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Analysis of blood and dialysate flow in a hemodialyzer by perfusion computed tomography

Analysis of blood and dialysate flow in a hemodialyzer by pe...

World Congress on Medical Physics and biomedical engineering: Diagnostic and Therapeutic Instrumentation, Clinical engineering

作者： Kim, J.C. Kim, J.H. Kim, H.-C. Kang, E. Ronco, C. Kim, H.C. Institute of Medical and Biological Engineering College of Medicine Seoul National University Seoul Korea Republic of Interdisciplinary Program in Bioengineering Major Seoul National University Seoul Korea Republic of Department of Radiology Seoul National University Hospital Seoul Korea Republic of Department of Internal Medicine Chung-Ang University Hospital Seoul Korea Republic of Vincenza Italy Department of Biomedical Engineering College of Medicine Seoul National University 28 Yeongeon-dong Jongno-gu Seoul 110-744 Korea Republic of

ISBN: (纸本)9783642038846

Perfusion computed tomography (PCT) is a means to rapidly and easily evaluate cerebral perfusion in patients presenting with acute stroke symptoms, which pro-vides insights into capillary-level hemodynamics. In this study, we used PCT to analyze the 3-dimensional blood and dialysate flow in a low-flux hemodialyzer equipped with a standard fiber bundle. The dynamic CT studies were performed with 64-channel multi-detector row CT (MDCT) at a dialysate flow rate of 500 ml/min and a 1.0 ml/sec injection rate of contrast agent. Central volume principle was used to calculate hydro-dynamic parameters by deconvolution of time-density curves (TDCs). Functional maps of PCT parameters quantitatively described the blood and dialysate flow maldistribution, varia-tions in fiber packing, and perfusion pressure distribution in a hemodialyzer. PCT was able to overcome the limitations of conventional imaging techniques for analyzing dialysate flow distributions in hollow-fiber dialyzers. Therefore, PCT is a quantitative analysis method to provide better insights into hemodynamics of hollow-fiber dialyzers and is expected to contribute to optimization of artificial kidneys. © 2009 Springer-Verlag.

关键词： Computerized tomography

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Personal dialysis using a web-based, portable system - C-PAK (Carry-on Pulse Artificial Kidney)

Personal dialysis using a web-based, portable system - C-PAK...

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BIODEVICES 2008 - 1st International Conference on biomedical Electronics and Devices

作者： Lee, Jung Chan Kim, Wook Eun Lim, Ki Moo Kim, Jeong Chul Min, Byoung Goo Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Biomedical Engineering Seoul National University Seoul Korea Republic of

ISBN: (纸本)9789898111173

While the number of patients suffering from acute and chronic renal failure has been steadily increasing every year, the mortality rate is not improving. For the purpose of improvement on the quality of life and mortality of renal disease patients, we employ the hemofiltration principle to treat the end-stage renal disease patients. Hemofiltration equipment can be installed without additional plumbing and electrical power construction;operated only with several pre-packaged fluid bags without a huge water treatment facility. This paper describes the development of portable renal treatment equipment based on hemofiltration treatment, Carry-on Pulse Artificial Kidney (C-PAK), and reports the results of animal test using the equipment. The web-based remote monitor/control system for C-PAK is introduced also. We expect that our portable hemofiltration device for chronic renal failure patient would be an alternative for conventional hemodialysis machine and a solution to home renal treatment.

关键词： Diseases

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Ionic Circuits Based on Polyelectrolyte Diodes on a Microchip†

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Angewandte Chemie 2009年第21期121卷

作者： Ji‐Hyung Han Kwang Bok Kim Hee Chan Kim Taek Dong Chung Department of Chemistry Seoul National University Seoul 151‐747 (Korea) Fax: (+82) 887‐4354 http://www.niel.or.kr/ Interdisciplinary Program Bioengineering Major Seoul National University Seoul 110‐744 (Korea) Department of Biomedical Engineering College of Medicine and Institute of Medical and Biological Engineering Medical Research Center Seoul National University Seoul 110‐744 (Korea)

Bei Grün gehen : Eine Polyelektrolytdiode auf einem Mikrochip zeigt ein eindeutiges nichtlineares Gleichrichterverhalten. Mit diesem System lässt sich in Echtzeit die dynamische Verteilung von Ionen in einer geladenen Polymerphase im elektrischen Feld mithilfe von Fluoreszenzbildern visualisieren. Mehrere Polyelektrolytdioden wurden auf einem Mikrochip integriert, um vielfältige Logikgatter auf Basis ionischer Schaltkreise herzustellen (siehe Bild).

关键词： Fluoreszenz Gleichrichter Ionische Schaltkreise Mikrochips Polyelektrolyte

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Application of an elastic biodegradable poly(L-lactide-co-Ε- caprolactone) scaffold for cartilage tissue regeneration

Application of an elastic biodegradable poly(L-lactide-co-Ε...

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作者： Jung, Youngmee Kim, Soo Hyun You, Hee Jin Kim, Sang-Heon Ha Kim, Young Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O. Box 131 Cheongryang Seoul 136-650 Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology Gwangju Korea Republic of Department of Biomedical Engineering Seoul National University Seoul Korea Republic of

In cartilage tissue regeneration, it is important that an implant inserted into a defect site can maintain its mechanical integrity and endure stress loads from the body, in addition to being biocompatible and able to induce tissue growth. These factors are crucial in the design of scaffolds for cartilage tissue engineering. We developed an elastic biodegradable scaffold from poly(L-lactideco-Ε-caprolactone) (PLCL) for application in cartilage treatment. Biodegradable PLCL co-polymer was synthesized from L-lactide and Ε-caprolactone in the presence of stannous octoate as a catalyst. A highly elastic PLCL scaffold was fabricated by a gel-pressing method with 80% porosity and 300-500 μm pore size. The tensile mechanical and recovery tests were performed in order to examine mechanical and elastic properties of the PLCL scaffold. They could be easily twisted and bent and exhibited almost complete (over 94%) recoverable extension up to breaking point. For examining cartilaginous tissue formation, rabbit chondrocytes were seeded on scaffolds. They were then cultured in vitro for 5 weeks or implanted in nude mice subcutaneously. From in vitro and in vivo tests, the accumulation of extracellular matrix on the constructs showed that chondrogenic differentiation was sustained onto PLCL scaffolds. Histological analysis showed that cells onto PLCL scaffolds formed mature and well-developed cartilaginous tissue, as evidenced by chondrocytes within lacunae. From these results, we are confident that elastic PLCL scaffolds exhibit biocompatibility and as such would provide an environment where cartilage tissue growth is enhanced and facilitated. © 2008 VSP.

关键词： Tissue regeneration

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Cartilaginous tissue formation using human adipose tissue derived stromal cells and TGF-β1 loaded functional nanoparticle-hydrogel-PLCL complex

Cartilaginous tissue formation using human adipose tissue de...

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8th World Biomaterials Congress 2008, WBC 2008

作者： Jung, Youngmee Kim, Soo Hyun Chung, Yong-Il Tae, Giyoong Kim, Sang-Heon Kim, Young Ha Lee, Jong Won Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology Seoul Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology Gwangju Korea Republic of Department of Plastic Surgery Catholic University of Korea Seoul Korea Republic of Department of Biomedical Engineering Seoul National University Seoul Korea Republic of

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Cell chip to monitor the influence of electric field on the human mesendhymal stem cells 11

Cell chip to monitor the influence of electric field on the ...

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11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

作者： Kwon, Gu-Han Lee, Kwang Ho Lee, Eun-Joong Lee, Sang-Hoon Department of Biomedical Engineering College of Medicine Korea University Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Korea Republic of

ISBN: (纸本)9780979806407

A new micro cell chip which can induce stem cells to differentiate into specific body cell types has been designed and fabricated for tissue engineering. This paper presents the fabrication and preliminary test results of a MEMS cell electric stimulator. It provides a new tool of cell electric stimulation, culture and analysis for stem cell research. This study provides the controlling proliferation as well as morphology of human mesenchymal stem cell on the microchip. DC 1V, 5V, 12V, AC 5V, 1 Hz, 1K Hz, 1M Hz were compared with electric stimulation for their impact on the expansion and morphology of mesenchymal stem cells (MSCs). It provides a new generation of cell culture, stimulation and analysis devices for stem cell research and tissue engineering. © 2007 CBMS.

关键词： Stem cells

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Cartilage tissue engineering using a elastic poly (L-lactide-co-Ε- caprolactone) scaffold

Cartilage tissue engineering using a elastic poly (L-lactide...

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作者： Jung, Youngmee Kim, Soo Hyun Kim, Sang-Heon Kim, Young Ha Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O.Box 131 Cheongryang Seoul 130-650 Korea Republic of Interdisciplinary Program Medical and Biological Engineering Major Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology 1 Oryang Buk Gwangju 500-712 Korea Republic of Department of Biomedical Engineering Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of

Mechano-active scaffolds were fabricated from very elastic poly(L-lactide-co-Ε-carprolactone). The scaffolds with 80% porosity and 300-500 um pore size were prepared by a gel-pressing method. As a control group for elastic properties of polymer scaffolds, rigid poly L-lactide scaffolds were fabricated. The scaffolds were seeded with chondrocytes and cultured to evaluate the effect of elastic properties of polymer scaffolds for the differentiation and the ECM secretion of chondrocytes. Also, the chondrocytes-seeded constructs were implanted in nude mice subcutaneously to investigate their biocompatibility and cartilage formation. From the biochemical analyses, chondrogenic differentiation was sustained and enhanced significantly and chondral extracellular matrix was increased through mechanical stimulation of dynamic environment in the dynamic body systems. Histological analysis showed that implants of PLCL constructs formed mature and well-developed cartilaginous tissue, as evidenced by chondrocytes within lacunae. Consequently, the elastic PLCL scaffolds could be used to engineer cartilage in mechanically dynamic environments.

关键词： Cartilage

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Cartilaginous tissue formation with an elastic PLCL scaffold and human adipose tissue-derived stromal cells

Cartilaginous tissue formation with an elastic PLCL scaffold...

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作者： Lee, So Eun Jung, Youngmee Kim, Soo Hyun Kim, Sang-Heon Rhie, Jong Won Kim, Young Ha Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O. Box 131 Cheonryang Seoul 130-650 Korea Republic of Interdisciplinary Program Medical and Biological Engineering Major Seoul National University 28 Yeongeon Jongro Seoul 110-744 Korea Republic of Department of Plastic Surgery Catholic University 505 Banpo Seocho Seoul 137-701 Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology 1 Oryong- Buk Gwangju 500-712 Korea Republic of Department of Biomedical Engineering Seoul National University 28 Yeongeon Jongro Seoul 110-744 Korea Republic of

In cartilage tissue engineering, as a cell source, adult stem cells are very attractive for clinical applications. Recent studies suggest that human adipose tissue-derived stromal cells (ASCs) have multilineage potential similar to bone marrow-derived stromal cells (BMSCs). ASCs are obtained from adipose tissue easily isolated by suction-assisted lipectomy in various body parts. Also, as one of major factors of cartilage tissue engineering, scaffolds have an important role in cartilage formation. Poly(L-lactide-co-Ε-carprolactone) scaffolds have physiological activity, biodegradability, high cell affinity, and mechano-activity. The object of this study is cartilaginous tissue formation using highly elastic PLCL scaffolds and ASCs in vitro and in vivo. Poly(L-lactide-co-Ε-carprolactone) copolymers were synthesized from lactide and Ε-carprolactone in the presence of stannous octoate as catalyst. The scaffolds with 85% porosity and 300-500μm pore size were fabricated by gel-pressing method. ASCs were seeded on scaffolds and cultured for 21days in vitro. Cell/polymer constructs were characterized by reverse transcriptase-polymerase chain reaction for confirming differentiation to chondrocytes onto PLCL scaffolds. Also, for examining cartilaginous tissue formation in vivo, ASCs seeded scaffolds which were induced chondrogenesis for 2 weeks were implanted in nude mice subcutaneously for up to 8weeks. Histological studies showed that implants partially developed cartilaginous tissue within lacunae. And there was an accumulation of sulfated glycoaminoglycans. Immunohistochemical analysis revealed that implants were positively stained for specific extracellular matrix. These results indicate that ASCs and PLCL scaffols could be used to cartilage tissue engineering.

关键词： Tissue engineering

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Mechano-active cartilage tissue engineering: The effect of dynamic compressive stimulation

Mechano-active cartilage tissue engineering: The effect of d...

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作者： Jung, Youngmee Kim, Soo Hyun Kim, Sang-Heon Kim, Young Ha Xie, Jun Matsuda, Takehisa Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O.Box 131 Cheongryang Seoul 130-650 Korea Republic of Interdisciplinary Program Medical and Biological Engineering Major Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology 1 Oryang Buk Gwangju 500-712 Korea Republic of Department of Orthopaedic Surgery School of Medicine Fukuoka University 8-19-1 Nanakuma Jonan Fukuoka 814-0180 Japan Genome and Biomedical Engineering Laboratory Kanazawa Institute of Technology 7-1 Ohgigaoka Nonoichi Ishikawa 921 - 8501 Japan Department of Biomedical Engineering Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of

Mechano-active scaffolds were fabricated from very elastic poly(lactide-co-carprolactone) by a gel-pressing method. The scaffolds were seeded with bone marrow stromal cells and the continuous compressive deformation was applied to cell-polymer constructs in the chondrogenic media. Then, they were implanted in nude mice subcutaneously to evaluate for the effect of dynamic compression for regeneration of cartilage. From the biochemical analyses, chondrogenic differentiation was sustained and enhanced significantly and chondral extracellular matrix was increased through mechanical stimulation. Histological analyses showed that implants stimulated mechanically formed mature and well-developed cartilaginous tissue, as evidenced by bone marrow derived chondrocytes within lacunae. Consequently, the periodic application of dynamic compression can encourage bone marrow stromal cells to differentiation to chondrogenic lineage and to maintain their phenotypes.

关键词： Cartilage

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Microfluidic cell culture chip employing polymeric nanofiber membrane

Microfluidic cell culture chip employing polymeric nanofiber...

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10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006

作者： Kim, Sung Rak Lee, Ki Hwa Lee, Kwang Ho Baek, Ju Yeoul Park, Yong Doo Sun, Kyung Lee, Sang Hoon Dept. of Biomedical Engineering Korea Univ. Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Korea Republic of Korea Republic of

In this paper, we have developed cell chip employing polymeric nanofiber membrane which was used for the better diffusion of nutrition or other materials suchas growth factor and for the scaffold of cell culture, and we evaluated the function of this chip by culturing the human mesenchymal stem cells (hMSCs) which have large potential applications in the tissue engineering. © 2006 Society for Chemistry and Micro-Nano Systems.

关键词： Cell culture

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