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Characterization of complete mitochondrial genome of coonstriped shrimpPandalus hypsinotus(Decapoda: Pandalidae)

Mitochondrial DNA Part B 2019年第1期4卷 294-295页

作者： Nack-keun Kim Sapto Andriyono Kyung Mi Jung Gwang Ho Choi Tae-Ho Yoon Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Fisheries and Marine Faculty Universitas Airlangga C Campus Jl. Mulyorejo Surabaya East Java Indonesia Dokdo Fisheries Research Center National Institute of Fisheries Science Pohang Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The complete mitochondrial genome of the coonstriped,Pandalus hypsinotuswas determined by the MiSeq sequencing platform. The mitogenome ofP. hypsinotus(15,909 bp) encoded the 13 protein-coding genes, 22 tRNA genes, two rRNA genes, non-coding, control region (D-Loop). Phylogenetic analysis based on the full mitochondrial genome sequences showed thatP. hypsinotusis most closely related toP. borealis(86%) clustering together withChlorotocus crassicornisin Pandalidae. The complete mitogenome sequence ofP. hypsinotuswould contribute to the scientific management for conservation of its resources in East/Japan Sea.

关键词： Next-generation sequencing decapoda mitogenome Dokdo Pandalidae

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Highly Wearable Galvanic Skin Response Sensor using Flexible and Conductive Polymer Foam

Highly Wearable Galvanic Skin Response Sensor using Flexible...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Jeehoon Kim Sungjun Kwon Sangwon Seo Kwangsuk Park Interdisciplinary Program of Bioengineering Seoul National University Seoul Korea Department of Biomedical Engineering Seoul National University Seoul Korea

Owing to advancements in daily physiological monitoring technology, diverse healthcare applications have emerged recently. The monitoring of skin conductance responses has extensive feasibility to support healthcare applications such as detecting emotion changes. In this study, we proposed a highly wearable and reliable galvanic skin response (GSR) sensor that measures the signals from the back of the user. To enhance its wearability and usability, we employed flexible conductive foam as the sensing material and designed it to be easily attachable to (and detachable from) a wide variety of clothes. We evaluated the sensing reliability of the proposed sensor by comparing its signal with a reference GSR. The average correlation between the two signals was 0.768;this is sufficiently high to validate the feasibility of the proposed sensor for reliable GSR sensing on the back.

关键词： Skin Correlation Sensors Reliability Electrodes biomedical monitoring Fingers

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Capacitive-Coupled ECG Measurement and Its Applications for Ubiquitous Healthcare

Capacitive-Coupled ECG Measurement and Its Applications for ...

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International Conference on Convergence Information Technology

作者： Ko Keun Kim Yong Gyu Lim Jung Soo Kim Kwang Suk Park Interdisciplinary Program in Biomedical Engineering Seoul National University Seoul South Korea Department of Oriental Biomedical Engineering Sangji University Wonju South Korea Department of Biomedical Engineering College of Medicine Seoul National University Seoul South Korea

Unconstrained ECG measurement is important for ubiquitous healthcare. The methods for this are being developed, and the capacitive-coupled ECG (CC- ECG) measurement is reported recently. In this paper, this measuremen... 详细信息

ISBN: (纸本)9781424431779

关键词： Electrocardiography Medical services biomedical measurements Electrodes biomedical engineering Surface impedance Rubber Textiles Skin Impedance measurement

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Improving the robustness of the immersed interface method through regularized velocity reconstruction

arXiv

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arXiv 2025年

作者： Sun, Qi Kolahdouz, Ebrahim M. Griffith, Boyce E. Department of Mathematics University of North Carolina Chapel HillNC United States Department of Biomedical Engineering University of North Carolina Chapel HillNC United States Carolina Center for Interdisciplinary Applied Mathematics University of North Carolina Chapel HillNC United States Computational Medicine Program University of North Carolina School of Medicine Chapel HillNC United States McAllister Heart Institute University of North Carolina School of Medicine Chapel HillNC United States

Robust, broadly applicable fluid-structure interaction (FSI) algorithms remain a challenge for computational mechanics. Efforts in this area are driven by the need to enhance predictive accuracy and efficiency in FSI simulations, align with experimental observations, and unravel complex multiscale and multiphysics phenomena, while addressing challenges in developing more robust and efficient methodologies. In previous work, we introduced an immersed interface method (IIM) for discrete surfaces and an extension based on an immersed Lagrangia-Eulerian (ILE) coupling strategy for modeling FSI involving complex geometries. The ability of the method to sharply resolve stress discontinuities induced by singular immersed boundary forces in the presence of low-regularity geometrical representations makes it a compelling choice for three-dimensional modeling of complex geometries in diverse engineering applications. Although the IIM we previously introduced offers many desirable advantages, it also imposes a restrictive mesh factor ratio, requiring the surface mesh to be coarser than the fluid grid to ensure stability. This is because when the mesh factor ratio constraint is not satisfied, parts of the structure motion are not controlled by the discrete FSI system. This constraint can significantly increase computational costs, particularly in applications involving multiscale geometries with highly localized complexity or fine-scale features. To address this limitation, we devise a stabilization strategy for the velocity restriction operator inspired by Tikhonov regularization. This study demonstrates that using a stabilized velocity restriction operator in IIM enables a broader range of structure-to-fluid grid-size ratios without compromising accuracy or altering the flow dynamics. This advancement significantly broadens the applicability of the method to real-world FSI problems involving complex geometries and dynamic conditions, offering a robust and computationally effi

关键词： Mesh generation

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Recent advances in molecularly imprinted polymers toward biomedical healthcare devices

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Biosensors and Bioelectronics 2025年

作者： Youngjun Seo Yonghwan Kim Jaeheung Kim Hyo Gi Jung Jae Won Jang Hyunji Kim Kyo Seon Hwang Dongtak Lee Sang Won Lee Jeong Hoon Lee Dae Sung Yoon School of Biomedical Engineering Korea University Seoul 02841 Republic of Korea Interdisciplinary Program in Precision Public Health Korea University Seoul 02841 Republic of Korea Department of Clinical Pharmacology and Therapeutics College of Medicine Kyung Hee University Seoul 02447 Republic of Korea Department of Bioengineering & Nano-bioengineering Research Center for Bio Materials and Process Development Incheon National University Incheon 22012 Republic of Korea Division of Bioengineering Incheon National University Incheon 22012 Republic of Korea Terasaki Institute for Biomedical Innovation Los Angeles CA 90064 USA KU-KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea Department of Integrative Energy Engineering College of Engineering Korea University Seoul 02841 Republic of Korea Astrion Inc Seoul 02841 Republic of Korea

Following the increase in the global aging population, the importance of monitoring various disease-related biomarkers at an early stage has increased to ensure the health of the elderly. In an aging society, point-of-care (POC) systems are needed to care for elderly people who have physical and mental disorders. In light of the increasing prominence of POC systems, there is a growing effort to address the limitations associated with conventional receptors in wearable devices by substituting them with molecularly imprinted polymer (MIP). MIPs are well-known synthetic receptors engineered with specific binding cavities based on the "lock and key" principle. They could be synthesized in various configurations depending on specific types of monomers and templates. Compared to conventional receptors such as antibodies and aptamers, MIPs exhibit outstanding advantages, including good stability, cost-effectiveness, ease of synthesis, reusability, and broad applicability. These advantages have led to their extensive application in biomedical healthcare devices. This review summarizes a comparative analysis of sensors utilized for the detection of disease-specific biomarkers through diverse MIP applications and methodologies. Furthermore, we evaluated recent advancements in the miniaturization of MIPs and their integration with wearable biomedical devices for comprehensive healthcare monitoring applications. Finally, we delineated the existing limitations that need to be surmounted for the effective implementation of MIP-based biomedical devices and outlined future objectives for the enhancement of wearable and wireless biomedical healthcare monitoring devices.

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An immersed interface method for incompressible flows and geometries with sharp features

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Journal of Computational Physics 2025年 537卷

作者： Michael J. Facci Ebrahim M. Kolahdouz Boyce E. Griffith Department of Mathematics University of North Carolina Chapel Hill NC USA Flatiron Institute Simons Foundation New York NY USA Department of Biomedical Engineering University of North Carolina Chapel Hill NC USA Carolina Center for Interdisciplinary Applied Mathematics University of North Carolina Chapel Hill NC USA Computational Medicine Program University of North Carolina School of Medicine Chapel Hill NC USA McAllister Heart Institute University of North Carolina School of Medicine Chapel Hill NC USA

The immersed interface method (IIM) for models of fluid flow and fluid-structure interaction imposes jump conditions that capture stress discontinuities generated by forces that are concentrated along immersed boundaries. Most prior work using the IIM for fluid dynamics applications has focused on smooth interfaces, but boundaries with sharp features such as corners and edges can appear in practical analyses, particularly on engineered structures. The present study builds on our work to integrate finite element-type representations of interface geometries with the IIM. Initial realizations of this approach used a continuous Galerkin (CG) finite element discretization for the boundary, but as we show herein, these approaches generate large errors near sharp geometrical features. To overcome this difficulty, this study introduces an IIM approach using a discontinuous Galerkin (DG) representation of the jump conditions. Numerical examples explore the impacts of different interface representations on accuracy for both smooth and sharp boundaries, particularly flows interacting with fixed interface configurations. We demonstrate that using a DG approach provides accuracy that is comparable to the CG method for smooth cases. Further, we identify a time step size restriction for the CG representation that is directly related to the sharpness of the geometry. In contrast, time step size restrictions imposed by DG representations are demonstrated to be nearly insensitive to the presence of sharp features.

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Complete mitochondrial genome of green shrimp,Chlorotocus crassicornis(Crustacea: Decapoda: Pandalidae) in Korean water

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Mitochondrial DNA Part B 2019年第2期4卷 2206-2207页

作者： GyungRyul Kim Md. Jobaidul Alam Hyun-Woo Kim Sapto Andriyono Fisheries Resources Research Division National Institute of Fisheries Science (NIFS) Busan South KoreaInterdisciplinary program of Biomedical Engineering Pukyong National University Busan South Korea Interdisciplinary program of Biomedical Engineering Pukyong National University Busan South Korea Department of Marine Biology Pukyong National University Busan Korea Interdisciplinary program of Biomedical Engineering Pukyong National University Busan South KoreaDepartment of Marine Fisheries and Marine Faculty Universitas Airlangga C Campus Jl Mulyorejo Surabaya East Java Indonesia

The complete mitochondrial genome of green shrimp,Chlorotocus crassicornis(Costa, 1871) was generated by the combination of next-generation sequencing platform and long PCR technique. The mitochondrial genome ofC. crassicorniswas 16,500 bp, in which 13 protein-coding genes, two ribosomal RNAs, 22 transfer RNAs, and a putative control region was encoded. Based on the 13 protein-coding genes region, the phylogenetic tree was clearly demonstrated thatC. crassicornisis closest toPandalopsis japonicaandPandalus borealiswith 77% identity. This mitogenome information will be helpful for the further studies of deep-sea fisheries resources management strategies in Korea includingC. crassicornisspecies.

关键词： Chlorotocus crassicornis Pandalidae crustacean mitochondrial genome

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Bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair

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Bioactive Materials 2024年第10期40卷 306-317页

作者： Rachel H.Koh Junhee Kim Jeong-Uk Kim Seunghyun L.Kim Arun Kumar Rajendran Seunghun SLee Heesoo Lee Joo Hyun Kim Ji Hoon Jeong Yongsung Hwang Jong Woo Bae Nathaniel S.Hwang School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul08826South Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul08826South Korea Department of Biomedical Engineering Dongguk UniversitySeoul10326South Korea Soonchunhyang Institute of Medi-bio Science(SIMS) Soonchunhyang UniversityCheonan31151South Korea Department of Integrated Biomedical Science Soonchunhyang UniversityAsan31538South Korea Department of Orthopaedic Surgery Konkuk University Chungju HospitalKonkuk University School of MedicineChungju27376South Korea BioMAX Institute Seoul National UniversitySeoul08826South Korea

Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage *** or gradient scaffolds,often in conjunction with stem cells and growth factors,have been developed to mimic the respective layers for osteochondral defect *** this study,we designed a hyaline cartilage-hypertrophic cartilage bilayer graft(RGD/RGDW)with ***,we demonstrated that RGD peptide-modified chondroitin sulfate cryogel(RGD group)is chondro-conductive and capable of hyaline cartilage ***,we incorporated whitlockite(WH),a Mg^(2+)-containing calcium phosphate,into RGD cryogel(RGDW group)to induce chondrocyte hypertrophy and form collagen X-rich hypertrophic *** is the first study to use WH to produce hypertrophic ***-laden RGDW cryogel exhibited significantly upregulated expression of hypertrophy markers in vitro and formed ectopic hypertrophic cartilage in vivo,which mineralized into calcified cartilage in bone ***,RGD cryogel and RGDW cryogel were combined into bilayer(RGD/RGDW group)and implanted into rabbit osteochondral defect,where RGD layer supports hyaline cartilage regeneration and bioceramic-containing RGDW layer promotes calcified cartilage *** the RGD group(monolayer)formed hyaline-like neotissue that extends into the subchondral bone,the RGD/RGDW group(bilayer)regenerated hyaline cartilage tissue confined to its respective layer and promoted osseointegration for integrative defect repair.

关键词： Bioceramic Whitlockite Bilayer scaffold Chondrocyte hypertrophy Osteochondral defect repair

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System for unconstrained ECG measurement on a toilet seat using capacitive coupled electrodes : The efficacy and practicality

System for unconstrained ECG measurement on a toilet seat us...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Hyun Jae Baek Jung Soo Kim Ko Keun Kim Kwang Suk Park Interdisciplinary Program of Bioengineering Seoul National University Graduate School Republic of Korea Interdisciplinary Program in Medical and Biological Engineering Seoul National University Graduate School Republic of Korea Department of Biomedical Engineering Seoul National University Republic of Korea

Home healthcare is a common matter of concern to modern people. For the successful home healthcare, unconstrained bio-signal monitoring is important. Previously, unconstrained lavatory typed ECG measurement system was developed. It is enough to measure subject's ECG signal non-intrusively, but not practical because of moist environment of toilet. In this study, capacitive coupled electrode was employed for overcome above disadvantages. ECG was obtained by capacitive coupled electrode and compared with ECGs obtained from conventional Ag/AgCl electrode. Possible motion artifacts were investigated. Experimental results showed that toilet based capacitive coupled ECG signal was measured successfully.

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Characterization of complete mitochondrial genome of two-spot swimming crabCharybdis bimaculata(Miers, 1886)

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Mitochondrial DNA Part B 2018年第2期3卷 900-901页

作者： Nack-Keun Kim Sapto Andriyono Ah Ran Kim Chung Il Lee Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Fisheries and Marine Faculty Universitas Airlangga C Campus Jl Mulyorejo Surabaya East Java Indonesia Department of Marine Bioscience Gangneung-Wonju National University Gangneung Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The two-spot swimming crabCharybdis bimaculata(Miers,1886) is an important decapod species in the benthic ecosystem of Korean waters. In this study, we determined its complete mitochondrial genome by the combination of NGS analysis using MiSeq platform and PCR-based cloning method. The circular mitochondrial genome ofC. bimaculatawas 15,714 bp in length in which the standard set of 13 protein-coding genes, 22 tRNA genes, and 2 rRNA genes were encoded. Phylogenic analysis showed *** most closely related toCharybdis feriata. The complete mitogenome sequence information ofC. bimaculatawould provide useful data for the conservation of their population in the Pacific ocean.

关键词： Next generation sequencing Charybdis bimaculata mitogenome decapod phylogeny

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