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作者： Sung Lee, Jae Chee, Youngjoon Kim, Boyeon Lee, Jong Min Park, Kwang Suk Kwark, Cheoleun Lee, Myung Chul Interdisciplinary Program in Medical and Biological Engineering Major Department of Biomedical Engineering Seoul National University Korea Republic of

Cross-modality coregistration of functional and anatomical images has rapidly grown as the aid for the interpretation of functional images. Various methods have been previously investigated so that the coregistered images can be easily interpreted and realistically visualized. We used the time/intensityweighted alternation method to display the coregistered images simultaneously. Stereotactic registration was done with two methods. We realized the automated method of alignment using the boundary of head scalp extracted from the sinogram of a PET emission scan and surface-matching algorithm in brain, and the semi-automated method using a paired point-matching algorithm in the chest and abdomen. For the simultaneous display of the stereotactically registered images, rapid switching of the screens were applied on which both images were written with independent color scales. Rapid alternate display of two images, that is synchronized using the monitor scanning process, could induce the fusion of images in the human visual perception system. Also, intensification of an interesting image is possible by weighting the displaying time or global intensities of images with the degree of interest. These techniques could be useful for the interpretation and visualization of the coregistered images. © 1997 The authors.

关键词： Display devices

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Bioimplant-on-a-Chip for Facile Investigation of Periodontal Ligament Formation on Biogenic Hydroxyapatite/Ti6Al4 V Implants

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ACS applied materials & interfaces 2025年第21期17卷 2025 May 13页

作者： Sangbae Park Jae Eun Kim Juo Lee Woochan Kim Woobin Choi Myung Chul Lee Jae Woon Lim Kyoung-Je Jang Hoon Seonwoo Jangho Kim Jong Hoon Chung Department of Biosystems Engineering Seoul National University Seoul 08826 Korea. Research Institute of Agriculture and Life Sciences Seoul National University Seoul 08826 Republic of Korea. Integrated Major in Global Smart Farm College of Agriculture and Life Sciences Seoul National University Seoul 08826 Republic of Korea. Department of Convergent Biosystems Engineering College of Life Science and Natural Resources Sunchon National University Suncheon 57922 Republic of Korea. Department of Convergence Biosystems Engineering Chonnam National University Gwangju 61186 Republic of Korea. Department of Rural and Biosystems Engineering Chonnam National University Gwangju 61186 Republic of Korea. Interdisciplinary Program in IT-Bio Convergence System Chonnam National University Gwangju 61186 Republic of Korea. Medicinal Materials Research Center Biomedical Research Division Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of Korea. Department of Bio-Systems Engineering Institute of Smart Farm Gyeongsang National University Jinju 52828 Republic of Korea. Institute of Agriculture & Life Science Gyeongsang National University Jinju 52828 Republic of Korea. Interdisciplinary Program in IT-Bio Convergence System Sunchon National University Suncheon 57922 Republic of Korea. Institute of Nano-Stem Cells Therapeutics NANOBIOSYSTEM Co. Ltd Gwangju 61008 Republic of Korea. ELBIO Inc Seoul 08812 Republic of Korea.

Highly osseointegrative dental implants surrounded by reconstructed periodontal tissues represent a promising strategy for functional tooth replacement, as they mimic the structural and physiological characteristics of natural teeth. However, there is currently a lack of in vitro platforms that can effectively evaluate the integration of engineered periodontal ligament (PDL) tissues with bioimplants. In this study, we developed a bioimplant-on-a-chip (BoC) platform designed to recapitulate the native PDL-cementum interface and assess the early stage biological performance of bioimplants in vitro. The BoC consists of a dental implant, a calcium phosphate cement (CPC) insert, a nanopatterned polydimethylsiloxane (PDMS) substrate, and PDL-like tissue derived from human dental pulp stem cells (DPSCs). To establish viable culture conditions within the platform, surface coatings and cell seeding densities were optimized to support the formation of PDL-like tissue. Nanogrooved substrates were incorporated to guide cellular alignment, which was assessed through orientation analysis. Collagen fiber organization and matrix deposition were further examined as indicators of ligamentous tissue maturation. Cementogenic activity was evaluated by immunofluorescent staining of cementum protein-1 (CEMP-1) in response to varying biogenic hydroxyapatite (bHA) contents in the bioimplants. The results demonstrated successful reproduction of a PDL-like tissue interface and material-dependent differences in CEMP-1 expression. This platform provides a modular and reproducible tool for the comparative evaluation of bioimplants in a physiologically relevant setting and may be useful in advancing regenerative strategies in dental implantology.

关键词： bioimplant-on-a-chip bioimplants in vitro model periodontal ligament tissue engineering

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Non-cell autonomous effect of neuronal nicotinamide phosphoribosyl transferase on the function of neuromuscular junctions

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Neural Regeneration Research 2021年第2期16卷 302-303页

作者： Samuel Lundt Shinghua Ding Dalton Cardiovascular Research Center Interdisciplinary Neuroscience ProgramUniversity of MissouriColumbiaMOUSA Department of Biomedical Biological and Chemical EngineeringUniversity of MissouriColumbiaMOUSA

Nicotinamide adenine dinucleotide(NAD)is one of the most important metabolites in mammalian cells(Figure 1 A).Its oxidized form(NAD+)and reduced form(NADH)play a role in many reactions within cells,most prominently in... 详细信息

关键词： Figure autonomous oxidized

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Development of HIHM (home integrated health monitor) for ubiquitous home healthcare

Development of HIHM (home integrated health monitor) for ubi...

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29th Annual International Conference of IEEE-EMBS, engineering in Medicine and Biology Society, EMBC'07

作者： Kim, Jung Soo Kim, Beom Oh Park, Kwang Suk Interdisciplinary Program in Biomedical Engineering Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)1424407885

Home Integrated Health Monitor (HIHM) was developed for ubiquitous home healthcare. From quantitative analysis, we have elicited modal of chair. The HIHM could detect Electrocardiogram (ECG) and Photoplethysmography (PPG) non-intrusively. Also, it could estimate blood pressure (BP) non-intrusively, measure blood glucose and ear temperature. Detected signals and information were transmitted to home gateway and home server through Zigbee communication technology. Home server carried them to Healthcare Center, and specialists such as medical doctors could monitor by Internet. There was also feedback system. This device has a potential to study about ubiquitous home healthcare. © 2007 IEEE.

关键词： Health care

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Numerical Visualization of Air Intake Induced by Free Surface Vortex

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Journal of Thermal Science 2017年第6期26卷 540-544页

作者： Young Kyu Park Mohan Kumar Dey Yoon Hwan Choi Yeon Won Lee Research Institute of Industrial Science & Technology Pukyong National University Busan Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Korea Department of Mechanical Design Engineering Pukyong National University Busan Korea

Free surface vortex control is vital in a pump sump system because the air absorbed by free surface vortex induc- es noise, vibration, and cavitation corrosion on the pumping system. In this study, the change of free surface vor- tex and air absorption in a pump intake has been investigated by the Volume of Fraction （VOF） method with steady multiphase flow model in order to represent the behavior of the free surface vortex exactly. The homoge- neous free surface model is used to apply interactions of air and water. The results show that air intake by the free surface vortex motion can be visualized using the iso-surface of air volume fraction. The vortices make an air column from the free surface to the pump intake. Also, it was found that the flee surface vortex can be controlled by installing curtain walls.

关键词： free surface vortex numerical visualization curtain wall air intake

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Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung Min Bitna Yang You-Sun Kim Gyeong Min Park HyunAh Kim Hyojin Kim Eun-Ji Kim Yu Kyeong Hwang Eui-Cheol Shin Sungyoo Cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

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Laminar lifted methane jet flames in coflow-air diluted with helium and nitrogen 10

Laminar lifted methane jet flames in coflow-air diluted with...

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10th Asia-Pacific Conference on Combustion, ASPACC 2015

作者： Sapkal, Narayan P. Lee, Won June Park, Jeong Kwon, Oh Boong Department of Mechanical Engineering Pukyong National University Korea Republic of Interdisciplinary Program of Biomedical Engineering Pukyong National University Korea Republic of

Laminar lifted methane jet flames in co-flow air diluted with helium and nitrogen have been investigated experimentally. Such methane jet flames could be also lifted even at nozzle exit velocities much higher than the stoichiometric laminar flame speed despite the Schmidt number less than unity. The chemiluminescence intensities of OH∗ radical (good indicator of heat release rate), and the radius of curvature for triple flame were measured using an intensified charge-coupled device (ICCD) camera and digital camera at various conditions. The lifted flames were stabilized due to buoyancy-induced convection in buoyancy-dominated regime, causing an increase of reactant mass flux to edge flame and thereby increasing the reaction rate and subsequently edge flame speed. It was confirmed that increased OH∗ concentration caused an increase of edge flame speed via enhanced chemical reaction in buoyancy-dominated regime. In jet-momentum-dominated regime, an increase in radius of curvature in addition to the increased OH∗ concentration stabilizes such lifted flames. Based on the stabilization mechanism, detailed discussion on the stabilization of such lifted flame is made.

关键词： Methane

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Kinetics of Molecular Recognition Mediated Nanoparticle Self-Assembly

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Nano Research 2009年第1期2卷 78-84页

作者： Chinmay Soman Todd Giorgio Interdisciplinary Program in Materials Science Vanderbilt University201 West End AvenueNashvilleTN 37240USA Department of Biomedical Engineering Vanderbilt University201 West End AvenueNashvilleTN 37240USA

Nanoscale quantum dot-antibody conjugates have been shown to self-assemble to form micron-scale aggregates in the presence of specific proteomic *** self-assembly process exhibits sigmoidal kinetics,suggesting that nucleation limits ***-assembly kinetics in this study is characterized by flow cytometric analysis of the aggregation reaction over time.A range of physiologically relevant concentrations of the protein angiopoietin-2,a candidate cancer biomarker,are incubated with quantum dots conjugated with a polyclonal mixture of anti-angiopoietin-2 *** concentration modulates the slopes and inflection times of the sigmoidal kinetics *** understanding of self-assembly kinetics in this system may lead to improvements in sensitivity and specificity of this novel proteomic biomarker detection technique and improve the screening,diagnostics,and therapy response monitoring for cancers and other *** approach to studying the kinetics of nanoparticle self-assembly may also provide a valuable tool for understanding the fundamental characteristics of nanoscale particle aggregation.

关键词： Quantum dot self-assembly kinetics proteomics diagnostics has

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Capacitive-coupled ECG measurement and its applications for ubiquitous healthcare

Capacitive-coupled ECG measurement and its applications for ...

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2nd International Conference on Convergent Information Technology, ICCIT 07

作者： Kim, Ko Keun Lim, Yong Gyu Kim, Jung Soo Park, Kwang Suk Interdisciplinary Program in Biomedical Engineering Seoul National University Seoul Korea Republic of Department of Oriental Biomedical Engineering Sangji University Wonju Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)0769530389

Unconstrained ECG measurement is important for ubiquitous healthcare. The methods for this are being developed, and the capacitive-coupled ECG (CCECG) measurement is reported recently. In this paper, this measurement method and its applications are introduced. And the some problems and improving solution are presented. © 2007 IEEE.

关键词： Electrocardiograms

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STABLE AND SCALABLE engineering OF HUMAN PRIMARY T CELLS VIA MICROFLUIDIC CELL STRETCHING 25

STABLE AND SCALABLE ENGINEERING OF HUMAN PRIMARY T CELLS VIA...

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25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Hur, Jeongsoo Chung, Aram School of Biomedical Engineering Korea University Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Korea Republic of

ISBN: (纸本)9781733419031

A novel microfluidic approach specifically designed to engineer human primary T-lymphocytes effectively with high scalability while maintaining cell functionality is reported. The system employs a unique cell elongation-restoration phenomenon called "cell stretching," which enables highly effective intracellular delivery of external cargos into cells. Vortical recirculation flows are exerted where cells are hydrodynamically elongated and restored, resulting in effective permeabilization of the cellular membrane. Using the platform, highly efficient (>90%), low-material-cost (6 cells/min) delivery of various cargos into human primary T-cells was achieved, demonstrating the practical utility for chimeric antigen receptor (CAR) T-cell-based cancer immunotherapy. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： T-cells

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