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Dual Fluorescence Emission by Irradiation of Single Optical Source for Fluorescein Sodium and 5-ALA Applications

Journal of Engineering and Science in Medical Diagnostics and Therapy 2022年第1期5卷 011002页

作者： Kwon, So Yoon Yoon, Ki-Cheol Kim, Kwang Gi Interdisciplinary Program in Bioengineering Graduate School Seoul National University Korea Republic of Gachon University Gil Medical Center 21 774 beon-gil Namdong-daero Namdong-gu Incheon21565 Korea Republic of Department of Biomedical Engineering College of Medicine Gachon University 38-13 Dokjom-ro 3 Namdong-gu Incheon21565 Korea Republic of Medical Devices R&D Center Gachon University Gil Medical Center 21 774 beon-gil Namdong-daero Namdong-gu Incheon21565 Korea Republic of Gachon University 38-13 3 Dokjom-ro Namdong-gu Incheon21565 Korea Republic of

Most brain surgeries aim to completely resection a tumor. However, the arrangement of blood vessels around brain tumors is often complex. Moreover, the tumors and blood vessels have similar colors, making it difficult to identify the boundaries between them with the naked eye. Fluorescent staining is a method used to distinguish the borders between brain tumors and blood vessels. The fluorescent contrast agents commonly used to observe tumors are 5-aminolevulinic acid and fluorescein sodium, which have different surgical sensitivities, depending on the type of tumor. In this article, a dual band bandpass filter with dual-wavelength emission for 5-aminolevulinic acid and fluorescein sodium is designed, and the dual-band bandpass filter capable of inducing simultaneous fluorescence emission of fluorescein sodium and 5-aminolevulinic acid was investigated experimentally to improve accuracy, speed, and energy efficiency in clinical settings. The possibility of dual fluorescence emission with a single irradiation is proposed. The efficiency of transmission and reflection (optical density) is 98% and 0.01%, respectively, and the bandwidth is 50% in the proposed filter. The proposed fluorescent dual-band filter has the advantage of saving energy, reducing auxiliary manpower and unit costs, and reducing operating room space requirements by producing two fluorescence diagnostic effects using a single equipment. © 2022 American Society of Mechanical Engineers (ASME). All rights reserved.

关键词： Tumors

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BPS2025 - Studying self-assembly of bacterial proteins in cell-free protein synthesis systems

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Biophysical Journal 2025年第3期124卷 55a-55a页

作者： Jacob B. Miller Nolan W. Kennedy Danielle Tullman-Ercek Carolyn E. Mills Interdisciplinary Biological Sciences Program Northwestern University Evanston IL USA Department of Chemical and Biological Engineering Northwestern University Evanston IL USA Department of Bioengineering University of California Santa Barbara Santa Barbara CA USA

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Alerting Network Alteration in Idiopathic Rapid Eye Movement Sleep Behavior Disorder Patients with Mild Cognitive Impairment

Alerting Network Alteration in Idiopathic Rapid Eye Movement...

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亚洲睡眠医学会2021年学术大会暨第十三届中国睡眠研究会年会

作者： Jeong,El Cha,Kwang Su Sunwoo,Jun-Sang Jung,Ki-Young El Jeong Interdisciplinary Program in Bioengineering College of EngineeringSeoul National University Department of Neurology Seoul National University HospitalNeuroscience Research InstituteSeoul National University College of Medicine Department of Neurosurgery Seoul National University Hospital

Objective: It is reported that idiopathic REM sleep behavior disorder (iRBD) is associated with alteration of attention,executive functions,and visuospatial abilities. In addition,it is known that about half of the iRBD patients have mild cognitive impairment (MCI). The aim of this study was to explore the differences between iRBD patients with MCI and ones without MCI. Methods: 14 healthy controls (HC),24 iRBD patients without MCI (iRBD-nMCI),and 24 iRBD patients with MCI (iRBD-MCI) were recruited.

关键词： Alerting Network Alteration in Idiopathic Rapid Eye Movement Sleep Behavior Disorder Patients with Mild Cognitive Impairment

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Multi-class Segmentation of Anatomical Structures Using Deep Learning in CBCT Images Containing Metal Artifacts

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Transactions of the Korean Institute of Electrical Engineers 2022年第1期71卷 253-260页

作者： Yang, Su Chun, Soyoung Kim, Dael Jeoun, Bo Soung Yoo, Jiyong Kang, Se-Ryong Choi, Min-Hyuk Kim, Jo-Eun Huh, Kyung-Hoe Lee, Sam-Sun Heo, Min-Suk Yi, Won-Jin Dept. of Applied Bioengineering Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Republic of Interdisciplinary Program of Bioengineering Seoul National University Seoul Korea Republic of Dept. of Biomedical Radiation Sciences Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Republic of Dept. of Oral and Maxillofacial Radiology Seoul National University Dental Hospital Seoul Korea Republic of Dept. of Oral and Maxillofacial Radiology School of Dentistry and Dental Research Institute Seoul National University Seoul Korea Republic of

In order to perform preoperative surgical planning, accurate segmentation of anatomical structures in cone-beam computed tomography (CBCT) images is required. However, this image segmentation is often impeded by metal artifacts, and it takes a lot of time due to morphological variability in patients. In this paper, we proposed a deep learning based automatic multi-calss segmentation method for anatomical structures in CBCT images containing metal artifacts. Four U-Net based deep learning models were used for anatomical structure segmentation. Each deep learning model was constructed by changing the encoder of U-Net architecture to the backbones (DenseNet121, VGGNet16, ResNet101, and EfficienNetB4). For training and testing our method, we used 20744 CBCT images containing metal artifacts from 30 patient datasets. Experimental results show that the segmentation performances of the mandible, midfacial bone, mandibular canal, and maxillary sinus were achieved F1 scores of , , , and using DenseNet121 with Tversky loss, respectively. Furthermore, our method was able to perform robust and accurate segmentation of anatomical structures in CBCT images containing metal artifacts. © 2022 Korean Institute of Electrical Engineers. All rights reserved.

关键词： Image segmentation

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Brain MRI Synthesis from Amyloid PET/CT via Enhanced Denoising Diffusion Probabilistic Model

Brain MRI Synthesis from Amyloid PET/CT via Enhanced Denoisi...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： Y.J. Seol H.B. Yoo E.J. Yoon Y.K. Kim J.S. Lee Integrated Major in Innovative Medical Science Seoul National University Seoul Republic of Korea Seoul National University Interdisciplinary Program in Bioengineering Seoul Republic of Korea Department of Nuclear Medicine and WCU Department of Brain and Cognitive Sciences Seoul National University Seoul Republic of Korea Department of Nuclear Medicine Seoul National University-Seoul Metropolitan Government Boramae Medical Center Seoul Republic of Korea Department of Nuclear Medicine Seoul National University Seoul Republic of Korea Brightonix Imaging Inc Seoul Republic of Korea

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

In this study, we presents a novel method for generating synthetic brain MRI images from amyloid PET/CT scans using an enhanced Denoising Diffusion Probabilistic Model (DDPM) conditioned with the joint probability distribution. We explored the use of early and late-phase 18 F -Florbetaben PET scans to guide the synthesis process within our DDPM framework, verifying that early-phase scans significantly improved the quality of synthetic MRI generation compared to other deep learning models. In addition, the proposed DDPMs using early-phase PET/CT suggest promising results, particularly for enhancing the accuracy of regional gray matter volume measurements and facilitating PET partial volume corrections in settings where traditional MRI is unavailable.

关键词： Temperature measurement Temperature distribution Microwave integrated circuits Semiconductor detectors Magnetic resonance imaging Volume measurement Noise reduction

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High performance gamma-ray spectrometer based on Cs3Cu2I5 single crystal grown by room-temperature vacuum solvent-evaporation method

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Journal of Alloys and Compounds 2025年 1027卷

作者： Seo, Jiwon Song, Seungho Park, Minhwan Byun, Jangwon Park, Beomjun Park, Chansun Jang, Mee Yeom, Jung-Yeol Dept. of Health and Safety Convergence Science Korea University Seoul02841 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02841 Korea Republic of Dept. of Bioengineering Korea University Seoul02841 Korea Republic of Dept. of Materials Science and Engineering Korea University Seoul02841 Korea Republic of The Institute for High Technology Materials and Devices Korea University Seoul02841 Korea Republic of Global Health Technology Center Korea University Seoul02841 Korea Republic of Daejeon34057 Korea Republic of School of Biomedical Engineering Korea University Seoul02841 Korea Republic of

In this study, the properties of Cs3Cu2I5 (CCI) crystals grown using the Slow Vacuum Evaporation Technique (SVET) were examined. Crystals were grown at room temperature (300 K, 27 °C) under vacuum conditions, producing single crystals with maximum diameter of 13 mm over 23 days. We confirmed excellent crystallinity via X-ray diffraction (XRD), compositional uniformity via X-ray photoelectron spectroscopy (XPS), and homogeneity via electron probe micro analyzer (EPMA). UV-Vis measurements indicated a high transmittance of 83 % and a bandgap of 3.64 eV. The Stokes shift of 110 nm, smaller than previously reported values, contributed to faster decay times and improved low-energy detection feasibility. Time-resolved photoluminescence (TR-PL) showed a rapid decay component (4.1 ns), accounting for 95.11 % of the total decay, demonstrating superior properties compared to existing reports. The gamma-ray detection capabilities of the CCI crystals were evaluated using six radioactive sources (Am-241, Ba-133, Co-57, Na-22, Cs-137, and Mn-54), achieving excellent energy resolution, including 5.2 % at 662 keV. The crystals displayed a highly linear response to gamma radiation (R² = 0.99998) with a light yield of 55,613 photons/MeV. Moreover, assessments of multiple crystals grown under identical conditions showed consistent performance with a coefficient of variation (CV) of 1.23 %. These findings confirm that SVET is a highly effective and cost-efficient method for producing high-quality CCI crystals, offering significant advantages over other growth techniques. © 2025 Elsevier B.V.

关键词： Gamma ray spectrometers

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Dual Chemifunctional Tin(Iv) Oxide/Nanoperforated Graphene Interlayer as a Polysulfide Adsorbent for Use in High-Performance Lithium-Sulfur Batteries

SSRN

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SSRN 2023年

作者： Lee, Junho Jung, Nae Yeon Ahn, Wook Lim, Hyung-Kyu Kim, Hyun-Kyung Department of Battery Convergence Engineering Kangwon National University 1 Kangwondaehak-gil Chuncheon24341 Korea Republic of Interdisciplinary Program in Advanced Functional Materials and Devices Development Kangwon National University Chuncheon24341 Korea Republic of Division of Chemical Engineering and Bioengineering Kangwon National University 1 Kangwondaehak-gil Chuncheon24341 Korea Republic of Department of Energy Engineering Soonchunhyang University 22 Soonchunhyang-ro Shinchang-myeon Chungcheongnam-do Asan-Si31538 Korea Republic of

The development of Li-S batteries is limited by their levels of rapid capacity decay owing to polysulfide dissolution and diffusion in organic electrolytes. We addressed this critical issue by fabricating a dual chemifunctional interlayer comprising SnO2 nanoparticles and nanoperforated graphene (NPG) that could function as a polysulfide adsorbent. The synergistic effects of SnO2 and the high-density functional groups of NPG on polysulfide capture were conceptually confirmed. NPG not only supported the adsorption of Li polysulfides but also provided pathways for simple Li-ion motion within the SnO2/NPG interlayer. A cell assembled with the SnO2/NPG interlayer displayed a high rate capability and initial discharge capacity and good reversible capacity. The excellent high-rate cycling performance of the cathode could mainly be attributed to the strong chemical bonds formed between SnO2/NPG and the polysulfides, rapid electron transfer, and optimized ion diffusion pathways derived from the well-organized structure of the composite. Synthesizing dual chemifunctional interlayers using a composite of metal oxides and NPG may lead to the development of advanced Li-S batteries with numerous practical applications in the near future. © 2023, The Authors. All rights reserved.

关键词： Lithium sulfur batteries

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Isothermal amplification-mediated lateral flow biosensors for in vitro diagnosis of gastric cancer-related microRNAs

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TALANTA 2022年 246卷 123502页

作者： Seo, Seung Beom Hwang, Jin-Seong Kim, Eunjung Kim, Kyujung Roh, Seokbeom Lee, Gyudo Lim, Jaewoo Kang, Byunghoon Jang, Soojin Son, Seong Uk Kang, Taejoon Jung, Juyeon Kim, Jang-Seong Keun-Hur Han, Tae-Su Lim, Eun-Kyung Bionanotechnol Res Ctr Korea Res Inst Bioscience & Biotechnol KRIBB Daejeon 34141 South Korea Pusan Natl Univ Dept Cogno Mech Engn Pusan 46241 South Korea Biotherapeut Translat Res Ctr KRIBB Daejeon 34141 South Korea Univ Sci & Technol UST KRIBB Sch Biotechnol Dept Funct Genom Daejeon 34113 South Korea Incheon Natl Univ Dept Bioengineering Nano bioengineering Incheon 22012 South Korea Incheon Natl Univ Div Bioengineering Incheon 22012 South Korea Korea Univ Dept Biotechnol & Bioinformat Sejong 30019 South Korea Korea Univ Interdisciplinary Grad Program Artificial Intelli Sejong 30019 South Korea KRIBB Sch Biotechnol Dept Nanobiotechnol UST Daejeon 34113 South Korea Kyungpook Natl Univ Sch Med Dept Biochem & Cell Biol Daegu 41944 South Korea

MicroRNAs (miRNAs) are important diagnostic and prognostic biomarkers for various tumors. Currently, many diagnostic systems have been developed to detect miRNAs, but simple techniques for detecting miRNAs are still required. Recently, we reported that the expression of miRNA-135b is upregulated in gastric epithelial cells during gastric inflammation and carcinogenesis. Our aim was to develop an in vitro diagnostic platform to analyze the expression of gastric cancer-related biomarkers in the blood. The diagnostic platform comprised an isothermal amplification-based lateral flow biosensor (IA-LFB) that enables easy diagnosis of gastric cancer through visual observation. In this platform, trace amounts of biomarkers are isothermally amplified through rolling circle amplification (RCA), and the amplified product is grafted to the LFB. The performance of the IA-LFB was confirmed using RNAs extracted from in vitro and in vivo models. The platform could detect target miRNAs within 3 h with excellent sensitivity and selectivity. In particular, the IA-LFB could detect the overexpression of gastric cancer-related markers (miRNA-135b and miRNA-21) in RNAs extracted from the blood of patients with various stages (stages 1-4) of gastric cancer compared to that in healthy volunteers. Therefore, IA-LFB is a simple and sensitive in vitro diagnostic system for detecting gastric cancer-related biomarkers and can contribute to the early diagnosis and prognosis monitoring of gastric cancer. Furthermore, this technology can be applied to systems that can detect multiple biomarkers related to various diseases (such as infectious and genetic diseases).

关键词： Gastric cancer microRNAs Lateral flow biosensor Rolling circle amplification In vitro diagnosis

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Adaptive Biosensing Platform Using Immune Cell-Based Nanovesicles for Food Allergen Detection

SSRN

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SSRN 2022年

作者： Jeong, Jin-Young Kim, So-Ong Bang, Sunwoo Choi, Yoonji Shin, Junghyun Choi, Danmin Lee, Sang-Eun Park, Tai Hyun Hong, Seunghun Department of Physics and Astronomy Seoul National University Seoul08826 Korea Republic of School of Chemical and Biological Engineering Institute of Chemical Processes Seoul National University Seoul08826 Korea Republic of Interdisciplinary Program in Bioengineering Seoul National University Seoul08826 Korea Republic of Department of Physics and Astronomy Institute of Applied Physics Seoul National University Seoul08826 Korea Republic of

Adaptive immune system of human body programs immunological memories and acts to protect human bodies from the invasion of hazardous pathogens. Inspired by an adaptive immune system, we have developed an adaptive bioelectronic sensing platform which is based on nanovesicles for signal amplification and can be easily adapted to new target molecules. In this work, nanovesicles with anti-immunoglobulin E (anti-IgE) receptors are extracted from immune cells. Then, the nanovesicles are immobilized on a carbon nanotube-based transistor device, and desired IgE antibodies are linked to the nanovesicles to build a highly sensitive and selective biosensor. Our sensor can detect a peanut allergen, arachis hypogaea 2 (Ara h 2), down to 0.1 fM and selectively discriminate target allergens in real food samples such as peanut and egg white. As a proof of concept, we have demonstrated the detection of different target molecules using the same nanovesicles linked with different antibodies. Interestingly, our sensor platform is utilized to quantitatively evaluate the effect of allergy drug such as cromolyn. In this regard, our strategy can be utilized for basic research and versatile applications in food and pharmacological industries. © 2022, The Authors. All rights reserved.

关键词： Antibodies

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Verification of Geant4-DNA step-by-step-reaction-diffusion master equation model for long-term radiolysis simulation

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Physica Medica 2025年 133卷 104983-104983页

作者： Yoon, Euntaek Tran, Ngoc Hoang Incerti, Sebastien Choi, Chang Heon Interdisciplinary Program in Bioengineering Seoul National University Seoul 08826 Cuba Biomedical Research Institute Seoul National University Hospital Seoul 03080 Cuba Univ. Bordeaux CNRS LP2I UMR 5797 Gradignan F-33170 France Department of Radiation Oncology Seoul National University Hospital Seoul 03080 Cuba Institute of Radiation Medicine Seoul National University Medical Research Center Seoul 03080 Cuba Department of Radiation Oncology Seoul National University College of Medicine Seoul 03080 Cuba

Purpose: This paper describes the verification of the step-by-step-reaction-diffusion Master Equation (SBS-RDME) model, implemented in Geant4-DNA, for long-term radiolysis simulations in the Fricke dosimeter. Methods: Scaling for reaction rate constants due to the high acidity of the Fricke solution was applied. The secondary electrons generated by gamma irradiation from Co-60 were used as the radiation source for the simulations. Model parameters were optimized by observing changes in output and computation time in response to variations in the starting time t and initial voxel resolution ℎ of the compartment-based simulation. The yields of ferric ion G(Fe³⁺) and chemical species influencing its formation were calculated using the SBS-RDME model and using the IRT method for comparison. The time evolution of the yields of Fe³⁺, ^[rad]OH, H^[rad], HO₂^[rad], H₂O₂, and H₂ were compared, and the reactions affecting the yield of each chemical species were analyzed. Results: The model parameters were set to t = 5 ns and h = 12.5 nm. The yield trends over time for chemical species were consistent between the SBS-RDME model and the IRT method. At 50 s, the G(Fe³⁺) from the two calculations agreed within 3.2 %. Contribution analysis of the reactions affecting the generation/removal of each chemical species indicated that the main reason for this discrepancy between the two calculations might be the inability of the SBS method to consider specific reaction types during simulation. Conclusions: The SBS-RDME model was verified for long-term simulations by comparing its results to those obtained from the IRT method. © 2025 Associazione Italiana di Fisica Medica e Sanitaria

关键词： Fricke dosimetry Geant4-DNA RDME Water radiolysis

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