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11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

作者： Kwon, Gu-Han Lee, Kwang Ho Lee, Eun-Joong Lee, Sang-Hoon Department of Biomedical Engineering College of Medicine Korea University Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Korea Republic of

ISBN: (纸本)9780979806407

A new micro cell chip which can induce stem cells to differentiate into specific body cell types has been designed and fabricated for tissue engineering. This paper presents the fabrication and preliminary test results of a MEMS cell electric stimulator. It provides a new tool of cell electric stimulation, culture and analysis for stem cell research. This study provides the controlling proliferation as well as morphology of human mesenchymal stem cell on the microchip. DC 1V, 5V, 12V, AC 5V, 1 Hz, 1K Hz, 1M Hz were compared with electric stimulation for their impact on the expansion and morphology of mesenchymal stem cells (MSCs). It provides a new generation of cell culture, stimulation and analysis devices for stem cell research and tissue engineering. © 2007 CBMS.

关键词： Stem cells

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Second derivative of photoplethysmography for estimating vascular aging

Second derivative of photoplethysmography for estimating vas...

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6th International Special Topic Conference on ITAB, 2007

作者： Hyun, Jae Baek Jung, Soo Kim Yun, Sung Kim Haet, Bit Lee Kwang, Suk Park Interdisciplinary Program of Bioengineering Seoul National University Seoul Korea Republic of Interdisciplinary Program on Medical and Biological Engineering Seoul National University Seoul Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)9781424418688

Coronary artery disease (CAD) is one of the major causes of death. Therefore recurrent monitoring of arterial condition is important. The photoplethysmography (PPG) is simple and cost effective technique to measure blood volume change. As an application of PPG technique, the second derivative of photoplethysmography(SDPTG) was introduced for monitoring arterial condition. SDPTG consists of an a, b, c and d wave in systole and an e wave in diastole. The SDPTG wave pattern is determined by the proportions of the b, c, d, and e waves to the a wave. In the present study, it is confirmed that the b/a ratio and SDPTG-AI increased with age, and the c/a, d/a, and e/a ratios decreased with age. The informal method which substitutes formal SDPTG-AI was suggested. © 2008 IEEE.

关键词： Cost effectiveness

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Wavelet approach to artifact noise removal from Capacitive coupled Electrocardiograph

Wavelet approach to artifact noise removal from Capacitive c...

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30th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBS'08

作者： Seung, Min Lee Ko, Keun Kim Kwang, Suk Park Interdisciplinary Program of Bioengineering Seoul National University Graduate School Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Seoul National University Graduate School Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)9781424418152

Capacitive coupled Electrocardiography (ECG) is introduced as non-invasive measurement technology for ubiquitous health care and appliance are spread out widely. Although it has many merits, however, capacitive coupled ECG is very weak for motion artifacts for its non-skin-contact property. There are many studies for artifact problems which treats all artifact signals below 0.8Hz. In our capacitive coupled ECG measurement system, artifacts exist not only below 0.8Hz but also over than 10Hz. Therefore, artifact noise removal algorithm using wavelet method is tested to reject artifact-wandered signal from measured signals. It is observed that using power calculation each decimation step, artifact-wandered signal is removed as low frequency artifacts as high frequency artifacts. Although some original ECG signal is removed with artifact signal, we could level the signal quality for long term measure which shows the best quality ECG signals as we can get. © 2008 IEEE.

关键词： Electrocardiography

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Personal dialysis using a web-based, portable system - C-PAK (Carry-on Pulse Artificial Kidney)

Personal dialysis using a web-based, portable system - C-PAK...

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BIODEVICES 2008 - 1st International Conference on biomedical Electronics and Devices

作者： Lee, Jung Chan Kim, Wook Eun Lim, Ki Moo Kim, Jeong Chul Min, Byoung Goo Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Biomedical Engineering Seoul National University Seoul Korea Republic of

ISBN: (纸本)9789898111173

While the number of patients suffering from acute and chronic renal failure has been steadily increasing every year, the mortality rate is not improving. For the purpose of improvement on the quality of life and mortality of renal disease patients, we employ the hemofiltration principle to treat the end-stage renal disease patients. Hemofiltration equipment can be installed without additional plumbing and electrical power construction;operated only with several pre-packaged fluid bags without a huge water treatment facility. This paper describes the development of portable renal treatment equipment based on hemofiltration treatment, Carry-on Pulse Artificial Kidney (C-PAK), and reports the results of animal test using the equipment. The web-based remote monitor/control system for C-PAK is introduced also. We expect that our portable hemofiltration device for chronic renal failure patient would be an alternative for conventional hemodialysis machine and a solution to home renal treatment.

关键词： Diseases

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MICROFLUIDIC CELL SHEARING ENABLES HIGHLY EFFECTIVE MACROMOLECULE INTRACELLULAR DELIVERY 25

MICROFLUIDIC CELL SHEARING ENABLES HIGHLY EFFECTIVE MACROMOL...

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25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Kwon, Chan Kang, GeoumYoung Chung, Aram School of Biomedical Engineering Korea University Seoul Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul Korea Republic of

ISBN: (纸本)9781733419031

A novel microfluidic cell stretching platform using viscoelastic fluids is presented, enabling highly effective intracellular delivery of external biomolecules into various cell types. The cell suspended in methylcellulose (MC) solution is injected into the platform, where cells rapidly pass through a single constriction with a dimension slightly smaller than the cell diameter. Because of the MC solution, a high shear force is applied to the cells, effectively generating transient cell membrane discontinuities. With this approach, a high delivery efficiency (>97%), high throughput (>106 cells/min) and nearly clogging-free of various macromolecules into different immune cells were demonstrated for cancer immunotherapy applications. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Cells

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Luminescence of Eu^2＋ and Eu^2＋-Mn^2＋ in sodium scandium diphosphate NaScP2O7 crystal

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Journal of Rare Earths 2017年第5期35卷 453-459页

作者：张新民郑薇张宏志陈翠丽徐孝镇 School of Materials Science and Engineering Central South University of Forestry and Technology Changsha 410004 China Hunan Collaborative Innovation Center for Effective Utilizing of Wood & Bamboo Resource Changsha 410018 China Department of Physics and Interdisciplinary Program of Biomedical Mechanical & Electrical Engineering Pukyong National University Busan 608-737 Republic of Korea

In this work, the photoluminescence（PL） of NaScP2O7：Eu^2＋ and NaScP2O7：Eu^2＋,Mn^2＋ was investigated. Phase purity was checked using X-ray powder diffractometry（XRD）. PL excitation and emission spectra were recorded to elucidate the PL properties of NaScP2O7：Eu^2＋ and NaScP2O7：Eu^2＋,Mn^2＋. Furthermore, fluorescence lifetime measurements were performed. PL and lifetime measurements were carried out from 10 to 525 K. Moreover, the Eu^2＋ site occupation was discussed. It turned out that the incorporated Eu^2＋ ions substituted for Na＋ site and occupied two different sites. Temperature dependent PL measurements indicated the emission intensity decreased with increasing temperature due to temperature quenching in NaScP2O7：Eu^2＋. Fluorescence lifetimes of Eu^2＋ in NaScP2O7：Eu^2＋ almost did not change with a decay constant τ=~0.53 μs in the temperature range of 10–280 K, and then shortened due to temperature quenching. The luminescent lifetime reached ~0.05 μs at T=525 K. Finally, it was found that energy transfer occurred from Eu^2＋ to Mn^2＋ in co-doped NaScP2O7：Eu^2＋,Mn^2＋.

关键词： lifetime diffractometry luminescent diphosphate checked excitation incorporated decay elucidate luminescence

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A Reflection on Teaching Design Thinking to First-Year engineering Students

A Reflection on Teaching Design Thinking to First-Year Engin...

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2019 IEEE International Conference on engineering, Technology and Education, TALE 2019

作者： Maneeratana, Kuntinee Chancharoen, Ratchatin Thongnuek, Peerapat Sukmuen, Potcharawan Inkaew, Chamaiporn Suwannatthachote, Praweenya Chulalongkorn University Department of Mechanical Engineering Bangkok Thailand Chulalongkorn University Interdisciplinary Program of Biomedical Engineering Thailand Chulalongkorn University Department of Educational Communication and Technology Thailand

ISBN: (纸本)9781728126654

A short ***-style design thinking project was offered to first-year engineering students as an option in an introduction to engineering course. Using the Stanford *** bootcamp bootleg as the guideline, students went through the process - empathy, define, ideate, prototype, and test - very fast with different levels of depth. The works were evaluated using the *** rubric and found to gain limited success. In order to improve the instructional design, the formal developmental study was initiated. Using class observation, focus-group interview and comparison with similar classes, the instructional design was analyzed and weakness identified. The major problems included the student preparation, engagement, participation, core concept understanding as well as active learning activities, technology utilization, feedback and reflection, in short, the class control and facilitation. The instruction design was adjusted with detailed activities such that it would be implemented in the next iteration. © 2019 IEEE.

关键词： Students

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Quantitative measurements of pressure dependent laminar cribrosa microstructure in human eyes

Quantitative measurements of pressure dependent laminar crib...

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ASME 2011 Summer Bioengineering Conference, SBC 2011

作者： Yan, Dongmei Keyes, Joseph T. Vande Geest, Jonathan P. Aerospace and Mechanical Engineering University of Arizona United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona United States Biomedical Engineering University of Arizona United States BIO5 Institute University of Arizona United States

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Microfluidic cell culture chip employing polymeric nanofiber membrane

Microfluidic cell culture chip employing polymeric nanofiber...

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10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006

作者： Kim, Sung Rak Lee, Ki Hwa Lee, Kwang Ho Baek, Ju Yeoul Park, Yong Doo Sun, Kyung Lee, Sang Hoon Dept. of Biomedical Engineering Korea Univ. Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Korea Republic of Korea Republic of

In this paper, we have developed cell chip employing polymeric nanofiber membrane which was used for the better diffusion of nutrition or other materials suchas growth factor and for the scaffold of cell culture, and we evaluated the function of this chip by culturing the human mesenchymal stem cells (hMSCs) which have large potential applications in the tissue engineering. © 2006 Society for Chemistry and Micro-Nano Systems.

关键词： Cell culture

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Two unconstrained methods for blood pressure monitoring in a ubiquitous home healthcare

Two unconstrained methods for blood pressure monitoring in a...

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5th IASTED International Conference on biomedical engineering, BioMED 2007

作者： Jung, Soo Kim Ko, Keun Kim Yong, Gyu Lim Kwang, Suk Park Interdisciplinary Program in Biomedical Engineering Seoul National University Korea Republic of Advanced Biometric Research Center Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

We proposed two unconstrained methods for blood pressure monitoring in a ubiquitous home healthcare. Instead of a conventional oscillometric method, unconstrained pulse arrival time was used. Pulse arrival time is the time delay between Electrocardiogram (ECG) and Photoplethysmogram (PPG). In first method, ECG and PPG could be unconstrainedly obtained in a computer desk environment. In second method, ECG and PPG could be measured in a toilet seat unconstrainedly. The relationship between systolic blood pressure and pulse arrival time was investigated with several experiments. Additionally, the potential of pulse arrival time for blood pressure monitoring was validated in a practical application in a daily life. It showed that these methods were useful for the long term monitoring in a telemedicine.

关键词： Electrocardiograms

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