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Effect of latent semantic indexing for clustering clinical documents

Effect of latent semantic indexing for clustering clinical d...

IEEE/International Association for Computer and Information Science International Conference on Computer and Information Science

作者： Han, Choonghyun Choi, Jinwook Interdisciplinary Program of Bioengineering College of Engineering Seoul National University Seoul Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)9780769541471

The measurement of similarity between documents is usually influenced by sparseness of term-document matrix. Latent semantic indexing(LSI) is an alternative method to solve the problem, and the dimension reduction by LSI improves the performance of the measurement of the similarity. In this study, LSI is examined as a method to cluster clinical documents containing the same clinical problems or disorders. The similarity of clinical documents was measured effectively with LSI. LSI performed better on clinical documents which can be characterized with medical terms, various expressions for the same concepts, abbreviations and typos, than editorials. Our result showed that LSI is useful for the measurement of the similarity of the clinical documents examined in this study. And the correlation between co-occurrence of terms and similarity is also analyzed as an important aspect of LSI. Not only the co-occurring terms but unshared terms between documents were found as factors influencing the similarity. © 2010 IEEE.

关键词： Semantics

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Evaluation of electrohysterogram feature extraction to classify the preterm and term delivery groups 15

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15th International Conference on Biomedical Engineering, ICBME 2013

作者： Sim, Sooyoung Ryou, Hosuk Kim, Hanbyul Han, Jungmin Park, Kwangsuk Interdisciplinary program of Bioengineering College of Engineering Seoul National University Seoul Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)9783319029122

The prediction of preterm delivery is very important for investigating risk factors for preterm birth and initiating risk specific treatment but still remains a challenge for obstetricians. Based on the fact that the characteristics of unterine muscle activities change as pregnancy progresses, many researchers have tried to use noninavise Electrohysterogram (EHG) for separating the preterm and term delivery. To investigate novel and useful features to classify the preterm and term delivery groups, we randomly selected 40 records from Physionet EHG database. The records were classified into four groups depending on the time of recording (before or after the 26th week of gestation) and the length of gestation (term delivery: 1048725 37 weeks of pregnancy duration or preterm delivery: © Springer International Publishing Switzerland 2014.

关键词： Feature extraction

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Heart sounds measurement using PVDF film sensor and their comparison with RR intervals of ECG signals

Heart sounds measurement using PVDF film sensor and their co...

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IEEE-EMBS International Conference on Biomedical and Health Informatics, BHI 2012. In Conj. with the 8th Int. Symp.on Medical Devices and Biosensors and the 7th Int. Symp. on Biomedical and Health Engineering

作者： Lee, Won Kyu Chung, Gih Sung Baek, Hyun Jae Park, Kwang Suk Interdisciplinary Program for Bioengineering Seoul National University 111 Fundamental Medical Research Building I 101 Daehak-ro Jongno-gu Seoul Korea Republic of Interdisciplinary Program for Bioengineering Seoul National University 713 Fundamental Medical Research Building I 101 Daehak-ro Jongno-gu Seoul Korea Republic of Interdisciplinary Program for Bioengineering Seoul National University 807 Fundamental Medical Research Building I 101 Daehak-ro Jongno-gu Seoul Korea Republic of Department of Biomedical Engineering Seoul National University College of Medicine 103 Daehak-ro Jongno-gu Seoul Korea Republic of

ISBN: (纸本)9781457721779

Heart sounds are generated by the fluctuations of blood velocity and the vibrations of cardiac structure. The auscultation of heart sounds is one of the basic tools for patient diagnosis and provides a lot of information associated with cardiovascular systems. For converting mechanical sound waves into electronic signals, PVDF (polyvinylidene fluoride) film sensor was used as heart sounds measurement device. After suited filtering process, the first (S1) and the second (S2) heart sounds components were plainly distinguished and their peak timings were closely corresponded to reference heart sounds signals measured by microphone. Lastly, there was high correlation between S1 intervals (from PVDF signals) and RR intervals (from ECG signals). So it is expected that S1 intervals can replace RR intervals. In future application, these methods have possibilities for non-intrusive heart rate estimation. © 2012 IEEE.

关键词： Heart

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Charge-reversible solid surface and its application to DNA manipulation under microfluidic environments

Charge-reversible solid surface and its application to DNA m...

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14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

作者： Hwang, Kyu-Youn Kim, Joon-Ho Suh, Kahp-Yang Namgoong, Kak Paek, Sang-Hyun Huh, Nam Samsung Electronics Co. Korea Republic of Interdisciplinary Program of Bioengineering Seoul National University Korea Republic of School of Mechanical and Aerospace Engineering Seoul National University Korea Republic of

ISBN: (纸本)9781618390622

We have fabricated a charge-reversible solid surface based on poly(maleic anhydride) in order to manipulate nucleic acid electrostatically. Its surface charge could be controlled by changing pH of surrounding solution because it has both positively (imidazole) and negatively-charged (carboxyl) ionizable groups at the termination. Measurement of DNA binding efficiency and FT-IR spectra showed that the charge-reversible surface was properly generated on the solid support. It was successfully demonstrated that the charge-reversible surface on beads could be applied to manipulate DNA molecules under microfluidic environments by controlling solution pH.

关键词： Microfluidics

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A preliminary study of non-intrusive blood pressure monitoring using portable device

A preliminary study of non-intrusive blood pressure monitori...

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International Conference on Biomedical Electronics and Devices, BIODEVICES 2013

作者： Kim, Hanbyul Lee, Hongji Baek, Hyunjae Lee, Wonkyu Lee, Jungsu Park, Kwangsuk Interdisciplinary Program of Bioengineering College of Engineering Seoul National University Seoul Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Hospital Seoul Korea Republic of

ISBN: (纸本)9789898565341

Novel blood pressure (BP) monitoring device focused on portability was studied preliminarily. Electrocardiogram (ECG) and photoplethysmogram (PPG) was measured and pulse arrival time (PAT) was computed from these signals. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) showed a clear correlation with PAT. BP estimation model was constructed based on this result and verified by means of leave-one-out cross-validation (LOOCV). Estimated SBP, DBP were involved in two standards of means of original data. This device is expected to be useful to the people who want to monitor BP at any time and space.

关键词： Electrocardiograms

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Microfluidic system with spatiotemporally controlled micro-environment for studying C. elegans developmental arrest responses 20

Microfluidic system with spatiotemporally controlled micro-e...

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20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

作者： Zhuo, Weipeng McGrath, Patrick Lu, Hang School of Chemical and Biomolecular Engineering Georgia Institute of Technology United States School of Biology Georgia Institute of Technology United States Interdisciplinary Program in Bioengineering Georgia Institute of Technology United States

ISBN: (纸本)9780979806490

Many animals alter their development according to environmental changes. However, how temporal information is used for large-timescale developmental decisions is relatively unknown due to the difficulty in precise temporal environmental control for long developmental experiments. In this paper, we present an experimental platform capable of long-term large population culture of developing C. elegans while achieving spatial consistency and temporal environmental control of a variety of stimuli. In addition, we were also able to quantify the divergence of a population's behavioral and morphological developmental response to pheromone stimulation over several days.

关键词： Environmental management

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Cloning,purification and characterization of cold-adapted protease from Antarctic Enterobacter *** 25617

Cloning,purification and characterization of cold-adapted pr...

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The 14th China-Japan-Korea Joint Symposium on Enzyme Engineering

作者： Pak Seojeong Jong-il Choi Department of Biotechnology and Bioengineering Interdisciplinary Program of Bioenergy and BiomaterialsChonnam National University

In this study,Cold adapted protease gene from psychrophilic bacteria Enterobacter *** 25617 was cloned,purified and was *** protease was expression using *** expression *** recombinant strain expressed the protease fr... 详细信息

关键词： Cloning,purification and characterization of cold-adapted protease from Antarctic Enterobacter sp.PAMC 25617

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Production,purification,characterization and cloning of cold-adapted peptidase from Antarctic Janthinobacterium lividum

Production,purification,characterization and cloning of cold...

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The 14th China-Japan-Korea Joint Symposium on Enzyme Engineering

作者： Su-mi Kim Jong-il Choi Department of Biotechnology and Bioengineering Interdisciplinary Program of Bioenergy and BiomaterialsChonnam National University

In this study,production,purification,characterization,and gene cloning of an extracellular peptiase from a psychrophilic Janthinobacterium lividum PAMC 25641 strain were *** peptidase was purified to homogeneity by 80%ammonium sulphate precipitation,anion-exchange chromatography,with a 3.48-fold increase in specific *** purified peptidase with a molecular mass of about 106 kDa exhibited optimal activity at pH 7.5

关键词： Production,purification,characterization and cloning of cold-adapted peptidase from Antarctic Janthinobacterium lividum

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An On-Chip Disposable Salivary Glucose Sensor for Diabetes Control

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Journal of Diabetes Science and Technology 2016年第6期10卷 1344-1352页

作者： Du, Yunqing Zhang, Wenjun Wang, Ming L. Interdisciplinary Engineering Program College of Engineering Northeastern University 360 Huntington Ave SN400 Boston 02115 MA United States Civil and Environmental Engineering Bioengineering Department Northeastern University Boston MA United States

Background: Self-management of blood glucose (BG) is considered a norm for diabetes control. However, this invasive process is uncomfortable for patients, especially when intensive measurements with frequent finger pricks are required. Saliva, an alternative body fluid that is easily accessible and contains trace amount of glucose can be potentially used for the noninvasive monitoring of diabetes. Methods: As a solution for real-time glucose measurements using saliva for diabetic care, we have developed an on-chip disposable glucose nano-biosensor through a layer-by-layer assembly process. In this work, a clinical study of 10 healthy subjects was conducted to determine the potential usefulness of salivary glucose (SG) sensors for glycemic control. Results: Findings revealed (1) the individual BG/SG ratio at fasting was consistent over an entire year when there was no significant change of personal health;(2) the individual SG levels tracked closely with BG levels after meals;(3) a time difference of 15-30 minutes exists between peak levels of BG and SG;(4) 2 hours after a meal, the BG/SG ratio returned to a similar value at fasting. Conclusions: We propose to measure fasting and pre- and 2-hour postprandial SG levels for self-management of glycemic levels. As a result, this article is not intended to replace the common BG tests. With preliminary results, we believe SG itself could be used as means for reliable diabetes monitoring and a potential fluid for prognosis of future disease. © Diabetes Technology Society.

关键词： biochemistry diabetes enzymology oral diagnosis saliva salivary diagnostics

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An approach of reducing measure time of noninvasive thermometer: Application of curve-fitting method and autoregressive model for reducing the measure time of dual-heat-flux thermometer

An approach of reducing measure time of noninvasive thermome...

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作者： Sim, S.Y. Baek, H.J. Chung, G.S. Park, K.S. Interdisciplinary Program of Bioengineering Seoul National University Jongnogu Seoul Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Jongnogu Seoul Korea Republic of

ISBN: (纸本)9789898425355

Newly developed dual-heat-flux thermometer is expected to be useful in measuring core body temperature noninvasively. However, as it takes more than 30 min to measure, the additional process is needed to reduce the measure time. In this study, we made a dual-heat-flux thermometer to verify its performance and obtained an hour-long data from three subjects. Dual-heat-flux thermometer estimated the core body temperature very well in all subjects. In addition, least squares curve-fitting method predicted deep body temperature well with within 100 sec data. Autoregressive model with 10 sec data also seemed to be suitable method for shortening measure time of dual-heat-flux thermometer.

关键词： Heat flux

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