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Measurement system of hand tapping capacity for quantitative diagnosis of Parkinson's disease

World Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics

作者： Kim, Sang Kyong Jeon, Hyo Seon Han, Jonghee Choi, Yoon Jae Jeon, Beom Seok Yi, Won Jin Park, Kwang Suk Interdisciplinary Program of Bioengineering Seoul National University Seoul Korea Republic of Dept. of Neurology Seoul National University Hospital Seoul Korea Republic of Dept. of Oral and Maxillofacial Radiology College of Dentistry Seoul National University Seoul Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University 110-799 28 Yeongeon-dong Jongno-gu Seoul Korea Republic of

ISBN: (纸本)9783642038884

The Unified Parkinson's Disease Rating Scale (UPDRS) is commonly used to measure the patients' disorder in clinical therapeutics. However, UPDRS scores can be somewhat variable and subjective. Especially, there are only 5 scales at each item. It is necessary to develop a quantitative measurement of movement ability in PD patients. Hand Tapping test system was developed in this purpose. Here, we present hand tapping test system and some test such as simple reaction test and random response test. Twelve PD patients (7 men and 5 women) were evaluated. The result of tests show us good correlation between movement time and UPDRS partIII score (0.84, 0.72). On the other hand, the reaction time and UPDRS partIII score was not related to each other. Thus, we conclude that movement time of hand tapping test can be one of the feasible quantitative measurement methods of PD patients' movement. © 2009 Springer-Verlag.

关键词： Diagnosis

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Cold dialysate regeneration system (CDRS) for home hemodialysis - In vivo

Cold dialysate regeneration system (CDRS) for home hemodialy...

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World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering

作者： Kim, J.H. Kim, J.C. Moon, J.-H. Kang, E. Ronco, C. Kim, H.C. Interdisciplinary Program in Bioengineering Major Seoul National University Seoul Korea Republic of Institute of Medical and Biological Engineering Medical Research Center Seoul National University Seoul Korea Republic of Department of Internal Medicine Chung-Ang University Hospital Seoul Korea Republic of Vicenza Italy Department of Biomedical Engineering College of Medicine Seoul National University 28 Yeongeon-dong Jongno-gu Seoul Korea Republic of

ISBN: (纸本)9783642038846

We propose a new cold dialysate regeneration system that requires 10 L per treatment for home hemodialysis. In this system, by using cold dialysate and 2 activated carbon columns alternatively switched between adsorption and desorption. In animal experiments (n = 8, dogs) were conducted to validate the cold dialysate regeneration system. When it is used in a conventional hemodialysis, the urea reduction ration was 60.9 ± 6.3% and Kt/V was 1.0 ± 0.2. BUN concentration in the dialysate was 5.8 mg/dL and serum electrolytes remained stable. The proposed cold dialysate regeneration system using only a small volume of dialysate will be useful for home hemodialysis. © 2009 Springer-Verlag.

关键词： Urea

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Pushing the Limit of BGO-based Dual-ended Cherenkov PET Detector Through Photon Transit Time Correction

Pushing the Limit of BGO-based Dual-ended Cherenkov PET Dete...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： M. Yi G.-B. Ko J.S. Lee Interdisciplinary Program in Bioengineering Seoul National University Seoul Republic of Korea Integrated Major in Innovative Medical Science Seoul National University Seoul Republic of Korea Brightonix Imaging Inc. Seoul Republic of Korea

The rising production costs of commonly used lutetium-based fast scintillators and the development of silicon photomultipliers technology have made BGO a promising candidate for time-of-flight positron emission tomography (TOF PET) detectors due to its ability to generate prompt Cherenkov photons. However, using BGO as a hybrid scintillator presents challenges due to low photon statistics and a distribution that does not conform well to a single Gaussian. To mitigate this, a proposal was made to increase the likelihood of detecting the first Cherenkov photons by positioning two photosensors in opposition at the entrance and exit faces of the scintillator [1]. In the other hand, compensating for the photon transit time spread is known to enhance the timing performance of the dual-ended BGO Cherenkov TOF PET detector [2]. A 3 × 3 × 15 mm 3 unpolished BGO sample was prepared and tested. The high-frequency dual-ended BGO detector was implemented and coincidence events were acquired against a 3 × 3 × 3 mm 3 LYSO:Ce:Mg reference detector. The timing performance of dual-ended BGO detectors were analyzed using bottom, top, meantime, and adaptive timestamp methods. Through a depth-of-interaction based (DOI-based) correction of photon transit time spread, we demonstrated a further improvement in timing resolution of dual-ended BGO-based Cherenkov TOF PET detector with adaptive arrival time pickoff. The use of a dual-ended configuration resulted in a significant improvement in timing resolution compared to a single-ended readout configuration, particularly in terms of FWTM value. Although polishing the crystal surface was still favorable in terms of FWHM value, compensating for photon travel time by taking advantage of DOI information from unpolished crystals with relatively higher light loss enabled further enhancement in timing performance the polished crystals.

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Bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair

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Bioactive Materials 2024年第10期40卷 306-317页

作者： Rachel H.Koh Junhee Kim Jeong-Uk Kim Seunghyun L.Kim Arun Kumar Rajendran Seunghun SLee Heesoo Lee Joo Hyun Kim Ji Hoon Jeong Yongsung Hwang Jong Woo Bae Nathaniel S.Hwang School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul08826South Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul08826South Korea Department of Biomedical Engineering Dongguk UniversitySeoul10326South Korea Soonchunhyang Institute of Medi-bio Science(SIMS) Soonchunhyang UniversityCheonan31151South Korea Department of Integrated Biomedical Science Soonchunhyang UniversityAsan31538South Korea Department of Orthopaedic Surgery Konkuk University Chungju HospitalKonkuk University School of MedicineChungju27376South Korea BioMAX Institute Seoul National UniversitySeoul08826South Korea

Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage *** or gradient scaffolds,often in conjunction with stem cells and growth factors,have been developed to mimic the respective layers for osteochondral defect *** this study,we designed a hyaline cartilage-hypertrophic cartilage bilayer graft(RGD/RGDW)with ***,we demonstrated that RGD peptide-modified chondroitin sulfate cryogel(RGD group)is chondro-conductive and capable of hyaline cartilage ***,we incorporated whitlockite(WH),a Mg^(2+)-containing calcium phosphate,into RGD cryogel(RGDW group)to induce chondrocyte hypertrophy and form collagen X-rich hypertrophic *** is the first study to use WH to produce hypertrophic ***-laden RGDW cryogel exhibited significantly upregulated expression of hypertrophy markers in vitro and formed ectopic hypertrophic cartilage in vivo,which mineralized into calcified cartilage in bone ***,RGD cryogel and RGDW cryogel were combined into bilayer(RGD/RGDW group)and implanted into rabbit osteochondral defect,where RGD layer supports hyaline cartilage regeneration and bioceramic-containing RGDW layer promotes calcified cartilage *** the RGD group(monolayer)formed hyaline-like neotissue that extends into the subchondral bone,the RGD/RGDW group(bilayer)regenerated hyaline cartilage tissue confined to its respective layer and promoted osseointegration for integrative defect repair.

关键词： Bioceramic Whitlockite Bilayer scaffold Chondrocyte hypertrophy Osteochondral defect repair

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Alerting Network Alteration in Idiopathic Rapid Eye Movement Sleep Behavior Disorder Patients with Mild Cognitive Impairment

Alerting Network Alteration in Idiopathic Rapid Eye Movement...

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亚洲睡眠医学会2021年学术大会暨第十三届中国睡眠研究会年会

作者： Jeong,El Cha,Kwang Su Sunwoo,Jun-Sang Jung,Ki-Young El Jeong Interdisciplinary Program in Bioengineering College of EngineeringSeoul National University Department of Neurology Seoul National University HospitalNeuroscience Research InstituteSeoul National University College of Medicine Department of Neurosurgery Seoul National University Hospital

Objective: It is reported that idiopathic REM sleep behavior disorder (iRBD) is associated with alteration of attention,executive functions,and visuospatial abilities. In addition,it is known that about half of the iRBD patients have mild cognitive impairment (MCI). The aim of this study was to explore the differences between iRBD patients with MCI and ones without MCI. Methods: 14 healthy controls (HC),24 iRBD patients without MCI (iRBD-nMCI),and 24 iRBD patients with MCI (iRBD-MCI) were recruited.

关键词： Alerting Network Alteration in Idiopathic Rapid Eye Movement Sleep Behavior Disorder Patients with Mild Cognitive Impairment

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Sweet–Bitter Taste Interactions in Binary Mixtures of Sweeteners: Relationship of Taste Receptor Activities with Sensory Perception

SSRN

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SSRN 2024年

作者： Choi, Yoonha Wong, RunRou Cha, Yeon Kyung Park, Tai Hyun Kim, Yuri Chung, Seo-Jin Department of Nutritional Science and Food Management Ewha Womans University Seoul03760 Korea Republic of Interdisciplinary Program in Bioengineering Seoul National University Seoul08826 Korea Republic of Graduate Program in System Health Science and Engineering Ewha Womans University Seoul03760 Korea Republic of

Combining several low-calorie sweeteners in a food is a common strategy for reducing caloric sweeteners. The effects of binary sweetener mixtures on sweetness enhancement and sweet–bitter taste receptor interactions, specifically sensory perception and receptor activity, were investigated. Acesulfame K or saccharin was mixed with allulose, aspartame, erythritol, fructose, glucose, or sucrose to match a target sucrose sweetness. The effects of the mixtures on sweet and bitter taste receptors (expressed in HEK-293 cells) and sensory taste intensities were evaluated. Sweetness was enhanced in limited cases at the taste receptor level. Several monosaccharides reduced the bitter taste receptor activity triggered by acesulfame K or saccharin. The sweetness of acesulfame K and saccharin combined with any of the six sweeteners was perceptually enhanced, correlating with a reduction in their inherent bitterness. This finding suggested that sweetness perception likely increased because of the ability of monosaccharides to diminish bitter receptor activation by high-potency sweeteners. © 2024, The Authors. All rights reserved.

关键词： Binary mixtures

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Driver drowsiness detection using the in-ear EEG

Driver drowsiness detection using the in-ear EEG

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Taeho Hwang Miyoung Kim Seunghyeok Hong Kwang Suk Park Samsung Electronics DMC Research Center Seoul South Korea Interdisciplinary Program in Bioengineering Seoul National University Seoul South Korea Department of Biomedical Engineering Seoul National University College of Medicine Seoul South Korea

ISBN: (纸本)9781457702198

Driver drowsiness monitoring is one of the most demanded technologies for active prevention of severe road accidents. Electroencephalogram (EEG) and several peripheral signals have been suggested for the drowsiness monitoring. However, each type of signal has partial limitations in terms of either convenience or accuracy. Recent emerged concept of in-ear EEG raises expectations due to reduced obtrusiveness. It is yet unclear whether the in-ear EEG is effective enough for drowsiness detection in comparison with on-scalp EEG or peripheral signals. In this work, we evaluated performance of the in-ear EEG in drivers' alertness-drowsiness classification for the first time. Simultaneously, we also tested three peripheral signals including electrocardiogram (ECG), photoplethysmogram (PPG), and galvanic skin response (GSR) which have advantage in convenience of measurement. The classification analysis using the in-ear EEG resulted in high classification accuracy comparable to that of the individual on-scalp EEG channels. The ECG, PPG and GSR showed competitive performance but only when used together in pairwise combinations. Our results suggest that the in-ear EEG would be viable alternative to the single channel EEG or the individual peripheral signals for the drowsiness monitoring.

关键词： Electroencephalography Electrocardiography Monitoring Vehicles Wheels Standards Ear

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Parallel multi-time point cell stimulus and lysis in a microfluidic device using chaotic mixing and pressure resistance

Parallel multi-time point cell stimulus and lysis in a micro...

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2008 AIChE Annual Meeting, AIChE 100

作者： Hirsch, Alison Rivet, Catherine Zhang, Boyang Kemp, Melissa Lu, Hang Georgia Institute of Technology School of Chemical and Biomolecular Engineering 311 Ferst Dr. NW Atlanta GA 30332 United States Interdisciplinary Bioengineering Program Georgia Institute of Technology 311 Ferst Dr. NW Atlanta GA 30332 United States Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology 311 Ferst Dr. NW Atlanta GA 30332 United States

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Spike train distance metric reveals plasticity in discrimination of salient calls by putative excitatory cells of the auditory cortex

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BMC Neuroscience 2012年第1期13卷 1-2页

作者： Charles L Zhao Frank Lin Robert C Liu Biomedical Engineering Graduate Program Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University Atlanta GA 30332 USA Interdisciplinary Bioengineering Graduate Program Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University Atlanta GA 30332 USA Department of Biology Emory University Atlanta GA 30322 USA

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Continuous single-ended DOI measurement using highly (64:4) multiplexed signals

Continuous single-ended DOI measurement using highly (64:4) ...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： H. S. Shim M. J. Cho J. S. Lee Interdisciplinary Program of Bioengineering Seoul National University Seoul Republic of Korea Integrated Major in Innovative Medical Science Seoul National University Seoul Republic of Korea Department of Nuclear Medicine Seoul National University Seoul Republic of Korea

This study aims to investigate the feasibility of applying a multiplexing method that uses a high-pass filter and an artificial neural network proposed by the authors to a system. The accuracy of the proposed method was measured for four sampling rates ranging from 125MHz to 1GHz and three crystal configurations, including one-to-one coupling, light-sharing, and cDOI configuration. The accuracy was compared using the R 2 value between the true amplitude and estimated amplitude of the signal, and it was confirmed that the proposed method achieved an accuracy of 0.97 or higher in all situations. Furthermore, when measuring the DOI resolution using the cDOI configuration, the proposed method exhibited an accuracy of 0.97 or higher even under side irradiation conditions and achieved a DOI accurcacy of 74.4%. Therefore, it was confirmed that a sufficient DOI resolution could be obtained for an 8 × 8 SiPM array with a 3mm pitch attached with a 12 × 12 LSO array with a 2mm pitch using only four multiplexed readouts. This method guarantees high accuracy, sufficient multiplexing ratio, and operation at a suitable sampling rate for the system.

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