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Characterization of human primary chondrocytes of osteoarthritic cartilage at varying severity

Chinese Medical Journal 2011年第24期000卷 4245-4253页

作者： YIN Jing YANG Zheng CAO Yong-ping GE Zi-gang Department of Biomedical Engineering College of EngineeringPeking University Beijing 100871 China Department of Orthopaedic Surgery Yong Loo Lin School ofMedicine NUS Tissue Engineering Program National Universityof Singapore 119260 Singapore Department of Orthopaedics Peking University First Hospital Beijing 100034 China Center for Biomaterials and Tissue Engineering Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China

Background There is a difficulty in evaluating the in heterogeneity among cartilage affected by osteoarthritis vivo functionality of individual chondrocytes, and there is much （OA）. In this study, in vitro cultured chondrocytes harvested from varying stages of degeneration were studied as a projective model to further understand the pathogenesis of osteoarthritis. Methods Cartilage of varying degeneration of end-stage OA was harvested, while cell yield and matrix glycosaminoglycan （GAG） content were measured. Cell morphology, proliferation, and gene expression of collagen type 1,‘11, and X, aggrecan, matrix metalloproteinase 13 （MMP-13）, and ADAMTS5 of the acquired chondrocytes were measured during subsequent in vitro culture. Results Both the number of cells and the GAG content increased with increasing severity of OA. Cell spreading area increased and gradually showed spindle-like morphology during in vitro culture. Gene expression of collagen type II, collagen type X as well as GAG decreased with severity of cartilage degeneration, while expression of collagen type I increased. Expression of MMP-13 increased with severity of cartilage degeneration, while expression of ADAMTS-5 remained stable. Expression of collagen type II, X, GAG, and MMP-13 substantially decreased with in vitro culture. Expression of collagen type I increased with in vitro cultures, while expression of ADAMTS 5 remained stable. Conclusions Expression of functional genes such as collagen type Ⅱ and GAG decreased during severe degeneration of OA cartilage and in vitro dedifferentiation. Gene expression of collagen I and MMP-13 increased with severity of cartilage degeneration.

关键词： osteoarthritis chondroeyte differentiation

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Development of videostrobokymography for the quantitative analysis of laryngeal vibratory pattern

Development of videostrobokymography for the quantitative an...

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9th World Congress on Medical Informatics, MedInfo 1998

作者： Lee, Jae Sung Kim, Eomjun Park, Kwang Suk Sung, Mi Young Sung, Myung-Whun Kim, Kwang Hyun Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Computer Science Inchon University Inchon Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University 28 Yungun-Dong Chongno-Gu Seoul 110-744 Korea Republic of Department of Otolaryngology Head and Neck Surgery Seoul National University Seoul Korea Republic of

ISBN: (纸本)9051994079

We developed a new analysis technique for the assessment of irregular vibratory movement of vocal folds. Successive frames of pre-recorded video images from videostroboscopy were transferred to computer memory and vibratory track of one selected point was described as a waveform by displaying the same lines of all frames along the vertical direction. Glottal area waveform, which was normalized with glottal length, was composed to quantitatively assess the overall vibratory pattern of vocal folds. By applying this technique, irregular vibratory patterns of multiple regions, such as asynchronized registration of glottal cycles, could be easily visualized It would be possible to monitor and analyze the pathologic changes of vocal fold movement by means of this newly developed system. © 1998 IMIA. All rights reserved.

关键词： Speech

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Self-packaged stretchable printed circuits with ligand-bound liquid metal particles in elastomer

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Nature Communications 2025年第1期16卷 1-11页

作者： Hyeonyeob Seo Gun-Hee Lee Dong-Yeong Kim Kum Seok Nam Jiwoo Park Yeonzu Son Semin Kim Congqi Yang Seongjun Park Joonhee Won Hyunjun Kim Steve Park Jae-Young Bae Seung-Kyun Kang Jiheong Kang Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Departments of Cogno-Mechatronics Engineering Pusan National University Busan Republic of Korea Departments of Optics and Mechatronics Engineering Pusan National University Busan Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Program of Brain and Cognitive Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon South Korea Graduate School of Semiconductor Technology Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Medical Research Center Seoul National University Seoul Republic of Korea Department of Biomedical Sciences College of Medicine Seoul National University Seoul Republic of Korea School of Transdisciplinary Innovations Seoul National University Seoul Republic of Korea Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul Republic of Korea Department of Transdisciplinary Medicine Seoul National University Hospital Seoul South Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea KAIST Institute for NanoCentury Daejeon Republic of Korea Department of Materials Science and Engineering Seoul National University Seoul Republic of Korea Department of Chemistry Seoul National University Seoul Republic of Korea

Packaging in stretchable electronics is crucial to protect components from environmental damage while preserving mechanical flexibility and providing electrical insulation. The conventional packaging process involves multiple steps that increase in complexity as the number of circuit layers multiply. In this study, we introduce a self-packaged stretchable printed circuit board enabled by the in situ phase separation of liquid metal particles (LMPs) within various polymer matrices during solution-based printing processes. The ligand-bound LMPs (LB-LMPs), engineered to inhibit oxide growth, undergo in situ sintering, prompting vertical phase separation. This synthesis strategy not only achieves high initial conductivity of the LMPs but also encapsulates them within the polymer matrix, preventing leakage and providing electrical insulation. Our method enables multi-layer circuit printing, eliminating the need for additional activation and packaging processes. Furthermore, by integrating conductive materials into packaging layers for selective electrical conductivity, vertical interconnect accesses and conductive pads can be formed, enabling large-scale, stretchable, and leakage-free multi-layer electrical circuits and bio-interfaces.

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Correction: Recent progress in DNA data storage based on high-throughput DNA synthesis

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biomedical engineering letters 2024年第5期14卷 1147-1152页

作者： Seokwoo Jo Haewon Shin Sung-Yune Joe David Baek Chaewon Park Honggu Chun Department of Biomedical Engineering Korea University 466 Hana Science Hall Seoul 02841 Korea. Interdisciplinary Program in Precision Public Health Korea University 466 Hana Science Hall Seoul 02841 Korea.

[This corrects the article DOI: 10.1007/s13534-024-00386-z.].

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Validation of heart rate extraction using video imaging on a built-in camera system of a smartphone

Validation of heart rate extraction using video imaging on a...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Sungjun Kwon Hyunseok Kim Kwang Suk Park Interdisciplinary Program of Bioengineering Seoul National University Seoul 110 799 Korea Department of Biomedical Engineering College of Medicine Seoul National University Seoul 110 799 Korea

ISBN: (纸本)9781424441198

As a smartphone is becoming very popular and its performance is being improved fast, a smartphone shows its potential as a low-cost physiological measurement solution which is accurate and can be used beyond the clinical environment. Because cardiac pulse leads the subtle color change of a skin, a pulsatile signal which can be described as photoplethysmographic (PPG) signal can be measured through recording facial video using a digital camera. In this paper, we explore the potential that the reliable heart rate can be measured remotely by the facial video recorded using smartphone camera. First, using the front facing-camera of a smartphone, facial video was recorded. We detected facial region on the image of each frame using face detection, and yielded the raw trace signal from the green channel of the image. To extract more accurate cardiac pulse signal, we applied independent component analysis (ICA) to the raw trace signal. The heart rate was extracted using frequency analysis of the raw trace signal and the analyzed signal from ICA. The accuracy of the estimated heart rate was evaluated by comparing with the heart rate from reference electrocardiogram (ECG) signal. Finally, we developed FaceBEAT, an iPhone application for remote heart rate measurement, based on this study.

关键词： smartphone becoming measurement

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Leveraging wikipedia and context features for clinical event extraction from mixed-language discharge summary

Lecture Notes in Computer Science (including subseries Lectu...

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Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2014年 8870卷 302-313页

作者： Jeong, Kwang-Yong Yi, Wangjin Seol, Jae-Wook Choi, Jinwook Lee, Kyung-Soon Dept. of Computer Science & Engineering CAIIT Chonbuk National University Korea Republic of Interdisciplinary Program of Bioengineering Seoul National University Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

Unstructured clinical texts contain patients’ disease related narratives, but it is required elaborate work to mine the kind of information. Especially for the classification of semantic types of a clinical term, implementations of domain knowledge from resources such as the Unified Medical Language System (UMLS) are essential. The UMLS has a limitation in dealing with other languages. In this paper, we leverage Wikipedia as well as UMLS for clinical event extraction, especially from clinical narratives written in mixed-language. Semantic features for clinical terms are extracted based on semantic networks of hierarchical categories in Wikipedia. Semantic types for Korean clinical terms are detected by using translation links and semantic networks in Wikipedia. An additional remarkable feature is a controlled vocabulary of clue words which can be contextual evidence to determine clinical semantic types of a word. The experimental result on 150 discharge summaries written in English and Korean showed 75.9% in F1-measure. This result shows that the proposed features are effective for clinical event extraction. © Springer International Publishing Switzerland 2014.

关键词： Domain Knowledge

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Reduction of Reflected Light on Fluorescence Emission for Indocyanine Green

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Journal of engineering and Science in Medical Diagnostics and Therapy 2022年第1期5卷 011004页

作者： Kwon, So Yoon Yoon, Ki-Cheol Kim, Kwang Gi Interdisciplinary Program in Bioengineering Seoul National University Seoul08826 Korea Republic of Medical Devices R&D Center Gachon University Gil Medical Center 774 beon-gil Namdong-daero Namdong-gu Incheon21565 Korea Republic of Department of Biomedical Engineering College of Medicine Gachon University 38-13 Dokjom-ro 3 Namdong-gu Incheon21565 Korea Republic of Department of Biomedical Engineering College of Health Science Gachon University 191 Hambakmoero Yeonsu-gu Incheon21936 Korea Republic of Gachon University 38-13 3 Dokjom-ro Namdong-gu Incheon21565 Korea Republic of

Inside the brain tumor, the blood vessels are intricately composed, and the tumors and blood vessels are similar in color. Therefore, when observing tumors and blood vessels with the naked eye or a surgical microscope, it is difficult to distinguish between tumors and blood vessels. Fluorescence staining with indocyanine green (ICG) is performed to distinguish between brain tumors and blood vessels using a surgical microscope. However, when observing the blood circulation state of a tumor or blood vessel through a surgical microscope, light reflection occurs from the camera. In the process of observing the state of the blood vessel, due to the occurrence of light reflection, an obstruction phenomenon in which the observation field is blocked by the blood vessel of the object to be observed occurs. Therefore, it is difficult to diagnose the vascular condition. In this experiment, the 780 nm light-emitting diode (LED) was irradiated to the ICG phantom, and then, when the fluorescence expression image was observed, the polarizing filter such as circular polarized light (CPL) filter and linear polarized light (LPL) filter was inserted into the camera, and the reflected light was reduced. Therefore, it is possible to reduce the reflected light from the fluorescence expression image by using a polarizing filter, and it is expected to be applicable to surgery and diagnostic fields of cancer such as surgery. Copyright © 2022 by ASME.

关键词： Microscopes

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Comparable parameter related to arterial stiffness in blood pressure estimation method

Comparable parameter related to arterial stiffness in blood ...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Jung Soo Kim Ko Keun Kim Hyun Jae Baek Kwang Suk Park Medical Research Center Seoul National University South Korea Interdisciplinary Program in Biomedical Engineering Seoul National University South Korea Bio-engineering Department Seoul National University South Korea Department of Biomedical Engineering College of Medicine Seoul National University South Korea

Diastolic blood pressure estimation using only pulse arrival time was not sufficient. To overcome it, arterial stiffness was considered. Several parameters related to information, time, slop information in photoplethysmography signal were chosen and investigated. Five subjects executed Valsalva Maneuver which caused the blood pressure variation. Time from maximum point of first derivative wave to dicrotic notch point in photoplethysmography signal (TDB) was selected as the robust and correlated parameter with blood pressure. Especially, the parameter had correlated with diastolic blood pressure more than systolic blood pressure (R= -0.666 for SBP, R= -0.712 for DBP). It could be useful for blood pressure estimation method which was valid for only systolic blood pressure.

关键词： Blood pressure biomedical monitoring biomedical engineering Robustness Arteries Information technology Amplitude estimation Delay effects Electrocardiography Timing

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SU-E-T-717: Surface Coating for Prevention of Metallic Seed Migration in Tissues

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Medical Physics 2015年第6PART23期42卷 3501-3502页

作者： H Lee W Lee J Park Y Choy S Ye Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Interdisciplinary Program in Bioengineering Seoul National University College of Engineering Seoul Korea Department of Biomedical Engineering Seoul National University College of Medicine Seoul Korea Department of Radiation Oncology Seoul National University Hospital Seoul Korea

Purpose: In radiotherapy, metallic implants often detach from their deposited sites and migrate to other locations. This undesirable migration could cause inadequate dose coverage for permanent brachytherapy and difficulties in image-guided radiation delivery for patients. To prevent migration of implanted seeds, we propose a potential strategy to use of a biocompatible and tissue-adhesive material called polydopamine. Methods: In this study, non-radioactive dummy seeds that have the same geometry and composition as commercial I-125 seeds were coated in polydopamine. Using scanning electron microscopy and X-ray photoelectron spectroscopy, the surface of the polydopamine-coated and non-coated seeds was characterized. The detachment stress between the two types of seeds and the tissue was measured. The efficacy of polydopamine-coated seed was investigated through in-vitro migration tests by tracing the seed location after tissue implantation and shaking for given times. The cytotoxicity of the polydopamine coating was also evaluated. Results: The results of the coating characterization have shown that polydopamine was successfully coated on the surface of the seeds. In the adhesion test, the polydopamine-coated seeds had 2.1-fold greater detachment stress than non-coated seeds. From the in-vitro test, it was determined that the polydopamine-coated seed migrated shorter distances than the non-coated seed. This difference was increased with a greater length of time after implantation. Conclusion: We suggest that polydopamine coating is an effective technique to prevent migration of implanted seeds, especially for permanent prostate brachytherapy.

关键词： Tissues Brachytherapy Dosimetry Metallic coatings Scanning electron microscopy Biocompatibility Image guided radiation therapy Medical imaging X-ray photoelectron spectroscopy

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Cardiac Fibroblast-Mediated ECM Remodeling Regulates Maturation in an in vitro Cardiac Bundle Developmental Model

SSRN

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SSRN 2024年

作者： Jang, Yongjun Kang, Myeongjin Kang, Yong Guk Lee, Dongtak Jung, Hyo Gi Yoon, Dae Sung Kim, Jongseong Park, Yongdoo Department of Biomedical Sciences College of Medicine Korea University Seoul Korea Republic of School of Biomedical Engineering Korea University Seoul Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul Korea Republic of

Cardiac fibroblasts play an important role in heart homeostasis, regeneration, and disease by producing extracellular matrix (ECM) proteins and remodeling enzymes. Under normal conditions, fibroblasts exist in a quiescent state and maintain homeostasis, such as tissue structure and ECM turnover. However, if they become activated upon stimuli, such as injury, aging, or mechanical stress, which can lead to disease through excessive cell proliferation and ECM production. In addition to studying fibroblasts in disease progression, their role in cardiac maturation during development and whether the mechanism of cytokine and ECM production is similar to that observed during disease progression is unclear. In this study, we examined the functional and structural maturation of cardiac tissue by modulating fibroblast activity using an in vitro model of cardiac bundle formation. In this model, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and human cardiac fibroblasts (CFBs) were co-cultured in a fibrin gel and their morphology, beating characteristics, beating force, and mRNA expression profiles were analyzed. The results indicated that the cardiac bundle model matured structurally and functionally through tissue contraction and collagen deposition by fibroblasts, whereas inhibition of these ECM remodeling reduced maturation. In particular, the expression of second harmonic generation (SHG) and COL1A revealed that while activated fibroblasts induce structural maturation through sustained collagen deposition, excessive collagen accumulation can reduce functional maturation. Our data suggest that collagen type I expression by cardiac fibroblasts is essential for myocardial tissue maintenance and development through ECM remodeling. Furthermore, the regulation of collagen deposition by fibroblast activity is a crucial factor that influences cardiac development and disease progression. © 2024, The Authors. All rights reserved.

关键词： Stem cells

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