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3rd IASTED International Conference on Medical engineering 2005

作者： Han, Jonghee Shin, Hongbeom Jeong, Do-Un Park, Kwangsuk Department of Biomedical Engineering College of Medicine and Hospital Seoul National University Seoul Korea Republic of Interdisciplinary Program College of Medicine and Hospital Seoul National University Seoul Korea Republic of Department of Psychiatry and Behavioral Science College of Medicine and Hospital Seoul National University Seoul Korea Republic of

ISBN: (纸本)0889864780

Detection of sleep apnea is the one of the major tasks in sleep medicine. Various methods have been applied to detect sleep apnea by analyzing different bio-signals. This paper introduces an innovative algorithm that analyze slope of nasal airflow signal in polysomnography. In this study, slope is obtained by the moving average of an absolute differentiation of a signal with 3.8 seconds' time window followed by segmentation of 1 second. Apnea threshold is determined by 10% of the slope of normal breathing. If segments having slope below apnea threshold appear for 10 consecutive segments, those segments are marked as apnea. The presented algorithm analyzed polysomnography records from 13 subjects and detected 2500 apnea events. Performance of presented algorithm was evaluated by comparing its results against the sleep specialist's manual scoring on same records. The overall agreement rate between the two was 95.36% (κ=0.86). In considering its simplicity and lower computational load, the presented algorithm is robust and useful.

关键词： Sleep research

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Heart sounds measurement using PVDF film sensor and their comparison with RR intervals of ECG signals

Heart sounds measurement using PVDF film sensor and their co...

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IEEE-EMBS International Conference on biomedical and Health Informatics, BHI 2012. In Conj. with the 8th Int. Symp.on Medical Devices and Biosensors and the 7th Int. Symp. on biomedical and Health engineering

作者： Lee, Won Kyu Chung, Gih Sung Baek, Hyun Jae Park, Kwang Suk Interdisciplinary Program for Bioengineering Seoul National University 111 Fundamental Medical Research Building I 101 Daehak-ro Jongno-gu Seoul Korea Republic of Interdisciplinary Program for Bioengineering Seoul National University 713 Fundamental Medical Research Building I 101 Daehak-ro Jongno-gu Seoul Korea Republic of Interdisciplinary Program for Bioengineering Seoul National University 807 Fundamental Medical Research Building I 101 Daehak-ro Jongno-gu Seoul Korea Republic of Department of Biomedical Engineering Seoul National University College of Medicine 103 Daehak-ro Jongno-gu Seoul Korea Republic of

ISBN: (纸本)9781457721779

Heart sounds are generated by the fluctuations of blood velocity and the vibrations of cardiac structure. The auscultation of heart sounds is one of the basic tools for patient diagnosis and provides a lot of information associated with cardiovascular systems. For converting mechanical sound waves into electronic signals, PVDF (polyvinylidene fluoride) film sensor was used as heart sounds measurement device. After suited filtering process, the first (S1) and the second (S2) heart sounds components were plainly distinguished and their peak timings were closely corresponded to reference heart sounds signals measured by microphone. Lastly, there was high correlation between S1 intervals (from PVDF signals) and RR intervals (from ECG signals). So it is expected that S1 intervals can replace RR intervals. In future application, these methods have possibilities for non-intrusive heart rate estimation. © 2012 IEEE.

关键词： Heart

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Study of Cell Encapsulation System in Using Thai Silk Fibroin-Based Hydrogel

Study of Cell Encapsulation System in Using Thai Silk Fibroi...

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biomedical engineering International Conference (BMEiCON)

作者： Nitchaya Suksomthong Sasitorn Aueviriyavit Juthamas Ratanavaraporn Interdisciplinary Program of Biomedical Engineering Faculty of Engineering Chulalongkorn University Bangkok Thailand Nano Safety and Bioactivity Research Team National Nanotechnology Center National Science and Technology Development Agency (NSTDA) Pathum Thani Thailand Biomedical Engineering Program Biomedical Engineering Research Center Biomaterial Engineering for Medical and Health Research Unit Faculty of Engineering Chulalongkorn University Bangkok Thailand

Designing biomimetic tissue models and developing scaffolds under cell-compatible protocols are a challenge in the field of tissue engineering. Cell encapsulation technique was selected with hydrogel fabrication due to its similarity to the condition within the human body. This study proposed SF-based hydrogels with the aim of application as cell encapsulation matrix. The vital properties, including gelation, diffusion, and cell viability were evaluated. SF/DMPG hydrogels exhibited rapid gelation and sufficient diffusion. L929 cells encapsulated in SF/DMPG survived after the fabrication process, with proliferation occurred at day 1 of culture which was done in static condition. The developed hydrogels showed potential application as a cell encapsulation matrix using tissue engineering, especially bioink.

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FPGA-Based Single-Input Time-to-Digital Converter with Rise Time Correction and Sub-2 ps Resolution for Precision Timing Applications

FPGA-Based Single-Input Time-to-Digital Converter with Rise ...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： D. Lee M. Yi S.I. Kwon Biomedical Engineering University of California Davis Davis California United States of America Seoul National University Interdisciplinary Program in Bioengineering College of Engineering Seoul Republic of Korea

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

In numerous fields, including physics, industry, and medical technology, the precise measurement of extremely short time intervals, such as those below 100 ps, is essential. This research introduces an innovative FPGA-based time-to-digital converter (TDC) implemented on the UltraScale+ platform (VCU118, Xilinx). The UltraScale+ platform improves upon timing resolution by incorporating a CARRY8 primitive cell as a delay element, an improvement over the CARRY4, which was widely used in previous platforms. Through the novel end-of-propagation (EOP) technique, the implemented TDC achieves an average bin size of 1.11 ps, demonstrating significant resource efficiency compared to other reported FPGA-based TDCs. This study details the design, implementation, and empirical validation of the TDC. Additionally, a unique feature of the proposed TDC is its ability to measure the input pulse width and apply rise time correction without requiring additional inputs. To demonstrate its practical applicability, the developed TDC was connected to the output of an ultrafast Cherenkov-Radiator-Integrated (CRI)-MCP-PMT after evaluating its electrical performance. The preliminary coincidence timing resolution of a pair of CRI-MCP-PMTs shows improvements from 107 ps to 73 ps (FWHM) with the proposed rise time correction. These advancements highlight the potential of the TDC not only for next-generation medical applications but also for its transformative impact in applications demanding ultra-precise timing.

关键词： Industries Semiconductor device measurement Microwave integrated circuits Image resolution Semiconductor detectors Pulse measurements Medical services

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Slit-Wall Differentiation Method for Depth-of-Interaction Measurement for PET

Slit-Wall Differentiation Method for Depth-of-Interaction Me...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： D. Lee H. Hemmati M. Yi S.I. Kwon University of California Davis Biomedical Engineering Davis California United States of America Seoul National University Interdisciplinary Program in Bioengineering College of Engineering Seoul Republic of Korea

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

In positron emission tomography (PET), accurately measuring the Depth-of-Interaction (DOI) of 511 keV gamma ray interactions is essential for improving spatial resolution in small animal PET, especially at off-center detector positions. DOI resolution can be improved by modifying crystal structures, reflectors, or by using dual readout techniques. Most methods, except for the more electronics-intensive dual side readout, increase light sharing among pixels, thereby reducing photon availability per pixel. This study introduces a novel Slit-Wall Differentiation (SWD) method, designed to restrict light sharing to just four adjacent pixels, thus enhancing DOI accuracy. The SWD method involves placing strategic slits on the adjacent faces of each pixel, controlling light sharing depending on the DOI position. DOI information is calculated from the output patterns of Silicon Photomultiplier (SiPM) arrays. The effectiveness of the proposed method was validated through GATE simulations (vGATE 9.2) using a $3 \times 3$ Lutetium-Yttrium Oxyorthosilicate (LYSO) array with enhanced specular reflectors (ESRs). An LYSO array fabricated based on the proposed configuration was successfully prepared. For practical validation, an experimental setup using a 4 $\times 4$ NUV-HD-MT (Broadcom) SiPM array is also configured.

关键词： Temperature measurement Photomultipliers Semiconductor device measurement Semiconductor detectors Position measurement Silicon Positron emission tomography

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A Reflection on Teaching Design Thinking to First-Year engineering Students

A Reflection on Teaching Design Thinking to First-Year Engin...

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IEEE International Conference on Teaching, Assessment and Learning for engineering (TALE)

作者： Kuntinee Maneeratana Ratchatin Chancharoen Peerapat Thongnuek Potcharawan Sukmuen Chamaiporn Inkaew Praweenya Suwannatthachote Department of Mechanical Engineering Chulalongkorn University Bangkok Thailand Interdisciplinary Program of Biomedical Engineering Chulalongkorn University Thailand Department of Educational Communication and Technology Chulalongkorn University Thailand

The following topics are dealt with: computer aided instruction; educational courses; teaching; educational institutions; computer science education; further education; engineering education; learning (artificial inte... 详细信息

ISBN: (数字)9781728126654

ISBN: (纸本)9781728126661

关键词： Conferences Prototypes engineering students Interviews Product design Manufacturing

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Correction to: N‑doped carbon nanospheres as selective fluorescent probes for mercury detection in contaminated aqueous media: chemistry, fluorescence probing, cell line patterning, and liver tissue interaction

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Environmental science and pollution research international 2025年第20期32卷 2025 May 6页

作者： Soheil Sojdeh Ali Banitalebi Dehkordi Alireza Badiei Ali Zarrabi Pooyan Makvandi Milad Ashrafizadeh Mohammad Reza Saeb Eder C Lima Mohammad Rabiee Mohsen Asadnia Thomas J Webster Navid Rabiee School of Chemistry College of Science University of Tehran P.O. Box Tehran 14155‑6455 Iran. Department of Biomedical Engineering Faculty of Engineering and Natural Sciences Istinye University Istanbul Turkey. Centre for Materials Interfaces Istituto Italiano Di Tecnologia 56025 Pisa Italy. Sabanci University Orta Mahalle Üniversite Caddesi No. 27 Orhanlı Tuzla 34956 Istanbul Turkey. Department of Polymer Technology Gdańsk University of Technology G. Narutowicza 11/12 80‑233 Gdańsk Poland. Institute of Chemistry Federal University of Rio Grande Do Sul (UFRGS) Av. Bento Goncalves 9500 Postal Box 15003 Porto Alegre ZIP 91501‑970 Brazil. profederlima@***. Biomaterials Group Department of Biomedical Engineering Amirkabir University of Technology Tehran Iran. School of Engineering Macquarie University New South Wales Sydney 2109 Australia. School of Health Sciences and Biomedical Engineering Hebei University of Technology Tijian 300130 China. School of Engineering Saveetha University Chennai 602105 India. Interdisciplinary Laboratory for Advanced Materials (LIMAV) Materials Science and Engineering Graduate Program Federal University of Piaui Teresina 64049‑550 Brazil. Centre for Molecular Medicine and Innovative Therapeutics Murdoch University Perth 6150 Australia.

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The complete mitochondrial genome of a Pabdah catfish,Ompok pabda(Hamilton, 1822)

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Mitochondrial DNA Part B 2019年第1期4卷 507-508页

作者： Jobaidul Alam Sapto Andriyono Arif Hossain A. T. M. Eunus Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Fisheries Ministry of Fisheries and Livestock DhakaBangladesh Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaFisheries and Marine Faculty C Campus Jl. Mulyorejo Surabaya Universitas Airlangga Surabaya East Java Indonesia Department of Fisheries Ministry of Fisheries and Livestock DhakaBangladesh WorldFish Bangladesh and South Asia Office Dhaka Bangladesh Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The complete mitochondrial genome of Pabdah catfish,Ompok pabda(Hamilton, 1822) was determined by MiSeq platform. The genome was 16,512 bp in length, in which canonical 13 protein-coding genes, 22 tRNAs, 2 rRNAs, and a control region (D-Loop) were encoded. The overall A + T (55.10%) content was higher than G + C (44.90%). Total nine genes were located at the L strand, and remaining 28 genes were at the H strand. The start codon of 12 protein-coding genes was ATG, except for COX1 (GTG). Incomplete stop codon (TA−/T–) was identified in six genes including COXII, COXIII, ND2, ND3, ND4, and Cytb. The mitogenome ofO. pabdashowed highest sequence identity withO. bimaculatus(86%).

关键词： Next-generation sequencing Ompok pabda mitochondrial genome phylogeny

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Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis

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Scientific Reports 2025年第1期15卷 1-12页

作者： Wassamon Moyadee Jatuporn Rattanasrisomporn Sittiruk Roytrakul Janthima Jaresitthikunchai Narumon Phaonakrop Kiattawee Choowongkomon Sekkarin Ploypetch Natthasit Tansakul Amonpun Rattanasrisomporn Graduate Program in Animal Health and Biomedical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand Department of Companion Animal Clinical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency Pathum Thani Thailand Department of Biochemistry Faculty of Science Kasetsart University Bangkok Thailand Department of Clinical Sciences and Public Health Faculty of Veterinary Science Mahidol University Nakhon Pathom Thailand Department of Pharmacology Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand Interdisciplinary of Genetic Engineering and Bioinformatics Graduate School Kasetsart University Bangkok Thailand

Feline infectious peritonitis (FIP) is a lethal, viral-induced immune-mediated disease that remains a challenge for diagnosis and treatment in cats. Proteomic profiling, which analyzes the protein content of biological samples, offers the potential to identify novel biomarkers that could improve the diagnosis and management of FIP. This study aims to assess the serum proteome and identify proteins that differentiate healthy cats from cats diagnosed with effusive FIP using liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS). A total of 30 cats diagnosed with effusive FIP and 27 clinically normal cats were enrolled. Twenty-three proteins were significantly (p< 0.01, ≥ fivefold change in abundance) differentially expressed between cats with effusive FIP and controls. Among these, the P2X purinoceptor, DNA topoisomerase, Notch receptor 2, and cadherin-17 were identified as key proteins of interest in cats with effusive FIP. Our findings suggest that these differentially expressed proteins could serve as potential diagnostic biomarkers and therapeutic targets for FIP. However, further studies are needed to validate these findings and explore their potential applications.

关键词： Biomarkers Cats Coronavirus Feline infectious peritonitis Proteomics Serum

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Analysis on output polarization characteristics of fiber comb filters based on polarization-diversity loop structure

Analysis on output polarization characteristics of fiber com...

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International Conference on Photonics, Optics and Laser Technology (PHOTOPTICS)

作者： Songhyun Jo Kyoungsoo Park Sung Wook Choi Seul Lee Lee Jun Hyeog Jeong Jihoon Kim Yong Wook Lee School of Interdisciplinary Program of Biomedical Mechanical & Electrical Engineering Pukyong National University Busan Republic of Korea School of Electrical Engineering Pukyong National University Busan Korea Republic of

ISBN: (纸本)9781509058860

The output states of polarization (SOP's) were investigated within the bandwidth of a filter channel (0.8 nm) for a variety of optical fiber comb filters based on polarization-diversity loop structure including a zeroth-order comb filter, first-order Lyot-type and Solc-type comb filters, and a second-order Solc-type comb filter. The output SOP's (SOP out 's) of the filters were calculated at a flat-top band operation mode of each filter for four different input SOP's (SOP in 's) except for the zeroth-order filter. It was found that the SOP out of each filter had unique dependence on wavelength. Specifically, the SOP out 's of first-order and second-order comb filters vary periodically with spectral periods of a channel bandwidth (0.8 nm) and its half (0.4 nm), respectively. If an output linear polarizer is located at the output port of each filter, the specific portion of transmission spectra can be passed or rejected, and the rejected band can be continuously tuned in a limited wavelength range by controlling the SOP in . Moreover, the SOP in can be figured out by analyzing the location of the spectral dip at the output transmission spectra obtained above by using the output polarizer.

关键词： Optical fiber filters Optical fiber polarization Bandwidth Maximum likelihood detection Nonlinear filters Optical fiber couplers

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