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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Jong Min Choi Myung-Whun Sung Kwang Suk Park Medical and Biological Engineering Major Interdisciplinary Program Department of Otorhinolaryngology Head and Neck Surgery College of Medicine Department of Biomedical Engineering College of Medicine Seoul National University Seoul South Korea

Speech has been widely used for the diagnosis of the laryngeal function, and many methods have been developed in voice analysis. But, some methods cannot be applied in clinical cases. So, we present a scheme for the diagnosis of the voice using some parametric methods. We expect this scheme to be useful for the diagnosis of patients' voices.

关键词： Frequency Speech analysis Jitter Medical diagnostic imaging Pathology biomedical engineering Educational institutions Sampling methods Databases biomedical acoustics

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Characterization of the complete mitochondrial genome of Mauritian sardinella, Sardinella jussieu (Lacepède, 1803), collected in the Banten Bay, Indonesia

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Fisheries and Aquatic Sciences 2017年第1期20卷 26.1-26.9页

作者： Sektiana, Sinar Pagi Andriyono, Sapto Kim, Hyun-Woo Pukyong National University Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Busan 48513 South Korea Pukyong National University Department of Marine Biology Busan 48513 South Korea Jakarta Fisheries University Aquaculture Technology Study Program Jl. AUP Pasar Minggu Jakarta Selatan Jakarta 12520 Indonesia Fisheries and Marine Faculty C Campus Jl. Mulyorejo Surabaya 60115 Indonesia Universitas Airlangga Surabaya East Java Indonesia

Fishes in genus Sardinella are small pelagic species, which plays an important role in marine ecosystem as the first consumer. Those species are also commercially important, whose total catch reaches 278,600 tons in 2011 in Indonesia, but their identification has been difficult for their morphological similarity. In this study, we reported Sardinella jussieu for the first time in Indonesian coastal area (Banten Bay, Indonesia, 6° 0' 50.00" S-106° 10' 21.00" E). We were able to confirm the species by both its morphological characteristics including the black spot at dorsal fin origin, the dusky pigmentation at caudal fin, 31 total scute numbers, and DNA sequence identity in the GenBank database by the molecular analysis. Its total mitochondrial genome was determined by the combination of next-generation sequencing and typical PCR strategy. The total mitochondrial genome of Sardinella jussieu (16,695 bp) encoded 13 proteins, 2 ribosomal RNAs, 22 transfer RNAs, and the putative control region. All protein-coding genes started with ATG and typical stop codon and ended with TAA or TAG except for ND4 in which AGA is used. Phylogenetic analyses of both COI region and full mitochondrial genome showed that S. jussieu is most closely related to Sardinella albella and Sardinella gibbosa. © 2017 The Author(s).

关键词： Barcode Indonesia Mitochondrial genome Next-generation sequencing Sardinella

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Characterization of human primary chondrocytes of osteoarthritic cartilage at varying severity

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Chinese Medical Journal 2011年第24期000卷 4245-4253页

作者： YIN Jing YANG Zheng CAO Yong-ping GE Zi-gang Department of Biomedical Engineering College of EngineeringPeking University Beijing 100871 China Department of Orthopaedic Surgery Yong Loo Lin School ofMedicine NUS Tissue Engineering Program National Universityof Singapore 119260 Singapore Department of Orthopaedics Peking University First Hospital Beijing 100034 China Center for Biomaterials and Tissue Engineering Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China

Background There is a difficulty in evaluating the in heterogeneity among cartilage affected by osteoarthritis vivo functionality of individual chondrocytes, and there is much （OA）. In this study, in vitro cultured chondrocytes harvested from varying stages of degeneration were studied as a projective model to further understand the pathogenesis of osteoarthritis. Methods Cartilage of varying degeneration of end-stage OA was harvested, while cell yield and matrix glycosaminoglycan （GAG） content were measured. Cell morphology, proliferation, and gene expression of collagen type 1,‘11, and X, aggrecan, matrix metalloproteinase 13 （MMP-13）, and ADAMTS5 of the acquired chondrocytes were measured during subsequent in vitro culture. Results Both the number of cells and the GAG content increased with increasing severity of OA. Cell spreading area increased and gradually showed spindle-like morphology during in vitro culture. Gene expression of collagen type II, collagen type X as well as GAG decreased with severity of cartilage degeneration, while expression of collagen type I increased. Expression of MMP-13 increased with severity of cartilage degeneration, while expression of ADAMTS-5 remained stable. Expression of collagen type II, X, GAG, and MMP-13 substantially decreased with in vitro culture. Expression of collagen type I increased with in vitro cultures, while expression of ADAMTS 5 remained stable. Conclusions Expression of functional genes such as collagen type Ⅱ and GAG decreased during severe degeneration of OA cartilage and in vitro dedifferentiation. Gene expression of collagen I and MMP-13 increased with severity of cartilage degeneration.

关键词： osteoarthritis chondroeyte differentiation

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Development of videostrobokymography for the quantitative analysis of laryngeal vibratory pattern

Development of videostrobokymography for the quantitative an...

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9th World Congress on Medical Informatics, MedInfo 1998

作者： Lee, Jae Sung Kim, Eomjun Park, Kwang Suk Sung, Mi Young Sung, Myung-Whun Kim, Kwang Hyun Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Computer Science Inchon University Inchon Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University 28 Yungun-Dong Chongno-Gu Seoul 110-744 Korea Republic of Department of Otolaryngology Head and Neck Surgery Seoul National University Seoul Korea Republic of

ISBN: (纸本)9051994079

We developed a new analysis technique for the assessment of irregular vibratory movement of vocal folds. Successive frames of pre-recorded video images from videostroboscopy were transferred to computer memory and vibratory track of one selected point was described as a waveform by displaying the same lines of all frames along the vertical direction. Glottal area waveform, which was normalized with glottal length, was composed to quantitatively assess the overall vibratory pattern of vocal folds. By applying this technique, irregular vibratory patterns of multiple regions, such as asynchronized registration of glottal cycles, could be easily visualized It would be possible to monitor and analyze the pathologic changes of vocal fold movement by means of this newly developed system. © 1998 IMIA. All rights reserved.

关键词： Speech

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Effect modification by cardiovascular and metabolic disease onset on long-term PM2.5 exposure and mortality: a nationwide cohort study

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Scientific Reports 2025年第1期15卷 1-14页

作者： Hyemin Jang Jinah Park Jeongmin Moon Insung Song Ayoung Kim Cinoo Kang Jieun Oh Dohoon Kwon Ho Kim Eun Soo Lee Dongmug Kang Seoyeong Ahn Whanhee Lee Jieun Min Ejin Kim Michelle L. Bell Department of Public Health Sciences Graduate School of Public health Seoul National University Seoul South Korea Department of Occupational and Environmental Medicine Pusan National University Yangsan Hospital Yangsan South Korea Department of Preventive and Occupational & Environmental Medicine School of Medicine Pusan National University Yangsan South Korea School of Biomedical Convergence Engineering College of Information and Biomedical Engineering Pusan National University Yangsan South Korea Research and Management Center for Health Risk of Particulate Matter Seoul South Korea Department of Environmental Medicine College of Medicine Ewha Womans University Seoul South Korea Institute of Health and Environment Graduate School of Public Health Seoul National University Seoul South Korea School of the Environment Yale University New Haven CT USA Interdisciplinary Program in Precision Public Health Department of Public Health Sciences Graduate School of Korea University Seoul South Korea

Cardiovascular and metabolic diseases–specifically myocardial infarction, congestive heart failure, cerebrovascular disease, peripheral vascular disease, renal disease, and liver disease–are major public health concerns worldwide. However, studies examining how these diseases modify the relationship between long-term PM2.5exposure and mortality remain scarce. Using a Cox regression model with a population-representative cohort from South Korea, we estimated the modifying effects of six major cardiovascular and metabolic diseases on PM2.5-mortality association in two cohorts: (1) individuals without underlying diseases (NoUD) and (2) those with only hypertension and/or diabetes (HTN/DM). The interaction between PM2.5and each disease onset was used to estimate effect modification, with results presented as relative hazard ratios (RHRs) per 10 µg/m3increase in PM2.5. Among 183,834 subjects, non-accidental deaths occurred in 18.0% of the NoUD (N= 134,584) and 25.7% of the HTN/DM (N= 49,250). In the NoUD cohort, renal disease (RHR: 1.58; 95% CI: 1.27–1.97), myocardial infarction (1.41; 1.15–1.73), and liver disease (1.40; 1.25–1.57) significantly modified the effect of PM2.5on mortality. In the HTN/DM cohort, renal disease (1.74; 1.43–2.12), myocardial infarction (1.62; 1.29–2.05), and cerebrovascular disease (1.32; 1.17–1.51) showed higher RHRs. Our findings highlight the importance of consistent and preemptive care for renal disease and myocardial infarction and provide evidence for target-specific interventions to reduce the risk of PM2.5on mortality.

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Self-packaged stretchable printed circuits with ligand-bound liquid metal particles in elastomer

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Nature Communications 2025年第1期16卷 1-11页

作者： Hyeonyeob Seo Gun-Hee Lee Dong-Yeong Kim Kum Seok Nam Jiwoo Park Yeonzu Son Semin Kim Congqi Yang Seongjun Park Joonhee Won Hyunjun Kim Steve Park Jae-Young Bae Seung-Kyun Kang Jiheong Kang Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Departments of Cogno-Mechatronics Engineering Pusan National University Busan Republic of Korea Departments of Optics and Mechatronics Engineering Pusan National University Busan Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Program of Brain and Cognitive Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon South Korea Graduate School of Semiconductor Technology Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Medical Research Center Seoul National University Seoul Republic of Korea Department of Biomedical Sciences College of Medicine Seoul National University Seoul Republic of Korea School of Transdisciplinary Innovations Seoul National University Seoul Republic of Korea Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul Republic of Korea Department of Transdisciplinary Medicine Seoul National University Hospital Seoul South Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea KAIST Institute for NanoCentury Daejeon Republic of Korea Department of Materials Science and Engineering Seoul National University Seoul Republic of Korea Department of Chemistry Seoul National University Seoul Republic of Korea

Packaging in stretchable electronics is crucial to protect components from environmental damage while preserving mechanical flexibility and providing electrical insulation. The conventional packaging process involves multiple steps that increase in complexity as the number of circuit layers multiply. In this study, we introduce a self-packaged stretchable printed circuit board enabled by the in situ phase separation of liquid metal particles (LMPs) within various polymer matrices during solution-based printing processes. The ligand-bound LMPs (LB-LMPs), engineered to inhibit oxide growth, undergo in situ sintering, prompting vertical phase separation. This synthesis strategy not only achieves high initial conductivity of the LMPs but also encapsulates them within the polymer matrix, preventing leakage and providing electrical insulation. Our method enables multi-layer circuit printing, eliminating the need for additional activation and packaging processes. Furthermore, by integrating conductive materials into packaging layers for selective electrical conductivity, vertical interconnect accesses and conductive pads can be formed, enabling large-scale, stretchable, and leakage-free multi-layer electrical circuits and bio-interfaces.

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Correction: Recent progress in DNA data storage based on high-throughput DNA synthesis

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biomedical engineering letters 2024年第5期14卷 1147-1152页

作者： Seokwoo Jo Haewon Shin Sung-Yune Joe David Baek Chaewon Park Honggu Chun Department of Biomedical Engineering Korea University 466 Hana Science Hall Seoul 02841 Korea. Interdisciplinary Program in Precision Public Health Korea University 466 Hana Science Hall Seoul 02841 Korea.

[This corrects the article DOI: 10.1007/s13534-024-00386-z.].

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Validation of heart rate extraction using video imaging on a built-in camera system of a smartphone

Validation of heart rate extraction using video imaging on a...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Sungjun Kwon Hyunseok Kim Kwang Suk Park Interdisciplinary Program of Bioengineering Seoul National University Seoul 110 799 Korea Department of Biomedical Engineering College of Medicine Seoul National University Seoul 110 799 Korea

ISBN: (纸本)9781424441198

As a smartphone is becoming very popular and its performance is being improved fast, a smartphone shows its potential as a low-cost physiological measurement solution which is accurate and can be used beyond the clinical environment. Because cardiac pulse leads the subtle color change of a skin, a pulsatile signal which can be described as photoplethysmographic (PPG) signal can be measured through recording facial video using a digital camera. In this paper, we explore the potential that the reliable heart rate can be measured remotely by the facial video recorded using smartphone camera. First, using the front facing-camera of a smartphone, facial video was recorded. We detected facial region on the image of each frame using face detection, and yielded the raw trace signal from the green channel of the image. To extract more accurate cardiac pulse signal, we applied independent component analysis (ICA) to the raw trace signal. The heart rate was extracted using frequency analysis of the raw trace signal and the analyzed signal from ICA. The accuracy of the estimated heart rate was evaluated by comparing with the heart rate from reference electrocardiogram (ECG) signal. Finally, we developed FaceBEAT, an iPhone application for remote heart rate measurement, based on this study.

关键词： smartphone becoming measurement

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Leveraging wikipedia and context features for clinical event extraction from mixed-language discharge summary

Lecture Notes in Computer Science (including subseries Lectu...

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Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2014年 8870卷 302-313页

作者： Jeong, Kwang-Yong Yi, Wangjin Seol, Jae-Wook Choi, Jinwook Lee, Kyung-Soon Dept. of Computer Science & Engineering CAIIT Chonbuk National University Korea Republic of Interdisciplinary Program of Bioengineering Seoul National University Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

Unstructured clinical texts contain patients’ disease related narratives, but it is required elaborate work to mine the kind of information. Especially for the classification of semantic types of a clinical term, implementations of domain knowledge from resources such as the Unified Medical Language System (UMLS) are essential. The UMLS has a limitation in dealing with other languages. In this paper, we leverage Wikipedia as well as UMLS for clinical event extraction, especially from clinical narratives written in mixed-language. Semantic features for clinical terms are extracted based on semantic networks of hierarchical categories in Wikipedia. Semantic types for Korean clinical terms are detected by using translation links and semantic networks in Wikipedia. An additional remarkable feature is a controlled vocabulary of clue words which can be contextual evidence to determine clinical semantic types of a word. The experimental result on 150 discharge summaries written in English and Korean showed 75.9% in F1-measure. This result shows that the proposed features are effective for clinical event extraction. © Springer International Publishing Switzerland 2014.

关键词： Domain Knowledge

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Reduction of Reflected Light on Fluorescence Emission for Indocyanine Green

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Journal of engineering and Science in Medical Diagnostics and Therapy 2022年第1期5卷 011004页

作者： Kwon, So Yoon Yoon, Ki-Cheol Kim, Kwang Gi Interdisciplinary Program in Bioengineering Seoul National University Seoul08826 Korea Republic of Medical Devices R&D Center Gachon University Gil Medical Center 774 beon-gil Namdong-daero Namdong-gu Incheon21565 Korea Republic of Department of Biomedical Engineering College of Medicine Gachon University 38-13 Dokjom-ro 3 Namdong-gu Incheon21565 Korea Republic of Department of Biomedical Engineering College of Health Science Gachon University 191 Hambakmoero Yeonsu-gu Incheon21936 Korea Republic of Gachon University 38-13 3 Dokjom-ro Namdong-gu Incheon21565 Korea Republic of

Inside the brain tumor, the blood vessels are intricately composed, and the tumors and blood vessels are similar in color. Therefore, when observing tumors and blood vessels with the naked eye or a surgical microscope, it is difficult to distinguish between tumors and blood vessels. Fluorescence staining with indocyanine green (ICG) is performed to distinguish between brain tumors and blood vessels using a surgical microscope. However, when observing the blood circulation state of a tumor or blood vessel through a surgical microscope, light reflection occurs from the camera. In the process of observing the state of the blood vessel, due to the occurrence of light reflection, an obstruction phenomenon in which the observation field is blocked by the blood vessel of the object to be observed occurs. Therefore, it is difficult to diagnose the vascular condition. In this experiment, the 780 nm light-emitting diode (LED) was irradiated to the ICG phantom, and then, when the fluorescence expression image was observed, the polarizing filter such as circular polarized light (CPL) filter and linear polarized light (LPL) filter was inserted into the camera, and the reflected light was reduced. Therefore, it is possible to reduce the reflected light from the fluorescence expression image by using a polarizing filter, and it is expected to be applicable to surgery and diagnostic fields of cancer such as surgery. Copyright © 2022 by ASME.

关键词： Microscopes

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