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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： J. H. Jung S. H. Yoon J. H. Kim I. C. Kim A. Y. Jeon S. Y. Ye B. C. Kim B. J. Shin J. H. Ro K. G. Nam Y. J. Kim G. R. Jeon Department of Interdisciplinary program in Biomedical Engineering Pusan National University Busan Korea PhysioLab Corp. Busan Korea Department of Physics Inje University Kyungnam Korea BK21 Medical Science Education Center School of medicine Pusan National Universiry Busan Korea Department of BioSystems Engineering Pusan National University Kyungnam Korea Department of Biomedical Engineering College of Medicine Pusan National University Busan Korea Department Electronics Engineering Pusan National University Busan Korea Department of Family Medicine Pusan National University Busan Korea PhysioLab Corporation Busan South Korea

An analysis of the conventional blood pressure estimation method of the oscillometric sphygmomanometer was performed through a computer simulation using an arterial pressure-volume(APV) model. A more accurate blood pressure estimation method was proposed from the analysis. Traditionally, the maximum amplitude algorithm was applied on the oscillation waveforms of the APV model to get the mean arterial pressure and the characteristic ratio. In doing so, the shape of pressure waveforms and the cutoff frequency of high-pass filter circuitry strongly affected the estimation of mean arterial pressure and characteristic ratio. This resulted in errors when estimating blood pressure. To find an algorithm independent from the influence of waveform shapes and filter parameters, the volume oscillation of the APV model and the phase shift of the oscillation with FFT were identified by increasing the cuff pressure from 1 mmHg to 200 mmHg (1 mmHg per second). The phase shift between the ranges of volume oscillation was then only observed between the systolic and diastolic blood pressures. The same results were obtained from simulations performed on two different arterial blood pressure waveforms and one hyperthermia waveform.

关键词： Blood pressure Shape Filters Performance analysis Computer simulation Cutoff frequency Circuits Frequency estimation Arterial blood pressure Hyperthermia

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Multivalent‐Interaction‐Driven Assembly of Discrete, Flexible, and Asymmetric Supramolecular Protein Nano‐Prisms

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Angewandte Chemie 2020年第51期132卷 23444-23451页

作者： Suyeong Han Dr. Yu‐na Kim Gyunghee Jo Dr. Young Eun Kim Prof. Dr. Ho Min Kim Dr. Jeong‐Mo Choi Prof. Dr. Yongwon Jung Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Korea These authors contributed equally to this work. Biomedical Science and Engineering Interdisciplinary Program KAIST Daejeon 34141 Korea Graduate School of Medical Science & Engineering KAIST Daejeon 34141 Korea Center for Biomolecular & Cellular Structure Institute for Basic Science (IBS) Daejeon 34126 Korea Natural Science Research Institute KAIST Daejeon 34141 Korea Department of Chemistry Busan National University Busan 46241 Korea

Multivalent interactions between protein‐oligomer‐fused binding pairs allowed highly monodisperse assembly of two protein oligomers, where spacing between oligomers can be widely varied. Two different oligomers or three oligomers can also be discretely assembled into protein layer structures via this *** approaches to design monodisperse protein assemblies require rigid, tight, and symmetric interactions between oligomeric protein units. Herein, we introduce a new multivalent‐interaction‐driven assembly strategy that allows flexible, spaced, and asymmetric assembly between protein oligomers. We discovered that two polygonal protein oligomers (ranging from triangle to hexagon) dominantly form a discrete and stable two‐layered protein prism nanostructure via multivalent interactions between fused binding pairs. We demonstrated that protein nano‐prisms with long flexible peptide linkers (over 80 amino acids) between protein oligomer layers could be discretely formed. Oligomers with different structures could also be monodispersely assembled into two‐layered but asymmetric protein nano‐prisms. Furthermore, producing higher‐order architectures with multiple oligomer layers, for example, 3‐layered nano‐prisms or nanotubes, was also *** a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the *** note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

关键词： multivalent interaction protein assembly protein design protein engineering protein–protein interactions

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Nucleic Acid Amplification: Mie Scatter and Interfacial Tension Based Real-Time Quantification of Colloidal Emulsion Nucleic Acid Amplification (Adv. Biosys. 10/2017)

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Advanced Biosystems 2017年第10期1卷

作者： Ariana M. Nicolini Tyler D. Toth Samuel Y. Kim M. Alejandra Mandel David W. Galbraith Jeong-Yeol Yoon Biomedical Engineering Graduate Interdisciplinary Program and Department of Biomedical Engineering The University of Arizona Tucson AZ 85721 USA School of Plant Sciences The University of Arizona Tucson AZ 85721 USA

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Caco-2 Cell-Derived Biomimetic Electrochemical Biosensor for Cholera Toxin Detection

SSRN

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SSRN 2022年

作者： Kim, Yonghwan Lee, Dongtak Seo, Youngjun Jung, Hyo Gi Jang, Jae Won Park, Dongsung Kim, Insu Lee, Gyudo Hwang, Kyo Seon Kim, Seung-Hyun Lee, Sang Won Lee, Jeong Hoon Yoon, Dae Sung School of Biomedical Engineering Korea University Seoul02841 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02841 Korea Republic of Department of Clinical Pharmacology and Therapeutics College of Medicine Kyung Hee University Seoul02447 Korea Republic of Department of Biotechnology and Bioinformatics Korea University Sejong30019 Korea Republic of Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Korea University Sejong30019 Korea Republic of School of Engineering Brown University ProvidenceRI02912 United States Department of Electrical Engineering and Computer Science University of California IrvineCA92697 United States Department of Electrical Engineering Kwangwoon University Seoul01897 Korea Republic of Astrion Inc Seoul02841 Korea Republic of

Cholera is a highly contagious and lethal waterborne disease induced by an infection with Vibrio cholerae (V. cholerae) secreting cholera toxin (CTx). Cholera toxin subunit B (CTxB) from the CTx specifically binds with monosialo-tetra-hexosyl-ganglioside (GM1) found on the exterior cell membrane of an enterocyte. Owing to the pathological process of CTx, a biomimetic electrochemical biosensor (CCB) was developed by applying GM1-expressing Caco-2 cell membrane (CCM) on the electrode surface of the biosensor for CTx detection. Briefly, the electrode surface was functionalized with CCM using the vesicle fusion method. The specific binding between GM1 and CTxB on the electrode surface was verified using confocal laser scanning microscopy and atomic force microscopy. The CTxB detection performances of the CCB, including sensitivity, selectivity, and long-term stability, were determined using electrochemical impedance spectroscopy (EIS). Based on the results, the CCB had an excellent limit of detection of ~11.46 nM and a detection range spanning 100 ng/mL - 1 mg/mL. Further, the CCB had high selectivity for the CTxB compared to different interfering molecules, which are abundant constituents of intestinal fluid and fecal matter in the human body. The long-term stability of the CCBs was also verified for 3 weeks using EIS. Overall, the CCB was found to have an excellent potential for application to point-of-care and cost-effective testing for CTxB detection in developing countries. © 2022, The Authors. All rights reserved.

关键词： Electrochemical impedance spectroscopy

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Correction: Synthesis, structure and optical performance of red-emitting phosphor Ba5AlF13:Mn4+

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RSC Advances 2017年第86期7卷 54554-54554页

作者： Lin Qin Peiqing Cai Cuili Chen Jing Wang Hyo Jin Seo Department of Physics and Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan 608-737 Republic of Korea

Correction for ‘Synthesis, structure and optical performance of red-emitting phosphor Ba5AlF13:Mn4+’ by Lin Qin et al., RSC Adv., 2017, 7, 49473–49479.

Correction for ‘Synthesis, structure and optical performance of red-emitting phosphor Ba₅AlF₁₃:Mn⁴⁺’ by Lin Qin et al., RSC Adv., 2017, 7, 49473–49479.

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Residue detection in the large intestine from colonoscopy video using the support vector machine method

Residue detection in the large intestine from colonoscopy vi...

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International Conference on Control, Automation and Systems ( ICCAS)

作者： M. Cho H. J. Kong J. H. Kim B. Jeon K. S. Hong S. Kim Interdisciplinary Program in Bioengineering Graduate School Seoul National University Seoul Republic of Korea Department of Biomedical Engineering Chungnam National University College of Medicine Daejeon Korea Department of Gastroenterology Seoul National University Boramae Medical Center Seoul Korea Department of Gastroenterology Mediplex Sejong Hospital Incheon Korea Institute of Medical and Biological Engineering Medical Research Center Seoul National University Seoul Republic of Korea

ISBN: (纸本)9781538670804;9788993215168

As colonoscopy is the gold standard screening test for colorectal cancer, studies of applying image processing to colonoscopy video are increasing. When performing colonoscopy or applying image processing to colonoscopy video, the presence of a residue in the large intestine is a negative affecting factor. In this reason, the colonoscopist evaluates and records the colon cleanliness after performing colonoscopy. However, these assessments can be influenced by the subjectivity of the colonoscopist. In order to quantify the frequency of residues in the large intestine, we applied image processing and machine learning techniques to the digital images obtained from colonoscopy. Support vector machine technique was applied to distinguish informative frames from colonoscopy videos, and to classify residue frames and the others. The sensitivity, specificity, and accuracy were evaluated for five patients.

关键词： Colonoscopy Support vector machines Intestines Image processing Endoscopes Cancer Colon

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Wireless,multimodal sensors for continuous measurement of pressure,temperature,and hydration of patients in wheelchair

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npj Flexible Electronics 2023年第1期7卷 479-493页

作者： Seokjoo Cho Hyeonseok Han Hyunwoo Park Sung-Uk Lee Jae-Hwan Kim Sung Woo Jeon Mengqiu Wang Raudel Avila Zhaoqian Xi Kabseok Ko Minsu Park Jungyup Lee Myungwoo Choi Je-Sang Lee Weon Gi Min Byeong-Ju Lee Soyeong Lee Jungrak Choi Jimin Gu Jaeho Park Min Seong Kim Junseong Ahn Osman Gul Chankyu Han Gihun Lee Seunghwan Kim Kyuyoung Kim Jeonghyun Kim Chang-Mo Kang Jahyun Koo Sung Soo Kwak Sungbong Kim Dong Yun Choi Seokwoo Jeon Hyung Jin Sung Yong Bae Park Minkyu Je Young Tae Cho Yong Suk Oh Inkyu Park Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Advanced 3D Printing Technology Development Division Korea Atomic Energy Research InstituteDaejeon 34057Republic of Korea Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of TechnologyDalian 116023P.R.China Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA DUT-BSU Joint Institute Dalian University of TechnologyDalian 116023China Ningbo Institute of Dalian University of Technology Ningbo 315016China Department of Electronics Engineering Kangwon National UniversityChuncheon 24341Republic of Korea Querrey-Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Sibel Health Inc NilesIL 60714USA Department of Materials Science and Engineering KAIST Institute for The Nanocentury(KINC)Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Rehabilitation Medicine Gimhae Hansol Rehabilitation&Convalescent HospitalGimhae 50924Republic of Korea Department of planning and development Gimhae Hansol Rehabilitation&Convalescent HospitalGimhae 50924Republic of Korea Department of rehabilitation medicine Pusan national university hospitalBusan 49241Republic of Korea Department of AI Convergence Network Ajou UniversitySuwon 16499Republic of Korea Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897Republic of Korea Korea Photonics Technology Institute Gwangju 61007Republic of Korea School of Biomedical Engineering Korea UniversitySeoul 02841Republic of Korea Interdisciplinary Program in Precision Public Health Korea UniversitySeoul 02841Republic of Korea Center

Individuals who are unable to walk independently spend most of the day in a *** population is at high risk for developing pressure injuries caused by ***,early diagnosis and prevention of these injuries still remain ***,we introduce battery-free,wireless,multimodal sensors and a movable system for continuous measurement of pressure,temperature,and hydration at skin *** device design includes a crack-activated pressure sensor with nanoscale encapsulations for enhanced sensitivity,a temperature sensor for measuring skin temperature,and a galvanic skin response sensor for measuring skin hydration *** movable system enables power harvesting,and data communication to multiple wireless devices mounted at skin-cushion interfaces of wheelchair users over full body *** evaluations and numerical simulations of the devices,together with clinical trials for wheelchair patients,demonstrate the feasibility and stability of the sensor system for preventing pressure injuries caused by sitting.

关键词： injuries modal mounted

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High-Resolution Hydrogen Molecule Detection Utilizing a Nanocandle-Based Optical Sensor

High-Resolution Hydrogen Molecule Detection Utilizing a Nano...

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Pacific Rim Conference on Lasers and Electro-Optics (CLEO/Pacific Rim)

作者： Nu-Ri Park Min-Joong Kim Jongsu Lee Minah Seo Yong-Sang Ryu Myung-Ki Kim KU-KIST Graduate School of Converging Science and Technology Korea University Seoul Republic of Korea Sensor System Research Center Korea Institute of Science and Technology Seoul Republic of Korea Department of Electrical Engineering and Computer Science Northwestern University Evanston IL USA School of Biomedical Engineering Korea University Seoul Republic of Korea Interdisciplinary Program in Precision Public Health Korea University Seoul Republic of Korea

Our research introduces a novel method for safe hydrogen detection. We've developed an advanced nano-candle sensor, combining Pd with nano-candles, enabling accurate detection of low-concentration hydrogen (<3%... 详细信息

ISBN: (数字)9798350372076

ISBN: (纸本)9798350372083

关键词： Electric potential Accuracy Hydrogen Lasers and electrooptics Optical sensors Electro-optical waveguides

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Simulation to assess user needs for the development of a bedside robot

Simulation to assess user needs for the development of a bed...

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International Conference on Ubiquitous Robots and Ambient Intelligence (URAI)

作者： Hyeongsuk Lee Jeongeun Kim Sukwha Kim Jisan Lee Ahjung Byun Hyeongju Ryu Hyoun-Joong Kong Seoul Women's College of Nursing Seoul Korea Interdisciplinary Program of Medical Informatics Seoul National University Seoul Korea Department of Reconstructive Plastic Surgery Seoul National University College of Medicine Seoul Korea College of Nursing Seoul National University Seoul Korea Department of Biomedical Engineering Chungnam National University College of Medicine Daejeon Korea

The purpose of the simulation performed in this study was to assess the requirements for a point-of-care (POC) bedside robot for patient education and emotional care; the simulation also facilitates defining the essential elements and functions of a robot before robot system development. The major functionalities evaluated in the simulation were: 1) bidirectional video system; 2) support system of doctor counseling; 3) voice recognition, and 4) ability to recognize non-verbal expressions. The evaluators reported the high feasibility and satisfactory performance of the POC bedside robot. While there are challenges, incorporating this technology into healthcare services will enhance the quality of inpatient hospital experiences and help healthcare providers in supporting patients.

关键词： Robots Speech recognition Hospitals Electronic mail Employee welfare Schedules

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New model of subconjunctival tumor development in rabbits

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Journal of biomedical Optics 2013年第7期18卷 070501页

作者： Hwang, Sang Seok Kim, Jeong Eun Chun, Bong-Kwon Jung, Sangbong Park, Eun-Kee Lee, Hu-Jang Jung, Mannhong Lee, Sang-Joon Noh, Gwang Myung Masanganise, Rangarirai Oak, Chulho Ahn, Yeh-Chan Pukyong National University Department of Biomedical Engineering Interdisciplinary Program of Medical Biotechnology Application Engineering Busan 608-737 Korea Republic of Kosin University College of Medicine Department of Pathology Busan 602-702 Korea Republic of Kosin University College of Medicine Institute for Global Health and Environment Cooperation Busan 602-702 Korea Republic of Gimhae College Department of Clinical Laboratory Science Gimhae 621-706 Korea Republic of Kosin University College of Medicine Department of Medical Humanities and Social Medicine Busan 602-702 Korea Republic of Gyeongsang National University College of Veterinary Medicine Research Institute of Life Sciences Chinju 660-701 Korea Republic of Kosin University College of Medicine Department of Internal Medicine Busan 602-702 Korea Republic of Kosin University College of Medicine Department of Ophthalmology Busan 602-702 Korea Republic of University of Zimbabwe College of Medicine Department of Ophthalmology Harare Zimbabwe

Conjunctival squamous cell carcinoma (SCC) is an uncommon disease. However, SCC has recently become an important clinical problem due the identification of a significantly high incidence of SCC among a group of black African patients with AIDS. However, basic research concerning SCC, including both intraepithelial and invasive squamous neoplasia, is limited due to the lack of an ocular tumor animal model. Specifically, current ocular imaging and treatment modalities are insufficient for investigating currently available small animal models, because the conjunctival space is not comparable to that of humans. We describe the development of a reproducible model of subconjunctival squamous carcinoma in moderate-sized immunocompetent rabbits. Under optical coherence tomography guidance, 1 × 107 VX2 carcinoma cells are inoculated into the subconjunctival space of 3 to 4-kg New Zealand white rabbits. Malignant tumor involvement developed on the subconjunctival space after an average of 1 to 2 weeks. This subconjunctival tumor model induction method will likely facilitate a broad range of investigation of subconjunctival cancer diagnostics and therapeutics. © Society of Photo-Optical Instrumentation Engineers.

关键词： Tumors

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