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Cancer Informatics: Profiling Age-Related Epigenetic Markers of Stomach Adenocarcinoma in Young and Old Subjects

Cancer Informatics 2015年 14卷

作者： Byoung-Chul Kim Hyoung Oh Jeong Daeui Park Chul-Hong Kim Eun Kyeong Lee Dae Hyun Kim Eunok Im Nam Deuk Kim Sunghoon Lee Byung Pal Yu Jong Bhak Hae Young Chung Molecular Inflammation Research Center for Aging Intervention Pusan National University Busan Republic of Korea.Interdisciplinary Research Program of Bioinformatics and Longevity Science Pusan National University Busan Republic of Korea. Genomictree Inc. Yuseong-gu Daejeon Republic of Korea. Molecular Inflammation Research Center for Aging Intervention Pusan National University Busan Republic of Korea. Personal Genomics Institute Genome Research Foundation Suwon Republic of Korea.BioMedical Engineering UNIST Ulsan Republic of Korea. Department of Physiology University of Texas Health Science Center at San Antonio San Antonio TX USA.

The purpose of our study is to identify epigenetic markers that are differently expressed in the stomach adenocarcinoma (STAD) condition. Based on data from The Cancer Genome Atlas (TCGA), we were able to detect an age-related difference in methylation patterns and changes in gene and miRNA expression levels in young (n = 14) and old (n = 70) STAD subjects. Our analysis identified 323 upregulated and 653 downregulated genes in old STAD subjects. We also found 76 miRNAs with age-related expression patterns and 113 differentially methylated genes (DMGs), respectively. Our further analysis revealed that significant upregulated genes (n = 35) were assigned to the cell cycle, while the muscle system process (n = 27) and cell adhesion-related genes (n = 57) were downregulated. In addition, by comparing gene and miRNA expression with methylation change, we identified that three upregulated genes (ELF3, IL1β, and MMP13) known to be involved in inflammatory responses and cell growth were significantly hypomethylated in the promoter region. We further detected target candidates for age-related, downregulated miRNAs (hsa-mir-124-3, hsa-mir-204, and hsa-mir-125b-2) in old STAD subjects. This is the first report of the results from a study exploring age-related epigenetic biomarkers of STAD using high-throughput data and provides evidence for a complex clinicopathological condition expressed by the age-related STAD progression.

关键词： stomach adenocarcinoma age TCGA RNAseq miRNA DNA methylation

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Biomechanical and microstructural response of recurrent laryngeal nerve in pigs

Biomechanical and microstructural response of recurrent lary...

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ASME 2013 Summer Bioengineering Conference, SBC 2013

作者： Williams, Megan Barkmeier-Kraemer, Julie Utzinger, Urs Geest, Jonathan Vande Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ United States BIO5 Institute University of Arizona Tucson AZ United States Department of Biomedical Engineering University of Arizona Tucson AZ United States Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ United States Voice and Swallowing Center University of California-Davis Davis CA United States

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Changes in bilateral phase synchronization in parkinsonian tremor related to amplitude difference

Changes in bilateral phase synchronization in parkinsonian t...

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10th IASTED International Conference on biomedical engineering, BioMed 2013

作者： Kim, Sang Kyong Jeon, Hyo Seon Kim, Han Byul Kim, Ko Keun Jeon, Beom Seok Park, Kwang Suk Interdisciplinary Program for Bioengineering Seoul National University Seoul 152-742 Korea Republic of Center for Cognition and Sociality Institute for Basic Science Daejeon 305-811 Korea Republic of Department of Neurology Seoul National University Hospital Seoul 110-744 Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul 152-742 Korea Republic of

ISBN: (纸本)9780889869530

Tremor, which is a manifestation of the Parkinson's disease, is rhythmic and involuntary oscillation in the frequency range from 3 to 8 Hz. Physiological mechanisms of parkinsonian tremor have not been clearly revealed even though there have been many related studies. In this study, we attempted to analyze bilateral phase synchronization between both hands in order to interpret parkinsonian tremor dynamics which can be helpful to speculate the mechanisms of parkinsonian tremor. Eighteen subjects with Parkinson's disease participated in this study. Tremor was measured for 30 seconds by three axis accelerometer placed over the middle finger with sampling frequency of 64Hz and 12 bit A/D converter while subjects were resting on a chair and relaxing both hands on their knees. Three kinds of synchronization indexes, p, y and X, were employed to assess the synchronization strength for tremor between both hands. As a result, when bilateral difference of tremor amplitude became larger than specific value, phase synchronization strength was significantly increased. Therefore, we may suppose that the dynamics of parkinsonian tremor have two modes of the non-phase synchronization and phase synchronization between both limbs.

关键词： Synchronization

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Progressive alterations in microstructural organization and biomechanical response in the ApoE mouse model of aneurysm

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Biomatter 2013年第3期3卷 e24648页

作者： Haskett, Darren Azhar, Mohamad Utzinger, Urs Vande Geest, Jonathan P. Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States

AAA is a complex disease that leads to a localized dilation of the infrarenal aorta that develops over years. Longitudinal information in humans has been difficult to obtain for this disease, therefore mouse models have become increasingly used to study the development of AAAs. The objective of this study was to determine any changes that occur in the biomechanical response and fiber microstructure in the ApoE(-/-) AngII mouse model of aneurysm during disease progression. Adult ApoE(-/-) AngII infused mice along with wild-type controls were taken at 14 and 28 d. Aortas were excised and tested simultaneously for biaxial mechanical response and ECM organization. Data sets were fit to a Fung-type constitutive model to give peak strains and stiffness values. Images from two photon microscopy were quantified in order to assess the preferred fiber alignment and degree of fiber orientation. Biomechanical results found significant differences that were present at 14 d had returned to normal by 28 d along with significant changes in fiber orientation and dispersion indicating remodeling occurring within the aneurysmal wall. This return of some of the normal biomechanical function, in addition the continuing changes that occur in the microstructure suggest a restorative response that occurs in the ApoE(-/-) AngII infused model after the initial aneurysm formation.

关键词： AAA aneurysm AngII ApoE mechanical microstructure mouse model two-photon

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Hybrid Solar Cells: Enhanced Light Absorption of Silicon Nanotube Arrays for Organic/Inorganic Hybrid Solar Cells (Adv. Mater. 21/2014)

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Advanced Materials 2014年第21期26卷

作者： Huisu Jeong Hui Song Yusin Pak Il Keun Kwon Kyubong Jo Heon Lee Gun Young Jung School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju 500‐712 Republic of Korea Department of Maxillofacial Biomedical Engineering & Institute of Oral Biology School of Dentistry Kyung Hee University Seoul 130‐701 Republic of Korea Department of Chemistry and Interdisciplinary Program of Integrated Biotechnology Sogang University Seoul 121‐741 Republic of Korea Department of Materials Science and Engineering Korea University Seoul 136‐701 Republic of Korea

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Carbon fiber based custom orthoses for augmenting net ankle moment in gait

Carbon fiber based custom orthoses for augmenting net ankle ...

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SAMPE 2013 Conference and Exhibition: Education and Green Sky - Materials Technology for a Better World

作者： Khattra, Narinder S. Tierney, John J. Yarlagadda, Shridhar Shevchenko, Nicholas Gillespie Jr., John W. Schrank, Elisa S. Stanhope, Steven J. Center for Composite Materials University of Delaware Newark DE 19716 United States Department of Mechanical Engineering University of Delaware Newark DE 19716 United States Department of Civil and Environmental Engineering University of Delaware Newark DE 19716 United States Department of Materials Science and Engineering University of Delaware Newark DE 19716 United States Department of Kinesiology and Applied Physiology University of Delaware Newark DE 19716 United States Department of Biomedical Engineering University of Delaware Newark DE 19716 United States Biomechanics and Movement Science Interdisciplinary Program University of Delaware Newark DE 19716 United States

ISBN: (纸本)9781934551158

Passive-dynamic ankle-foot orthoses (PD-AFOs) are a common form of assistive braces prescribed to improve gait of patients having impaired ankle joint function. The PD-AFO structural bending response is used to compensate for a patient's reduced ankle moment. This work focuses on the design and analysis of a carbon fiber based composite PD-AFO that provides a thin, lighter weight alternative to the more commonly used plastic based PD-AFOs. The purpose of this study was to demonstrate feasibility of designing composite PD-AFOs having desired bending stiffness. A custom, 3D surface model of the brace is used to create the overall geometry. The composite lay-up and associated stiffness of the composite PD-AFO is determined numerically, as a function of ankle angle for the foot-flat phase of the gait cycle. It is shown that the brace can be designed to augment the lost natural ankle stiffness of a patient to match that of a healthy person. The results indicate that the geometry of a PD-AFO, composite lay-up and the material properties are key factors in achieving the desired stiffness characteristics. Copyright 2013 by Aurora Flight Sciences.

关键词： Carbon fibers

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Effective falls detection method using twotri-axial accelerometers

Effective falls detection method using twotri-axial accelero...

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2012 International Conference on Biomaterial and Bioengineering, ICBB 2012

作者： Jeon, Gye-Rok Kim, Young-Jae Jeon, Ah-Young Lee, Sang-hoon Kim, Jae-hyung Kim, Min-Seok Lee, Seong-Ho Kim, Ji-Hyun Dept. of Biomedical Engineering School of Medicine Pusan National Univ. Korea Republic of Dept. of Anesthesia and Pain Medicine Busan Paik Hospital College of Medicine Inje University Korea Republic of Dept. of Interdisciplinary Program in Biomedical Engineering Graduated School Pusan National University Korea Republic of Dept. of Computer Simulation Inje Univ. Korea Republic of Dept. of Honours Specialization in Medical Science University of Western ON Canada Dept. of Anesthesiology Samsung Changwon Hospital School of Medicine SungkyunKwan Univ Korea Republic of Dept. of Anesthesia and Pain Medicine School of Medicine Pusan Natl. Univ. Korea Republic of

ISBN: (纸本)9783037855973

Falls detection systems have been developed in recent years because falls are detrimental events that can have a devastating effect on health of the elderly population. Current fall detecting methods mainly employ accelerometer to discriminate falls from activities of daily living (ADL). However, this makes it difficult to distinguish real falls from certain fall-like activities such as jogging and jumping. In this paper, an accurate fall detection system was implemented using two tri-axial accelerometers. By attaching the accelerometers on the chest and the abdomen, our system can effectively differentiate between falls and non-fall *** Diff_Z and Sum_diff_Z parameter resulted in falls detection rate of 100%, respectively. © (2013) Trans Tech Publications, Switzerland.

关键词： Fall detection

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Abstracts from the Food Allergy and Anaphylaxis Meeting 2016 Abstracts

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CLINICAL AND TRANSLATIONAL ALLERGY 2017年第SUPPL 1期7卷 10-10页

作者： [Anonymous] Department of Pediatrics Children’s Hospital Roubaix France Division of Pulmonology and Allergology Department of Pediatrics Faculty of Medicine and Children’s Hospital Lille France Allergy Vigilance Network Vandoeuvre les Nancy France Université Lille 2 CHU Lille EA 2694 - Santé Publique: épidémiologie et qualité des soins Lille France Biostatistics Unit Maison Régionale de la Recherche Clinique CHRU Lille Lille France Department of Allergology Emile Durkheim Hospital Epinal France Centre d’Epidémiologie sur les Causes Médicales de Décès INSERM CHU de Bicêtre Le Kremlin-Bicêtre France The Allergy Vigilance Network University Hospital Nancy Nancy France Pediatric Pulmonology and Allergy Department Hôpital Jeanne de Flandre CHU Lille Lille France Charité - Universitätsmedizin Berlin Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Charité - Universitätsmedizin Berlin Berlin Germany Institute of Social Medicine Epidemiology and Health Economics Charité Universitätsmedizin Berlin Berlin Germany Department of Dermatology and Allergology Comprehensive Allergy Center Charité Charité – Universitätsmedizin Berlin Berlin Germany Department of Dermatology and Allergy Allergie-Centrum-Charité Charité-Universiätsmedizin Berlin Berlin Germany Department of Dermatology and Allergology Comprehensive Allergy Center Charité Charité Universitätsmedizin Berlin Berlin Germany University Hospital Basel Basel Switzerland Allergy Unit Department of Dermatology University Hospital Basel Switzerland Universitätsklinikum Salzburg Salzburg Austria Department of Dermatology and Allergy Centre Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark Odense University Hospital Odense Denmark Serviço de ImunoalergologiaCentro Hospitalar de São João E.P.E. Porto Portugal GRIAC Research Institute University of Groningen University Medical Center Groningen Groningen The Netherlands Serviço de Imunoalergologia Centr

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New model of subconjunctival tumor development in rabbits

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Journal of biomedical Optics 2013年第7期18卷 070501页

作者： Hwang, Sang Seok Kim, Jeong Eun Chun, Bong-Kwon Jung, Sangbong Park, Eun-Kee Lee, Hu-Jang Jung, Mannhong Lee, Sang-Joon Noh, Gwang Myung Masanganise, Rangarirai Oak, Chulho Ahn, Yeh-Chan Pukyong National University Department of Biomedical Engineering Interdisciplinary Program of Medical Biotechnology Application Engineering Busan 608-737 Korea Republic of Kosin University College of Medicine Department of Pathology Busan 602-702 Korea Republic of Kosin University College of Medicine Institute for Global Health and Environment Cooperation Busan 602-702 Korea Republic of Gimhae College Department of Clinical Laboratory Science Gimhae 621-706 Korea Republic of Kosin University College of Medicine Department of Medical Humanities and Social Medicine Busan 602-702 Korea Republic of Gyeongsang National University College of Veterinary Medicine Research Institute of Life Sciences Chinju 660-701 Korea Republic of Kosin University College of Medicine Department of Internal Medicine Busan 602-702 Korea Republic of Kosin University College of Medicine Department of Ophthalmology Busan 602-702 Korea Republic of University of Zimbabwe College of Medicine Department of Ophthalmology Harare Zimbabwe

Conjunctival squamous cell carcinoma (SCC) is an uncommon disease. However, SCC has recently become an important clinical problem due the identification of a significantly high incidence of SCC among a group of black African patients with AIDS. However, basic research concerning SCC, including both intraepithelial and invasive squamous neoplasia, is limited due to the lack of an ocular tumor animal model. Specifically, current ocular imaging and treatment modalities are insufficient for investigating currently available small animal models, because the conjunctival space is not comparable to that of humans. We describe the development of a reproducible model of subconjunctival squamous carcinoma in moderate-sized immunocompetent rabbits. Under optical coherence tomography guidance, 1 × 107 VX2 carcinoma cells are inoculated into the subconjunctival space of 3 to 4-kg New Zealand white rabbits. Malignant tumor involvement developed on the subconjunctival space after an average of 1 to 2 weeks. This subconjunctival tumor model induction method will likely facilitate a broad range of investigation of subconjunctival cancer diagnostics and therapeutics. © Society of Photo-Optical Instrumentation Engineers.

关键词： Tumors

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Alterations in finite element results given constitutive models from tubular and planar biaxial testing of the same porcine coronary arteries

Alterations in finite element results given constitutive mod...

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ASME 2012 Summer Bioengineering Conference, SBC 2012

作者： Keyes, Joseph T. Lockwood, Danielle R. Vande Geest, Jonathan P. Graduate Interdisciplinary Program in Biomedical Engineering University of Arizona Tucson AZ 85721 United States Department of Biomedical Engineering University of Arizona Tucson AZ 85721 United States Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ 85721 United States

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