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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Se-Ryong Kang Woo-Jin Lee Sang-Yoon Woo Dae-Seung Kim Won-Jin Yi Department of Biomedical Radiation Sciences Graduate School of Convergence Science and Technology Seoul National University Interdisciplinary Program in Radiation Applied Life Science College of Medicine Seoul National University Department of Oral and Maxillofacial Radiology School of Dentistry Seoul National University Department of Oral and Maxillofacial Radiology School of Dentistry and the Department of Biomedical Radiation Sciences Graduate School of Convergence Science and Technology Seoul National University

ISBN: (纸本)9781424479276

This paper presents K-edge filtering and energy weighting methods which enhance the contrast with less radiation does. Usually, energy weighting methods are used with photon-counting detector based CT for each energy bin data obtained to enhance the quality of image. However, we used these methods combine with K-edge filtering in energy-integrating detector. Using K-edge filtering, different energy bin data for energy weighting methods were obtained, and then energy weighting factors were calculated to enhance the contrast of image. We report an evaluation of the contrast-to-noise ratio (CNR) of reconstructed image with and without these two methods. This evaluation was proceeded with two phantoms;one is the phantom created personally, and the other is Sendentexct IQ dental CBCT (SENDENTEXCT, EU). As for the phantom created personally, the CNR of images reconstructed with these methods were increased than CNR of standard images. It was seen that 31% to 81% in each energy weighting method for optimizing each material (cortical bone, inner bone, soft tissue, iodine (18.5g/l), iodine (37g/l)). In conclusion, we can enhance the contrast of CT images with less radiation dose using K-edge filtering and energy weighting method.

关键词： Computed tomography Image reconstruction Materials Filtering Dentistry Bones

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Phase-change metal ink with pH-controlled chemical sintering for versatile and scalable fabrication of variable stiffness electronics

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science Advances 2025年第22期11卷

作者： Simok Lee Gun-Hee Lee Inho Kang Woojin Jeon Semin Kim Yejin Ahn Choong Yeon Kim Do A Kwon Michael D. Dickey Steve Park Seongjun Park Jae-Woong Jeong School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. Medical Research Center Seoul National University Seoul 03080 Republic of Korea. Departments of Cogno-Mechatronics Engineering and Optics and Mechatronics Engineering Pusan National University Busan 46241 Republic of Korea. Graduate School of Semiconductor Technology Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. KAIST Information and Electronics Research Institute Daejeon 34141 Republic of Korea. Research Laboratory of Electronics Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA. Department of Mechanical Engineering Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA. Department of Chemical and Biomolecular Engineering North Carolina State University (NCSU) Raleigh NC 27606 USA. Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. KAIST Institute for NanoCentury Daejeon 34141 Republic of Korea. Department of Biomedical Sciences College of Medicine Seoul National University Seoul 03080 Republic of Korea. School of Transdisciplinary Innovations Seoul National University Seoul 03080 Republic of Korea. Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul 08826 Republic of Korea. Department of Transdisciplinary Medicine Seoul National University Hospital Seoul 03080 Republic of Korea. KAIST Institute for Health Science and Technology Daejeon 34141 Republic of Korea.

Variable stiffness electronics represent the forefront of adaptive technology, integrating rigid and soft electronics in a single system through dynamic mechanical modulation. While gallium’s high modulus tuning ratio and rapid phase transitions make it ideal for transformative electronic systems (TES), its liquid-state instability, high surface tension, and unintended phase transitions during processing pose substantial challenges. Here, we introduce STiffness-Adjustable temperature-Responsive ink (STAR ink), a chemically sinterable gallium composite electronic ink designed to overcome these obstacles. STAR ink enables high-resolution (~50 micrometers) circuit patterning, large-scale batch fabrication, and three-dimensional structure coating at room temperature. Through pH-controlled chemical sintering, STAR ink–based TES exhibits exceptional mechanical tunability (tuning ratio: 1465) and electrical conductivity (2.27 × 106 siemens per meter). Demonstrated applications—from multilayered variable stiffness printed circuit boards (PCBs) matching standard PCBs’ complexity to body-temperature responsive neural probe—underscore STAR ink’s potential for reconfigurable electronics across consumer electronics and biomedical devices.

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Quantitative Radiation Dosimetry by Measuring Thermoluminescence of Resistors in Electronic Personal Dosimeters

SSRN

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SSRN 2024年

作者： Lee, Hyunseok Ye, Sung-Joon Kim, Hong Suk Kim, Ah Reum Yu, Hyungjoon Kim, Myung-Jin Korea Institute of Nuclear Safety Daejeon Korea Republic of Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Republic of Research Institute for Convergence Science Seoul National University Seoul Korea Republic of Advanced Institute of Convergence Technology Seoul National University Suwon Korea Republic of RADPION Inc. Daejeon Korea Republic of

A study on retrospective dosimetry was performed using electronic personal dosimeters (EPDs) for reconstructing doses received by radiographic testing workers. The dosimetric properties of the thermoluminescence (TL) peak in the temperature range of 100-200 °C were investigated by measuring the TL of the resistor extracted from the EPDs in a darkroom environment. Results showed that this TL peak exhibited optimal dosimetric properties, with a minimum detectable dose as low as 13 mGy. To calculate the absorbed dose using the resistor, a simplified single aliquot regenerative (SAR) dose method using the TL peak was employed. The zero dose of the commercial EPD (model CLOVER) was determined to be 58 ± 72 mGy through the random selection of six EPDs. Additionally, a dose overestimation correction factor of 1.73 ± 0.09 was calculated. Furthermore, it was observed that the TL signal faded exponentially to approximately 60% over a period of 12 weeks. Subsequently, retrospective dosimetry was performed by irradiating EPDs with a standard gamma ray dose of 1 Gy. The radiation exposure dose calculated from the TL peak of the resistor was found to be approximately 10% lower. These findings showed that the retrospective dosimetry with EPD can be utilized for accurately estimating the radiation exposure dose. © 2024, The Authors. All rights reserved.

关键词： Thermoluminescence

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Emerging MOT education in Japan

Emerging MOT education in Japan

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IEEE International Conference on Engineering Management (EMC)

作者： A. Kameoka S.W. Collins Meng Li M. Hashimoto Graduate School of Knowledge Science Japan Advanced Institute of Science and Technology Tatsunokuchi Ishikawa Japan Program Interdisciplinary Arts & Sciences University of Washington Bothell WA USA Ministry of Economy Trade and Industry University-Industry Cooperation Chiyoda Tokyo Japan

Formal MOT (management of technology) education programs have boomed in the past year after a long period of fermentation. The coming of MOT education provides an additional approach for Japanese firms and industries to revitalize their global competitive advantages that have eroded in the past ten years. This paper analyzes the back-ground of this phenomenon and explores basic driving forces behind it. On the one hand, firms and industry have need for creative professionals in identifying opportunities in emerging technology, planning proper projects and leading timely actions for selected targets; on the other hand, government has a strong desire to create dynamic venturing business by supporting suitable education programs for supplying needed talents. Japan is experiencing a fundamental paradigm shift from technology follower to front-runner in many industries. Firms operating in the new paradigm require workers with different capabilities than those demanded in the previous paradigm. However, the current education system for technology management has failed to provide the requisite creativity and leadership. Needed today are leaders who can generate creative product concepts, formulate strategies to realize those concepts, and implement the chosen strategy; these are the so-called "techno-producers", the concept of which was proposed earlier by Kameoka. Under most circumstances, these key persons do not appear spontaneously. Rather an education system that provides formal training in management is needed to systematically supply these innovators, who later may become techno-producers, especially in high-tech and high-growth industries.

关键词： Technological innovation technology management Educational technology Educational products Management training Educational programs Art technology planning Government Business

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Genome-wide CRISPR screens identify PTPN21 and WDR26 as modulators of the mitochondrial stress-induced ISR

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Life Metabolism 2024年第4期3卷 55-61页

作者： Wen Li Mingyue Dong Kaiyu Gao Jialiang Guan Ying Liu State Key Laboratory of Membrane Biology New Cornerstone Science LaboratoryInstitute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Beijing Advanced Innovation Center for Genomics Beijing 100871China PKU-Tsinghua-NIBS Graduate Program Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China

Dear Editor,Organisms have evolved mitochondrial stress response pathways to surveil mitochondrial function and activate repair programs upon detection of mitochondrial dysfunction[1].Failure to respond to mitochondrial perturbation has been implicated in aging and age-related diseases[2,3].Mitochondrial perturbation in mammals primarily activates the integrated stress response(ISR).

关键词： stress diseases primarily

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A novel N6-Deoxyadenine methyltransferase METL-9 modulates *** immunity via dichotomous mechanisms

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细胞研究（英文版） 2023年第8期33卷 628-639页

作者： Chengchuan Ma Tingling Xue Qi Peng Jie Zhang Jialiang Guan Wanqiu Ding Yi Li Peixue Xia Liankui Zhou Tianyu Zhao Sheng Wang Li Quan Chuan-Yun Li Ying Liu State Key Laboratory of Membrane Biology New Cornerstone Science LaboratoryInstitute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijingChina Peking-Tsinghua Center for Life Sciences Peking UniversityBeijingChina Beijing Advanced Innovation Center for Genomics BeijingChina Research Center for Stem Cell and Regenerative Medicine Institute of Blood TransfusionChinese Academy of Medical Sciences and Peking Union Medical CollegeChengduSichuanChina State Key Laboratory of Membrane Biology New Cornerstone Science LaboratoryInstitute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijingChina Peking-Tsinghua Center for Life Sciences Peking UniversityBeijingChina Laboratory of Bloinformatics and Genomic Medicine Institute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijingChina State Key Laboratory of Membrane Biology New Cornerstone Science LaboratoryInstitute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijingChina PKU-Tsinghua-NIBS Graduate Program Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingChina State Key Laboratory of Membrane Biology New Cornerstone Science LaboratoryInstitute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijingChina Shanghai Zelixir Biotech Company Ltd. ShanghaiChina State Key Laboratory of Membrane Biology New Cornerstone Science LaboratoryInstitute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijingChina Peking-Tsinghua Center for Life Sciences Peking UniversityBeijingChina Beijing Advanced Innovation Center for Genomics BeijingChina

N6-Methyldeoxyadenine(6mA)has been rediscovered as a DNA modification with potential biological function in ***,the physiological function and regulatory mechanisms regarding the establishment,maintenance and removal of 6mA in eukaryotes are still poorly *** we show that genomic 6mA levels change in response to pathogenic infection in Caenorhabditis elegans(***).We further identify METL-9 as the methyltransferase that catalyzes DNA 6mA modifications upon pathogen *** of METL-9 impairs the induction of innate immune response genes and renders the animals more susceptible to pathogen ***,METL-9 functions through both 6mA-dependent and-independent mechanisms to transcriptionally regulate innate *** findings reveal that 6mA is a functional DNA modification in immunomodulation in ***.

关键词： DNA methylation Methylation analysis

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2-[(Hydroxymethyl)amino]ethanol in water as a preservative: Study of formaldehyde released by Taguchi's method 5

2-[(Hydroxymethyl)amino]ethanol in water as a preservative: ...

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5th International Conference on Chemical and Bioprocess Engineering, ICCBPE 2015

作者： Wisessirikul, W. Loykulnant, S. Montha, S. Fhulua, T. Prapainainar, P. Interdisciplinary Graduate Program in Advanced and Sustainable Environmental Engineering Thailand Advanced Institute of Science and Technology Tokyo Institute of Technology Kasetsart University Bangkok10900 Thailand Natural Rubber Focus Unit National Metal and Materials Technology Center NSTDA 111 Paholyothin Rd. Klong 1 Klong Luang Pathumthani12120 Thailand Environment Research Unit National Metal and Materials Technology Center NSTDA 111 Paholyothin Rd. Klong 1 Klong Luang Pathumthani12120 Thailand National Center of Excellence for Petroleum Petrochemicals and Advance Materials Department of Chemical Engineering Faculty of Engineering Kasetsart University Thailand Center of Excellence of Nanotechnology Kasetsart University Thailand

This research studied the quantity of free formaldehyde released from 2- [(hydroxymethyl)amino]ethanol (HAE) in DI water and natural rubber latex mixture using high-performance liquid chromatography (HPLC) technique. The quantity of formaldehyde retained in the solution was cross-checked by using titration technique. The investigated factors were the concentration of preservative (HAE), pH, and temperature. Taguchi's method was used to design the experiments. The number of experiments was reduced to 16 experiments from all possible experiments by orthogonal arrays (3 factors and 4 levels in each factor). Minitab program was used as a tool for statistical calculation and for finding the suitable condition for the preservative system. HPLC studies showed that higher temperature and higher concentration of the preservative influence the amount of formaldehyde released. It was found that conditions at which formaldehyde was released in the lowest amount were 1.6%w/v HAE, 4 to 40 °C, and the original pH. Nevertheless, the pH value of NR latex should be more than 10 (the suitable pH value was found to be 13). This preservative can be used to replace current preservative systems and can maintain the quality of latex for long-term storage. Use of the proposed preservative system was also shown to have reduced impact on the toxicity of the environment. © Published under licence by IOP Publishing Ltd.

关键词： Formaldehyde

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Gate-Insulator-Capacitance-Dependent Field-Effect Mobility in Solution-Processed Oxide Semiconductor Thin-Film Transistors

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ECS Meeting Abstracts 2014年第47期MA2014-02卷

作者： Eungkyu Lee Keon-Hee Lim Si Yun Park Kyongjun Kim Youn Sang Kim Seoul National University The Graduate School of Convergence Science and Technology Program in Nano Science and Technology Advanced Institutes of Convergence Technology

We theoretically and experimentally investigate how the field-effect mobility (MFE) depends on the gate capacitances (CI) in solution-processed oxide semiconductor (OS) thin-film transistors (TFTs). With recently developed solution-based techniques, high quality OS films can be deposited onto flexible substrates at low temperatures, which accelerate applying of flexible, transparent, and ink-jet printable OS TFTs to future mobile display and electronics. Meanwhile, another important issue is to sustainably use of portable devices using integrated OS TFT circuits for a long time. Empirically, Increasing CI has been used to increase the drain current (ID) for high-performance and low-energy consuming OS TFTs, which is based on a theory of conventional metal-oxide-semiconductor field-effect transistors (MOSFETs): ID∝CI. However, it has been observed that incremental features of ID as increasing CI in solution-processed OS TFTs are quite different to that of MOSFETs. It is because disordered metal ions and dense grain boundaries in the solution-processed OSs make MFE depend on total number of accumulated electrons. Thus, MFE relies on CI, and ID cannot be linear relationship to CI. Therefore, grasping the relationship between MFE and CI in theoretical manner is important to realize high-performance, low-operational voltage devices, and it is also useful to design, optimize, and integrate OS TFT circuits. The disordering nature of solution-processed OSs can be classified into nanocrystalline and amorphous states, which are determined by how many numbers of metal ions component are contained. When the number of metal ion component is '1', such as ZnO, InO2, and SnO2, the solution-processed OS films have nanocrystalline phase. As the number of metal ion component is larger than '1'(for example, ZnSnO, InGaZnO, InZnO), the states of the OS films are amorphous. Although electronic properties of both amorphous and nanocrystalline OS films arising from their atomic arrangement

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Dose Optimization of rhIL-7-hyFc for Patients With Lymphopenia Using a Neonatal Fc Receptor-Mediated Recycling-Based and Target-Mediated Drug Disposition Pharmacokinetic Model

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Clinical and translational science 2025年第5期18卷 e70252页

作者： Hye Seon Jeon Sang Won Lee Woojin Jung Heeyoon Jung Donghoon Choi Mi-Sun Byun Hwi-Yeol Yun Soyoung Lee Anhye Kim Jung-Woo Chae Howard Lee College of Pharmacy Chungnam National University Daejeon Republic of Korea. Department of Pharmacology Hanyang University College of Medicine Seoul Republic of Korea. Department of Clinical Pharmacology and Therapeutics Hanyang University Seoul Hospital Seoul Republic of Korea. Population Health Sciences Program Department of Population and Quantitative Health Sciences University of Massachusetts Chan Medical School Worcester Massachusetts USA. Research Institute of NeoImmuneTech Inc. Pohang Republic of Korea. Clinical Development Department Genexine Inc. Seoul Republic of Korea. Department of Bio-AI Convergence Chungnam National University Daejeon Republic of Korea. Department of Clinical Pharmacology and Therapeutics CHA University Bundang Medical Center Seongnam Republic of Korea. Department of Pharmacology CHA University School of Medicine CHA University Seongnam Republic of Korea. Institute for Biomedical Informatics CHA University School of Medicine CHA University Seongnam Republic of Korea. Department of Clinical Pharmacology and Therapeutics Seoul National University Hospital Seoul Republic of Korea. Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and Technology Seoul National University Seoul Republic of Korea. Advanced Institute of Convergence Technology Suwon Republic of Korea.

Recombinant human interleukin-7 hybrid Fc (rhIL-7-hyFc) is a homodimer of rhIL-7 fused to a hyFc. Exogenous IL-7 promotes T cell proliferation and increases lymphocyte count, making it a potential treatment option for lymphopenia and cancer. To improve therapeutic efficacy, rhIL-7-hyFc was developed as a long-acting IL-7. This study aimed to create a pharmacokinetic model for rhIL-7-hyFc by incorporating neonatal Fc receptor (FcRn)-mediated recycling and target-mediated drug disposition (TMDD) of the IL-7 receptor. Data were collected from a randomized, double-blind, placebo-controlled phase 1 trial involving 30 healthy volunteers who received single doses of rhIL-7-hyFc. Volunteers received 20 or 60 mg/kg subcutaneously, 60 mg/kg intramuscularly (IM), or a placebo. Clinical data were provided by Genexine Inc. (Seoul, Republic of Korea). A TMDD-FcRn-mediated recycling pharmacokinetic model was developed using NONMEM 7.5 software, assisted by PsN 5.3.1 software. A quasi-steady-state approximation was used to describe drug-receptor and drug-FcRn interactions. The model evaluation included goodness of fit, visual predictive checks, and bootstrap analysis. Based on the pharmacokinetic parameters of the final model, a simulation was conducted to select the dosage regimen, ensuring a probability of at least 0.8 for meeting both safety and efficacy criteria. The model successfully described the pharmacokinetic profiles of 24 patients administered rhIL-7-hyFc. Based on the simulation results, 670-800 μg/kg every 3 weeks, 1010-1530 μg/kg every 6 weeks, and 1510-2190 μg/kg every 9 weeks IM were proposed. These results may help further understand rhIL-7-hyFc characteristics and, moreover, provide guidance for selecting the appropriate dosing regimen in future clinical trials.

关键词： lymphopenia optimal dosing for clinical trials rhIL‐7‐hyFc semi‐mechanistic model

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Norm selection for evaluation criterion for placement planning of active damping devices in structure

Norm selection for evaluation criterion for placement planni...

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International Conference on Informatics in Control, Automation and Robotics (ICINCO)

作者： Kou Miyamoto Jinhua She Hiroshi Hashimoto Min Wu Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology Yokohama Kanagawa Japan School of Automation China University of Geosciences Wuhan China School of Engineering Tokyo University of Technology Tokyo Japan Master Program of Innovation for Design and Engineering Advanced Institute of Industrial Technology Tokyo Japan

Active vibration control has been widely investigated in civil engineering. This study considers the problem of selecting a norm for an evaluation criterion for the planning of the placement of active damping devices (ADDs) in a structure in active vibration control. Using a 4-degree-of-freedom system as an example, we compare the commonly used 2-norm and ∞-norm, and show that the 2-norm is a suitable choice for the performance index of the placement planning of ADDs.

关键词： Earthquakes Planning Damping Vibration control Optimization Performance analysis

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