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9th World Congress on Medical Informatics, MedInfo 1998

作者： Yi, Won Jin Park, Kwang Suk Paick, Jae Seung Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Korea Republic of Department of Biomedical Engineering Seoul National University Korea Republic of Departmemt of Urology Seoul National University Korea Republic of

ISBN: (纸本)9051994079

In male reproducible health and fertility and IVF (in-vitro fertilization), morphological analysis of sperm has been most important. But the traditional tools for semen analysis are subjective, imprecise, inaccurate, difficult to standardize, and reproduce mainly due to their manually oriented operations. The purpose of morphological analysis of sperm is to microscopically type-classify sperm according to their morphological characteristics of heads. Until now, the strict criteria method has long been used in clinic to discriminate normal sperm from abnormal. This method cannot classify the diverse groups of abnormal sperm in detail and shows large variations in inter-operators and intra-operator. In this paper, we have studied a new method of sperm morphological classification using artificial neural networks that are widely used in pattern recognition and image processing. With a multi-layer perceptron trained by the error back-propagation algorithm, profile features from digitized sperm images were classified into four classes that consisted of one normal group and three abnormal groups according to their morphological characteristics. © 1998 IMIA. All rights reserved.

关键词： Multilayer neural networks

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A novel artificial renal microchip employing polymeric nanofibers membrane

A novel artificial renal microchip employing polymeric nanof...

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10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006

作者： Lee, Kwang Ho Kim, Jae Gwan Kim, Duck Joong Lee, Sang Hoon Min, Byoung Goo Interdisciplinary Program in Biomedical Engineering Major Seoul National University Korea Republic of School of Mechanical and Aerospace Engineering Seoul National University Korea Republic of Dept. Biomedical Engineering College of Medicine Korea University Korea Republic of Dept. Biomedical Engineering College of Medicine Seoul National University Korea Republic of

In this study, a novel artificial renal replacement system is presented using a biocompatible polymeric nanofibers and MEMS technology. Usually, a classical artificial renal replacement system employs a semi-permeable membrane based hemodialyzer that replaces an ability of the kidney by removing metabolic toxins through diffusion and hydraulic pressure gradients. But, it has some limits in efficient filtration of metabolic byproducts (e.g.: urea, creatinine, and so on). We have developed PDMS based artificial renal microchips (AR chip) integrating biocompatible polymeric nanofibers which are utilized for the filtration of blood. Here, we demonstrate a novel artificial renal chip by integrating a high efficient biocompatible polymeric nanofibers membrane with the PDMS based micro-fluidic platform. Via the optimization of PDMS micro fluidic channel network and the multiple packaging of nanofibers membrane, we will realize the portable and wearable artificial kidney system. © 2006 Society for Chemistry and Micro-Nano Systems.

关键词： Nanofibers

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Registration of finger vein image using skin surface information for authentication

Registration of finger vein image using skin surface informa...

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Image Processing: Machine Vision Applications II

作者： Noh, SeungWoo Kong, Hyoun-Joong Park, SangYun Kim, JiMan Lee, Seung-Rae Kim, Taejeong Kim, Hee Chan Interdisciplinary Program Bioengineering Major Graduate School Seoul National University Seoul Korea Republic of Interdisciplinary Program Biomedical Engineering Major Graduate School Seoul National University Seoul Korea Republic of Institute of Medical and Biological Engineering Medical Research Center Seoul National University Seoul Korea Republic of Department of Electrical Engineering and Computer Sciences Seoul National University Seoul Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)9780819475015

The finger vein image acquired with an acquisition system should be properly aligned to proceed with comparing algorithm. However it is not easy to find control the points since the images are naturally blurred with an inherent scattering property. To overcome this problem, we propose a novel finger vein registration method utilizing skin surface information (i.e. wrinkles and outlines). We assumed that finger crooking was insignificant. Images were sampled with intended translation and rotation. Each time, two images were acquired successively by switching the light source;one with infrared light and the other with white light. Degree of rotation and translation of sampled image were calculated using outline features in the white light image and then the infrared image was transformed according to the calculated data. To validate our method, correlation values were computed between identical subjects and different subjects. High correlation values were shown between identical subjects whereas low values were shown between different subjects. © 2009 SPIE.

关键词： Authentication

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Development of Web-based remote monitoring system for the moving-actuator artificial heart

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ASAIO Journal 2000年第2期46卷 199-199页

作者： Chung, Jinhan Lee, Jihoon Jo, Yungho Min, ByoungGoo Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Department of Biomedical Engineering Seoul National University College of Medicine

The remote monitoring system including hemodynamic information and pump status of the implanted animal could be helpful during the in vivo experiment or clinical trial for an artificial heart implantation. In order to monitor the course of the in vivo experiment continuously and anywhere, web-based remote monitoring system was developed, which could be monitored pressures (AoP, LAP, RAP, PAP) and flow information as well as the pump operating conditions. The system consists of the several parts including data sending, storing, viewer part. The data sending part was constructed using component object model and the viewer part was constructed using the Java applet. In addition, the dialog box was introduced to communicate each other instantly and the alarming function was also introduced when the hemodynamic values were out of the desired ranges. The developed remote monitoring system was applied during the in vivo experiment of the VVAD implantation for 1 month and showed designed work without fail.

关键词： Heart valve prostheses

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Digital ionic circuits on a microfluidic chip

Digital ionic circuits on a microfluidic chip

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13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009

作者： Han, Ji-Hyung Kim, Kwang Bok Kim, Hee Chan Chung, Taek Dong Department of Chemistry Seoul National University Korea Republic of Interdisciplinary Program Bioengineering Major Graduate School Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)9780979806421

A sophisticatedly designed polyelectrolyte diode was fabricated on a microchip and exhibited well-defined nonlinear rectifying behavior. Multiple polyelectrolyte diodes were integrated on a microchip to produce a variety of logic gates based on ionic circuits. By employing a fluorescent dye, the polyelectrolyte micro plugs also acted as optical indicators displaying the input signals applied to individual diodes in the ionic circuit on a microchip. Also, this system visualized the dynamic distribution of ions in a charged polymer phase under an electric field on a real time basis through fluorescence images. © 2009 CBMS.

关键词： Polyelectrolytes

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Sleep Stage Scoring by EEG Spectral Information Based on Fuzzy Clustering Only

Sleep Stage Scoring by EEG Spectral Information Based on Fuz...

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The 4th ASRS Congress

作者： Jung-Su Oh Jin Woo Seo Byunghun Choi Do-Un Jeong Kwang-Suk Park Interdisciplinary Program-Biomedical Engineering Major Graduate School Seoul National University Interdisciplinary Program-Biomedical Engineering Major Graduate School Seoul National University Interdisciplinary Program-Biomedical Engineering Major Graduate School Seoul National University Department of Psychiatry and Behavioral Science Seoul National University College of Medicine and Division of Sleep Studies Seoul National University Hospital Department of Biomedical Engineering Seoul National University College of Medicine Seoul Republic of Korea

The quantity and quality of human sleep draw more attention as the society becomes more sophisticated. The unique and common method for evaluating human sleep is polysomnography (PSG) and it generates sleep architecture with functional variables. Sleep stages are nonuniform constituents of sleep architecture and each 30-second epoch should be scored accu-

关键词： EOG EMG Sleep Stage Scoring by EEG Spectral Information Based on Fuzzy Clustering Only Fuzzy

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Automatic stress-relieving music recommendation system based on photoplethysmography-derived heart rate variability analysis

Automatic stress-relieving music recommendation system based...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Il-hyung Shin Jaepyeong Cha Gyeong Woo Cheon Choonghee Lee Seung Yup Lee Hyung-Jin Yoon Hee Chan Kim Interdisciplinary Program Biomedical Engineering Major Graduate School Seoul National University Department of Electrical and Computer Engineering Johns Hopkins University Interdisciplinary Program Bioengineering Major Graduate School Seoul National University Department of Biomedical Engineering University of Michigan Department of Biomedical Engineering College of Medicine Seoul National University

ISBN: (纸本)9781424479276

This paper presents an automatic stress-relieving music recommendation system (ASMRS) for individual music listeners. The ASMRS uses a portable, wireless photoplethysmography module with a finger-type sensor, and a program that translates heartbeat signals from the sensor to the stress index. The sympathovagal balance index (SVI) was calculated from heart rate variability to assess the user's stress levels while listening to music. Twenty-two healthy volunteers participated in the experiment. The results have shown that the participants' SVI values are highly correlated with their prespecified music preferences. The sensitivity and specificity of the favorable music classification also improved as the number of music repetitions increased to 20 times. Based on the SVI values, the system automatically recommends favorable music lists to relieve stress for individuals.

关键词： Heart rate variability Stress Recommender systems Indexes Multiple signal classification Educational institutions Music

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Indirect ophthalmoscopic stereo video system using three-dimensional LCD

Indirect ophthalmoscopic stereo video system using three-dim...

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Stereoscopic Displays and Applications XX

作者： Kong, Hyoun-Joong Seo, Jong Mo Hwang, Jeong Min Kim, Hee Chan Interdisciplinary Program Biomedical Engineering Major Graduate School Seoul National University Seoul Korea Republic of Department of Electrical Engineering and Computer Sciences Seoul National University Seoul Korea Republic of Department Ophthalmology College of Medicine Seoul National University Seoul Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

Binocular indirect ophthalmoscope (BIO) provides a wider view of fundus with stereopsis contrary to the direct one. Proposed system is composed of portable BIO and 3D viewing unit. The illumination unit of BIO utilized high flux LED as a light source, LED condensing lens cap for beam focusing, color filters and small lithium ion battery. In optics unit of BIO, beam splitter was used to distribute an examinee's fundus image both to examiner's eye and to CMOS camera module attached to device. Captured retinal video stream data from stereo camera modules were sent to PC through USB 2.0 connectivity. For 3D viewing, two video streams having parallax between them were aligned vertically and horizontally and made into side-by-side video stream for cross-eyed stereoscopy. And the data were converted into autostereoscopic video stream using vertical interlacing for stereoscopic LCD which has glass 3D filter attached to the front side of it. Our newly devised system presented the real-time 3-D view of fundus to assistants with less dizziness than cross-eyed stereoscopy. And the BIO showed good performance compared to conventional portable BIO (Spectra Plus, Keeler Limited, Windsor, UK). © 2009 SPIE-IS&T.

关键词： Stereo image processing

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Measurements of absorption coefficients within biological tissue in vitro

Measurements of absorption coefficients within biological ti...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Nam Jung Kim Hyun Soo Lim Interdisciplinary Program of Biomedical Engineering Major Chungnam National University South Korea Department of Biomedical Engineering College of Medicine Chungnam National University South Korea

The authors have examined the absorption coefficients of biological tissue in vitro. To develop the medical instruments for most applications, they have used as a light source the specific fixed wavelengths of lasers. So there are some restrictions while using the optical properties of biological tissue. To broaden the selection of wavelength, the authors experimented with 660/spl sim/940 nm on the highly scattering turbid medium to find out optical properties. The results shows that the absorption coefficients are different depending on wavelength and for each biological tissue.

关键词： Biological tissues In vitro Optical scattering biomedical optical imaging Optical sensors Light scattering Light sources X-ray scattering Electromagnetic wave absorption Equations

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A study on the modeling of nonlinear system using genetic programming

A study on the modeling of nonlinear system using genetic pr...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Boyeon Kim Kwangsuk Park Interdisciplinary Program of Biomedical Engineering Major Seoul National University South Korea Department of Biomedical Engineering College of Medicine Seoul National University South Korea

Even though there are several deterministic methods for the modeling of linear systems, there is no standard method for the modeling of nonlinear systems. Most biological systems can be thought of as nonlinear systems. For the modeling of biological systems the authors have studied nonlinear systems using genetic programming. Time series were generated from the simple known nonlinear dynamics. Then nonlinear dynamics was estimated from these time series using genetic programming. For the tested nonlinear systems this suggested method estimated the nonlinear dynamics correctly. This method also has been applied for the modeling of the dynamics of the 24-hour electrocardiogram.

关键词： Nonlinear systems Genetic programming Nonlinear equations Dynamic programming Time measurement Biological system modeling Nonlinear dynamical systems Biological systems Genetic mutations Biological cells

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