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Cellucalst enzyme-assisted extraction of Sargassum horneri enhances the immunomodulation by regulating TLR4/MyD88/NF-kB pathway in murine splenocytes with or without Concanavalin A

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Biomedicine and Pharmacotherapy 2024年 181卷 117673-117673页

作者： Yang, Jiwon Kim, Hyo Jin Herath, Kalahe Hewage Iresha Nadeeka Madushani Jee, Youngheun Interdisciplinary Graduate Program in Advanced Convergence Technology & Science Jeju National University Jeju 63243 South Korea Department of Food Bioengineering Jeju National University Jeju 690-756 South Korea Department of Environmental Health Harvard T.H. Chan School of Public Health Harvard University Boston Massachusetts United States Department of Biosystems Engineering Faculty of Agriculture and Plantation Management Wayamba University Gonawila Makandura 60170 Sri Lanka Department of Veterinary Medicine and Veterinary Medical Research Institute Jeju National University Jeju 64243 South Korea

Sargassum horneri (S. horneri) is an edible species of large brown algae inhabiting along the coasts of northeastern Asia. The study focuses on the impact of celluclast enzyme extract of S. hoeneri (SHC) on various immune cell populations in splenocytes including granulocytes, macrophages, dendritic cells, and T lymphocytes. SHC alone increased the population of granulocytes and macrophages and the secretion of M1 macrophage-derived cytokines (TNF-α, IL-22), and M2 macrophage-derived cytokines (IL-4, IL-10). Interestingly, however, SHC suppressed the concanavalin A (Con A)-expanded populations of macrophages, dendritic cells, granulocytes, T and B cells, and Con A-promoted secretion of M1-macrophage derived cytokines (IFN-γ, IL-1β, TNF-α, IL-17, IL-22) and M2-macrophage derived cytokines (IL-4, IL-10, IL-13, TGF-β). SHC further restrained the Th1, Th2, and Th17 cell responses through attenuating the expression of respective transcription factors T-bet, Gata3, and Rorγt. The anti-inflammatory property of SHC is highlighted through its influence on cytokine production, particularly in the NF-κB pathway, and the attenuation of Toll-like receptor (TLR) signaling. The results reveal that SHC acts as both an immunostimulator and an inhibitor of hyperimmune reactions, showcasing its potential therapeutic applications in conditions involving dysregulated immune responses such as autoimmune diseases and inflammatory disorders. This positions SHC as a promising candidate for the development of functional ingredients with diverse applications encompassing the realms of food, pharmaceuticals, and cosmetics. © 2024

关键词： Celluclast Concanavalin A S. horneri Splenocytes

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Bioinspired electronics for intelligent soft robots

Nature Reviews Electrical Engineering

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Nature Reviews Electrical Engineering 2024年 597-613页

作者： Junhyuk Bang Seok Hwan Choi Kyung Rok Pyun Yeongju Jung Sangwoo Hong Dohyung Kim Youngseok Lee Daeyeon Won Seongmin Jeong Wooseop Shin Seung Hwan Ko Department of Mechanical Engineering Seoul National University Seoul Republic of Korea Institute of Engineering Research/Institute of Advanced Machinery and Design (SNU-IAMD) Seoul National University Seoul Republic of Korea Interdisciplinary Program in Bioengineering Seoul National University Gwanak-ro Gwanak-gu Seoul Republic of Korea

Soft robots, capable of safe interaction with delicate objects through their flexibility and compliance, are attracting attention in various real-world applications as manipulators, biomedical devices and wearable tools. As these technologies advance, the ability to perform complex tasks in a robust and reliable way becomes essential. Thus, the incorporation of embedded intelligence in soft robots, which enables them to perceive external environments and generate appropriate actions, is increasingly important. Inspiration from sophisticated biological systems, which exhibit optimized behaviours through the acquisition of external information, promotes the development of intelligent soft robots. Here, we introduce biomimicry strategies for intelligent soft robotics and highlight progress in how soft robots interact with their environment and perform tasks. First, we discuss sensors inspired by the sensory nervous systems and soft actuators inspired by the musculoskeletal systems. Furthermore, we investigate various applications such as manipulation, exploration, wearable devices, biomedical devices and imperceptible devices. We conclude discussing the challenges and offering a perspective on the future direction of this field.

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Multimodal Spatial Attention Network for Automatic Head and Neck Tumor Segmentation in FDG-PET and CT Images 1

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2nd 3D Head and Neck Tumor Segmentation in PET/CT Challenge, HECKTOR 2021, held in conjunction with 24th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2021

作者： Cho, Minjeong Choi, Yujin Hwang, Donghwi Yie, Si Young Kim, Hanvit Lee, Jae Sung School of Electrical and Electronics Engineering Chung-Ang University Seoul06974 Korea Republic of Department of Biomedical Engineering Kyunghee University College of Electronics and Information 1732 Deogyeong-daero Giheung-gu Gyeonggi-do Yongin-si Korea Republic of Department of Nuclear Medicine Seoul National University College of Medicine Seoul03080 Korea Republic of Department of Biomedical Sciences Seoul National University College of Medicine Seoul03080 Korea Republic of Interdisciplinary Program in Bioengineering Seoul National University Graduate School Seoul Korea Republic of Integrated Major in Innovative Medical Science Seoul National University Graduate School Seoul Korea Republic of Ulsan Korea Republic of Artificial Intelligence Institute Seoul National University Seoul08826 Korea Republic of Brightonix Imaging Inc. Seoul04782 Korea Republic of

ISBN: (数字)9783030982539

ISBN: (纸本)9783030982522

Quantitative positron emission tomography/computed tomography (PET/CT), owing to the functional metabolic information and anatomical information of the human body that it presents, is useful to achieve accurate tumor delineation. However, manual annotation of a Volume Of Interest (VOI) is a labor-intensive and time-consuming task. In this study, we automatically segmented the Head and Neck (H&N) primary tumor in combined PET/CT images. Herein, we propose a convolutional neural network named Multimodal Spatial Attention Network (MSA-Net), supplemented with a Spatial Attention Module (SAM), which uses a PET image as an input. We evaluated this model on the MICCAI 2021 HEad and neCK TumOR (HECKTOR) segmentation challenge dataset. Our method delivered a competitive cross-validation efficiency, with Dice Similarity Coefficient (DSC) 0.757, precision 0.788, and recall 0.785. When we tested out method on test dataset, we achieved an average DSC and Hausdorff Distance at 95% (HD95) of 0.766 and 3.155 respectively. Our team name is ‘Heck_Uihak’. © 2022, Springer Nature Switzerland AG.

关键词： Tumors

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Low-Power Unobtrusive ECG Sensor System for Wireless Power Transfer

Low-Power Unobtrusive ECG Sensor System for Wireless Power T...

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IEEE Wireless Power Transfer Conference (WPTC)

作者： Dongseok Lee Yonggyu Lim Kwangsuk Park Interdisciplinary Program in Bioengineering Seoul National University Seoul Korea Sangji University Wonju Korea Institute of Medical and Biological Engineering (Medical Research Center) Seoul National University Seoul Korea

ISBN: (数字)9781728142388

ISBN: (纸本)9781728142395

Electrocardiogram (ECG) is one of the most widely used physiological signal that provides fundamental health information. Conventional ECG uses gel-type ECG electrodes, however, the gel-type ECG electrode is inconvenient for long-term or daily-life ECG monitoring. Capacitive ECG sensor was implemented to overcome the shortcoming of gel-type ECG electrodes. The wireless power transfer (WPT) technology can improve ubiquitous healthcare, but the power consumption is an important factor of the system based on WPT. Previous study did not consider the power consumption of the system. In this study, we implemented a low-power capacitive ECG monitoring system. The supply power of the system was 5V, and Bluetooth low energy (BLE) module was applied to decrease the power consumption in wireless data transmission. The total power consumption of the system was 16.4 mW.

关键词： Electrocardiography Electrodes Power demand Wireless sensor networks Wireless communication Monitoring Data communication

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Correction: Nucleic acid detection with single-base specificity integrating isothermal amplification and light-up aptamer probes

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Nanoscale 2024年第44期16卷 20774页

作者： Jaekyun Baek Jihyun Park Youngeun Kim Interdisciplinary Program in Bioengineering Seoul National University Seoul 08826 Republic of Korea. youngeunkim@snu.ac.kr. Research Institute of Advanced Materials Seoul National University Seoul 08826 Republic of Korea. Department of Materials Science and Engineering Seoul National University Seoul 08826 Republic of Korea.

Correction for 'Nucleic acid detection with single-base specificity integrating isothermal amplification and light-up aptamer probes' by Jaekyun Baek , , 2024, https://***/10.1039/D4NR01638F.

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Corrigendum: RGD-incorporated biomimetic cryogels for hyaline cartilage regeneration (2022 Biomed. Mater. 17 024106)

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Biomedical Materials 2023年第6期18卷 069503-069503页

作者： Rachel H Koh Jisoo Kim Seunghyun L Kim Nathaniel S Hwang School of Chemical and Biological Engineering Institute of Chemical Processes Seoul National University Seoul 08826 Republic of Korea Interdisciplinary Program in Bioengineering Seoul National University Seoul 08826 Republic of Korea BioMAX/N-BIO Institute Seoul National University Seoul 08826 Republic of Korea

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Dehydroacteoside rejuvenates senescence via TVP23C-CDRT4 regulation

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Experimental Gerontology 2025年 207卷 112800页

作者： Lee, Yoo Jin Song, Eun Seon Lee, Yun Haeng Lee, Kyeong Seon So, Byeonghyeon Park, Ji Ho Yoon, Jee Hee Kim, Duyeol Kim, Minseon Kwon, Hyung Wook Byun, Youngjoo Lee, Ki Yong Park, Joon Tae Division of Life Sciences College of Life Sciences and Bioengineering Incheon National University Incheon 22012 South Korea College of Pharmacy Korea University Sejong 30019 South Korea Interdisciplinary Major Program in Innovative Pharmaceutical Sciences Korea University Sejong 30019 South Korea Convergence Research Center for Insect Vectors Incheon National University Incheon 22012 South Korea

One of the major factors inducing senescence is reactive oxygen species (ROS) produced from dysfunctional mitochondria. Therapeutic strategies that reduce mitochondrial ROS generation are considered essential for rejuvenating senescence, but effective methods have not yet been established. Here, we screened phenylpropanoids (PPs), secondary metabolites produced in response to oxidative stress in plants, and identified dehydroacteoside as a potential candidate. Dehydroacteoside restored mitochondrial function, thereby reducing mitochondrial ROS generated by inefficient electron transport. Furthermore, senescence-associated phenotypes were restored by dehydroacteoside-mediated ROS reduction. Using RNA sequencing, we identified TVP23C-CDRT4 as a gene that plays a critical role in dehydroacteoside-mediated senescence rejuvenation. Knockdown of TVP23C-CDRT4 showed similar effects to dehydroacteoside, reducing ROS and subsequently restoring senescence-associated phenotypes. Taken together, our study uncovered a novel mechanism by which dehydroacteoside reduces mitochondrial ROS generation, thereby restoring senescence. Our findings open the way to a new field of anti-aging therapy aimed at controlling senescence by modulating ROS production in mitochondria. © 2025

关键词： Dehydroacteoside Reactive oxygen species Senescence rejuvenation TVP23C-CDRT4

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Rosa multiflora fructus and its active compound ellagic acid improve depressive-like behaviors in mice via monoamine oxidase inhibition

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Biomedicine and Pharmacotherapy 2025年 188卷 118169-118169页

作者： Kim, Minji Lim, Dong Wook Kim, Min-Sun Nam, Heejin Shin, Sooim Lee, Changho Um, Min Young Food Functionality Research Division Korea Food Research Institute Wanju 55365 South Korea Department of Food Biotechnology University of Science & Technology Daejeon 34113 South Korea Interdisciplinary Program of Bioenergy and Biomaterials Graduate School College of Engineering Chonnam National University Gwangju 61186 South Korea Department of Biotechnology & Bioengineering College of Engineering Chonnam National University Gwangju 61186 South Korea

Depression is a significant global health challenge, imposing severe social and economic burdens. Rosa multiflora fructus possesses a range of biological properties;however, its role in reducing stress hormone-induced depression remains unclear. This study examined the antidepressant effects of Rosa multiflora fructus extract (RMFE) on corticosterone (CORT)-induced depressive-like behaviors in mice and explored the underlying molecular mechanisms. ICR mice were administered CORT (40 mg/kg/day, i.p.) for 8 weeks to induce depressive-like behaviors. They were then treated with RMFE (100 or 300 mg/kg/day, p.o.) or selegiline (10 mg/kg/day, p.o.) as a positive control. RMFE treatment significantly alleviated depressive-like behaviors, as evaluated by the tail suspension and forced swimming tests. Furthermore, RMFE reduced hippocampal astrocyte hypertrophy and lowered the protein and mRNA expression of monoamine oxidase A and B (MAOA and MAOB). Phytochemical analysis using UPLC-MS/MS identified five flavonoids in RMFE, including ellagic acid (EA), hyperoside, isoquercetin, quercetin, and quercetin-3-glucuronide. In silico molecular docking revealed that these phenolic compounds interact with MAOA and MAOB, with EA exhibiting the strongest binding affinity. Consistently, EA administration effectively alleviated depressive-like behaviors and increased monoamine neurotransmitter levels in CORT-treated mice. These results suggest that RMFE exerts antidepressant effects by inhibiting MAO, restoring monoamine levels, and modulating hippocampal astrocytic hypertrophy, with EA identified as the primary bioactive compound driving its efficacy. © 2025

关键词： Corticosterone Depression Ellagic acid Monoamine oxidase Rosa multiflora fructus

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Zwitterionic Polymer on Silicone Implants Inhibits Pathogenesis and Progress of Breast Implant-Associated Anaplastic Large Cell Lymphoma

SSRN

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SSRN 2023年

作者： Kim, Jungah Kang, Sunah Choi, Min-Ha Park, Sohyun Nam, So Hee Park, Ji-Ung Lee, Yan Department of Chemistry College of Natural Sciences Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of Department of Plastic and Reconstructive Surgery Seoul National University Boramae Medical Center Seoul National University College of Medicine 5 Gil 20 Boramae-ro Dongjak-gu Seoul07061 Korea Republic of Institute of Medical and Biological Engineering Seoul National University College of Medicine 103 Daehak-ro Jongno-gu Seoul03080 Korea Republic of Interdisciplinary Program in Bioengineering Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of College of Pharmacy Dongduk Women’s University 60 Hwarang-ro 13-gil Seongbuk-gu Seoul02748 Korea Republic of

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) occurs in the capsule surrounding breast implants. Malignant transformation of T cells by bacteria-driven chronic inflammation may be underlying BIA-ALCL mechanism. Here, we covalently grafted 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymers on a silicone surface and examined its effects against BIA-ALCL pathogenesis. MPC grafting strongly inhibited the adhesion of bacteria and bacteria-causing inflammation. Additionally, cancer T cell proliferation and capsule-derived fibroblast-cancer cell communication were effectively inhibited by MPC grafting. We further demonstrated the effect of MPC against the immune responses causing BIA-ALCL around human silicone implants in micro-pigs. Finally, we generated a xenograft anaplastic T cell lymphoma mouse model around the silicone implants and demonstrated that MPC grafting could effectively inhibit the lymphoma progression. This study is the first to show that bacteria-driven induction and progression of BIA-ALCL can be effectively inhibited by surface modification of implants. © 2023, The Authors. All rights reserved.

关键词： Bacteria

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Nanomaterials-based flexible and stretchable bioelectronics

Nanomaterials-based flexible and stretchable bioelectronics

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作者： Song, Jun-Kyul Do, Kyungsik Koo, Ja Hoon Son, Donghee Kim, Dae-Hyeong School of Chemical and Biological Engineering Seoul National University Korea Republic of Interdisciplinary Program for Bioengineering Seoul National University Korea Republic of Biomedical Research Institute Korea Institute of Science and Technology Korea Republic of Seoul National University Korea Republic of

Conventional silicon-based electronics have faced challenges in the realization of soft bioelectronics, such as wearable and implantable integrated devices, which necessitate electrically and mechanically interactive biotic-abiotic interfacing without disturbing the daily life of the user or posing biocompatibility issues. Recently, much effort has been directed at overcoming the mechanical limitations of conventional rigid electronics by replacement of bulky, thick, and rigid electronic materials with biocompatible, soft, and nanoscale electronic materials, which exhibit intrinsic mechanical deformability as well as superior electrical properties. Recent advances in the synthesis of unconventional nanomaterials, surface functionalization methods, and integrated device fabrication techniques have resulted in further improvements in the performance of nanomaterials-based soft bioelectronics. Numerous studies have focused on the biological, electrical, and mechanical analyses of heterogeneous nanomaterial-biosystem interfaces as well as the development of efficient integration processes of soft nanomaterials into devices. In this article, we summarize the latest advances and future prospects in nanomaterials synthesis, processing, and integration strategies for flexible and stretchable bioelectronics, and their application to wearable and implantable devices. © Materials Research Society 2019.

关键词： Flexible electronics

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