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29th Annual International Conference of IEEE-EMBS, engineering in Medicine and Biology Society, EMBC'07

作者： Park, Sangyun Kong, Hyoun-Joong Moon, Woo Kyoung Kim, Hee Chan Interdisciplinary Program Graduate School Seoul National University Seoul Korea Republic of Department of Radiology Seoul National University Seoul 110-744 Korea Republic of Department of Biomedical Engineering College of Medicine and Institute of Medical and Biological Engineering Seoul National University Seoul Korea Republic of

ISBN: (纸本)1424407885

An accurate segmentation of solid nodules in ultrasonographic (US) breast image is presented. 1-level 2-dimensional Discrete Wavelet Transform (DWT) is used to create features reflecting the texture information of the original image. Using these features, the texture classification is achieved. Finally, solid nodule region is segmented from the classified texture region. Proper threshold for texture classification is automatically decided. Empirically acquired information about the relationship between the texture characteristic of the original image and the optimal threshold is examined and used. Presented algorithm is applied to 284 malignant solid nodules and 300 benign solid nodules and the resulting images are presented. © 2007 IEEE.

关键词： Ultrasonography

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186 – Inefficient neural network during spatial working memory task in subjects at high genetic-risk for schizophrenia

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Schizophrenia Research 2008年 98卷 110-110页

作者： Han, J.Y. Park, J.Y. Kang, D.H. Choi, J.S. Jung, M.H. Choi, C.H. Jung, Y.S. Lee, J.M. Kwon, J.S. Interdisciplinary Program in Cognitive and Brain Science Seoul National University Seoul Republic of Korea Department of Psychiatry Seoul National University College of Medicine Seoul Republic of Korea Clinical Cognitive Neuroscience Center Neuroscience Institute SNU-MRC Seoul Republic of Korea Department of Radiology National Medical Center Seoul Republic of Korea Department of Biomedical Engineering Hanyang University School of Medicine Seoul Republic of Korea

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Activity energy expenditure assessment system based on activity classification using multi-site triaxial accelerometers

Activity energy expenditure assessment system based on activ...

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29th Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBS 2007), vol.6

作者： Kim Dongwoo Hee Chan Kim Interdisciplinary Program Seoul National University Seoul Korea Department of Biomedical Engineering Seoul National University Seoul Korea

Wireless networked multi-site triaxial accelerometry system was proposed to estimate activity energy expenditure during daily life. Proposed system used different estimation algorithms according to activity classification based on measured acceleration signals. The estimation results showed higher correlation (R{sup}2=0.98) and smaller standard errors of estimation (SEE=0.66 kcal) than any other system in preceding reports.

关键词： Accelerometers Acceleration biomedical engineering Legged locomotion Signal processing algorithms biomedical measurements Differential equations Wrist engineering in medicine and biology Energy measurement

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Capacitive-Coupled ECG Measurement and Its Applications for Ubiquitous Healthcare

Capacitive-Coupled ECG Measurement and Its Applications for ...

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International Conference on Convergence Information Technology

作者： Ko Keun Kim Yong Gyu Lim Jung Soo Kim Kwang Suk Park Interdisciplinary Program in Biomedical Engineering Seoul National University Seoul South Korea Department of Oriental Biomedical Engineering Sangji University Wonju South Korea Department of Biomedical Engineering College of Medicine Seoul National University Seoul South Korea

Unconstrained ECG measurement is important for ubiquitous healthcare. The methods for this are being developed, and the capacitive-coupled ECG (CC- ECG) measurement is reported recently. In this paper, this measuremen... 详细信息

ISBN: (纸本)9781424431779

关键词： Electrocardiography Medical services biomedical measurements Electrodes biomedical engineering Surface impedance Rubber Textiles Skin Impedance measurement

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Multivariate feature selection using random subspace classifiers for gene expression data

Multivariate feature selection using random subspace classif...

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7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE

作者： Kamath, Vidya P. Hall, Lawrence O. Yeatman, Timothy J. Eschrich, Steven A. Biomedical Engineering Program University of South Florida H. Lee Moffitt Cancer Center and Research Institute Tampa FL United States Dept. of Computer Science and Engineering University of South Florida Tampa FL United States Dept. Interdisciplinary Oncology H. Lee Moffitt Cancer Center and Research Institute Tampa FL United States

ISBN: (纸本)1424415098

Gene expression analysis techniques identify important genes that predict specified outcomes based on sample characteristics. Given the small sample sizes common to these studies and the large dimensionality of the data, feature selection methods are essential. In addition, cancer-related expression analysis often involves imbalanced datasets due to rare forms of disease. Popular methods of feature selection employ univariate techniques to identify the features most suitable for analysis. We propose a multivariate technique for selecting accurate subsets of features using an approach based on random subspaces. The random subspace method is used to explore random combinations of features and only subspaces that produce accurate classifiers are retained. The method is tested on two independent gene expression datasets and compared with a univariate approach. The multivariate feature selection method resulted in a 33% improvement in classification accuracy overall and 90% improvement in classification accuracy for the minority class. ©2007 IEEE.

关键词： Gene expression

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The relationship between HRV parameters and stressful driving situation in the real road

The relationship between HRV parameters and stressful drivin...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Haet Bit Lee Jung Soo Kim Yun Seong Kim Hyun Jae Baek Myung Suk Ryu Kwang Suk Park Seoul National University South Korea Interdisciplinary Program in Medical and Biological Engineering Graduate School Republic of Korea Advanced Biometric Research Center Republic of Korea Department of Biomedical Engineering Seoul National University Republic of Korea

The aim of this paper is to find a relation between HRV parameters of ECG and stressful driving situation in the real road through various tests. First, we gave a stress to the subject by increasing the driving speed using driving simulator in the laboratory. Second, the subject drove the vehicle on the real road. Through let him drove in the busy narrow street, we evoked stress. ECG and PPG signal was recorded from steering wheel and back cushion each unconsciously. The driving experiment with simulator was not suitable to reproduce actual traffic condition because the adaptation was occurred. On the other hand, in real driving test, the results show that the heart rate is increase, and SDNN, RMSSD, pNN50 were decreased. The heart rate is the strongest indicator and other parameters tend to be changed depend on a personal. The blood pressure had no significant changes. Our results show the good possibility of that the time parameters of the HRV could be used as an instantaneous stress indicator.

关键词： Heart rate variability Stress Electrocardiography Testing Heart rate Laboratories Road vehicles Wheels Traffic control Blood pressure

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Computational Strategies for Protein Quantitation in 2D Electrophoresis Gel Image Processor for Matlab

Computational Strategies for Protein Quantitation in 2D Elec...

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Frontiers in the Convergence of Bioscience and Information Technologies, FBIT

作者： Umer Zeeshan Ijaz Safee Ullah Chaudhary Moon Sang Don Kyung Youn Kim Department of Electronic Engineering Cheju National University Cheju South Korea Department of Bio-Analytical Science Korea University of Science and Technology Daejeon South Korea Postgraduate Interdisciplinary Program Biomedical Engineering Cheju National University Cheju South Korea

In this paper, computational strategies are defined for protein quantisation by considering the shapes of the protein spots. The technique uses the clustering techniques like K-mean and fuzzy C-mean to distinguish between different types of protein spots and unwanted artifacts. The resulting technique is used in 2D electrophoresis gel image processor for Matlab with other image manipulation techniquies on the experimental data to evaluate its performance.

关键词： Electrokinetics Silver Protein engineering Proteomics biomedical engineering Anodes Cathodes Pipelines Signal processing algorithms Information technology

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Cartilage tissue engineering using a elastic poly (L-lactide-co-Ε- caprolactone) scaffold

Cartilage tissue engineering using a elastic poly (L-lactide...

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作者： Jung, Youngmee Kim, Soo Hyun Kim, Sang-Heon Kim, Young Ha Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O.Box 131 Cheongryang Seoul 130-650 Korea Republic of Interdisciplinary Program Medical and Biological Engineering Major Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology 1 Oryang Buk Gwangju 500-712 Korea Republic of Department of Biomedical Engineering Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of

Mechano-active scaffolds were fabricated from very elastic poly(L-lactide-co-Ε-carprolactone). The scaffolds with 80% porosity and 300-500 um pore size were prepared by a gel-pressing method. As a control group for elastic properties of polymer scaffolds, rigid poly L-lactide scaffolds were fabricated. The scaffolds were seeded with chondrocytes and cultured to evaluate the effect of elastic properties of polymer scaffolds for the differentiation and the ECM secretion of chondrocytes. Also, the chondrocytes-seeded constructs were implanted in nude mice subcutaneously to investigate their biocompatibility and cartilage formation. From the biochemical analyses, chondrogenic differentiation was sustained and enhanced significantly and chondral extracellular matrix was increased through mechanical stimulation of dynamic environment in the dynamic body systems. Histological analysis showed that implants of PLCL constructs formed mature and well-developed cartilaginous tissue, as evidenced by chondrocytes within lacunae. Consequently, the elastic PLCL scaffolds could be used to engineer cartilage in mechanically dynamic environments.

关键词： Cartilage

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Unconstrained Heart Rate Estimation System in Bed

Unconstrained Heart Rate Estimation System in Bed

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International Conference on Convergence Information Technology

作者： Gih Sung Chung Byoung Hoon Choi Ko Keun Kim Yong Gyu Lim Jin Wook Choi Do-Un Jeong Kwang Suk Park Interdisciplinary Program in Medical & Biological Engineering Seoul National University South Korea Department of Oriental Biomedical Engineering Sangji University Wonju South Korea Department of Biomedical Engineering College of Medicine Seoul National University South Korea Department of Neuropsychiatry and Division of Sleep Studies and Clinical Research Institute College of Medicine and Hospital Seoul National University South Korea

ISBN: (纸本)9780769530383

It is widely known that autonomic nervous system (ANS) is one of the indices to indicate the wakefulness of person. Therefore measuring the biosignals relating with the ANS during sleep is required to evaluate sleep quality. There are many researches that heart rate derived from the electrocardiogram (ECG) is good index to show the sympathetic or parasympathetic activities. To assess the quality of sleep, polysomnagraphy is used as golden standard but subjects have to attach many of sensors to their body and it is not only complicate, but also influence their sleep. In this study, to measure the autonomic nervous activities, we introduce newly developed system using load-cell. The sensors installed bottom of the bed measure the ballistocardiogram, mechanical vibration of heart. Ballistocardiogram is one of the nonintrusive methods to measure the heart rates unconstrainedly. By comparing with reference signal, ECG using Ag-AgCl electrodes, we validated our system with the four subjects. The results show comparison of LF/HF ratio, one of the heart rate variability, measured from the load-cells and Ag-AgCl electrodes for the each sleep stage, deep sleep, light sleep and REM sleep. It shows the different pattern for the light and deep sleep but contrary to our expectation, REM sleep doesn't indicate the highest value. LF/HF ratio measured from both methods have no significant differences.

关键词： Heart rate Sleep Electrocardiography Mechanical sensors Vibration measurement Electrodes Hafnium Autonomic nervous system Mechanical variables measurement Heart rate variability

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Mechano-active cartilage tissue engineering: The effect of dynamic compressive stimulation

Mechano-active cartilage tissue engineering: The effect of d...

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作者： Jung, Youngmee Kim, Soo Hyun Kim, Sang-Heon Kim, Young Ha Xie, Jun Matsuda, Takehisa Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O.Box 131 Cheongryang Seoul 130-650 Korea Republic of Interdisciplinary Program Medical and Biological Engineering Major Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology 1 Oryang Buk Gwangju 500-712 Korea Republic of Department of Orthopaedic Surgery School of Medicine Fukuoka University 8-19-1 Nanakuma Jonan Fukuoka 814-0180 Japan Genome and Biomedical Engineering Laboratory Kanazawa Institute of Technology 7-1 Ohgigaoka Nonoichi Ishikawa 921 - 8501 Japan Department of Biomedical Engineering Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of

Mechano-active scaffolds were fabricated from very elastic poly(lactide-co-carprolactone) by a gel-pressing method. The scaffolds were seeded with bone marrow stromal cells and the continuous compressive deformation was applied to cell-polymer constructs in the chondrogenic media. Then, they were implanted in nude mice subcutaneously to evaluate for the effect of dynamic compression for regeneration of cartilage. From the biochemical analyses, chondrogenic differentiation was sustained and enhanced significantly and chondral extracellular matrix was increased through mechanical stimulation. Histological analyses showed that implants stimulated mechanically formed mature and well-developed cartilaginous tissue, as evidenced by bone marrow derived chondrocytes within lacunae. Consequently, the periodic application of dynamic compression can encourage bone marrow stromal cells to differentiation to chondrogenic lineage and to maintain their phenotypes.

关键词： Cartilage

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