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IEEE Symposium (IUS) Ultrasonics

作者： Dong-Guk Paeng B.S. Kim MinJoo Choi R.Y. Chiao K.K. Shung Interdisciplinary Program of Biomedical Engineering Cheju National University Jeju South Korea Department of Biomedical Engineering University of Southern California Los Angeles CA USA GE Medical Systems Milwaukee WI USA

A cyclic variation of blood echogenicity from human iliac arteries in vivo was first observed using an intravascular 30 MHz ultrasound imaging device. Several studies have confirmed the temporal variation of the backscattered power during a flow cycle but they were all from in vitro experiments. In this paper, cyclic variation of echogenicity in vivo on human carotid arteries (7 males and 3 females) was observed from harmonic images of a GE LOGIQ 700 expert system with an M12L probe. Blood echogenicity increased at early systole, reaching a maximum at peak systole, and then decreased to be weak during diastole. Echogenicity during systole was about 40 to 60 % higher than that during diastole for all radial positions. The ratio of the maximum echogenicity during systole to the mean echogenicity during diastole was small at the center and near the vessel wall, and became large between them. The cyclic variation of blood echogenicity is thought to be due to erythrocyte aggregation enhancement by the combined effects of flow acceleration and shear rate during systole.

关键词： In vivo Blood Humans Carotid arteries In vitro Expert systems biomedical engineering biomedical imaging Ultrasonic imaging Acceleration

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Development of an integrated home telemedicine system

Development of an integrated home telemedicine system

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IEEE EMBS Asian-Pacific Conference on biomedical engineering

作者： Honggu Chun Ki-jung Kim Jae Min Kang Hee Chan Kim Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul South Korea Department of Biomedical Engineering College of medicine Seoul National University Seoul South Korea

ISBN: (纸本)0780379438

We developed an integrated home telemedicine system equipped with automatic diagnosis and consultation function for patients with chronic disease such as cardiac disease, respiratory disease, diabetes and hypertension. The system measures standard 12ch ECG, respiratory function, blood glucose level and non-invasive blood pressure (NIBP). The measured data were stored on the system and transmitted to the central server everyday through the Internet. The system performed automatic diagnosis at every measurement and offered medical consultation to the patient. If there was any abnormality in the diagnostic result, the system gave a real-time alarm to the healthcare center for adequate teleconsultation or medical service. We have installed the developed system on an apartment for the performance evaluation and confirmed the possibility of the system as an effective tool for the telemedicine.

关键词： Telemedicine Cardiac disease Cardiovascular diseases Medical services Diabetes Hypertension Pressure measurement Measurement standards Electrocardiography Blood

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Application of non-intrusive physiological data monitoring in normal apartment style house

Application of non-intrusive physiological data monitoring i...

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IEEE EMBS Asian-Pacific Conference on biomedical engineering

作者： K.S. Park W.J. Yi J.W. Seo J.M. Choi J.H. Han K.H. Hong Department of Biomedical Engineering College of Medicine Seoul National University Seoul South Korea Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul South Korea

We have installed and applied the developed nonintrusive type physiological data monitoring methods in already existing normal apartment style house. Physiological data are collected from beds, toilet seat and sensors installed throughout rooms. Collected data are transmitted by wireless communication to the home server, which collects, processes and finally transmits data to central server. Home server communicate with central server through installed high-speed Internet line. By the monitoring windows, doctors and caring staffs can access collected data on central server.

关键词： biomedical monitoring Patient monitoring Electrocardiography Web server Medical services biomedical measurements Weight measurement Textiles Electrodes Electrical resistance measurement

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Gait analysis for freezing detection in patients with movement disorder using three dimensional acceleration system

Gait analysis for freezing detection in patients with moveme...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Jong Hee Han Won Jin Lee Tae Beom Ahn Beom Suk Jeon Kwang Suk Park Interdisciplinary program in Medical and Biological Engineering Major Seoul National University South Korea Department of Biomedical Engineering College of medicine Seoul National University South Korea Department of Neurology Seoul National University South Korea

ISBN: (纸本)0780377893

Due to the aging process, the aftereffect of an accident or the problems in brain, some people can experience difficulties in walking. It could be helpful in the treatment of these individuals suffering walking difficulties to monitor their movement. The unconstrained activity monitoring system (U-AMS) was developed to monitor the body's acceleration. It can be attached easily and doesn't interfere with daily activity. The hardware consists of 3-axis accelerometer, which records data for long periods of time. The movement image was simultaneously recorded by a camcorder. To collect data from U-AMS and analyze them, several programs were developed. The data were transferred to a computer by RS-232 module and displayed through viewing program made by MFC (Microsoft, USA). The analyzing program, which links viewing program to MATLAB (Mathworks, USA), analyzes the data to detect movement disorder. In this paper, freezing, which is characterized as start hesitation., was the target disorder. Using the different characteristics in frequency domain between freezing and normal gait, freezing appearances were detected. By comparing with movement image, the accuracy of the freezing detection was verified to have a good performance.

关键词： Acceleration Legged locomotion Aging Accidents Patient monitoring Hardware Accelerometers Video equipment Computer displays MATLAB

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New method in acoustic analysis for the diagnosis of the laryngeal functions

New method in acoustic analysis for the diagnosis of the lar...

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Proceedings of the 2002 IEEE engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the biomedical engineering Society (BMES / EMBS)

作者： Choi, Jong Min Sung, Myung-Whun Park, Kwang Suk Interdisciplinary Program Medical and Biological Eng. Major Seoul National University Seoul Korea Republic of Dept. of Otorhinol. Head Neck Surg. College of Medicine Seoul National University Seoul Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

Speech has been widely used for the diagnosis of the laryngeal function, and many methods have been developed in voice analysis. But, some methods cannot be applied in clinical case. So, we intend to present the new schemes for the diagnosis of the voice using some parametric methods. We expect this scheme to be useful for the diagnosis of the patients' voices.

关键词： Speech analysis

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New method in acoustic analysis for the diagnosis of the laryngeal functions

New method in acoustic analysis for the diagnosis of the lar...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Jong Min Choi Myung-Whun Sung Kwang Suk Park Medical and Biological Engineering Major Interdisciplinary Program Department of Otorhinolaryngology Head and Neck Surgery College of Medicine Department of Biomedical Engineering College of Medicine Seoul National University Seoul South Korea

Speech has been widely used for the diagnosis of the laryngeal function, and many methods have been developed in voice analysis. But, some methods cannot be applied in clinical cases. So, we present a scheme for the diagnosis of the voice using some parametric methods. We expect this scheme to be useful for the diagnosis of patients' voices.

关键词： Frequency Speech analysis Jitter Medical diagnostic imaging Pathology biomedical engineering Educational institutions Sampling methods Databases biomedical acoustics

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Current density reconstruction with multi-scale grid approach

Current density reconstruction with multi-scale grid approac...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： J.-M. Han I.B. Lee J.H. Hahm Y.J. Kim K.S. Park Institute of Biomedical Engineering Seoul National University South Korea Interdisciplinary Program in Biomedical Engineering Seoul National University South Korea Department of Biomedical Engineering Seoul National University Seoul South Korea

The computational cost of solving an electroencephalographic (EEG) or magnetoencephalographic (MEG) inverse problem is extremely high due to the inversion of a matrix configured with a priori information. The matrix size is proportional to the number of points in source grid. We present a multi-scale grid approach to solve the inverse problem using FOCUSS algorithms which is one of the current density reconstruction (CDR) methods and tested the algorithm with simulated EEG data. The multi-scale grid approach dramatically reduces grid points without loss of the resolution.

关键词： Current density Electroencephalography Inverse problems Magnetic heads Brain modeling biomedical engineering biomedical measurements Testing Current measurement Magnetic field measurement

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The photon diffusion in biological tissue for PDT

The photon diffusion in biological tissue for PDT

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Pacific Rim Conference on Lasers and Electro-Optics (CLEO/Pacific Rim)

作者： D.J. Lee J.M. Kim S.H. Kim H.S. Lim Interdisciplinary Program in Biomedical Engineering Chungnam National University Taejon South Korea Department of Biomedical Engineering College of Medicine Chungnam National University Taejon South Korea

This paper studied the accessible depth by photons within biological tissue for photodynamic therapy. For the measurements of light propagation within tissue we applied the diode laser of 660 nm wavelength and then by assuming the medium to be homogeneous, we neglect the effects of any refractive index mismatches between the tissue layers. The result have yielded the penetration depth of light within biological tissue.

关键词： Biological tissues Optical propagation Power lasers Diode lasers Power measurement Cancer Medical treatment Wavelength measurement Heating Muscles

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The light propagation in biological tissue for cancer treatment

The light propagation in biological tissue for cancer treatm...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： H.S. Lim D.J. Lee J.M. Kim S.H. Kim Department of Biological Engineering Chungnam National University South Korea Interdisciplinary Program in Biomedical Engineering Chungnam National University South Korea

Studies the accessible depth by photons within biological tissue for photodynamic therapy of cancer. For measurements of light propagation within tissue, we applied a diode laser of 660 nm wavelength and by assuming the medium to be homogeneous, we neglect the effects of any refractive index mismatches between the tissue layers. The result have yielded the penetration depth of light within biological tissue.

关键词： Optical propagation Biological tissues Cancer Diode lasers Power lasers Power measurement Medical treatment Wavelength measurement Heating Density measurement

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Surface enhancements accelerate bone bonding to CPC-coated strain gauges†

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Journal of biomedical Materials Research Part B: Applied Biomaterials 2001年第1期56卷

作者： Nicholas M. Cordaro John A. Szivek Don W. DeYoung Orthopaedic Research Laboratory Department of Orthopedic Surgery and Biomedical Engineering Interdisciplinary Program University of Arizona Tucson Arizona 85724 University Animal Care University of Arizona Tucson Arizona 85721

Calcium phosphate ceramic (CPC)-coated strain gauges have been used for in vivo bone strain measurements for up to 18 weeks, but they require 6 to 9 weeks for sufficient bonding. Osteogenic protein-1 (OP-1), PepTite™ (a proprietary ligand), calcium sulfate dihydrate (CSD), transforming growth factor β-1 (TGF-β1 ), and an endothelial cell layer with and without TGF-β1 were used as surface enhancements to accelerate bone-to-CPC bonding. Young male Sprague–Dawley rats were implanted with unenhanced and enhanced CPC-coated gauges. Animals were allowed normal activity for 3 weeks and then calcein labeled. Femurs were explanted following euthanasia. A gauge was attached with cyanoacrylate to the opposite femur in the same position as the CPC-coated gauge. Bones were cantilever-loaded to assess strain transfer. They were sectioned and stained with mineralized bone stain (MIBS) and examined with transmitted and ultraviolet light. Mechanical testing indicated increased sensing accuracy for TGF-β1 and OP-1 enhancements to 105 ± 14% and 92 ± 12% versus 52 ± 44% for the unenhanced gauges. The PepTite™ and the endothelial-cell-layer-enhanced gauges showed lower sensing accuracy, and histology revealed a vascular layer near CPC particles. TGF-β1 increased bone formation when used prior to endothelial cell sodding. CSD prevented strain transfer to the femur. TGF-β1 and OP-1 surface enhancements produced accurate in vivo strain sensing on the rat femur after 3 weeks. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res 56: 109–119, 2001

关键词： strain gauge calcium phosphate ceramics transforming growth factor β-1 osteogenic protein-1 endothelial cells

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