Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitati...
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Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze continued...challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative
Major depressive disorder (MDD) is a prevalent psychiatric condition that affects millions of people worldwide and is a leading cause of disability. Chronic stress is a key factor in the development of MDD, leading to...
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Major depressive disorder (MDD) is a prevalent psychiatric condition that affects millions of people worldwide and is a leading cause of disability. Chronic stress is a key factor in the development of MDD, leading to hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis and elevated glucocorticoid levels, which in turn affect brain function and structure. Astrocytes, crucial for maintaining central nervous system (CNS) homeostasis, play a significant role in the pathophysiology of MDD. Dysregulation of glucocorticoid signaling in astrocytes contributes to changes in astrocyte survival, reactivity, metabolism, neurotrophic support, gliotransmitter release, and neuroinflammation, exacerbating depressive symptoms. This review explains the necessity for exploring the effects of glucocorticoid in astrocytes and subsequent MDD progression. Firstly, we briefly explore the glucocorticoid signaling and the multifaceted function of astrocytes. Then, this study discusses the mechanisms by which chronic stress and glucocorticoid exposure induce astrocyte-mediated neurodegenerative changes, highlighting the importance of targeting glucocorticoid-related signaling of astrocytes in developing therapeutic interventions for MDD. Understanding these mechanisms could lead to the development of more effective treatments aimed at restoring astrocyte function and alleviating MDD.
We propose a simple and generic construction of the variational tensor network operators to study the quantum spin systems by the synergy of ideas from the imaginary-time evolution and variational optimization of tria...
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The responses of the western North Pacific (WNP) tropical cyclone (TC) genesis and associated large-scale atmospheric environment to varying CO2pathways are investigated using an idealized CO2removal experiment. In th...
The responses of the western North Pacific (WNP) tropical cyclone (TC) genesis and associated large-scale atmospheric environment to varying CO2pathways are investigated using an idealized CO2removal experiment. In the experiment, CO2concentration is first increased at the rate of 1% year−1until quadrupled and then decreased at the same rate until it reaches the initial level. Our results indicate asymmetric changes in WNP peak-season (July–September) TC genesis between CO2ramp-up and ramp-down periods, showing a significant reduction of TC genesis over the Philippine Sea and landfalling TCs in East Asia when the CO2concentration is reduced. Such TC activity changes are attributed to the development of WNP anticyclonic circulation in the ramp-down period, in association with an El Niño-like delayed response in sea surface temperature. This asymmetric response of WNP TC activities to symmetric CO2pathway may provide a reference for regional TC disaster prevention and preparations under mitigation conditions.
Kilonova spectra provide us with information of r-process nucleosynthesis in neutron star mergers. However, it is still challenging to identify individual elements in the spectra mainly due to lack of experimentally a...
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Recognizing the tremendous improvements that the integration of generative AI can bring to intelligent transportation systems, this article explores the integration of generative AI technologies in vehicular networks,...
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Cholera is a highly contagious and lethal waterborne disease induced by an infection with Vibrio cholerae (V. cholerae) secreting cholera toxin (CTx). Cholera toxin subunit B (CTxB) from the CTx specifically binds wit...
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XERICO's capacity to enhance ABA-driven stress responses across diverse crops, its regulatory crosstalk with other hormonal pathways, and its compatibility with advanced genetic engineering tools highlight its cen...
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We present two results of a search for MeV-scale neutrino and anti-neutrino events correlated with gravitational wave events/candidates and large solar flares with KamLAND. The KamLAND detector is a large-volume neutr...
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