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Correction to: N‑doped carbon nanospheres as selective fluorescent probes for mercury detection in contaminated aqueous media: chemistry, fluorescence probing, cell line patterning, and liver tissue interaction

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Environmental science and pollution research international 2025年第20期32卷 2025 May 6页

作者： Soheil Sojdeh Ali Banitalebi Dehkordi Alireza Badiei Ali Zarrabi Pooyan Makvandi Milad Ashrafizadeh Mohammad Reza Saeb Eder C Lima Mohammad Rabiee Mohsen Asadnia Thomas J Webster Navid Rabiee School of Chemistry College of Science University of Tehran P.O. Box Tehran 14155‑6455 Iran. Department of Biomedical Engineering Faculty of Engineering and Natural Sciences Istinye University Istanbul Turkey. Centre for Materials Interfaces Istituto Italiano Di Tecnologia 56025 Pisa Italy. Sabanci University Orta Mahalle Üniversite Caddesi No. 27 Orhanlı Tuzla 34956 Istanbul Turkey. Department of Polymer Technology Gdańsk University of Technology G. Narutowicza 11/12 80‑233 Gdańsk Poland. Institute of Chemistry Federal University of Rio Grande Do Sul (UFRGS) Av. Bento Goncalves 9500 Postal Box 15003 Porto Alegre ZIP 91501‑970 Brazil. profederlima@***. Biomaterials Group Department of Biomedical Engineering Amirkabir University of Technology Tehran Iran. School of Engineering Macquarie University New South Wales Sydney 2109 Australia. School of Health Sciences and Biomedical Engineering Hebei University of Technology Tijian 300130 China. School of Engineering Saveetha University Chennai 602105 India. Interdisciplinary Laboratory for Advanced Materials (LIMAV) Materials Science and Engineering Graduate Program Federal University of Piaui Teresina 64049‑550 Brazil. Centre for Molecular Medicine and Innovative Therapeutics Murdoch University Perth 6150 Australia.

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Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis

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Scientific Reports 2025年第1期15卷 1-12页

作者： Wassamon Moyadee Jatuporn Rattanasrisomporn Sittiruk Roytrakul Janthima Jaresitthikunchai Narumon Phaonakrop Kiattawee Choowongkomon Sekkarin Ploypetch Natthasit Tansakul Amonpun Rattanasrisomporn Graduate Program in Animal Health and Biomedical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand Department of Companion Animal Clinical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency Pathum Thani Thailand Department of Biochemistry Faculty of Science Kasetsart University Bangkok Thailand Department of Clinical Sciences and Public Health Faculty of Veterinary Science Mahidol University Nakhon Pathom Thailand Department of Pharmacology Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand Interdisciplinary of Genetic Engineering and Bioinformatics Graduate School Kasetsart University Bangkok Thailand

Feline infectious peritonitis (FIP) is a lethal, viral-induced immune-mediated disease that remains a challenge for diagnosis and treatment in cats. Proteomic profiling, which analyzes the protein content of biological samples, offers the potential to identify novel biomarkers that could improve the diagnosis and management of FIP. This study aims to assess the serum proteome and identify proteins that differentiate healthy cats from cats diagnosed with effusive FIP using liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS). A total of 30 cats diagnosed with effusive FIP and 27 clinically normal cats were enrolled. Twenty-three proteins were significantly (p< 0.01, ≥ fivefold change in abundance) differentially expressed between cats with effusive FIP and controls. Among these, the P2X purinoceptor, DNA topoisomerase, Notch receptor 2, and cadherin-17 were identified as key proteins of interest in cats with effusive FIP. Our findings suggest that these differentially expressed proteins could serve as potential diagnostic biomarkers and therapeutic targets for FIP. However, further studies are needed to validate these findings and explore their potential applications.

关键词： Biomarkers Cats Coronavirus Feline infectious peritonitis Proteomics Serum

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Integration of MRI and somatosensory evoked potentials facilitate diagnosis of spinal cord compression

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Scientific Reports 2023年第1期13卷 1-12页

作者： Sun, Shu-Pin Phang, Chun-Ren Tzou, Shey-Cherng Chen, Chang-Mu Ko, Li-Wei International Ph.D. Program in Interdisciplinary Neuroscience (UST) College of Biological Science and Technology National Yang Ming Chiao Tung University 734 Engineering Bldg. 5 1001 Daxue Road Hsinchu 30010 Taiwan Department of Medical Research National Taiwan University Hospital Hsin-Chu Branch Hsinchu 300 Taiwan Institute of Molecular Medicine and Bioengineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Department of Surgery College of Medicine and Hospital National Taiwan University No. 7 Zhongshan South Road Taipei 10002 Taiwan Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Institute of Electrical and Control Engineering Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Department of Biomedical Science and Environment Biology and the Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung 807 Taiwan

This study aimed to integrate magnetic resonance imaging (MRI) and related somatosensory evoked potential (SSEP) features to assist in the diagnosis of spinal cord compression (SCC). MRI scans were graded from 0 to 3 according to the changes in the subarachnoid space and scan signals to confirm differences in SCC levels. The amplitude, latency, and time–frequency analysis (TFA) power of preoperative SSEP features were extracted and the changes were used as standard judgments to detect neurological function changes. Then the patient distribution was quantified according to the SSEP feature changes under the same and different MRI compression grades. Significant differences were found in the amplitude and TFA power between MRI grades. We estimated three degrees of amplitude anomalies and power loss under each MRI grade and found the presence or absence of power loss occurs after abnormal changes in amplitude only. For SCC, few integrated approach combines the advantages of both MRI and evoked potentials. However, integrating the amplitude and TFA power changes of SSEP features with MRI grading can help in the diagnosis and speculate progression of SCC. © 2023, The Author(s).

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Simulating Cardiac Fluid Dynamics in the Human Heart

arXiv

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arXiv 2023年

作者： Davey, Marshall Puelz, Charles Rossi, Simone Smith, Margaret Anne Wells, David R. Sturgeon, Gregory M. Segars, W. Paul Vavalle, John P. Peskin, Charles S. Griffith, Boyce E. University of North Carolina Chapel HillNC United States Department of Pediatrics-Cardiology Baylor College of Medicine Texas Children’s Hospital HoustonTX United States Department of Mathematics University North Carolina Chapel HillNC United States Department of Radiology Duke University Medical Center DurhamNC United States Division of Cardiology Department of Medicine University of North Carolina School of Medicine Chapel HillNC United States Courant Institute of Mathematical Sciences New York University New YorkNY United States Departments of Mathematics and Biomedical Engineering University of North Carolina Chapel HillNC United States Carolina Center for Interdisciplinary Applied Mathematics University of North Carolina Chapel HillNC United States Computational Medicine Program University of North Carolina School of Medicine Chapel HillNC United States McAllister Heart Institute University of North Carolina School of Medicine Chapel HillNC United States

Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering, and medical interest in creating mathematical models of the heart that capture, explain, and predict these fluid-structure interactions. However, existing computational models that account for interactions among the blood, the actively contracting myocardium, and the cardiac valves are limited in their abilities to predict valve performance, resolve fine-scale flow features, or use realistic descriptions of tissue biomechanics. Here we introduce and benchmark a comprehensive mathematical model of cardiac fluid dynamics in the human heart. A unique feature of our model is that it incorporates biomechanically detailed descriptions of all major cardiac structures that are calibrated using tensile tests of human tissue specimens to reflect the heart’s microstructure. Further, it is the first fluid-structure interaction model of the heart that provides anatomically and physiologically detailed representations of all four cardiac valves. We demonstrate that this integrative model generates physiologic dynamics, including realistic pressure-volume loops that automatically capture isovolumetric contraction and relaxation, and predicts fine-scale flow features. None of these outputs are prescribed;instead, they emerge from interactions within our comprehensive description of cardiac physiology. Such models can serve as tools for predicting the impacts of medical devices or clinical interventions. They also can serve as platforms for mechanistic studies of cardiac pathophysiology and dysfunction, including congenital defects, cardiomyopathies, and heart failure, that are difficult or impossible to perform in patients. Copyright © 2023, The Authors. All rights reserved.

关键词： Heart

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Multivalent‐Interaction‐Driven Assembly of Discrete, Flexible, and Asymmetric Supramolecular Protein Nano‐Prisms

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Angewandte Chemie 2020年第51期132卷 23444-23451页

作者： Suyeong Han Dr. Yu‐na Kim Gyunghee Jo Dr. Young Eun Kim Prof. Dr. Ho Min Kim Dr. Jeong‐Mo Choi Prof. Dr. Yongwon Jung Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Korea These authors contributed equally to this work. Biomedical Science and Engineering Interdisciplinary Program KAIST Daejeon 34141 Korea Graduate School of Medical Science & Engineering KAIST Daejeon 34141 Korea Center for Biomolecular & Cellular Structure Institute for Basic Science (IBS) Daejeon 34126 Korea Natural Science Research Institute KAIST Daejeon 34141 Korea Department of Chemistry Busan National University Busan 46241 Korea

Multivalent interactions between protein‐oligomer‐fused binding pairs allowed highly monodisperse assembly of two protein oligomers, where spacing between oligomers can be widely varied. Two different oligomers or three oligomers can also be discretely assembled into protein layer structures via this *** approaches to design monodisperse protein assemblies require rigid, tight, and symmetric interactions between oligomeric protein units. Herein, we introduce a new multivalent‐interaction‐driven assembly strategy that allows flexible, spaced, and asymmetric assembly between protein oligomers. We discovered that two polygonal protein oligomers (ranging from triangle to hexagon) dominantly form a discrete and stable two‐layered protein prism nanostructure via multivalent interactions between fused binding pairs. We demonstrated that protein nano‐prisms with long flexible peptide linkers (over 80 amino acids) between protein oligomer layers could be discretely formed. Oligomers with different structures could also be monodispersely assembled into two‐layered but asymmetric protein nano‐prisms. Furthermore, producing higher‐order architectures with multiple oligomer layers, for example, 3‐layered nano‐prisms or nanotubes, was also *** a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the *** note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

关键词： multivalent interaction protein assembly protein design protein engineering protein–protein interactions

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Mitochondrial genome of Mola carplet,Amblypharyngodon mola(Hamilton, 1822) and its evolutional relationship in subfamily Danioninae

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Mitochondrial DNA Part B 2019年第1期4卷 650-651页

作者： Md. Jobaidul Alam Sapto Andriyono A. T. M. Eunus Md. Mofizur Rahman Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Fisheries Ministry of Fisheries and Livestock Dhaka Bangladesh Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaFaculty of Fisheries and Marine C Campus Jl. Mulyorejo Surabaya Universitas Airlangga East Java Indonesia World Fish Bangladesh and South Asia Office Dhaka Bangladesh Department of Marine Biology Pukyong National University Busan Republic of KoreaDepartment of Fisheries and Marine Science Noakhali Science and Technology University Sonapur Bangladesh Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The complete mitochondrial genome in Mola carplet,Amblypharyngodon mola(Hamilton, 1822) was determined by MiSeq platform for the first time in the genus. The mitogenome ofA. molawas circular and 16,545 bp in length, which harbours a canonical 13 protein-coding genes, 22 tRNAs, 2 rRNAs, and a control region (D-Loop). Twenty eight genes were encoded on the H strand and the other 9 genes were on the L strand. The incomplete stop codon (TA-/T–) was identified in seven genes (COX2,COX3,ND2,ND3,ND4,ATP6, andCytb). The mitogenome ofA. molashowed highest (82%) sequence identity withRasbora vaterifloris(GenBank No. NC015531), which is endemic to Sri Lanka.

关键词： Next generation sequencing Amblypharyngodon mola mitochondrial genome Danioninae Bangladesh

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A hybrid semi-Lagrangian cut cell method for advection-diffusion problems with robin boundary conditions in moving domains

arXiv

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arXiv 2021年

作者： Barrett, Aaron Fogelson, Aaron L. Griffith, Boyce E. Department of Mathematics University of Utah Salt Lake CityUT United States Departments of Mathematics and Bioengineering University of Utah Salt Lake CityUT United States Departments of Mathematics Applied Physical Sciences and Biomedical Engineering University of North Carolina Chapel HillNC United States Carolina Center for Interdisciplinary Applied Mathematics University of North Carolina Chapel HillNC United States Computational Medicine Program University of North Carolina Chapel HillNC United States McAllister Heart Institute University of North Carolina Chapel HillNC United States

We present a new discretization approach to advection-diffusion problems with Robin boundary conditions on complex, time-dependent domains. The method is based on second order cut cell finite volume methods introduced by Bochkov et al. [8] to discretize the Laplace operator and Robin boundary condition. To overcome the small cell problem, we use a splitting scheme along with a semi-Lagrangian method to treat advection. We demonstrate second order accuracy in the L1, L2, and L∞norms for both analytic test problems and numerical convergence studies. We also demonstrate the ability of the scheme to convert one chemical species to another across a moving boundary. © 2021, CC BY-SA.

关键词： Advection

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Corrigendum to "Mathematical model of modified hybrid pump mechanism for cardiopulmonary resuscitation" [Computer methods and programs in biomedicine 206 (2021) 106106]

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Computer methods and programs in biomedicine 2022年 218卷 106711页

作者： Dong Ah Shin Jung Chan Lee Interdisciplinary Program in Bioengineering Graduate School Seoul National University Seoul 08826 Republic of Korea. Department of Biomedical Engineering College of Medicine and Institute of Medical and Biological Engineering Medical Research Center Seoul National University Seoul 03080 Republic of Korea Institute of BioEngineering Bio-MAX Institute Seoul National University Seoul 08826 Republic of Korea. Electronic address: ljch@snu.ac.kr.

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Frontispiece: Visible Light-Driven Molecular Switches and Motors: Recent Developments and Applications

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Chemistry – A European Journal 2022年第18期28卷

作者： Dr. Hao Wang Dr. Hari Krishna Bisoyi Xinfang Zhang Dr. Fathy Hassan Prof. Quan Li Advanced Materials and Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State University Kent Ohio 44242 USA Department of Chemistry Faculty of Science Tanta University Tanta El-Gharbia 31527 Egypt Institute of Advanced Materials School of Chemistry and Chemical Engineering and Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research Southeast University Nanjing 211189 China

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Topographical pattern of blood-brain barrier impairment in preclinical and clinical Alzheimer’s disease

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Alzheimer's & Dementia 2023年第S17期19卷

作者： Dahyun Yi Min Soo Byun Joon Sik Park Gihwan Byeon Hyejin Ahn Gijung Jung Koung Mi Kang Chul-Ho Sohn Jaeseok Park Dong Young Lee Seoul National University Seoul Korea Republic of (South) Institute of Human Behavioral Medicine Medical Research Center Seoul National University Seoul Korea Republic of (South) Correspondece Seoul National University College of Medicine Seoul Korea Republic of (South) Seoul National University Hospital Seoul Korea Republic of (South) Sungkyunkwan University Department of Biomedical Engineering Seoul Korea Republic of (South) Kangwon National University Hospital Chuncheon Korea Republic of (South) Interdisciplinary program of cognitive science Seoul National University College of Humanities Seoul Korea Republic of (South) Sungkyunkwan University Biomedical Institute for Convergence Seoul Korea Republic of (South)

Background While blood-brain barrier (BBB) damage in some brain regions has been suggested in Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI), the topographical pattern of BBB impairment associated with AD process in whole brain level is still poorly understood. Using high-resolution 3-dimensional (3D) dynamic contrast-enhanced (DCE) scans of BBB permeability ( K trans ) for the whole brain, we aimed to reveal topographical pattern of BBB impairment related to Alzheimer’s disease (AD) including preclinical as well as clinically impaired state. Method Ninety-one participants were included in the study [45 cognitively normal (CN) older adults, 24 individuals with mild cognitive impairment (MCI), and 22 patients with AD dementia]. Comprehensive clinical and neuropsychological assessments were administered to all participants. High-resolution DCE- as well as T 1 -weighted-MRI scans were obtained in addition to amyloid-PET scans. Amyloid-beta (Ab) positivity was obtained using previously established cut-offs. Preprocessing of K trans maps incorporated FreeSurfer-based (v6.0) segmentation to ensure exclusion of the voxels within cerebrospinal fluid (CSF) spaces. Voxel-wise analyses were conducted using SPM12 implemented in MATLAB 2018b. Result Subtle BBB impairment, as measured by K trans map images based on high-resolution 3D DCE-MRI, was observed at multiple brain regions even in preclinical AD (i.e., Ab-positive CN) as well as AD with cognitive impairment (i.e., Ab-positive MCI and AD). The brain regions with impaired K trans closely corresponded to the AD-signature regions (Figure). Compared to Ab-negative CN, Ab-positive CN showed increased breakdown of BBB in the precuneus, posterior-cingulate cortex, and medial temporal lobe. Moreover, compared to Ab-negative CN, Ab-positive MCI and AD patients showed increased breakdown of BBB in more diffuse regions including bilateral frontal, parietal and inferior temporal areas. In contrast, when using lo

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