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The complete mitochondrial genome of black-spot snapper,Lutjanus fulviflamma(Perciformes: Lutjanidae)

Mitochondrial DNA Part B 2019年第1期4卷 366-367页

作者： Sapto Andriyono Sinar Pagi Sektiana Jobaidul Alam Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Fisheries and Marine Faculty Universitas Airlangga C Campus Jl. Mulyorejo Surabaya East Java Surabaya Indonesia Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The complete mitochondrial genome sequence of Dory snapper,Lutjanus fulviflamma,was determined by high-throughput sequencing (HTS) technique. The circular mitogenome ofL. fulviflammawas 16,512bp in length encoding 37 genes (13 proteins, 22 tRNAs, 2 ribosomal RNAs) and 2 conserved noncoding elements; the control region (D-Loop) and the origin of light strand synthesis (OL). Among the protein-coding genes, unusual start codons were identified in ND2, COX1 and ND3 genes and incomplete stop codons were identified in seven genes. Phylogenetic analysis with the currently known mitogenomes in genus Lutjanus revealed thatL. fulviflammawas most closely related toLutjanus russelliiwith 91% sequence identity.

关键词： High-throughput sequencing Lutjanidae mitogenome snapper coral reef

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Fall detection algorithm for the elderly using acceleration sensors on the shoes

Fall detection algorithm for the elderly using acceleration ...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： S. Y. Sim H. S. Jeon G. S. Chung S. K. Kim S. J. Kwon W. K. Lee K. S. Park Interdisciplinary program of bioengineering College of Engineering Seoul national university Department of biomedical engineering College of Medicine Seoul National University

ISBN: (纸本)9781424441211

The rate of increase in the number of aging population in Korea is very rapid among OECD-member countries. And fall accident is one of the most common factors that threaten the health of the elderly. Therefore, it is needed to develop a fall detection system for the elderly. Most fall detection systems use accelerometers attached on the torso. And in various studies, it was verified that these systems have high sensitivity and high specificity. However, the elderly would feel uncomfortable when banding a sensor on the chest every day. Therefore, in this study, we attached an accelerometer on the shoes to detect fall in the elderly. This prototype system would be improved as a smaller, low-power system in the next study. Also, applying energy harvesting device to this shoe system is being developed to reduce the weight of battery.

关键词： footwear Detection systems acceleration transducer aged person accelerometers falls Fall Autumn Detection algorithms Torso energy harvesting accidents and falls

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Characterization of the complete mitochondrial genome ofBothrocara hollandi(Perciformes: Zoarcidae)

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Mitochondrial DNA Part B 2019年第1期4卷 523-524页

作者： Nack-Keun Kim Sapto Andriyono Jobaidul Alam Sung-Tae Kim Kyung Mi Jung Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaFisheries and Marine Faculty Universitas Airlangga Surabaya Indonesia Dokdo Fisheries Research Center National Institute of Fisheries Science Pohang Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The full mitogenome ofBothrocara hollandiwas determined by high-throughput sequencing (HTS) platform. The genome was 16,732 bp in length, which included 13 protein-coding genes, 22 tRNAs, two ribosomal RNAs (12S and 16S), and a control region (D-Loop). The overall composition of G + C in the mitogenome was 45.90%, which was lower than A + T contents (54.10%). Except for COX1 (GTG), the other twelve protein-coding genes begin with typical start codon, ATG. The incomplete stop codon (TA − or T–) was identified in five genes, including COXI, COXII, COXIII, ND3, and ND4. The phylogenetic analysis with the currently reported mitogenome sequences showed thatB. hollandiwas most closely related toLycodes tanakae, suggesting that additional mitogenome sequences in genusBothrocaraare required for its clear evolutional relationship.

关键词： High-throughput sequencing Bothrocara hollandi mitogenome phylogenetic eelpout

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Coaxial electrospinning of gelatin/polyvinyl alcohol composite nanofibers and evaluation of their material properties

Coaxial electrospinning of gelatin/polyvinyl alcohol composi...

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Annual Northeast Bioengineering Conference

作者： Valerie Merkle Xiaoyi Wu Biomedical Engineering Interdisciplinary Program University of Arizona Tucson AZ Aerospace & Mechanical Engineering Department University of Arizona Tucson AZ

Electrospinning has been used to fabricate nanofibrous scaffolds from a variety of synthetic and natural materials, including polyvinyl alcohol (PVA) and gelatin. Although PVA possesses appealing mechanical properties for tissue engineering applications, it lacks adequate cellular recognition sites, which limits the material's bioactivity. In contrast, gelatin has desirable bioactivity but lacks adequate mechanical properties and can be difficult to handle. Therefore, coaxial electrospinning is employed to create nanofibers of these materials in a core/shell structure with gelatin forming the shell and PVA forming the core of the fibers. In this study, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), mechanical testing, and cellular studies were utilized to evaluate the morphology and material properties of coaxially electrospun PVA/gelatin nanocomposite scaffolds in comparison to scaffolds composed of solely PVA or gelatin. This study yields insight into the potential of combining synthetic and natural polymers together in the engineering of composite nanofibers for a variety of tissue engineering applications.

关键词： Zinc Testing Material properties Fabrication

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Current density reconstruction with multi-scale grid approach

Current density reconstruction with multi-scale grid approac...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： J.-M. Han I.B. Lee J.H. Hahm Y.J. Kim K.S. Park Institute of Biomedical Engineering Seoul National University South Korea Interdisciplinary Program in Biomedical Engineering Seoul National University South Korea Department of Biomedical Engineering Seoul National University Seoul South Korea

The computational cost of solving an electroencephalographic (EEG) or magnetoencephalographic (MEG) inverse problem is extremely high due to the inversion of a matrix configured with a priori information. The matrix size is proportional to the number of points in source grid. We present a multi-scale grid approach to solve the inverse problem using FOCUSS algorithms which is one of the current density reconstruction (CDR) methods and tested the algorithm with simulated EEG data. The multi-scale grid approach dramatically reduces grid points without loss of the resolution.

关键词： Current density Electroencephalography Inverse problems Magnetic heads Brain modeling biomedical engineering biomedical measurements Testing Current measurement Magnetic field measurement

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Validation of heart rate extraction through an iPhone accelerometer

Validation of heart rate extraction through an iPhone accele...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Sungjun Kwon Jeongsu Lee Gih Sung Chung Kwang Suk Park Interdisciplinary Program of Bioengineering Seoul National University Department of Biomedical Engineering College of Medicine Seoul National University

ISBN: (纸本)9781424441211

Ubiquitous medical technology may provide advanced utility for evaluating the status of the patient beyond the clinical environment. The iPhone provides the capacity to measure the heart rate, as the iPhone consists of a 3-axis accelerometer that is sufficiently sensitive to perceive tiny body movements caused by heart pumping. In this preliminary study, an iPhone was tested and evaluated as the reliable heart rate extractor to use for medical purpose by comparing with reference electrocardiogram. By comparing the extracted heart rate from acquired acceleration data with the extracted one from ECG reference signal, iPhone functioning as the reliable heart rate extractor has demonstrated sufficient accuracy and consistency.

关键词： Heart rate Accelerometer IPhone Ubiquitous healthcare

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Segmentation of solid nodules in ultrasonographic breast image based on wavelet transform

Segmentation of solid nodules in ultrasonographic breast ima...

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29th Annual International Conference of IEEE-EMBS, engineering in Medicine and Biology Society, EMBC'07

作者： Park, Sangyun Kong, Hyoun-Joong Moon, Woo Kyoung Kim, Hee Chan Interdisciplinary Program Graduate School Seoul National University Seoul Korea Republic of Department of Radiology Seoul National University Seoul 110-744 Korea Republic of Department of Biomedical Engineering College of Medicine and Institute of Medical and Biological Engineering Seoul National University Seoul Korea Republic of

ISBN: (纸本)1424407885

An accurate segmentation of solid nodules in ultrasonographic (US) breast image is presented. 1-level 2-dimensional Discrete Wavelet Transform (DWT) is used to create features reflecting the texture information of the original image. Using these features, the texture classification is achieved. Finally, solid nodule region is segmented from the classified texture region. Proper threshold for texture classification is automatically decided. Empirically acquired information about the relationship between the texture characteristic of the original image and the optimal threshold is examined and used. Presented algorithm is applied to 284 malignant solid nodules and 300 benign solid nodules and the resulting images are presented. © 2007 IEEE.

关键词： Ultrasonography

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Nonconstrained sleep monitoring system and algorithms using air-mattress with balancing tube method

Nonconstrained sleep monitoring system and algorithms using ...

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作者： Shin, Jae Hyuk Chee, Young Joon Jeong, Do-Un Park, Kwang Suk Interdisciplinary Program on Biomedical Engineering Seoul National University Graduate School Chongno-Ku Seoul 110-799 Korea Republic of Department of Biomedical Engineering Ulsan University Ulsan 680-190 Korea Republic of Department of Neuropsychiatry Clinical Research Institute Seoul National University College of Medicine and Hospital Chongno-Ku Seoul 110-799 Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Chongno-Ku Seoul 110-799 Korea Republic of

We evaluated the performance of a bed-type sensor system using the air-mattress with balancing tube (AMBT) method to noninvasively monitor the signals of heartbeat, respiration, and events of snoring, sleep apnea and body movement of subject on the system. The proposed system consists of multiple cylindrical air cells, two sensor cells and 18 support cells, and the small physiological signals were measured by the changes in pressure difference between the sensor cells, and the dc component was removed by balancing tube that is connecting the sensor cells. Using newly developed AMBT method, heartbeat, respiration, snoring, and body movement signals were clearly measured. For the concept of a home healthcare system, two automatic processing algorithms were developed: one is to estimate the mean heart and respiration rates for every 30 s, and another one is to detect the snoring, sleep apnea, and body movement events from the measured signals. In the beat-to-beat heart rate and breath-by-breath respiration rate analyses, the correlation coefficients of the heart and respiration rates from the proposed AMBT method compared with reference methods, electrocardiogram, and respiration effort signal from piezoelectric belt, were 0.98 (p

关键词： Electrocardiograms

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Ballistocardiography for Nonintrusive Sleep Structure Estimation

Ballistocardiography for Nonintrusive Sleep Structure Estima...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Kwang Suk Park Su Hwan Hwang Da Woon Jung Hee Nam Yoon Won Kyu Lee Department of Biomedical Engineering Seoul National University Interdisciplinary Program of Bioengineering Graduate School Seoul National University

ISBN: (纸本)9781424479276

Based on the its nonintrusive characteristics, ballistocardiography (BCG) has applied in the estimation of sleep structure without attaching any sensors to the subject's body. Loadcell or polyvinylidenefluoride (PVDF) film sensors are installed on the mattress for the monitoring of BCG. BCG peak was detected and heart rate variability parameters are derived. Parameters representing sleep structure and quality are estimated using these parameters. Sleep efficiency, four stages of sleep structure and sleep onset latency are estimated and results are compared with the results derived from polysomnographic recording.

关键词： Sleep apnea Heart rate Estimation Electrocardiography biomedical monitoring Blood pressure

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The photon diffusion in biological tissue for PDT

The photon diffusion in biological tissue for PDT

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Pacific Rim Conference on Lasers and Electro-Optics (CLEO/Pacific Rim)

作者： D.J. Lee J.M. Kim S.H. Kim H.S. Lim Interdisciplinary Program in Biomedical Engineering Chungnam National University Taejon South Korea Department of Biomedical Engineering College of Medicine Chungnam National University Taejon South Korea

This paper studied the accessible depth by photons within biological tissue for photodynamic therapy. For the measurements of light propagation within tissue we applied the diode laser of 660 nm wavelength and then by assuming the medium to be homogeneous, we neglect the effects of any refractive index mismatches between the tissue layers. The result have yielded the penetration depth of light within biological tissue.

关键词： Biological tissues Optical propagation Power lasers Diode lasers Power measurement Cancer Medical treatment Wavelength measurement Heating Muscles

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