检索结果-内蒙古大学图书馆

REVIEW ARTICLE: Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury

Journal of Pineal Research 2010年第3期49卷

作者： Yonggeun Hong K. J. Palaksha Kanghui Park Sookyoung Park Hyun-Dong Kim Russel J. Reiter Kyu-Tae Chang Cardiovascular & Metabolic Disease Center Department of Rehabilitation Science in Interdisciplinary PhD Program College of Biomedical Science & Engineering Inje University Gimhae National Primate Research Center (NPRC) Korea Research Institute of Bioscience and Biotechnology (KRIBB) Ochang Department of PM & R. (Physical Medicine and Rehabilitation) College of Medicine Inje University Busan Korea Department of Cellular & Structural Biology The UT Health Science Center San Antonio TX USA

Abstract: Spinal cord injury (SCI) is damage to the spinal cord caused by the trauma or disease that results in compromised or loss of body function. Subsequent to SCI in humans, many individuals have residual motor and sensory deficits that impair functional performance and quality of life. The available treatments for SCI are rehabilitation therapy, activity-based therapies, and pharmacological treatment using antioxidants and their agonists. Among pharmacological treatments, the most efficient and commonly used antioxidant for experimental SCI treatment is melatonin, an indolamine secreted by pineal gland at night. Melatonin’s receptor-independent free radical scavenging action and its broad-spectrum antioxidant activity makes it an ideal antioxidant to protect tissue from oxidative stress-induced secondary damage after SCI. Owing to the limitations of an activity-based therapy and antioxidant treatment singly on the functional recovery and oxidative stress-induced secondary damages after SCI, a melatonin plus exercise treatment may be a more effective therapy for SCI. As suggested herein, supplementation with melatonin in conjunction with exercise not only would improve the functional recovery by enhancing the beneficial effects of exercise but would reduce the secondary tissue damage simultaneously. Finally, melatonin may protect against exercise-induced fatigue and impairments. In this review, based on the documented evidence regarding the beneficial effects of melatonin, activity-based therapy and the combination of both on functional recovery, as well as reduction of secondary damage caused by oxidative stress after SCI, we suggest the melatonin combined with exercise would be a novel neurorehabilitative strategy for the faster recovery after SCI.

关键词： animal model exercise melatonin rehabilitation secondary/oxidative damage spinal cord injury

来源：评论

学校读者我要写书评

暂无评论

Integration of MRI and somatosensory evoked potentials facilitate diagnosis of spinal cord compression

引用

Scientific Reports 2023年第1期13卷 1-12页

作者： Sun, Shu-Pin Phang, Chun-Ren Tzou, Shey-Cherng Chen, Chang-Mu Ko, Li-Wei International Ph.D. Program in Interdisciplinary Neuroscience (UST) College of Biological Science and Technology National Yang Ming Chiao Tung University 734 Engineering Bldg. 5 1001 Daxue Road Hsinchu 30010 Taiwan Department of Medical Research National Taiwan University Hospital Hsin-Chu Branch Hsinchu 300 Taiwan Institute of Molecular Medicine and Bioengineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Department of Surgery College of Medicine and Hospital National Taiwan University No. 7 Zhongshan South Road Taipei 10002 Taiwan Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Institute of Electrical and Control Engineering Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Department of Biomedical Science and Environment Biology and the Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung 807 Taiwan

This study aimed to integrate magnetic resonance imaging (MRI) and related somatosensory evoked potential (SSEP) features to assist in the diagnosis of spinal cord compression (SCC). MRI scans were graded from 0 to 3 according to the changes in the subarachnoid space and scan signals to confirm differences in SCC levels. The amplitude, latency, and time–frequency analysis (TFA) power of preoperative SSEP features were extracted and the changes were used as standard judgments to detect neurological function changes. Then the patient distribution was quantified according to the SSEP feature changes under the same and different MRI compression grades. Significant differences were found in the amplitude and TFA power between MRI grades. We estimated three degrees of amplitude anomalies and power loss under each MRI grade and found the presence or absence of power loss occurs after abnormal changes in amplitude only. For SCC, few integrated approach combines the advantages of both MRI and evoked potentials. However, integrating the amplitude and TFA power changes of SSEP features with MRI grading can help in the diagnosis and speculate progression of SCC. © 2023, The Author(s).

关键词：

来源：评论

学校读者我要写书评

暂无评论

Simulating Cardiac Fluid Dynamics in the Human Heart

arXiv

引用

arXiv 2023年

作者： Davey, Marshall Puelz, Charles Rossi, Simone Smith, Margaret Anne Wells, David R. Sturgeon, Gregory M. Segars, W. Paul Vavalle, John P. Peskin, Charles S. Griffith, Boyce E. University of North Carolina Chapel HillNC United States Department of Pediatrics-Cardiology Baylor College of Medicine Texas Children’s Hospital HoustonTX United States Department of Mathematics University North Carolina Chapel HillNC United States Department of Radiology Duke University Medical Center DurhamNC United States Division of Cardiology Department of Medicine University of North Carolina School of Medicine Chapel HillNC United States Courant Institute of Mathematical Sciences New York University New YorkNY United States Departments of Mathematics and Biomedical Engineering University of North Carolina Chapel HillNC United States Carolina Center for Interdisciplinary Applied Mathematics University of North Carolina Chapel HillNC United States Computational Medicine Program University of North Carolina School of Medicine Chapel HillNC United States McAllister Heart Institute University of North Carolina School of Medicine Chapel HillNC United States

Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering, and medical interest in creating mathematical models of the heart that capture, explain, and predict these fluid-structure interactions. However, existing computational models that account for interactions among the blood, the actively contracting myocardium, and the cardiac valves are limited in their abilities to predict valve performance, resolve fine-scale flow features, or use realistic descriptions of tissue biomechanics. Here we introduce and benchmark a comprehensive mathematical model of cardiac fluid dynamics in the human heart. A unique feature of our model is that it incorporates biomechanically detailed descriptions of all major cardiac structures that are calibrated using tensile tests of human tissue specimens to reflect the heart’s microstructure. Further, it is the first fluid-structure interaction model of the heart that provides anatomically and physiologically detailed representations of all four cardiac valves. We demonstrate that this integrative model generates physiologic dynamics, including realistic pressure-volume loops that automatically capture isovolumetric contraction and relaxation, and predicts fine-scale flow features. None of these outputs are prescribed;instead, they emerge from interactions within our comprehensive description of cardiac physiology. Such models can serve as tools for predicting the impacts of medical devices or clinical interventions. They also can serve as platforms for mechanistic studies of cardiac pathophysiology and dysfunction, including congenital defects, cardiomyopathies, and heart failure, that are difficult or impossible to perform in patients. Copyright © 2023, The Authors. All rights reserved.

关键词： Heart

来源：评论

学校读者我要写书评

暂无评论

Corrigendum to “Navigating the site for embryo implantation: Biomechanical and molecular regulation of intrauterine embryo distribution” [Molecular Aspects of Medicine 34 (2013) 1024–1042]

引用

Molecular Aspects of Medicine 2013年第6期34卷 1257-1257页

作者： Qi Chen Ying Zhang David Elad Ariel J. Jaffa Yujing Cao Xiaoqin Ye Enkui Duan State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Department of Biomedical Engineering Faculty of Engineering Tel-Aviv University Tel-Aviv 69978 Israel Ultrasound Unit in Obstetrics and Gynecology Lis Maternity Hospital Tel-Aviv Medical Center Tel-Aviv 64239 and Sackler Faculty of Medicine Tel-Aviv University Tel-Aviv 69978 Israel Department of Physiology and Pharmacology College of Veterinary Medicine & Interdisciplinary Toxicology Program The University of Georgia Athens GA 30602 USA

来源：评论

学校读者我要写书评

暂无评论

Bone Remodeling: Theranostic Bioabsorbable Bone Fixation Plate with Drug‐Layered Double Hydroxide Nanohybrids (Adv. Healthcare Mater. 21/2016)

引用

Advanced Healthcare Materials 2016年第21期5卷

作者： Myung Hun Kim Woojune Hur Goeun Choi Hye Sook Min Tae Hyun Choi Young Bin Choy Jin‐Ho Choy Center for Intelligent Nano‐Bio Materials (CINBM) Department of Chemistry and Nano Science Ewha Womans University Seoul 03760 Republic of Korea Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul 08826 Republic of Korea Biomedical Research Institute Seoul National University Hospital Seoul 03080 Republic of Korea Department of Plastic and Reconstructive Surgery Institute of Human‐Environment Interface Biology College of Medicine Seoul National University Seoul 03080 Republic of Korea Department of Preventive Medicine Graduate School of Public Health Seoul National University Seoul 08826 Korea Institute of Medical and Biological Engineering Medical Research Center and Department of Biomedical Engineering College of Medicine Seoul National University Seoul 03080 Republic of Korea

来源：评论

学校读者我要写书评

暂无评论

Cover Picture: Addressing Environmental Challenges of Porphyrin Mixtures Obtained from Statistical Syntheses (Chemistry - Methods 3/2021)

Chemistry–Methods

引用

Chemistry–Methods 2021年第3期1卷

作者： Helen Hölzel Maximilian Muth Prof. Dr. Dominik Lungerich Prof. Dr. Norbert Jux Department of Chemistry and Pharmacy & Interdisciplinary Center for Molecular Materials (ICMM) Friedrich-Alexander-University Erlangen-Nuernberg Nikolaus-Fiebiger-Str. 10 91058 Erlangen Germany Center for Nanomedicine Institute for Basic Science (IBS) 50 Yonsei-ro Seodaemun-gu Seoul 03722 South Korea Graduate Program for Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 South Korea

来源：评论

学校读者我要写书评

暂无评论

Towards optimal design of patient isolation units in emergency rooms to prevent airborne virus transmission: From computational fluid dynamics to data-driven modeling

引用

Computers in Biology and Medicine 2024年 173卷 108309-108309页

作者： Lee, Jong Hyeon Shim, Jae Woo Lim, Min Hyuk Baek, Changhoon Jeon, Byoungjun Cho, Minwoo Park, Sungwoo Choi, Dong Hyun Kim, Byeong Soo Yoon, Dan Kim, Young Gyun Cho, Seung Yeon Lee, Kyung-Min Yeo, Myoung-Souk Zo, Hangman Shin, Sang Do Kim, Sungwan Interdisciplinary Program in Bioengineering Graduate School Seoul National University 1 Gwanak-ro Gwanak-gu Seoul Korea Republic of 50 UNIST-gil Eonyang-eup Ulju-gun Ulsan Korea Republic of 50 UNIST-gil Eonyang-eup Ulju-gun Ulsan Korea Republic of Department of Transdisciplinary Medicine Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul Korea Republic of Innovative Medical Technology Research Institute Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul Korea Republic of Medical Research Center Seoul National University 103 Daehak-ro Jongno-gu Seoul Korea Republic of Office of Hospital Information Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul Korea Republic of Department of Biomedical Engineering Seoul National University College of Medicine 103 Daehak-ro Jongno-gu Seoul Korea Republic of International Vaccine Institute 1 Gwanak-ro Gwanak-gu Seoul Korea Republic of Department of Architecture and Architectural Engineering Seoul National University College of Engineering 1 Gwanak-ro Gwanak-gu Seoul Korea Republic of Laboratory of Emergency Medical Services Biomedical Research Institute Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul Korea Republic of Department of Emergency Medicine Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul Korea Republic of Department of Emergency Medicine Seoul National University College of Medicine 103 Daehak-ro Jongno-gu Seoul Korea Republic of Institute of Bioengineering Seoul National University 1 Gwanak-ro Gwanak-gu Seoul Korea Republic of Artificial Intelligence Institute Seoul National University 1 Gwanak-ro Gwanak-gu Seoul Korea Republic of

Background: Patient isolation units (PIUs) can be an effective method for effective infection control. Computational fluid dynamics (CFD) is commonly used for PIU design;however, optimizing this design requires extensive computational resources. Our study aims to provide data-driven models to determine the PIU settings, thereby promoting a more rapid design process. Method: Using CFD simulations, we evaluated various PIU parameters and room conditions to assess the impact of PIU installation on ventilation and isolation. We investigated particle dispersion from coughing subjects and airflow patterns. Machine-learning models were trained using CFD simulation data to estimate the performance and identify significant parameters. Results: Physical isolation alone was insufficient to prevent the dispersion of smaller particles. However, a properly installed fan filter unit (FFU) generally enhanced the effectiveness of physical isolation. Ventilation and isolation performance under various conditions were predicted with a mean absolute percentage error of within 13%. The position of the FFU was found to be the most important factor affecting the PIU performance. Conclusion: Data-driven modeling based on CFD simulations can expedite the PIU design process by offering predictive capabilities and clarifying important performance factors. Reducing the time required to design a PIU is critical when a rapid response is required. © 2024 Elsevier Ltd

关键词： COVID-19

来源：评论

学校读者我要写书评

暂无评论

Topographical pattern of blood-brain barrier impairment in preclinical and clinical Alzheimer’s disease

引用

Alzheimer's & Dementia 2023年第S17期19卷

作者： Dahyun Yi Min Soo Byun Joon Sik Park Gihwan Byeon Hyejin Ahn Gijung Jung Koung Mi Kang Chul-Ho Sohn Jaeseok Park Dong Young Lee Seoul National University Seoul Korea Republic of (South) Institute of Human Behavioral Medicine Medical Research Center Seoul National University Seoul Korea Republic of (South) Correspondece Seoul National University College of Medicine Seoul Korea Republic of (South) Seoul National University Hospital Seoul Korea Republic of (South) Sungkyunkwan University Department of Biomedical Engineering Seoul Korea Republic of (South) Kangwon National University Hospital Chuncheon Korea Republic of (South) Interdisciplinary program of cognitive science Seoul National University College of Humanities Seoul Korea Republic of (South) Sungkyunkwan University Biomedical Institute for Convergence Seoul Korea Republic of (South)

Background While blood-brain barrier (BBB) damage in some brain regions has been suggested in Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI), the topographical pattern of BBB impairment associated with AD process in whole brain level is still poorly understood. Using high-resolution 3-dimensional (3D) dynamic contrast-enhanced (DCE) scans of BBB permeability ( K trans ) for the whole brain, we aimed to reveal topographical pattern of BBB impairment related to Alzheimer’s disease (AD) including preclinical as well as clinically impaired state. Method Ninety-one participants were included in the study [45 cognitively normal (CN) older adults, 24 individuals with mild cognitive impairment (MCI), and 22 patients with AD dementia]. Comprehensive clinical and neuropsychological assessments were administered to all participants. High-resolution DCE- as well as T 1 -weighted-MRI scans were obtained in addition to amyloid-PET scans. Amyloid-beta (Ab) positivity was obtained using previously established cut-offs. Preprocessing of K trans maps incorporated FreeSurfer-based (v6.0) segmentation to ensure exclusion of the voxels within cerebrospinal fluid (CSF) spaces. Voxel-wise analyses were conducted using SPM12 implemented in MATLAB 2018b. Result Subtle BBB impairment, as measured by K trans map images based on high-resolution 3D DCE-MRI, was observed at multiple brain regions even in preclinical AD (i.e., Ab-positive CN) as well as AD with cognitive impairment (i.e., Ab-positive MCI and AD). The brain regions with impaired K trans closely corresponded to the AD-signature regions (Figure). Compared to Ab-negative CN, Ab-positive CN showed increased breakdown of BBB in the precuneus, posterior-cingulate cortex, and medial temporal lobe. Moreover, compared to Ab-negative CN, Ab-positive MCI and AD patients showed increased breakdown of BBB in more diffuse regions including bilateral frontal, parietal and inferior temporal areas. In contrast, when using lo

关键词：

来源：评论

学校读者我要写书评

暂无评论

The molecular identification and phylogenetic reconstruction of Palaemonid and Penaeid shrimp from the southern part of Bangladesh

引用

IOP Conference Series: Earth and Environmental Science 2019年第1期236卷

作者： M J Alam S Andriyono A T M Eunus H W Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan 48513 Republic of Korea Department of Fisheries Ministry of Fisheries and Livestock Bangladesh Fisheries and Marine Faculty C Campus Jl. Mulyorejo Surabaya 60115. Universitas Airlangga Surabaya East Java Indonesia WorldFish Bangladesh and South Asia Office H#22B Road#7 Block-F Banani Dhaka- 1213 Bangladesh Department of Marine Biology Pukyong National University Republic of Korea

The study aimed to reveal the molecular identification and relationships between Palaemonid prawns and Penaeid shrimp in Bangladesh. Combined, they form an important economic part of tropical and subtropical fisheries. These species have a wide distribution range around the mangrove ecosystems, rivers, estuaries, flood plains, inundated natural depression water bodies, rice fields and other inland water bodies. Some of these species have a lack of information available about their biological and molecular characteristics. This study revealed the identification of prawn and shrimp species based on the molecular approach employed using mitochondrial COI gene markers, PCR, sequencing and matching the sequence to that stored in the NCBI database; four Palaemonid species (Macrobrachiumrosenbergii, M. lamarrei, M. kistnense,Palaemonstyliferus) and one Penaeid shrimp (Penaeus monodon) were confirmed with 99-100% confirmation of identity with multiple sequencing alignments. The inter-specific genetic divergence (K2P distance) among the family Palaemonid (Macrobrachium and Palaemon) is 0.171-0.257 %, and intraspecific genetic distance was revealed to be 0.243-0.302%. This result will be useful for obtaining the basic genetic information of these species and it will be helpful for future studies looking into the genetic biodiversity of the population structure, and finally, for the conservation and management of these resources in the southern part of Bangladesh.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis

arXiv

引用

arXiv 2017年

作者： Sung, Jaeyun Kim, Seunghyeon Cabatbat, Josephine Jill T. Jang, Sungho Jin, Yong-Su Jung, Gyoo Yeol Chia, Nicholas Kim, Pan-Jun Asia Pacific Center for Theoretical Physics Pohang Gyeongbuk37673 Korea Republic of Center for Computational and Integrative Biology Massachusetts General Hospital Harvard Medical School BostonMA02114 United States Broad Institute of MIT and Harvard CambridgeMA02142 United States Department of Physics Pohang University of Science and Technology Pohang Gyeongbuk37673 Korea Republic of Abdus Salam International Centre for Theoretical Physics Trieste34151 Italy Department of Chemical Engineering Pohang University of Science and Technology Pohang Gyeongbuk37673 Korea Republic of Department of Food Science and Human Nutrition University of Illinois at Urbana-Champaign UrbanaIL61801 United States Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign UrbanaIL61801 United States School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology Pohang Gyeongbuk37673 Korea Republic of Microbiome Program Center for Individualized Medicine Mayo Clinic RochesterMN55905 United States Department of Surgery Mayo Clinic RochesterMN55905 United States Department of Biomedical Engineering Mayo College RochesterMN55905 United States Department of Physics Korea Advanced Institute of Science and Technology Daejeon34141 Korea Republic of

A system-level framework of complex microbe-microbe and host-microbe chemical cross-talk would help elucidate the role of our gut microbiota in health and disease. Here we report a literature-curated interspecies network of the human gut microbiota, called NJS16. This is an extensive data resource composed of ~570 microbial species and 3 human cell types metabolically interacting through >4,400 small-molecule transport and macromolecule degradation events. Based on the contents of our network, we develop a mathematical approach to elucidate representative microbial and metabolic features of the gut microbial community in a given population, such as a disease cohort. Applying this strategy to microbiome data from type 2 diabetes patients reveals a context-specific infrastructure of the gut microbial ecosystem, core microbial entities with large metabolic influence, and frequently-produced metabolic compounds that might indicate relevant community metabolic processes. Our network presents a foundation towards integrative investigations of community-scale microbial activities within the human gut. Copyright © 2017, The Authors. All rights reserved.

关键词： Bacteria

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：