleven patients of abdominal cancer were retrospectively analyzed for the evaluation. Results: The mean phase error of gated signal and full signal between RPM and our software ranged from 1.50% to 3.08% and 1.52% to 3.08%, respectively. Average phase shift was not significant but in-gate phase difference between RVS and RPM was found to be higher than 4% in two cases. At times, real-time phase calculation from RPM caused the beam to be turned on at incorrect time of the breathing cycle when the patient breathing was not regular. The total displacement varied from 0.672 cm to 1.732 cm, which showed patient-specific baseline shift during treatment. Conclusion: The developed software demonstrated competency in analyzing RPM signal and evaluating patient-specific respiratory parameters of radiotherapy. Thus, it can be used as an independent quality assurance tool for RPM phase-based gating treatment.

关键词： Quality assurance Computer software Radiation therapy Cancer Acoustic noise measurement

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SU-E-J-98: Evaluating Commercial Orthopedic Metal Artifact Reduction Tool (OMAR) for CT Simulation in Radiotherapy for Head-And-Neck Cases

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Medical Physics 2013年第6PART8期40卷 173-173页

作者： H Kwon J Kim K Kim Y Chun J Park S Ye Interdisciplinary program in Radiation Applied Life Science Seoul National University College of Medicine Seoul Korea Biomedical Research Institute Seoul National University Hospital Seoul Korea Institute of Radiation Medicine Seoul National University Medical Research Center Seoul Korea Department of Radiation Oncology Seoul National University Hospital Seoul Korea Department of Radiation Oncology Seoul National University College of Medicine Seoul Korea Philips Healthcare Korea Seoul Korea Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Korea

Purpose: Many head-and-neck (H&N) patients have dental implants which can induce severe metal artifacts in CT images. This study assessed the performance and the effectiveness of the commercial orthopedic metal artifact reduction function (O-MAR) for radiotherapy of H&N patients. Methods: 20 H&N images scanned by Philips Brilliance Big Bore CT were used for the assessment. After O-MAR correction, the CT Hounsfield number and noise were measured and compared between the original and OMAR corrected images. Structures were contoured by a radiation oncologist on each of the two image sets. These contoured structure volumes on the original CT image were compared with those on O-MAR corrected CT image by radiation therapy planning system. After volumetric-modulated arc therapy (VMAT) planning was performed on the original CT image, this plan was translated and calculated on O-MAR corrected images. Each DVH was compared and the gamma passing rate was calculated for comparing dose distributions. Results: CT Hounsfield numbers became closer to the reference values after O-MAR correction. The standard deviations of the selected ROIs were reduced from 323.9 HU to 195.6 HU in air and from 43.5 HU to 24.7 HU in tissue. The volumes of contoured structure showed minute change. The difference between two DVH was less than 0.5%. The gamma pass rates of dose distributions calculated on the original and OMAR corrected images were higher than 99.9% in the case of closed-mouth-images but were about 80% in the case of opened-mouth-images when using 1mm and 1% distance-to-agreement criterion. Conclusion: The O-MAR algorithm is suitable for the entire radiation treatment planning process by increasing the accuracy of CT Hounsfield numbers and reducing noises. Although there was no significant difference in dose distribution for most cases, the O-MAR correction was shown to have an impact on opened-mouth-images.

关键词： Medical imaging Computed tomography Dosimetry Radiation therapy Medical image noise Tissues Medical image artifacts Radiation treatment Cancer

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2-[(Hydroxymethyl)amino]ethanol in water as a preservative: Study of formaldehyde released by Taguchi's method

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IOP Conference Series: Earth and Environmental science 2016年第1期36卷

作者： W Wisessirikul S Loykulnant S Montha T Fhulua P Prapainainar Interdisciplinary Graduate Program in Advanced and Sustainable Environmental Engineering Thailand Advanced Institute of Science and Technology and Tokyo Institute of Technology Kasetsart University Bangkok 10900 Thailand Natural Rubber Focus Unit National Metal and Materials Technology Center NSTDA 111 Paholyothin Rd. Klong 1 Klong Luang Pathumthani 12120 Thailand Environment Research Unit National Metal and Materials Technology Center NSTDA 111 Paholyothin Rd. Klong 1 Klong Luang Pathumthani 12120 Thailand National Center of Excellence for Petroleum Petrochemicals and Advance Materials Department of Chemical Engineering Faculty of Engineering Kasetsart University Thailand Center of Excellence of Nanotechnology Kasetsart University Thailand

This research studied the quantity of free formaldehyde released from 2- [(hydroxymethyl)amino]ethanol (HAE) in DI water and natural rubber latex mixture using high-performance liquid chromatography (HPLC) technique. The quantity of formaldehyde retained in the solution was cross-checked by using titration technique. The investigated factors were the concentration of preservative (HAE), pH, and temperature. Taguchi's method was used to design the experiments. The number of experiments was reduced to 16 experiments from all possible experiments by orthogonal arrays (3 factors and 4 levels in each factor). Minitab program was used as a tool for statistical calculation and for finding the suitable condition for the preservative system. HPLC studies showed that higher temperature and higher concentration of the preservative influence the amount of formaldehyde released. It was found that conditions at which formaldehyde was released in the lowest amount were 1.6%w/v HAE, 4 to 40 °C, and the original pH. Nevertheless, the pH value of NR latex should be more than 10 (the suitable pH value was found to be 13). This preservative can be used to replace current preservative systems and can maintain the quality of latex for long-term storage. Use of the proposed preservative system was also shown to have reduced impact on the toxicity of the environment.

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Author Correction: Highly efficient, heat dissipating, stretchable organic light-emitting diodes based on a MoO3/Au/MoO3 electrode with encapsulation

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Nature communications 2021年第1期12卷 7355页

作者： Dae Keun Choi Dong Hyun Kim Chang Min Lee Hassan Hafeez Subrata Sarker Jun Su Yang Hyung Ju Chae Geon-Woo Jeong Dong Hyun Choi Tae Wook Kim Seunghyup Yoo Jinouk Song Boo Soo Ma Taek-Soo Kim Chul Hoon Kim Hyun Jae Lee Jae Woo Lee Donghyun Kim Tae-Sung Bae Seung Min Yu Yong-Cheol Kang Juyun Park Kyoung-Ho Kim Muhammad Sujak Myungkwan Song Chang-Su Kim Seung Yoon Ryu Division of Display and Semiconductor Physics Display Convergence College of Science and Technology Korea University Sejong Campus Sejong City Republic of Korea. Department of Applied Physics Korea University Sejong Campus Sejong City Republic of Korea. E-ICT-Culture-Sports Convergence Track Korea University Sejong Campus Sejong City Republic of Korea. Division of Display and Semiconductor Physics Display Convergence College of Science and Technology Korea University Sejong Campus Sejong City Republic of Korea. hassaniskt@***. Department of Applied Physics Korea University Sejong Campus Sejong City Republic of Korea. hassaniskt@***. School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea. Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea. Department of Advanced Materials Chemistry College of Science and Technology Korea University Sejong Campus Sejong City Republic of Korea. Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Korea University Sejong Republic of Korea. Jeonju Center Korea Basic Science Institute (KBSI) Analysis & Researcher Division Jeollabuk-do Republic of Korea. Department of Chemistry Pukyong National University 45 Yongso-Ro Nam-gu Busan Republic of Korea. Department of Physics Chungbuk National University Cheongju Republic of Korea. Surface Materials Division Korea Institute of Materials Science (KIMS) Changwon Republic of Korea. Surface Materials Division Korea Institute of Materials Science (KIMS) Changwon Republic of Korea. cskim1025@kims.re.kr. Division of Display and Semiconductor Physics Display Convergence College of Science and Technology Korea University Sejong Campus Sejong City Republic of Korea. justie74@korea.ac.kr. Department of Applied Physics Korea University Sejong Campus Sejong City Republic of Korea. justie74@korea.ac.kr. E-ICT-Culture-Sports Conve

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Quantum Dots: Ultrasensitive, Biocompatible, Quantum‐Dot‐Embedded Silica Nanoparticles for Bioimaging (Adv. Funct. Mater. 9/2012)

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advanced Functional Materials 2012年第9期22卷

作者： Bong‐Hyun Jun Do Won Hwang Heung Su Jung Jaeho Jang Hyunsoo Kim Homan Kang Taegyu Kang San Kyeong Hyeokjae Lee Dae Hong Jeong Keon Wook Kang Hyewon Youn Dong Soo Lee Yoon‐Sik Lee School of Chemical and Biological Engineering Seoul National University Seoul 151‐747 Korea Department of Nuclear Medicine Seoul National University College of Medicine Seoul 110‐744 Korea Institute of Radiation Medicine Medical Research Center Seoul 110‐744 Korea Nanosquare Inc. ENG BLD39‐122 Seoul National University Seoul 151‐747 Korea WCU Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and Technology Seoul National University Seoul 151‐747 Korea Nano Systems Institute and Interdisciplinary Program in Nano‐Science and Technology Seoul National University Seoul 151‐747 Korea Department of Chemistry Education Seoul National University Seoul 151‐747 Korea Cancer Imaging Center Seoul National University Cancer Hospital Cancer Research Institute Seoul National University College of Medicine Seoul 110‐799 Korea

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Correction to: Dietary intervention using (1,3)/(1,6)-β-glucan, a fungus-derived soluble prebiotic ameliorates high-fat diet-induced metabolic distress and alters beneficially the gut microbiota in mice model

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European journal of nutrition 2021年第4期60卷 2273页

作者： Karthika Muthuramalingam Vineet Singh Changmin Choi Seung In Choi Young Mee Kim Tatsuya Unno Moonjae Cho Department of Biochemistry School of Medicine Jeju National University Jeju 63243 Republic of Korea. Faculty of Biotechnology School of Life Sciences SARI Jeju National University Jeju 63243 Republic of Korea. Department of Pharmaceutical Research Institute Quegen Biotech Co. Ltd Seoul 429931 Republic of Korea. Faculty of Biotechnology School of Life Sciences SARI Jeju National University Jeju 63243 Republic of Korea. tatsu@jejunu.ac.kr. Subtropical/Tropical Organism Gene Bank Jeju National University Jeju 63243 Republic of Korea. tatsu@jejunu.ac.kr. Department of Biochemistry School of Medicine Jeju National University Jeju 63243 Republic of Korea. moonjcho@jejunu.ac.kr. Institute of Medical Science Jeju National University Jeju 63241 Republic of Korea. moonjcho@jejunu.ac.kr. Interdisciplinary Graduate Program in Advanced Convergence Technology & Science Jeju National University Jeju 63241 Republic of Korea. moonjcho@jejunu.ac.kr.

A correction to this paper has been published: https://***/10.1007/s00394-021-02537-9

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Corrigendum to "Dual regulatory effects of neferine on amyloid-β and tau aggregation studied by in silico, in vitro, and lab-on-a-chip technology" [Biomed. Pharmacother. 172 (2024) 1-14/116226]

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024年 181卷 117686页

作者： Yunkwon Nam Ritu Prajapati Sujin Kim Soo Jung Shin Da Yeon Cheong Yong Ho Park Hyun Ha Park Danyou Lim Yoojeong Yoon Gyudo Lee Hyun Ah Jung Insu Park Dong-Hyun Kim Jae Sue Choi Minho Moon Department of Biochemistry College of Medicine Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea. Department of Food and Life Science Pukyong National University Busan 48513 Republic of Korea. Department of Biochemistry College of Medicine Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea Research Institute for Dementia Science Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea. Department of Biotechnology and Bioinformatics Korea University Sejong 30019 Republic of Korea Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Korea University Sejong 30019 Republic of Korea. Department of Biomedical Engineering Konyang University Daejeon 35365 Republic of Korea. Department of Food Science and Human Nutrition Chonbuk National University Jeonju 54896 Republic of Korea. Department of Biomedical Engineering Konyang University Daejeon 35365 Republic of Korea. Electronic address: insupark@konyang.ac.kr. Departments of Pharmacology and Advanced Translational Medicine School of Medicine Konkuk University Seoul 05029 Republic of Korea. Electronic address: mose79@kku.ac.kr. Department of Food and Life Science Pukyong National University Busan 48513 Republic of Korea. Electronic address: choijs@pknu.ac.kr. Research Institute for Dementia Science Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea. Electronic address: hominmoon@konyang.ac.kr.

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