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Rosa multiflora fructus and its active compound ellagic acid improve depressive-like behaviors in mice via monoamine oxidase inhibition

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Biomedicine & Pharmacotherapy 2025年 188卷 118169-118169页

作者： Kim, Minji Lim, Dong Wook Kim, Min-Sun Nam, Heejin Shin, Sooim Lee, Changho Um, Min Young Food Functionality Research Division Korea Food Research Institute Wanju 55365 Republic of Korea Department of Food Biotechnology University of Science & Technology Daejeon 34113 Republic of Korea Interdisciplinary Program of Bioenergy and Biomaterials Graduate School College of Engineering Chonnam National University Gwangju 61186 Republic of Korea Department of Biotechnology & Bioengineering College of Engineering Chonnam National University Gwangju 61186 Republic of Korea

AbstractDepression is a significant global health challenge, imposing severe social and economic burdens. Rosa multiflora fructus possesses a range of biological properties; however, its role in reducing stress hormone-induced depression remains unclear. This study examined the antidepressant effects of Rosa multiflora fructus extract (RMFE) on corticosterone (CORT)-induced depressive-like behaviors in mice and explored the underlying molecular mechanisms. ICR mice were administered CORT (40 mg/kg/day, i.p.) for 8 weeks to induce depressive-like behaviors. They were then treated with RMFE (100 or 300 mg/kg/day, p.o.) or selegiline (10 mg/kg/day, p.o.) as a positive control. RMFE treatment significantly alleviated depressive-like behaviors, as evaluated by the tail suspension and forced swimming tests. Furthermore, RMFE reduced hippocampal astrocyte hypertrophy and lowered the protein and mRNA expression of monoamine oxidase A and B (MAOA and MAOB). Phytochemical analysis using UPLC-MS/MS identified five flavonoids in RMFE, including ellagic acid (EA), hyperoside, isoquercetin, quercetin, and quercetin-3-glucuronide. In silico molecular docking revealed that these phenolic compounds interact with MAOA and MAOB, with EA exhibiting the strongest binding affinity. Consistently, EA administration effectively alleviated depressive-like behaviors and increased monoamine neurotransmitter levels in CORT-treated mice. These results suggest that RMFE exerts antidepressant effects by inhibiting MAO, restoring monoamine levels, and modulating hippocampal astrocytic hypertrophy, with EA identified as the primary bioactive compound driving its efficacy.

关键词： BBB blood-brain barrier BDNF brain-derived neurotrophic factor CORT corticosterone DAPI fluoroshield™ with 4,6-diamidino-2-phenylindole DMSO dimethyl sulfoxide EA ellagic acid FST forced swim test GFAP glial fibrillary acidic protein HPA axis hypothalamic-pituitary-adrenal axis HYP hyperoside IL-6 interleukin 6 ISOQ isoquercetin MAO monoamine oxidase OFT open field test PBS phosphate-buffered saline QUE quercetin QUE-3-G quercetin-3-glucuronide RMFE Rosa multiflora fructus extract SEL selegiline SEM standard error of the mean TBS tris-buffered saline TST tail suspension test UPLC-MS ultra-performance liquid chromatography-mass spectrometry Corticosterone Depression Ellagic acid Monoamine oxidase Rosa multiflora fructus

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Multiscale Fabrication of Multiple Proteins and Topographical Structures by Combining Capillary Force Lithography and Microscope Projection Photolithography (vol 27, pg 3238, 2011)

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LANGMUIR 2011年第12期27卷 7966-7966页

作者： Kwon, Keon Woo Choi, Jong-Cheol Suh, Kahp-Yang Doh, Junsang School of Mechanical Aerospace Engineering ?World Class University Program on Multiscale Mechanical Design Seoul National University Seoul 151-742 Korea Department of Mechanical Engineering School of Interdisciplinary Bioscience Bioengineering (I-Bio) World Class University Program Division of Integrative Biosciences Biotechnology (IBB) Pohang University of Science Technology (POSTECH) San 31 Hyoja-dong Nam-Gu Pohang Gyeongbuk 790-784 Korea

We present new methods that enable the fabrication of multiscale, multicomponent protein-patterned surfaces and multiscale topologically structured surfaces by exploiting the merits of two well-established techniques: capillary force lithography (CFL) and microscope projection photolithography (MPP) based on a protein-friendly photoresist. We further demonstrate that, when hierarchically organized micro- and nanostructures were used as a cell culture platform, human colon cancer cells (cell line SW480) preferentially adhere and migrate onto the area with nanoscale topography over the one with microscale topography. These methods will provide many exciting opportunities for the study of cellular responses to multiscale physicochemical cues.

关键词： Cell Adhesion/physiology Cell Line, Tumor Cell Movement/physiology Humans Microscopy, Electron, Scanning Nanostructures/chemistry* Nanostructures/ultrastructure Nanotechnology/methods* Proteins/chemistry*

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Materials and devices for flexible and stretchable photodetectors and light-emitting diodes

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Nano Research 2021年第9期14卷 2919-2937页

作者： Jun-Kyul Song Min Sung Kim Seungwon Yoo Ja Hoon Koo Dae-Hyeong Kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

Recently,significant efforts have been directed at overcoming the limitations of conventional rigid optoelectronic devices,particularly their poor mechanical stability under bending,folding,and stretching *** of major approaches for rendering optoelectronic devices mechanically deformable is to replace the conventional electronic/optoelectronic materials with functional nanomaterials or organic materials that are intrinsically flexible/***,advanced device designs and unconventional fabrication methods have also contributed to the development of soft optoelectronic ***,new devices such as bio-inspired curved image sensors,wearable light emitting devices,and deformable bio-integrated optoelectronic devices have been *** this review,recent progress in the development of soft optoelectronic materials and devices is ***,various materials such as nanomaterials,organic materials,and their hybrids that are suitable for developing deformable photodetectors,are ***,the nanomaterials and organic/polymeric materials that are applicable in deformable light-emitting diodes are ***,representative system-level applications of flexible and stretchable photodetectors and light-emitting diodes are reviewed,and future prospects are discussed.

关键词： nanomaterial organic material photodetector light-emitting diode flexible optoelectronics stretchable optoelectronics

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Estimation of sleep onset latency based on the correlation between blood pressure and heart beat interval

Estimation of sleep onset latency based on the correlation b...

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IEEE-EMBS International Conference on Biomedical and Health Informatics, BHI 2012. In Conj. with the 8th Int. Symp.on Medical Devices and Biosensors and the 7th Int. Symp. on Biomedical and Health Engineering

作者： Jung, Da Woon Chung, Gih Sung Hwang, Su Hwan Park, Kwang Suk Interdisciplinary Program of Bioengineering Seoul National University Graduate School Seoul 100 799 Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul 100 799 Korea Republic of

ISBN: (纸本)9781457721779

Sleep onset latency (SOL) provides an objective assessment of sleepiness and it also clinically useful as a sleep deprivation diagnostic tool. In this study, we suggest a new approach to estimate SOL based on the correlation between blood pressure (BP) and heart beat interval (HBI). This approach facilitates less intrusive finding of SOL as compared with currently using polysomnographic method. We hypothesized that the arterial baroreflex, one kind of reflex mechanism to regulate BP, takes a role of maintaining sleep's toning-down effect on BP. At the time of transition from full wakefulness to sleep, the toning-down effect starts to drop the BP and the arterial baroreflex is activated to maintain lowered BP by leading to increase in HBI for the elevated BP. Consequently, there is a great contribution of arterial baroreflex to HBI control. With a quantitative evaluation of the contribution, we tried to estimate SOL. For six healthy subjects (27.5 ± 3.15 years), the mean absolute error (MAE) was 0.3 ± 0.42 minutes. We expect our method can be applicable to non-intrusive and automatic SOL estimation system by not using electroencephalogram (EEG) sensors. © 2012 IEEE.

关键词： Blood pressure

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Gapless protein patterning in microfluidic devices enabling mechanistic studies of pre-activation of type-1 diabetic platelets 20

Gapless protein patterning in microfluidic devices enabling ...

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20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

作者： Zhou, Fangyuan Zhu, Cheng Lu, Hang Woodruff School of Mechanical Engineering Georgia Institute of Technology United States Interdisciplinary Bioengineering Program Georgia Institute of Technology United States School of Chemical and Biomolecular Engineering Georgia Institute of Technology United States

ISBN: (纸本)9780979806490

During clotting, multi-step interactions are required to prime and then stabilize platelet activation. Much of the mechanistic details are still not well understood in both normal and pathological scenarios. Current techniques either lack the sensitivity or the necessary throughput for studying multi-step interaction of surface molecules, which bottlenecks the research. In this paper, we present a novel approach to fabricate precisely registered protein patterns in microfluidic devices and use this system to reveal the pre-activation of type-1 diabetic platelets.

关键词： Platelets

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COMBINATORIAL BIOSYNTHESIS OF EPIRUBICIN AND NOVEL GLYCOSYLATED DERIVATIVES OF RHODOMYCIN D

COMBINATORIAL BIOSYNTHESIS OF EPIRUBICIN AND NOVEL GLYCOSYLA...

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15th International Symposiium on the Biology of Actinomycetes(第十五届国际放线菌生物学大会)

作者： Ah Reum Han Eun Ji Kim So Ra Lee Ji Hye Paik Mi Sun Ahn Byung-Gee Kim Yeo Joon Yoon Interdisciplinary Program of Bioengineering Scoul National UniversitySeoulKorea Department of Chemistry and Nano Science Ewha Womans UnivcrsitySeoulKorea Interdisciplinary Program of Bioengineering Scoul National UniversitySeoulKorea Division of Chemic

Anthracycline antibiotics are clinically and commercially important anticancer agents [1].It has been reported that these drugs intercalate into DNA,and interact with topoisomerase Ⅱ-DNA complex [2] Many anthracyclines are composed of a tetracyclic aromatic polyketide planar scaffold coupled with *** sugar moieties of anthracyclines are critical for the anticancer activity,as is also the case for the biological activities of many other drugs,since the aglycones themselves are usually inactive [3].

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Capillarity guided patterning of microliquids on large surface 19

Capillarity guided patterning of microliquids on large surfa...

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19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015

作者： Kang, M. Na, S. Park, D. Paik, S. Park, J. Jeon, N.L. Division of WCU Multiscale Mechanical Design Seoul National University Korea Republic of School of Mechanical and Aerospace Engineering Seoul National University Korea Republic of Interdisciplinary Program for Bioengineering Seoul National University Korea Republic of

ISBN: (纸本)9780979806483

This paper describes a simple and novel approach for non-lithographic patterning of liquids and gels. Using a design that incorporates strategically placed microstructures, micro-liquids or gels can be spontaneously trapped and patterned using the surface tension between liquid and microstructures. The main advantage of this method is simplicity. Various liquid patterns with ∼1nL were patterned by simple liquid draining or wiping motion. The simplicity and robustness of the capillarity guided patterning will be attractive in developing novel in-vitro models of organ-on-a-chip, high-throughput screening and other biological experimental platforms amenable to observation of dynamic events using advanced imaging and analytical techniques. © 15CBMS-0001.

关键词： Cell culture

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Preparation of submicron-sized hydroxyapatite powders by spray pyrolysis

Preparation of submicron-sized hydroxyapatite powders by spr...

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23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011

作者： Cho, Jung Sang Rhee, Sang-Hoon Interdisciplinary Program of Bioengineering College of Engineering Seoul National University Seoul 152-742 Korea Republic of Department of Dental Biomaterials Science School of Dentistry Seoul National University Seoul 110-749 Korea Republic of

ISBN: (纸本)9783037852552

Dense and submicron-sized hydroxyapatite powders were synthesized through spray pyrolysis of calcium phosphate solution with polyethylene glycol (PEG). Irregular shaped and fragile hydroxyapatite aggregates, and spherical and hollow hydroxyapatite particles were obtained after spray pyrolysis at 1100 °C when using calcium phosphate solution with and without PEG, respectively. After dewaxing at 650 °C for 3 hours, the hydroxyapatite aggregates were broken into submicron-sized particles whereas micron-sized spherical hollow particles were almost intact. The relative densities of hydroxyapatite disks made by submicron and micron sized hydroxyapatite particles were about 90% and 81%, respectively, after sintering at 1110 °C for 3 hours. The results were explained in terms of the disintegrating function of carbon which was previously formed among the hydroxyapatite aggregates by the decomposition of PEG during spray pyrolysis. © (2012) Trans Tech Publications.

关键词： Carbon

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RRED: A Radiology Report Error Detector based on Deep Learning Framework 4

RRED: A Radiology Report Error Detector based on Deep Learni...

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4th Workshop on Clinical Natural Language Processing, ClinicalNLP 2022

作者： Min, Dabin Kim, Kaeun Lee, Jong Hyuk Kim, Yisak Park, Chang Min Department of Radiology Seoul National University Hospital Korea Republic of Interdisciplinary Program in Bioengineering Seoul National University Graduate School Korea Republic of Department of Radiology Seoul National University College of Medicine Korea Republic of

ISBN: (纸本)9781955917773

Radiology report is an official record of radiologists’ interpretation of patients’ radiographs and it’s a crucial component in the overall medical diagnostic process. However, it can contain various types of errors that can lead to inadequate treatment or delay in diagnosis. To address this problem, we propose a deep learning framework to detect errors in radiology reports. Specifically, our method detects errors between findings and conclusion of chest X-ray reports based on a supervised learning framework. To compensate for the lack of data availability of radiology reports with errors, we develop an error generator to systematically create artificial errors in existing reports. In addition, we introduce a Medical Knowledge-enhancing Pre-training to further utilize the knowledge of abbreviations and key phrases frequently used in the medical domain. We believe that this is the first work to propose a deep learning framework for detecting errors in radiology reports based on a rich contextual and medical understanding. Validation on our radiologist-synthesized dataset, based on MIMIC-CXR, shows 0.80 and 0.95 of the area under precision-recall curve (AUPRC) and the area under the ROC curve (AUROC) respectively, indicating that our framework can effectively detect errors in the real-world radiology reports. © 2022 Association for Computational Linguistics.

关键词： Errors

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Mussel-inspired sulfated hyaluronan cryogel patch with antioxidant, anti-inflammatory, and drug-loading properties for multifunctional wound adhesives

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Bioactive Materials 2024年第10期40卷 582-596页

作者： Wonmoon Song Young Hwan Choi Young Gi Moon Changyub Lee M.Nivedhitha Sundaram Nathaniel S.Hwang School of Chemical and Biological Engineering Institute for Chemical ProcessesSeoul National UniversitySeoul08826Republic of Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul08826Republic of Korea Bio-MAX/N-Bio Institute Institute of BioEngineeringSeoul National UniversitySeoul08826Republic of Korea Division of Pediatric Cardiac Surgery Department of SurgeryJohns Hopkins School of MedicineBaltimoreMDUSA Institute of Engineering Research Seoul National UniversitySeoul08826Republic of Korea

Wounds, characterized by the disruption of the continuity of body tissues resulting from external trauma,manifest in diverse types and locations. Although numerous wound dressings are available for various woundscenarios, it remains challenging to find an integrative wound dressing capable of addressing diverse woundsituations. We focused on utilizing sulfated hyaluronan (sHA), known for its anti-inflammatory properties andcapacity to load cationic drugs. By conjugating catechol groups to sHA (sHA-CA), we achieved several advantagesin wound healing: 1) Fabrication of patches through crosslinking with catechol-modified high-molecularweighthyaluronan (HA(HMW)-CA), 2) Adhesiveness that enabled stable localization, 3) Radical scavenging thatcould synergize with the immunomodulation of sHA. The sHA-CA patches demonstrated therapeutic efficacy inthree distinct murine wound models: diabetic wound, hepatic hemorrhage, and post-surgical adhesion. Collectively,these findings underscore the potential of the sHA-CA patch as a promising candidate for the nextgenerationwound dressing.

关键词： Adhesive patch Anti-inflammation Sulfated hyaluronic acid Post-surgical adhesion Diabetic wound Hemostasis

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