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Recent advances in molecularly imprinted polymers toward biomedical healthcare devices

Biosensors & bioelectronics 2025年 287卷 117637页

作者： Youngjun Seo Yonghwan Kim Jaeheung Kim Hyo Gi Jung Jae Won Jang Hyunji Kim Kyo Seon Hwang Dongtak Lee Sang Won Lee Jeong Hoon Lee Dae Sung Yoon School of Biomedical Engineering Korea University Seoul 02841 Republic of Korea Interdisciplinary Program in Precision Public Health Korea University Seoul 02841 Republic of Korea. Department of Clinical Pharmacology and Therapeutics College of Medicine Kyung Hee University Seoul 02447 Republic of Korea. Department of Bioengineering & Nano-bioengineering Research Center for Bio Materials and Process Development Incheon National University Incheon 22012 Republic of Korea Division of Bioengineering Incheon National University Incheon 22012 Republic of Korea. Terasaki Institute for Biomedical Innovation Los Angeles CA 90064 USA. Electronic address: skylsw5@korea.ac.kr. KU-KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea Department of Integrative Energy Engineering College of Engineering Korea University Seoul 02841 Republic of Korea. Electronic address: hellojhlee@korea.ac.kr. Interdisciplinary Program in Precision Public Health Korea University Seoul 02841 Republic of Korea Astrion Inc Seoul 02841 Republic of Korea. Electronic address: dsyoon@korea.ac.kr.

Following the increase in the global aging population, the importance of monitoring various disease-related biomarkers at an early stage has increased to ensure the health of the elderly. In an aging society, point-of-care (POC) systems are needed to care for elderly people who have physical and mental disorders. In light of the increasing prominence of POC systems, there is a growing effort to address the limitations associated with conventional receptors in wearable devices by substituting them with molecularly imprinted polymer (MIP). MIPs are well-known synthetic receptors engineered with specific binding cavities based on the "lock and key" principle. They could be synthesized in various configurations depending on specific types of monomers and templates. Compared to conventional receptors such as antibodies and aptamers, MIPs exhibit outstanding advantages, including good stability, cost-effectiveness, ease of synthesis, reusability, and broad applicability. These advantages have led to their extensive application in biomedical healthcare devices. This review summarizes a comparative analysis of sensors utilized for the detection of disease-specific biomarkers through diverse MIP applications and methodologies. Furthermore, we evaluated recent advancements in the miniaturization of MIPs and their integration with wearable biomedical devices for comprehensive healthcare monitoring applications. Finally, we delineated the existing limitations that need to be surmounted for the effective implementation of MIP-based biomedical devices and outlined future objectives for the enhancement of wearable and wireless biomedical healthcare monitoring devices.

关键词： Biomarker Healthcare monitoring Molecularly imprinted polymer Point-of-care Wearable biomedical devices

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Molecular basis for inhibition of methane clathrate growth by a deep subsurface bacterial protein

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PNAS NEXUS 2023年第8期2卷 pgad268页

作者： Huard, Dustin J. E. Johnson, Abigail M. Fan, Zixing Kenney, Lydia G. Xu, Manlin Drori, Ran Gumbart, James C. Dai, Sheng Lieberman, Raquel L. Glass, Jennifer B. Georgia Inst Technol Sch Chem & Biochem 901 Atlantic Dr NW Atlanta GA 30332 USA Georgia Inst Technol Sch Earth & Atmospher Sci 311 Ferst Dr NW Atlanta GA 30332 USA Georgia Inst Technol Interdisciplinary Bioengineering Grad Program 315 Ferst Dr NW Atlanta GA 30332 USA Yeshiva Univ Dept Chem & Biochem 245 Lexington Ave Room 548 New York NY 10016 USA Georgia Inst Technol Sch Phys 837 State St Atlanta GA 30332 USA Georgia Inst Technol Sch Civil & Environm Engn 790 Atlantic Dr NW Atlanta GA 30332 USA

Methane clathrates on continental margins contain the largest stores of hydrocarbons on Earth, yet the role of biomolecules in clathrate formation and stability remains almost completely unknown. Here, we report new methane clathrate-binding proteins (CbpAs) of bacterial origin discovered in metagenomes from gas clathrate-bearing ocean sediments. CbpAs show similar suppression of methane clathrate growth as the commercial gas clathrate inhibitor polyvinylpyrrolidone and inhibit clathrate growth at lower concentrations than antifreeze proteins (AFPs) previously tested. Unlike AFPs, CbpAs are selective for clathrate over ice. CbpA3 adopts a nonglobular, extended structure with an exposed hydrophobic surface, and, unexpectedly, its TxxxAxxxAxx motif common to AFPs is buried and not involved in clathrate binding. Instead, simulations and mutagenesis suggest a bipartite interaction of CbpAs with methane clathrate, with the pyrrolidine ring of a highly conserved proline residue mediating binding by filling empty clathrate cages. The discovery that CbpAs exert such potent control on methane clathrate properties implies that biomolecules from native sediment bacteria may be important for clathrate stability and habitability.

关键词： methane clathrate protein structure ocean sediment subsurface bacteria molecular simulations

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Clinical text generation through leveraging medical concept and relations

arXiv

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arXiv 2019年

作者： Lee, Wangjin Park, Hyeryun Yoon, Jooyoung Kim, Kyeongmo Choi, Jinwook Interdisciplinary Program in Bioengineering Graduate School Seoul National University Department of Biomedical Engineering College of Medicine Seoul National University

With a neural sequence generation model, this study aims to develop a method of writing the patient clinical texts given a brief medical history. As a proof-of-a-concept, we have demonstrated that it can be workable to use medical concept embedding in clinical text generation. Our model was based on the Sequence-to-Sequence architecture and trained with a large set of de-identified clinical text data. The quantitative result shows that our concept embedding method decreased the perplexity of the baseline architecture. Also, we discuss the analyzed results from a human evaluation performed by medical doctors. Copyright © 2019, The Authors. All rights reserved.

关键词： Embeddings

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Precise and extensive characterization of an optical resonator for cavity-based quantum networks

arXiv

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arXiv 2021年

作者： Lee, Dowon Kim, Myunghun Hong, Jungsoo Ha, Taegyu Kim, Junwoo Kang, Sungsam Choi, Youngwoon An, Kyungwon Lee, Moonjoo Pohang37673 Korea Republic of 145 Anam-ro Seongbuk-gu Seoul02841 Korea Republic of Department of Physics Korea University 145 Anam-ro Seongbuk-gu Seoul02841 Korea Republic of Department of Bioengineering Korea University Seoul02841 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02841 Korea Republic of Department of Physics and Astronomy Institute of Applied Physics Seoul National University Seoul08826 Korea Republic of

Cavity-based quantum node is a competitive platform for distributed quantum networks. Here, we characterize a high-finesse Fabry-Pérot optical resonator for coupling single or few atomic quantum registers. Our cavity consists of two mirrors with different reflectivities: One has minimal optical loss, and the other high transmission loss where more than 90% of the intracavity photons would be emitted. Cavity finesse, birefringent effects, and mechanical resonances are measured using the lasers at 780, 782, and 795 nm. In order to obtain cavity geometric parameters, we drive the adjacent longitudinal or transverse modes with two lasers simultaneously, and measure those frequencies using a precision wavelength meter (WLM). A major novelty of this method is that the parameters' uncertainties are solely determined by the resolution of the WLM, eliminating all of the temporal environment fluctuations. Our scheme makes it possible to quantify the atom-cavity coupling constant up to four significant figures, the most precise and accurate estimation so far, which would become a key ingredient for benchmarking a cavity-based quantum node. Furthermore, the distortion of polarized photonic qubits would be minimized owing to the small birefringent splitting, below 4.9% of the cavity linewidth. Our system should operate in the intermediate atom-cavity coupling regime that would allow us to implement various quantum network protocols. © 2021, CC BY.

关键词： Birefringence

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Corrigendum to "Mathematical model of modified hybrid pump mechanism for cardiopulmonary resuscitation" [Computer methods and programs in biomedicine 206 (2021) 106106]

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Computer methods and programs in biomedicine 2022年 218卷 106711页

作者： Dong Ah Shin Jung Chan Lee Interdisciplinary Program in Bioengineering Graduate School Seoul National University Seoul 08826 Republic of Korea. Department of Biomedical Engineering College of Medicine and Institute of Medical and Biological Engineering Medical Research Center Seoul National University Seoul 03080 Republic of Korea Institute of BioEngineering Bio-MAX Institute Seoul National University Seoul 08826 Republic of Korea. Electronic address: ljch@snu.ac.kr.

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Deep Learning Model for Diagnosis of Metabolic Bone Disease of Prematurity Using Wrist Radiographs

SSRN

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SSRN 2023年

作者： Park, Seul Gi Jeong, Seoi Cho, Minwoo Kim, Mi Jin Choi, Chang Won Kim, Ee-Kyung Cheon, Jung-Eun Kong, Hyoun-Joong Department of Pediatrics Seoul National University Children’s Hospital Seoul National University College of Medicine Seoul Korea Republic of Department of Pediatrics Seoul National University College of Medicine Seoul Korea Republic of Department of Pediatrics National Medical Center Seoul Korea Republic of Interdisciplinary Program in Bioengineering Seoul National University Seoul Korea Republic of Department of Transdisciplinary Medicine Institute of Convergence Medicine with Innovative Technology Seoul National University Hospital Seoul Korea Republic of Department of Medicine College of Medicine Seoul National University Hospital Seoul Korea Republic of Department of Pediatrics Seoul National University Bundang Hospital Seongnam Korea Republic of Department of Radiology Seoul National University Hospital Seoul Korea Republic of Department of Radiology Seoul National University College of Medicine Seoul Korea Republic of Institute of Radiation Medicine Seoul National University Medical Research Center Seoul Korea Republic of

Background: Metabolic bone disease (MBD) in preterm infants requires accurate diagnosis and timely intervention. Although wrist radiographs are used for diagnosis, radiographic interpretation is limited by clinicians’ subjective assessments. This study proposes a wrist radiography-based deep learning model for diagnosing MBD of prematurity and evaluate the impact of its decision support on diagnosis. Methods: This retrospective study included 814 and 261 preterm infants under 1500 g at the time of birth born at Seoul National University Hospital (SNUH) (internal dataset) and Seoul National University Bundang Hospital (SNUBH) (external dataset), respectively. Demographic and clinical information and wrist radiographs taken between postmenstrual age four and eight weeks were collected. The internal dataset was used to develop and train diagnostic models and the external dataset was used for validation. The performance of the model was evaluated using receiver operating characteristic (ROC) curves. A reader study was conducted to test model efficacy in a clinical setting. The chi-square test or Student’s t-test was used to analyze the patients' demographic and clinical features. A paired t-test or Wilcoxon signed-rank test was used for performance quality comparison. Findings: 14% of enrolled patients were diagnosed with MBD. A DenseNet-based model exhibited the highest performance with an area under ROC (AUROC) of 0·961 (sensitivity: 94·4% (51/54), specificity: 91·2% (151/171), and accuracy: 92·0% (207/225)). The validation study yielded an AUROC of 0·927, thereby indicating its potential applicability in a broad clinical setting. The reader study demonstrated an improved reading performance, especially for non-radiologists (from 63·2% to 82·0% accuracy;p = 0·008, among pediatricians). Interpretation: This study developed a deep learning model for detecting MBD of prematurity, allowing clinicians, especially non-radiologists, to better diagnose MBD. This model can ass

关键词： Diagnosis

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Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

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Cell 2025年

作者： Yan, Xiao Kuster, David Mohanty, Priyesh Nijssen, Jik Pombo-García, Karina Garcia Morato, Jorge Rizuan, Azamat Franzmann, Titus M. Sergeeva, Aleksandra Ly, Anh M. Liu, Feilin Passos, Patricia M. George, Leah Wang, Szu-Huan Shenoy, Jayakrishna Danielson, Helen L. Ozguney, Busra Honigmann, Alf Ayala, Yuna M. Fawzi, Nicolas L. Dickson, Dennis W. Rossoll, Wilfried Mittal, Jeetain Alberti, Simon Hyman, Anthony A. Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) Saxony Dresden 01307 Germany Biotechnology Center (BIOTEC) Center for Molecular and Cellular Bioengineering Technische Universität Dresden Saxony Dresden 01307 Germany Artie McFerrin Department of Chemical Engineering Texas A&M University College Station 77843 TX United States Edward Doisy Department of Biochemistry and Molecular Biology Saint Louis University St. Louis 63104 MO United States Department of Molecular Biology Cell Biology & Biochemistry Brown University Providence 02912 RI United States Center for Biomedical Engineering Brown University Providence 02912 RI United States Department of Chemistry Texas A&M University College Station 77843 TX United States Interdisciplinary Graduate Program in Genetics and Genomics Texas A&M University College Station 77843 TX United States Department of Neuroscience Mayo Clinic Jacksonville 32224 FL United States

Cytosolic aggregation of the nuclear protein TAR DNA-binding protein 43 (TDP-43) is associated with many neurodegenerative diseases, but the triggers for TDP-43 aggregation are still debated. Here, we demonstrate that TDP-43 aggregation requires a double event. One is up-concentration in stress granules beyond a threshold, and the other is oxidative stress. These two events collectively induce intra-condensate demixing, giving rise to a dynamic TDP-43-enriched phase within stress granules, which subsequently transition into pathological aggregates. Intra-condensate demixing of TDP-43 is observed in iPS-motor neurons, a disease mouse model, and patient samples. Mechanistically, intra-condensate demixing is triggered by local unfolding of the RRM1 domain for intermolecular disulfide bond formation and by increased hydrophobic patch interactions in the C-terminal domain. By engineering TDP-43 variants resistant to intra-condensate demixing, we successfully eliminate pathological TDP-43 aggregates in cells. We suggest that up-concentration inside condensates followed by intra-condensate demixing could be a general pathway for protein aggregation. © 2025 The Author(s)

关键词： ALS biomolecular condensate FTD intra-condensate demixing neurodegenerative diseases oxidative stress phase separation protein aggregation stress granules TDP-43

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Erratum to: Materials and devices for flexible and stretchable photodetectors and light-emitting diodes

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Nano Research 2021年第11期14卷 4362-4362页

作者： Jun-Kyul Song Min Sung Kim Seungwon Yoo Ja Hoon Koo Dae-Hyeong Kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul08826Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea

Erratum to Nano Research 2021,14(9):2919-2937 https://***/10.1007/s 12274-021-3447-3 The figure caption of Figure 1,instead of Figure 1 Schematic illustration of various nanomaterials and organic materials used in fle... 详细信息

关键词： diodes emitting Figure

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450P Incidence and risk factors for development of portal hypertension following trastuzumab emtansine in HER2-positive breast cancer

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ESMO Open 2025年 10卷 105022-105022页

作者： Park, H.W. Jang, S.Y. Choi, J.Y. Chang, W. Seo, J. Suh, K.J. Kim, S.H. Kim, Y.J. Jeong, S-H. Jee, J. Kim, J.H. Division of Hematology & Medical Oncology Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea Division of Hematology & Medical Oncology Department of Internal Medicine Seoul National University Hospital Seoul Republic of Korea Department of Radiology Seoul National University Bundang Hospital Seongnam Republic of Korea Division of Gastroenterology Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea Interdisciplinary Program of Bioengineering Seoul National University (SNU) - Main Campus Seoul Republic of Korea

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Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification

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Nature Communications 2024年第1期15卷 2187页

作者： Turner, Mackenzie E. Blum, Kevin M. Watanabe, Tatsuya Schwarz, Erica L. Nabavinia, Mahboubeh Leland, Joseph T. Villarreal, Delaney J. Schwartzman, William E. Chou, Ting-Heng Baker, Peter B. Matsumura, Goki Krishnamurthy, Rajesh Yates, Andrew R. Hor, Kan N. Humphrey, Jay D. Marsden, Alison L. Stacy, Mitchel R. Shinoka, Toshiharu Breuer, Christopher K. Center for Regenerative Medicine Research Institute at Nationwide Children’s Hospital Columbus OH United States Molecular Cellular and Developmental Biology Graduate Program The Ohio State University Columbus OH United States The Ohio State University College of Medicine Columbus OH United States Department of Biomedical Engineering Yale University New Haven CT United States Biomedical Sciences Graduate Program The Ohio State University College of Medicine Columbus OH United States Department of Exercise and Health Science National Taipei University of Nursing and Health Sciences Taipei City Taiwan Pathology Department at Nationwide Children’s Hospital and The Ohio State University Columbus OH United States Department of Medical Safety Management Tokyo Women’s Medical University Tokyo Japan Department of Radiology Nationwide Children’s Hospital and The Ohio State University Columbus OH United States Department of Pediatrics The Ohio State University College of Medicine Columbus OH United States The Heart Center Nationwide Children’s Hospital Columbus OH United States Departments of Pediatrics and Bioengineering Stanford University Stanford CA United States Department of Surgery The Ohio State University College of Medicine Columbus OH United States Interdisciplinary Biophysics Graduate Program The Ohio State University Columbus OH United States Department of Cardiothoracic Surgery Nationwide Children’s Hospital Columbus OH United States Department of Surgery Nationwide Children’s Hospital Columbus OH United States

Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to the long-term viability of prosthetic biomaterials in these procedures. Herein, we describe the natural history of calcification in the most frequently used vascular conduits, expanded polytetrafluoroethylene grafts. Through a retrospective clinical study and an ovine model, we compare the degree of calcification between tissue-engineered vascular grafts and polytetrafluoroethylene grafts. Results indicate superior durability in tissue-engineered vascular grafts, displaying reduced late-term calcification in both clinical studies (p < 0.001) and animal models (p < 0.0001). Further assessments of graft compliance reveal that tissue-engineered vascular grafts maintain greater compliance (p < 0.0001) and distensibility (p < 0.001) than polytetrafluoroethylene grafts. These properties improve graft hemodynamic performance, as validated through computational fluid dynamics simulations. We demonstrate the promise of tissue engineered vascular grafts, remaining compliant and distensible while resisting long-term calcification, to enhance the long-term success of congenital heart surgeries. © The Author(s) 2024.

关键词： Translational research Cardiac device therapy Cardiovascular models

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