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Diet-Driven Inflammation and Insulinemia and Risk of Interval Breast Cancer

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 2022年第9期74卷 3179-3193页

作者： Zhang, Zhenzhen Tabung, Fred K. Jin, Qi Curran, Grace Irvin, Veronica L. Shannon, Jackilen Velie, Ellen M. Manson, JoAnn E. Simon, Michael S. Vitolins, Mara Valencia, Celina I. Snetselaar, Linda Jindal, Sonali Schedin, Pepper Oregon Hlth & Sci Univ Div Oncol Sci 3181 SW Sam Jackson Pk Rd Portland OR 97239 USA Ohio State Univ Coll Med Columbus OH 43210 USA Ohio State Univ Ctr Comprehens Canc Columbus OH 43210 USA Ohio State Univ Interdisciplinary PhD Program Nutr Columbus OH 43210 USA Oregon Hlth & Sci Univ Canc Early Detect Adv Res Ctr Portland OR 97201 USA Oregon State Univ Coll Publ Hlth & Human Sci Corvallis OR 97331 USA Oregon Hlth & Sci Univ OHSU PSU Sch Publ Hlth Portland OR 97201 USA Univ Wisconsin Zilber Sch Publ Hlth Milwaukee WI 53201 USA Med Coll Wisconsin Dept Med Wauwatosa WI USA Med Coll Wisconsin Dept Pathol Wauwatosa WI USA Harvard Med Sch Brigham & Womens Hosp Dept Med Boston MA 02115 USA Harvard TH Chan Sch Publ Hlth Dept Epidemiol Boston MA USA Wayne State Univ Dept Oncol Karmanos Canc Inst Detroit MI USA Wake Forest Sch Med Dept Epidemiol & Prevent Winston Salem NC 27101 USA Univ Arizona Dept Family & Community Med Coll Med Tucson Tucson AZ USA Univ Iowa Dept Epidemiol Coll Publ Hlth Iowa City IA USA Oregon Hlth & Sci Univ Dept Cell Dev & Canc Biol Portland OR 97201 USA

Interval breast cancers (IBCs) emerge after a non-suspicious mammogram and before the patient's next scheduled screen. Risk factors associated with IBC have not been identified. This study evaluated if the empirical dietary inflammatory pattern (EDIP) or empirical dietary index for hyperinsulinemia (EDIH) scores are associated with IBC compared to screen-detected breast cancer. Data were from women 50-79 years-old in the Women's Health Initiative cohort who completed food frequency questionnaires at baseline (1993-98) and were followed through March 31, 2019 for breast cancer detection. Women were identified as having either IBC diagnosed within 1-year after their last negative screening mammogram (N = 317) or screen-detected breast cancer (N = 1,928). Multivariable-adjusted logistic regression analyses were used to estimate odds ratios for risk of IBC compared to screen-detected cancer in dietary index tertiles. No associations were observed between EDIP or EDIH and IBC. Odds ratios comparing the highest to the lowest dietary index tertile were 1.08;95%CI, 0.78-1.48 for EDIP and 0.92;95%CI, 0.67-1.27 for EDIH. The null associations persisted when stratified by BMI categories. Findings suggest that diet-driven inflammation or insulinemia may not be substantially associated with IBC risk among postmenopausal women. Future studies are warranted to identify modifiable factors for IBC prevention.

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Effects of Different Chenopodium formosanum Parts on Antioxidant Capacity and Optimal Extraction Analysis by Taguchi Method

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MATERIALS 2021年第16期14卷 4679-4679页

作者： Wu, Chin-Tung Wang, Wei-Hsun Lin, Wen-Shin Hu, Shiou-Yih Chen, Cheng-You Chang, Min-Yun Lin, Yung-Sheng Li, Chi-Ping Natl Yunlin Univ Sci & Technol Coll Future Bachelor Program Interdisciplinary Studies Touliu 640301 Yunlin Taiwan Changhua Christian Hosp Dept Orthoped Surg Changhua 500209 Taiwan Kaohsiung Med Univ Sch Med Kaohsiung 807378 Taiwan Chaoyang Univ Technol Dept Golden Ager Ind Management Taichung 413310 Taiwan Shu Zen Jr Coll Med & Management Dept Med Imaging & Radiol Kaohsiung 821004 Taiwan Natl Chung Hsing Univ Coll Med Taichung 402202 Taiwan Natl United Univ Dept Chem Engn Miaoli 360001 Taiwan Natl Pingtung Univ Sci & Technol Dept Plant Ind Pingtung 912301 Taiwan Natl United Univ PhD Program Mat & Chem Engn Miaoli 360001 Taiwan Natl Yang Ming Chiao Tung Univ Inst Food Safety & Hlth Risk Assessment Taipei 112304 Taiwan

Chenopodium formosanum (CF), rich in nutrients and antioxidants, is a native plant in Taiwan. During the harvest, the seeds are collected, while the roots, stems, and leaves remain on the field as agricultural waste. In this study, di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical scavenging ability and 2,2 '-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging ability experiments of seeds, leaves, stems, and roots were designed using the Taguchi method (TM) under three conditions: Ethanol concentration (0-100%), temperature (25-65 degrees C), and extraction time (30-150 min). The result demonstrates that seeds and leaves have higher radical scavenging ability than stems and roots. Many studies focused on CF seeds. Therefore, this study selected CF leaves and optimized DPPH, ABTS, total phenol content (TPC), total flavonoid content (TFC), and reducing power (RP) through TM, showing that the predicted value of the leaf is close to the actual value. The optimized results of CF leaves were DPPH 85.22%, ABTS 46.51%, TPC 116.54 mu g GAE/mL, TFC 143.46 mu g QE/mL, and RP 23.29 mu g VCE (vitamin C equivalent)/mL. The DPPH and ABTS of CF leaves were second only to the results of CF seeds. It can be seen that CF leaves have the potential as a source of antioxidants and help in waste reduction.

关键词： antioxidant Chenopodium formosanum leaf extract design of experiment Taguchi method

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Enhanced Na⁺-K⁺-2Cl^- cotransporter 1 underlies motor dysfunction in huntington's disease

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MOVEMENT DISORDERS 2019年第6期34卷 845-857页

作者： Hsu, Yi-Ting Chang, Ya-Gin Liu, Yu-Chao Wang, Kai-Yi Chen, Hui-Mei Lee, Ding-Jin Yang, Sung-Sen Tsai, Chon-Haw Lien, Cheng-Chang Chern, Yijuang China Med Univ PhD Program Translat Med Taipei Taiwan Acad Sinica Taipei Taiwan China Med Univ Hosp Dept Neurol Taichung Taiwan Natl Yang Ming Univ Inst Neurosci Taipei 112 Taiwan Natl Yang Ming Univ Taiwan Int Grad Program Interdisciplinary Neurosc Taipei Taiwan Acad Sinica Inst Biomed Sci Taipei 115 Taiwan Triserv Gen Hosp Div Nephrol Dept Med Natl Def Med Ctr Taipei Taiwan Natl Yang Ming Univ Brain Res Ctr Taipei Taiwan

Background Altered gamma-aminobutyric acid signaling is believed to disrupt the excitation/inhibition balance in the striatum, which may account for the motor symptoms of Huntington's disease. Na-K-2Cl cotransporter-1 is a key molecule that controls gamma-aminobutyric acid-ergic signaling. However, the role of Na-K-2Cl cotransporter-1 and efficacy of gamma-aminobutyric acid-ergic transmission remain unknown in Huntington's disease. Methods We determined the levels of Na-K-2Cl cotransporter-1 in brain tissue from Huntington's disease mice and patients by real-time quantitative polymerase chain reaction, western blot, and immunocytochemistry. Gramicidin-perforated patch-clamp recordings were used to measure the E gamma-aminobutyric acid in striatal brain slices. To inhibit Na-K-2Cl cotransporter-1 activity, R6/2 mice were treated with an intraperitoneal injection of bumetanide or adeno-associated virus-mediated delivery of Na-K-2Cl cotransporter-1 short-hairpin RNA into the striatum. Motor behavior assays were employed. Results Expression of Na-K-2Cl cotransporter-1 was elevated in the striatum of R6/2 and Hdh(150Q/7Q) mouse models. An increase in Na-K-2Cl cotransporter-1 transcripts was also found in the caudate nucleus of Huntington's disease patients. Accordingly, a depolarizing shift of E gamma-aminobutyric acid was detected in the striatum of R6/2 mice. Expression of the mutant huntingtin in astrocytes and neuroinflammation were necessary for enhanced expression of Na-K-2Cl cotransporter-1 in HD mice. Notably, pharmacological or genetic inhibition of Na-K-2Cl cotransporter-1 rescued the motor deficits of R6/2 mice. Conclusions Our findings demonstrate that aberrant gamma-aminobutyric acid-ergic signaling and enhanced Na-K-2Cl cotransporter-1 contribute to the pathogenesis of Huntington's disease and identify a new therapeutic target for the potential rescue of motor dysfunction in patients with Huntington's disease. (c) 2019 International Parkinson and Movement D

关键词： bmetanide GABAergic signaling inflammation mutant Huntingtin NKCC1

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Implications of Sugarcane Straw Removal for Soil Greenhouse Gas Emissions in Sao Paulo State, Brazil

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BIOENERGY RESEARCH 2019年第4期12卷 843-857页

作者： Gonzaga, Leandro Carolino Zotelli, Luciana do Carmo Quassi de Castro, Sergio Gustavo de Oliveira, Bruna Goncalves Bordonal, Ricardo de Oliveira Cantarella, Heitor Nunes Carvalho, Joao Luis Natl Ctr Res Energy & Mat CNPEM Brazilian Biorenewables Natl Lab LNBR Rua Giuseppe Maximo Scolfaro 10000 BR-13083100 Campinas SP Brazil Univ Campinas UNICAMP Interdisciplinary PhD Program Bioenergy Rua Monteiro Lobato 80Cidade Univ BR-13083862 Campinas SP Brazil State Univ Campinas UNICAMP Fac Mech Engn Program Energy Syst Planning Rua Mendeleyev 200Cidade Univ Zeferino Vaz BR-13083860 Campinas SP Brazil Agron Inst Campinas IAC Soils & Environm Resources Ctr Ave Barao de Itapura 1481 BR-13020902 Campinas SP Brazil

The use of sugarcane straw is a promising option to enhance bioenergy production. But the implications of straw removal for soil greenhouse gas (GHG) emission are not yet fully understood due to scarcity of studies under Brazilian conditions. Four field experiments were designed to assess soil N2O and CH4 emissions derived from nitrogen (N) fertilization under scenarios of sugarcane straw removal in Sao Paulo state, Brazil. Our focus was also to derive the direct N2O emission factor (EF) that represents the regional conditions of sugarcane production, taking into account the data obtained from this study and those from the literature. In each field study, four straw removal rates (no removal (NR);low removal (LR)-removal of 5 Mg ha(-1);high removal (HR)-removal of 10 Mg ha(-1);and total removal (TR)-removal of 15 Mg ha(-1)) were arranged in a randomized block design. This study shows a clear evidence that CH4 fluxes are very low for all assessed sites regardless of straw removal rates, indicating a predominance of CH4 consumption by the soil. Cumulative N2O emissions ranged from 0.20 to 4.09 kg ha(-1) year(-1) and were significantly affected by straw removal in two sites, indicating that straw removal reduces N2O emissions. The average direct N2O EFs obtained from this study and from the literature were 0.28, 0.44, 0.70, and 0.56% for TR, HR, LR, and NR treatments, respectively, which are consistently lower than the EF of 1% suggested by the IPCC. Based on our regional-specific EF (Tier 2), the direct N2O emissions derived from N fertilization under scenarios of straw removal showed a reduction of at least 50% in relation to IPCC approach. Our findings are a step forward in providing regional-specific data to reduce the high level of uncertainty concerning N2O emission assessments of sugarcane ethanol in Brazil, but further studies are needed to evaluate how straw removal for bioenergy production and the associated changes in soil organic carbon stocks affect the GH

关键词： Saccharum spp CH4 emissions N2O emissions N2O emission factor IPCC methodology Tier 2 Crop residues

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The efficacy of league formats in ranking teams

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STATISTICAL MODELLING 2018年第5-6期18卷 411-435页

作者： Lasek, Jan Gagolewski, Marek Polish Acad Sci Inst Comp Sci Interdisciplinary PhD Studies Program Warsaw Poland Warsaw Univ Technol Fac Math & Informat Sci Warsaw Poland Polish Acad Sci Syst Res Inst Warsaw Poland

The efficacy of different league formats in ranking teams according to their true latent strength is analysed. To this end, a new approach for estimating attacking and defensive strengths based on the Poisson regression for modelling match outcomes is proposed. Various performance metrics are estimated reflecting the agreement between latent teams' strength parameters and their final rank in the league table. The tournament designs studied here are used in the majority of European top-tier association football competitions. Based on numerical experiments, it turns out that a two-stage league format comprising of the three round-robin tournament together with an extra single round-robin is the most efficacious setting. In particular, it is the most accurate in selecting the best team as the winner of the league. Its efficacy can be enhanced by setting the number of points allocated for a win to two (instead of three that is currently in effect in association football).

关键词： association football league formats rankings rating systems simulation tournament design

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An mHealth Intervention to Reduce Gestational Obesity (mami-educ): Protocol for a Randomized Controlled Trial

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JMIR RESEARCH PROTOCOLS 2023年第1期12卷 e44456页

作者： Chiarello, Delia Indira Pardo, Fabian Moya, Jessica Pino, Maricela Rodriguez, Andrea Araneda, Maria Eugenia Bertini, Ayleen Gutierrez, Jaime Univ San Sebastian Fac Med & Sci Sch Med Technol Cellular Signaling & Differentiat Lab Santiago Chile Univ Valparaiso Interdisciplinary Ctr Res Terr Hlth Aconcagua Vall Ctr Biomed Res Metab Dis Res Lab San Felipe Chile Univ Valparaiso Fac Med Sch Med Campus San Felipe San Felipe Chile Univ San Sebastian Fac Sci Hlth Care Sch Nutr & Dietet Santiago Chile Univ San Sebastian Fac Sci Hlth Care Sch Obstet Santiago Chile Univ Catolica Silva Henriquez Sch Psychol Santiago Chile Univ Valparaiso Fac Med PhD Program Doctorado Ciencias Ingn Salud Valparaiso Chile Univ San Sebastian Sch Med Technol Fac Med & Sci Cellular Signaling & Differentiat Lab Lota 2465 Santiago 7510157 Chile

Background: The World Federation of Obesity warns that the main health problem of the next decade will be childhood obesity. It is known that factors such as gestational obesity produce profound effects on fetal programming and are strong predictors of overweight and obesity in children. Therefore, establishing healthy eating behaviors during pregnancy is the key to the primary prevention of the intergenerational transmission of obesity. Mobile health (mHealth) programs are potentially more effective than face-to-face interventions, especially during a public health emergency such as the COVID-19 outbreak. Objective: This study aims to evaluate the effectiveness of an mHealth intervention to reduce excessive weight gain in pregnant women who attend family health care centers. Methods: The design of the intervention corresponds to a classic randomized clinical trial. The participants are pregnant women in the first trimester of pregnancy who live in urban and semiurban areas. Before starting the intervention, a survey will be applied to identify the barriers and facilitators perceived by pregnant women to adopt healthy eating behaviors. The dietary intake will be estimated in the same way. The intervention will last for 12 weeks and consists of sending messages through a multimedia messaging service with food education, addressing the 3 domains of learning (cognitive, affective, and psychomotor). Descriptive statistics will be used to analyze the demographic, socioeconomic, and obstetric characteristics of the respondents. The analysis strategy follows the intention-to-treat principle. Logistic regression analysis will be used to compare the intervention with routine care on maternal pregnancy outcome and perinatal outcome. Results: The recruitment of study participants began in May 2022 and will end in May 2023. Results include the effectiveness of the intervention in reducing the incidence of excessive gestational weight gain. We also will examine the maternal-feta

关键词： gestational obesity mHealth primary care randomized controlled trial

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Using video microscopy to improve quantitative estimates of protozoal motility and cell volume

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JOURNAL OF DAIRY SCIENCE 2018年第2期101卷 1060-1073页

作者： Wenner, B. A. Wagner, B. K. Firkins, J. L. Ohio State Univ Dept Anim Sci 2029 Fyffe Ct Columbus OH 43210 USA Ohio State Univ Interdisciplinary PhD Program Nutr Columbus OH 43210 USA Perdue AgriBusiness Salisbury MD 21804 USA

The objective of this study was to apply digital imaging to improve quantification of rumen protozoal biomass and distinguish treatment differences in cell motility and volume among ruminal protozoa. Observations of protozoa in rumen fluid treated with essential oils (CinnaGar, CIN;Provimi North America, Brookville, OH) or an ionophore (monensin, MON) indicated possible cell shrinkage. We hypothesized that MON would decrease protozoal motility and interact with CIN on cell volume. In addition, we hypothesized that analysis of still frames from video of swimming protozoa would improve volume prediction accuracy. Flocculated rumen fluid was incubated in batch culture dosed with N-free feed only (control), MON, CIN, or a combination of MON+ CIN. Samples were taken at 0, 3, or 6 h post-treatment and wet-mounted on a microscope fitted with a high-definition camera. At 3 h post-inoculation, there was a treatment interaction for average speed such that CIN attenuated the effect of MON, with treatment means of 243, 138, 211, and 183 mu m/s for control, MON, CIN, and MON+ CIN, respectively. At 6 h post-inoculation, MON decreased average speed by 79.2 mu m/s compared with the main effect mean without MON. We measured both minimum and maximum diameters (depth and width, respectively) perpendicular to the longitudinal axis of swimming protozoa, yielding a 3-dimensional estimate of protozoal volume. The ellipsoid formula (4 3) pi abc, where a = 1/2 length, b = 1/2 width, and c = 1/2 depth, was compared with previously published volume estimations using genera-specific coefficients (genera-specific coefficient x length x width(2)). Residuals (genera-specific coefficients-ellipsoid) were plotted against predicted (ellipsoid) and centered to the mean X-i -(x) over bar to evaluate both mean and slope biases. For Entodinium spp., Y = 0.248 (+/- 0.037) (Xi-7.98 x 10(4)) + 1.97 x 10(4) (+/- 1.48 x 10(3));n = 100;r(2) [ coefficient of determination (squared correlation coefficient)] = 0

关键词： rumen protozoa protozoal volume protozoal motility monensin

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Role of dietary potassium and salt substitution in the prevention and management of hypertension

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HYPERTENSION RESEARCH 2025年第1期48卷 301-313页

作者： Chia, Yook-Chin He, Feng J. Cheng, Maong-Hui Shin, Jinho Cheng, Hao-Min Sukonthasarn, Apichard Wang, Tzung-Dau Van Huynh, Minh Buranakitjaroen, Peera Sison, Jorge Siddique, Saulat Turana, Yuda Verma, Narsingh Tay, Jam Chin Schlaich, Markus P. Wang, Ji-Guang Kario, Kazoumi Sunway Univ Sch Med & Life Sci Dept Med Sci Bandar Sunway Malaysia Univ Malaya Fac Med Dept Primary Care Med Kuala Lumpur Malaysia Queen Mary Univ London Wolfson Inst Populat Hlth Barts & London Sch Med & Dent Charterhouse Sq London England Hanyang Univ Fac Cardiol Serv Med Ctr Seoul South Korea Natl Yang Ming Chiao Tung Univ PhD Program Interdisciplinary Med PIM Coll Med Taipei Taiwan Taipei Vet Gen Hosp Div Fac Dev Taipei Taiwan Taipei Vet Gen Hosp Ctr Evidence Based Med Taipei Taiwan Natl Yang Ming Chiao Tung Univ Coll Med Inst Publ Hlth Taipei Taiwan Natl Yang Ming Chiao Tung Univ Coll Med Inst Hlth & Welf Policy Taipei Taiwan Chiang Mai Univ Fac Med Div Cardiol Dept Internal Med Chiang Mai Thailand Natl Taiwan Univ Hosp Cardiovasc Ctr Dept Internal Med Taipei Taiwan Natl Taiwan Univ Hosp Div Cardiol & Hosp Med Dept Internal Med Taipei Taiwan Univ Med & Pharm Hue Univ Dept Internal Med Hue City Vietnam Mahidol Univ Fac Med Siriraj Hosp Dept Med Div Hypertens Bangkok Thailand Med Ctr Manila Sect Cardiol Manila Philippines Punjab Med Ctr Lahore Pakistan Atma Jaya Catholic Univ Indonesia Sch Med & Hlth Sci Dept Neurol Jakarta Indonesia King Georges Med Univ Dept Physiol Lucknow Uttar Pradesh India Tan Tock Seng Hosp Dept Gen Med Singapore Singapore Univ Western Australia Royal Perth Hosp Unit Med Sch Dobney Hypertens Ctr Perth WA Australia Univ Western Australia Royal Perth Hosp Res Fdn Perth WA Australia Shanghai Jiao Tong Univ Shanghai Inst Hypertens Ctr Epidemiol Studies & Clin TrialsDept Hyperten Shanghai Key Lab HypertensRuijin HospSch Med Shanghai Peoples R China Jichi Med Univ Dept Med Div Cardiovasc Med Sch Med Shimotsuke Tochigi Japan

Cardiovascular diseases (CVD) continue to be the leading cause of deaths and disability worldwide and the major contributor is hypertension. Despite all the improvements in detecting hypertension together with technological advances and affordable, efficacious and relatively free of adverse effects anti-hypertensive agents, we continue to struggle to prevent the onset of hypertension and to control blood pressure (BP) to acceptable targets. The poor control of hypertension is commonly due to non-adherence to medications. Another reason is the failure to adopt diet and lifestyle changes. Reduction of dietary salt intake is important for lowering BP but the role of potassium intake is also important. Globally the intake of sodium is double that of the recommended 2 gm per day (equivalent to 5 gm of sodium chloride/salt) and half that of the daily recommended intake of potassium of 3500 mg/day, giving a sodium-to-potassium ratio of >1, when ideally it should be <1. Many studies have shown that a higher potassium intake is associated with lower BPs, particularly when coupled concurrently with a lower sodium intake giving a lower sodium to potassium ratio. Most hypertension guidelines, while recommending reduction of salt intake to a set target, do not specifically recommend a target for potassium intake nor potassium supplementation. Here we review the role of potassium and salt substitution with potassium in the management of hypertension. Hence, the focus of dietary changes to lower BP and improve BP control should not be on reduction of salt intake alone but more importantly should include an increase in potassium intake.

关键词： Dietary potassium Salt substitution Prevention Hypertension Sodium to potassium ratio

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SSVEP-assisted RSVP brain-computer interface paradigm for multi-target classification

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JOURNAL OF NEURAL ENGINEERING 2021年第1期18卷

作者： Ko, Li-Wei Sankar, D. Sandeep Vara Huang, Yufei Lu, Yun-Chen Shaw, Siddharth Jung, Tzyy-Ping Natl Chiao Tung Univ Coll Biol Sci & Technol Dept Biol Sci & Technol Inst Bioinformat & Syst Biol Hsinchu 300 Taiwan Natl Chiao Tung Univ Coll Biol Sci & Technol Int PhD Program Interdisciplinary Neurosci Hsinchu 300 Taiwan Natl Chiao Tung Univ Ctr Intelligent Drug Syst & Smart BioDevices IDS2 Hsinchu 300 Taiwan Kaohsiung Med Univ Drug Dev & Value Creat Res Ctr Kaohsiung 807 Taiwan Univ Calif San Diego Swartz Ctr Computat Neurosci San Diego CA 92103 USA Univ Texas San Antonio Dept Elect & Comp Engn San Antonio TX USA

Brain-computer Interface (BCI) is actively involved in optimizing the communication medium between the human brain and external ***. Rapid serial visual presentation (RSVP) is a robust and highly efficient BCI technique in recognizing target objects but suffers from limited target selections. Hybrid BCI systems that combine steady-state visual evoked potential (SSVEP) and RSVP can mitigate this limitation and allow users to operate on multiple targets. Approach. This study proposes a novel hybrid SSVEP-RSVP BCI to improve the performance of classifying the target/non-target objects in a multi-target scenario. In this paradigm, SSVEP stimulation helps in identifying the user's focus location and RSVP stimuli that elicit event-related potentials differentiate target and non-target objects. Main results. The proposed model achieved an offline accuracy of 81.59% by using 12 electroencephalography (EEG) channels and an online (real-time) accuracy of 78.10% when only four EEG channels are considered. Further, the biomarkers of physiological states are analyzed to assess the cognitive states (mental fatigue and user attention) of the participants based on resting theta and alpha band powers. The results indicate an inverse relationship between the BCI performance and the resting EEG power, validating that the subjects' performance is affected by physiological states for long-term use of the BCI. Significance. Our findings demonstrate that the combination of SSVEP and RSVP stimuli improves the BCI performance and further enhances the possibility of performing multiple user command tasks, which are inevitable in real-world applications. Additionally, the cognitive state biomarkers discussed imply the need for an efficient and attractive experimental paradigm that reduces the physiological state disparities and provide enhanced BCI performance.

关键词： electroencephalography brain– computer interface visual evoked potential event-related potential physiological biomarkers multiple targets

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AgroSeek: a system for computational analysis of environmental metagenomic data and associated metadata

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BMC BIOINFORMATICS 2021年第1期22卷 117-117页

作者： Liang, Xiao Akers, Kyle Keenum, Ishi Wind, Lauren Gupta, Suraj Chen, Chaoqi Aldaihani, Reem Pruden, Amy Zhang, Liqing Knowlton, Katharine F. Xia, Kang Heath, Lenwood S. Virginia Polytech Inst & State Univ Dept Comp Sci Blacksburg VA 24061 USA Virginia Polytech Inst & State Univ Dept Civil & Environm Engn Blacksburg VA 24061 USA Virginia Polytech Inst & State Univ Dept Biol Syst Engn Blacksburg VA 24061 USA Virginia Polytech Inst & State Univ Interdisciplinary PhD Program Genet Bioinformat & Blacksburg VA 24061 USA Virginia Polytech Inst & State Univ Dept Dairy Sci Blacksburg VA 24061 USA Virginia Polytech Inst & State Univ Sch Plant & Environm Sci Blacksburg VA 24061 USA Wuhan Univ Sch Resource & Environm Sci Wuhan 430072 Peoples R China

Background: Metagenomics is gaining attention as a powerful tool for identifying how agricultural management practices influence human and animal health, especially in terms of potential to contribute to the spread of antibiotic resistance. However, the ability to compare the distribution and prevalence of antibiotic resistance genes (ARGs) across multiple studies and environments is currently impossible without a complete re-analysis of published datasets. This challenge must be addressed for metagenomics to realize its potential for helping guide effective policy and practice measures relevant to agricultural ecosystems, for example, identifying critical control points for mitigating the spread of antibiotic resistance. Results: Here we introduce AgroSeek, a centralized web-based system that provides computational tools for analysis and comparison of metagenomic data sets tailored specifically to researchers and other users in the agricultural sector interested in tracking and mitigating the spread of ARGs. AgroSeek draws from rich, user-provided metagenomic data and metadata to facilitate analysis, comparison, and prediction in a user-friendly fashion. Further, AgroSeek draws from publicly-contributed data sets to provide a point of comparison and context for data analysis. To incorporate metadata into our analysis and comparison procedures, we provide flexible metadata templates, including user-customized metadata attributes to facilitate data sharing, while maintaining the metadata in a comparable fashion for the broader user community and to support large-scale comparative and predictive analysis. Conclusion: AgroSeek provides an easy-to-use tool for environmental metagenomic analysis and comparison, based on both gene annotations and associated metadata, with this initial demonstration focusing on control of antibiotic resistance in agricultural ecosystems. Agroseek creates a space for metagenomic data sharing and collaboration to assist policy makers, stakeh

关键词： Metagenomics Metadata Web server Data science Antibiotic resistance

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