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20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

作者： Lee, S.M. Chung, M.H. Son, K.M. Jeon, N.L. Interdisciplinary Program for Bioengineering Seoul National University Korea Republic of School of Mechanical Engineering Seoul National University Korea Republic of

ISBN: (纸本)9780979806490

Blood-brain barrier (BBB) is neurovascular unit strictly controlling the exchange of nutrients and signals between neural and vascular system. Although critical roles of BBB on neural disease and drug delivery effectiveness has been issued lately, still the mechanism of barrier function and even their developmental process has not been clearly verified yet. Therefore some in vitro models were developed through the last decades but most of them could not satisfy both morphological and physiological properties to become a research model. Here we introduce a microfluidic platform which enables to co-culture three main cell types(endothelial cell, astrocyte and pericyte) comprising BBB in three dimensional (3D) hydrogel. Through our device, we could mimic neurovascular niche in its similar morphology and also physiological properties. Also we could verify that by quantifying increased expression of junctions and transportation systems related with barrier function.

关键词： Microfluidics

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A one-step pipetting platform for large-scale sequential drug combination assay with a network-based approach to cancer research 21

A one-step pipetting platform for large-scale sequential dru...

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21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

作者： Kim, Su Deok Song, Seo Woo Oh, Dong Yoon Lee, Yongju Kwon, Sunghoon Electrical and Computer Engineering Seoul National University Korea Republic of Interdisciplinary Program of Bioengineering Seoul National University Korea Republic of

ISBN: (纸本)9780692941836

The importance of sequential drug combinations for therapeutic benefit has been demonstrated in recent years in that it can dynamically rewire signaling networks of a cancer cell over time. However, conventional methods of finding sequential pair out of numerous sequential combinations demands laborious work and high reagent cost. Here we report a novel handling technique of chemical substances using a combination of heterogeneous encoded drug-laden microparticles(DLPs) and a plastic microwell array with a rigid-body and pillar structure for easy assembly allowing sequential screening with ease without conventional numerous pipetting. We demonstrated its capability in large-scale sequential drug screening assay with reduced assay cost and time. © 17CBMS-0001.

关键词： Diseases

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3D vascular networks co-cultured with various types of colorectal cancer cells for validation of natural killer cell cytotoxicity 24

3D vascular networks co-cultured with various types of color...

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24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020

作者： Choi, Hyeri Song, Jiyoung Park, Dohyun Jeon, Noo Li Interdisciplinary Program for Bioengineering Seoul National University Korea Republic of Departement of Mechanical Engineering Seoul National University Korea Republic of

ISBN: (纸本)9781733419017

Given that vascular networks are essential for the delivery of nutrients and oxygen during tumor progression, tumor models composed of blood vessels have been substantially needed in in vitro studies. Therefore, we developed a tumor vasculature model using various types of colorectal cancer cells on an injection-molded microfluidic platform. This model enabled high-throughput experiments and imaging, as well as demonstrated the typical characteristics of tumor vasculature including abnormality. The functional blood vessels are expected to be further used for delivering anticancer drugs to tumor sites or elucidating cytotoxic lymphocyte infiltration. © 2020 CBMS-0001

关键词： Microfluidics

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MedRep: Medical Concept Representation for General Electronic Health Record Foundation Models

arXiv

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arXiv 2025年

作者： Kim, Junmo Lee, Namkyeong Kim, Jiwon Kim, Kwangsoo Interdisciplinary Program in Bioengineering Seoul National University Korea Republic of Dept. of Industrial and Systems Engineering KAIST Korea Republic of Interdisciplinary Program of Medical Informatics Seoul National University Korea Republic of Dept. of Transdisciplinary Medicine ICMIT Seoul National University Hospital Korea Republic of Center for Data Science Healthcare AI Research Institute Seoul National University Hospital Korea Republic of Dept. of Medicine College of Medicine Seoul National University Korea Republic of

Electronic health record (EHR) foundation models have been an area ripe for exploration with their improved performance in various medical tasks. Despite the rapid advances, there exists a fundamental limitation: Processing unseen medical codes out of the vocabulary. This problem limits the generality of EHR foundation models and the integration of models trained with different vocabularies. To deal with this problem, we propose MedRep for EHR foundation models based on the observational medical outcome partnership (OMOP) common data model (CDM), providing the integrated medical concept representations and the basic data augmentation strategy for patient trajectories. For concept representation learning, we enrich the information of each concept with a minimal definition through large language model (LLM) prompts and enhance the text-based representations through graph ontology of OMOP vocabulary. Trajectory augmentation randomly replaces selected concepts with other similar concepts that have closely related representations to let the model practice with the concepts out-of-vocabulary. Finally, we demonstrate that EHR foundation models trained with MedRep better maintain the prediction performance in external datasets. Our code implementation is publicly available at https://***/kicarussays/MedRep. Copyright © 2025, The Authors. All rights reserved.

关键词： Electronic health record

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High-throughput behavioral drug screening using dedicated low-cost microscopy system for monitoring C. Elegans 19

High-throughput behavioral drug screening using dedicated lo...

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19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015

作者： Bates, Kathleen E. Lu, Hang Interdisciplinary Program in Bioengineering Georgia Institute of Technology United States School of Chemical and Biomolecular Engineering Georgia Institute of Technology United States

ISBN: (纸本)9780979806483

We report a low-cost, automated, integrated microscopy and microfluidic system for the monitoring of small model organisms on chip and demonstrate its capabilities via monitoring of the nematode Caenorhabditis elegans behavior over extended time scales. Digital to analog conversion of chemical stimuli allows simple incorporation of temporal concentration control on chip, while automated image processing on a microcomputer allows on-line processing and hardware control for a cost under $150 US. © 15CBMS-0001.

关键词： Digital to analog conversion

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Spontaneous and Induced Oscillations in Confined Epithelia

PRX Life

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PRX Life 2025年第1期3卷 013002-013002页

作者： Toshi Parmar Liam P. Dow Beth L. Pruitt M. Cristina Marchetti Department of Physics University of California Santa Barbara Santa Barbara California 93106 USA Interdisciplinary Program in Quantitative Biosciences University of California Santa Barbara Santa Barbara California 93106 USA Departments of Bioengineering and of Mechanical Engineering University of California Santa Barbara Santa Barbara California 93106 USA

The feedback between mechanical and chemical signals plays a key role in controlling many biological processes and collective cell behavior. Here we focus on the emergence of spatiotemporal density waves in a one-dimensional “cell train.” Combining a minimal theoretical model with in vitro experiments on MDCK epithelial cells confined to a linear pattern, we examine the spontaneous oscillations driven by feedback between myosin activation and mechanical deformations, as well as their effect on the response of the tissue to externally applied deformations. We show that the nature and frequency of spontaneous oscillations is controlled by the size of the cell train, with a transition from size-dependent standing waves to intrinsic spontaneous waves at the natural frequency of the tissue. The response to external boundary perturbations exhibits a resonance at this natural frequency, providing a possible venue for inferring the mechanochemical couplings that control the tissue behavior from rheological experiments.

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Design of an Fc Mutation to Abrogate Fcγ Receptor Binding Based on Residue Interaction Network Analysis

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ACS Synthetic Biology 2025年 2025 Apr 29页

作者： Jebamani, Petrina Jo, Migyeong Park, Suhyun Kim, Suyeon Jung, Sang Taek Lee, Sun-Gu Wu, Sangwook Department of Chemical Engineering Pusan National University Busan 46241 South Korea Institute of Chemical Processes Seoul National University Seoul 08826 South Korea Department of Chemical and Biological Engineering Seoul National University Seoul 08826 South Korea Department of Physics Pukyong National University Busan 48513 South Korea Interdisciplinary Program for Bioengineering Seoul National University Seoul 08826 South Korea PharmCADD 1102-ho 60 Centum Jungang-ro Haeundae-gu Busan 48059 South Korea Department of Biomedical Sciences Graduate School Korea University Seongbuk-gu Seoul 02841 South Korea BK21 Graduate Program Department of Biomedical Sciences Korea University College of Medicine Seoul 02841 South Korea

Immunoglobulins mediate their immune responses through interactions with Fc γ-receptors (FcγRs) on immune cells, triggering crucial responses such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). While enhancing these interactions can be beneficial, in certain therapeutic scenarios, such as cytokine or receptor blockade therapies, it is critical to reduce FcγR binding to avoid adverse immune reactions. This study aims to design negative mutations in the Fc region to reduce Fcγ receptor binding based on the residue interaction network analysis. The mutation sites of Fc were targeted through betweenness centrality analysis, and mutations were designed by focusing on hydrophobic to hydrophilic residue changes. The negative effect of the designed mutants on binding affinity was verified by previous reports and binding experiments. From this study, we identified a new Fc variant candidate (V263(B)D) that lacks a binding affinity for Fcγ receptors. This research highlights a strategic approach for designing Fc mutations that effectively reduce immune activation, which may be valuable in therapeutic contexts, where immune response moderation is crucial. © 2025 American Chemical Society.

关键词： betweenness centrality Fc FcγRIIIa IgG inhibiting mutations residue interaction network analysis

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Spatiotemporal pixelization method based on vertical sub-sampling to improve reading ability for visual prosthesis

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World Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics

作者： Kim, H.S. Shin, J.H. Park, K.S. Interdisciplinary Program of Bioengineering Seoul National University Seoul Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)9783642038884

We proposed the spatiotemporal pixelization method based on vertical sub-sampling to improve reading ability for visual prosthesis. To evaluate proposed method, we simulated a test of reading performance of visual prosthesis with five different frame rates at 8×8 pixel arrays. The proposed method showed better reading performance than static pixelization method. The maximum reading speed was found at 50Hz of spatiotemporal pixelization method. © 2009 Springer-Verlag.

关键词： Prosthetics

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Wavelet approach to artifact noise removal from Capacitive coupled Electrocardiograph

Wavelet approach to artifact noise removal from Capacitive c...

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30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08

作者： Seung, Min Lee Ko, Keun Kim Kwang, Suk Park Interdisciplinary Program of Bioengineering Seoul National University Graduate School Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Seoul National University Graduate School Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)9781424418152

Capacitive coupled Electrocardiography (ECG) is introduced as non-invasive measurement technology for ubiquitous health care and appliance are spread out widely. Although it has many merits, however, capacitive coupled ECG is very weak for motion artifacts for its non-skin-contact property. There are many studies for artifact problems which treats all artifact signals below 0.8Hz. In our capacitive coupled ECG measurement system, artifacts exist not only below 0.8Hz but also over than 10Hz. Therefore, artifact noise removal algorithm using wavelet method is tested to reject artifact-wandered signal from measured signals. It is observed that using power calculation each decimation step, artifact-wandered signal is removed as low frequency artifacts as high frequency artifacts. Although some original ECG signal is removed with artifact signal, we could level the signal quality for long term measure which shows the best quality ECG signals as we can get. © 2008 IEEE.

关键词： Electrocardiography

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Second derivative of photoplethysmography for estimating vascular aging

Second derivative of photoplethysmography for estimating vas...

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6th International Special Topic Conference on ITAB, 2007

作者： Hyun, Jae Baek Jung, Soo Kim Yun, Sung Kim Haet, Bit Lee Kwang, Suk Park Interdisciplinary Program of Bioengineering Seoul National University Seoul Korea Republic of Interdisciplinary Program on Medical and Biological Engineering Seoul National University Seoul Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)9781424418688

Coronary artery disease (CAD) is one of the major causes of death. Therefore recurrent monitoring of arterial condition is important. The photoplethysmography (PPG) is simple and cost effective technique to measure blood volume change. As an application of PPG technique, the second derivative of photoplethysmography(SDPTG) was introduced for monitoring arterial condition. SDPTG consists of an a, b, c and d wave in systole and an e wave in diastole. The SDPTG wave pattern is determined by the proportions of the b, c, d, and e waves to the a wave. In the present study, it is confirmed that the b/a ratio and SDPTG-AI increased with age, and the c/a, d/a, and e/a ratios decreased with age. The informal method which substitutes formal SDPTG-AI was suggested. © 2008 IEEE.

关键词： Cost effectiveness

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