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Environmental Chromium Exposure Drives Osteoarthritis Pathogenesis via NF-κB–Hif-2α/Zip8 Signaling in Articular Cartilage

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Osteoarthritis and Cartilage 2025年 33卷 S376-S377页

作者： Dinesh Suminda Godagama Gamaarachchige Yunhui Min Yunji Heo minhye Kim myeongyeon shin Md. M. Ansari Young-Ok Son Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University Jeju Korea(the Republic of) Animal biothchnology jeju national university Jeju-si Korea(the Republic of) Next Generation Convergence Science and Technology Cooperative Course Jeju National University Jeju Korea (the Democratic People's Republic of) Department of Animal Biotechnology Jeju National University Jeju Jeju self-governing Province Korea (the Republic of)

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Synovial chondromatosis of the foot: Two case reports and literature review

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World Journal of Orthopedics 2019年第11期10卷 404-415页

作者： Luca Monestier Giacomo Riva Placido Stissi Mahfuz Latiff Michele Francesco Surace Orthopedic and Trauma Unit ASST Settle LaghiVarese 21100Italy Residency Program in Orthopedics and Trauma University of InsubriaVarese 21100Italy Interdisciplinary Research Centre for Pathology and Surgery of the Musculoskeletal System Department of Biotechnology and Life SciencesUniversity of InsubriaVarese 21100Italy

BACKGROUND Primary synovial chondromatosis(PSC) is a rare arthropathy of the synovial joints characterized by the formation of cartilaginous nodules, which may detach and become loose bodies within the joint and may undergo secondary proliferation. PSC of the foot and ankle is exceedingly rare, with only a few cases reported in the literature. The diagnosis may be difficult and delayed until operative treatment, when it is confirmed by histological assessment. PSC may degenerate into chondrosarcoma. Operative treatment is the gold standard aiming to minimize pain, improve function, prevent or limit progression of arthritis. Surgical treatment consists in debridement by arthrotomic or arthroscopic management, but there is no consensus in the literature about timing of surgery and surgical technique. Thus, the aim of this study is to report the outcomes of the surgical treatment of two cases, together with a literature *** SUMMARY We report two cases of patients affected by PSC of the foot in stage III, according to the Milgram classification: the former PSC localized in the ankle that underwent open surgery consisted of loose bodies removal;the latter in the subtalar joint, and the choice of treatment was the arthrotomy and debridement from loose bodies, in addition to the subtalar arthrodesis. Both patients returned to complete daily and working life after *** Synovial chondromatosis is a rare benign pathology, even rarer in the ankle joint and especially in the foot. Surgery should be minimal in patients with ankle PSC,choosing the correct timing, waiting if possible until stage III. More aggressive and early surgery should be performed in patients with PSC of the foot,particularly the subtalar joint, due to the high risk of arthritic evolution.

关键词： Synovial chondromatosis Foot Ankle Review Treatment Case report

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Correction to: Simultaneous detection of four lily‑infecting viruses by a multiplex RT‑PCR assay

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Journal of General Plant Pathology 2021年第4期87卷 225-225页

作者： Lim, Mi Sang Min, Dong Joo Hong, Jin Sung Choi, Sun Hee Department of Horticulture Biotechnology and Landscape Architecture Seoul Women’s University Seoul Korea Interdisciplinary Program in Smart Agriculture Kangwon National University Chuncheon Korea

A correction to this paper has been published: https://***/10.1007/s10327-021-01008-7

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Harnessing microalgae to mitigate the environmental impact of the cement industry: Emission reduction and bio-cement production

Carbon Capture Science & Technology

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Carbon Capture Science & Technology 2025年 16卷

作者： Ve Van Le Maranda Esterhuizen Quynh-Giao Tran Jin-Ho Yun Man-Young Jung Sang-Ah Lee Faculty of Biotechnology College of Applied Life Sciences Jeju National University 102 Jejudaehak-Ro Jeju 63243 South Korea University of Helsinki Ecosystems and Environment Research Programme Faculty of Biological and Environmental Sciences Niemenkatu 73 Lahti 15140 Finland Cell factory Research Centre Korea Research Institute of Bioscience & Biotechnology 125 Gwahak-ro Yuseong-gu Daejeon 34141 South Korea Department of Environmental Biotechnology KRIBB School of Biotechnology University of Science & Technology Daejeon 34113 South Korea Department of Integrative Biotechnology Sungkyunkwan University Suwon 16419 South Korea Interdisciplinary Graduate Program in Advance Convergence Technology and Science Jeju National University 102 Jejudaehak-ro Jeju 63243 South Korea Bio-Health Materials Core-Facility Center Jeju National University 102 Jejudaehak-ro Jeju 63243 South Korea Department of Biology Education Jeju National University Jeju 63243 South Korea

The cement industry has been the cornerstone of economic development since the Industrial Revolution. However, the calcination process used to produce cement raw materials releases various pollutants, such as carbon dioxide, nitrogen oxides, and sulfur oxides, which are key contributors to global warming. Therefore, innovative technologies are urgently needed to minimize the environmental impact of the cement industry. In recent years, microalgae have gained attention because of their advantages in recovering resources and reducing the impacts of industrial pollutants. The use of microalgae to address the environmental challenges associated with cement production remains largely overlooked in current reviews. This review summarizes the recent advances in the utilization of microalgae to address the environmental challenges posed by the cement industry. Microalgae offer two main pathways for environmental mitigation: the (i) production of bio-cement as an eco-friendly alternative for construction and (ii) conversion of cement flue gases into biomass feedstock with high-value downstream applications. We also identify existing challenges and propose an integrative “Microalgae–Bacteria Consortium” system as a sustainable strategy for the significant reduction of the environmental footprint of cement production. This approach has the potential to transform the cement industry into a more sustainable and eco-friendlier sector. Overall, microalgae provide an innovative and sustainable platform to revolutionize the cement industry into a greener sector, supporting the global shift toward a low-carbon, circular economy.

关键词： Microalgae–bacteria consortium Microalgae Cement calcination Bio-cement Flue gas Sustainable construction Greenhouse gas

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Metabolic Engineering of Yarrowia lipolytica for Enhanced Production of Naringenin-Derived Flavonoids: Apigenin and Acacetin

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Journal of agricultural and food chemistry 2025年第23期73卷 2025 May 29页

作者： Nahye Park Yangsub Ham Seungwoo Cha Byeongseon Jang Gyeongmin Kim Seung-Ho Baek Ji-Sook Hahn Interdisciplinary Program for Biochemical Engineering and Biotechnology Seoul National University 1 Gwanak-ro Gwanak-gu Seoul 08826 Republic of Korea. Department of Chemical and Biological Engineering Institute of Chemical Processes Seoul National University 1 Gwanak-ro Gwanak-gu Seoul 08826 Republic of Korea. Center for Bio-Based Chemistry Korea Research Institute of Chemical Technology (KRICT) Ulsan 44429 Republic of Korea.

Apigenin and acacetin are flavonoids with potent antioxidant, anti-inflammatory, and anticancer activities, making them attractive for pharmaceutical and nutraceutical applications. However, their low natural abundance presents a challenge to large-scale production. In this study, we engineered for the biosynthesis of apigenin and acacetin from naringenin. To enhance naringenin production from l-tyrosine, we introduced four heterologous genes, optimized the flux through the l-tyrosine pathway, and eliminated the competing homogentisate pathway. Malonyl-CoA availability was increased by downregulating (fatty acid synthase 1), while erythrose-4-phosphate levels were elevated through overexpression of (transketolase 1). Additionally, genes encoding flavone synthase and flavonoid 4'-O-methyltransferase were integrated to convert naringenin into apigenin, and subsequently apigenin into acacetin. Under fed-batch fermentation with an optimized carbon-to-nitrogen ratio, acacetin production reached 1.10 g/L─the highest titer reported to date in a microbial system. These results highlight as a promising chassis for scalable flavonoid biosynthesis.

关键词： Yarrowia lipolytica acacetin apigenin flavonoids naringenin

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Integrated synchrotron radiation-based fourier transform infrared (SR-FTIR) microscopy and tandem-mass spectrometry (LC-MS/MS) used to elucidate the apoptotic effect of chamuangone in A549 cells

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Biochemical and Biophysical Research Communications 2025年 764卷 151826页

作者： Wanaragthai, Panatda Yingchutrakul, Yodying Panichayupakaranant, Pharkphoom Vongsvivut, Jitraporn Aonbangkhen, Chanat Yang, Meng Chieh Maiuthed, Arnatchai Chanvorachote, Pithi Wood, Bayden R. Choowongkomon, Kiattawee Krobthong, Sucheewin Interdisciplinary Program of Genetic Engineering and Bioinformatics Kasetsart University Bangkok Thailand National Center for Genetic Engineering and Biotechnology NSTDA Pathum Thani 12120 Thailand Phytomedicine and Pharmaceutical Biotechnology Excellence Center Faculty of Pharmaceutical Sciences Prince of Songkla University Hat-Yai Thailand ANSTO-Australian Synchrotron 800 Blackburn Road Clayton Victoria Australia Center of Excellence in Natural Products Chemistry (CENP) Department of Chemistry Faculty of Science Chulalongkorn University Bangkok 10330 Thailand Department of Anatomy Faculty of Medicine Srinakharinwirot University Bangkok 10110 Thailand Centre of Biopharmaceutical Science for Healthy Ageing Faculty of Pharmacy Mahidol University Bangkok 10400 Thailand Department of Pharmacology Faculty of Pharmacy Mahidol University Bangkok 10400 Thailand Center of Excellence in Cancer Cell and Molecular Biology Faculty of Pharmaceutical Sciences Chulalongkorn University Bangkok 10330 Thailand Department of Pharmacology and Physiology Faculty of Pharmaceutical Sciences Chulalongkorn University Bangkok 10330 Thailand Bio-spectroscopy Group School of Chemistry Monash University Clayton Victoria 3800 Australia Department of Biochemistry Faculty of Science Kasetsart University Bangkok Thailand

Chamuangone, a natural compound extracted from Garcinia cowa leaves, has demonstrated potential in cancer therapeutics, but its effects on lung cancer cells remain unclear. This study investigates the apoptotic effects of Chamuangone on human lung adenocarcinoma cells (A549). The A549 cells were treated with Chamuangone, and the cytotoxic effects were evaluated using an MTT assay, revealing a dose-dependent inhibition of cell proliferation with an IC₅₀ value of 19.43 μM. Annexin V assays further confirmed that Chamuangone induces apoptosis in A549 cells, showing increased levels of late apoptosis with higher concentrations. Synchrotron radiation-based Fourier transform infrared (SR-FTIR) microscopy provided insights into macromolecular changes, highlighting significant alterations in proteins, lipids, and nucleic acids. These structural changes in key cellular macromolecules were supported by proteomic analysis, which identified the upregulation of apoptosis-related proteins, including Peroxiredoxin-2 and Na⁺/H⁺ exchange regulatory cofactor NHE-RF1. Canonical pathway analysis indicated that Chamuangone affects oxidative phosphorylation and mitochondrial dysfunction, both crucial pathways for apoptosis. Additionally, upstream regulator analysis demonstrated significant inhibition of the epidermal growth factor receptor (EGFR), a key player in lung cancer progression. These findings suggest that Chamuangone triggers apoptosis through mitochondrial pathways and EGFR inhibition, positioning it as a promising therapeutic candidate for lung cancer treatment. © 2025 Elsevier Inc.

关键词： Epidermal growth factor receptor Garcinia cowa Mitochondrial dysfunction Oxidative phosphorylation Proteomics

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Efficient ( S )-acetoin production in Saccharomyces cerevisiae by modulating α-acetolactate decarboxylase stereospecificity

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Bioresource Technology 2025年 434卷

作者： Seungwoo Cha Byeongseon Jang Daeyeol Lee Injae Cho Wooyoung Park Youngmin Lee Hyesoo Shin Minyoung Kim Changmin Sung Ji-Sook Hahn Department of Chemical and Biological Engineering Institute of Chemical Processes Seoul National University 1 Gwanak-ro Gwanak-gu Seoul 08826 Republic of Korea Doping Control Center Korean Institute of Science and Technology 5 Hwarang-ro 14-gil Seongbuk-gu Seoul 02792 Republic of Korea Interdisciplinary Program for Biochemical Engineering and Biotechnology Seoul National University 1 Gwanak-ro Gwanak-gu Seoul 08826 Republic of Korea

Acetoin, a four-carbon α-hydroxyketone with a chiral center, exists as two stereoisomers—( R )- and ( S )-acetoin—both of which hold potential pharmaceutical applications. While microbial production of ( R )-acetoin has been well studied, fermentative production of ( S )-acetoin remains limited due to its reliance on non-enzymatic spontaneous decarboxylation of unstable intermediates. As a result, costly precursors like diacetyl or 2,3-butanediol are often used, posing challenges for economic scale-up. In this study, we engineered Saccharomyces cerevisiae to produce stereospecific ( S )-acetoin directly from glucose, a low-cost and abundant carbon source. The native racemic acetoin pathway was eliminated by disrupting pyruvate decarboxylase (PDC) activity, and the stereospecificity of Bacillus subtilis α-acetolactate decarboxylase (ALDC), which naturally favors ( R )-acetoin, was engineered to preferentially produce ( S )-acetoin. Oxygen uptake was genetically enhanced to support efficient conversion of intermediates and suppress byproducts. This work established a novel, enzyme-driven pathway for ( S )-acetoin biosynthesis with over 90% enantiomeric purity, without the addition of chemical compounds.

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BPS2025 - Artificial intelligence enabled image analysis of genomic DNA visualized under electron microscopy using nanoparticle-tagged peptides

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Biophysical Journal 2025年第3期124卷 311a-312a页

作者： Priyannth Ramasami Sundharbaabu Junhyuck Chang Yunchul Kim Youmin Shim Byoungsang Lee Chanyoung Noh Sujung Heo Seung S. Lee Sang-Hee Shim Kwang-il Lim Kyubong Jo Jung H. Lee Department of Advanced Materials Science and Engineering Sungkyunkwan University Suwon-si Republic of Korea Department of Chemistry and Interdisciplinary Program of Integrated Biotechnology Sogang University Seoul Republic of Korea School of Chemistry and Chemical Engineering University of Southampton Southampton United Kingdom Department of Chemistry Korea University Seoul Republic of Korea Department of Chemical and Biological Engineering Sookmyung Women’s University Seoul Republic of Korea Department of MetaBioHealth Sungkyunkwan University Suwon-si Republic of Korea

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The potency of hydrothermally prepared sulfated silica (SO4/SiO2) as a heterogeneous acid catalyst for ethanol dehydration into diethyl ether

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Chemosphere 2023年第1期341卷

作者： Pratika, Remi Ayu Wijaya, Karna Utami, Maisari Mulijani, Sri Patah, Aep Alarifi, Saud Ram Mani, Ravishankar Kumar Yadav, Krishna Ravindran, Balasubramani Chung, Woo Jin Chang, Soon Woong Munusamy-Ramanujam, Ganesh Study Program of Chemistry Faculty of Mathematics and Natural Sciences Universitas Palangka Raya Palangka Raya Indonesia Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Gadjah Mada Yogyakarta55281 Indonesia Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Islam Indonesia Yogyakarta55584 Indonesia Department of Chemistry Faculty of Mathematics and Natural Sciences Institut Pertanian Bogor Bogor Indonesia Department of Chemistry Faculty of Mathematics and Natural Sciences Institut Teknologi Bandung Bandung Indonesia Department of Zoology College of Science King Saud University P.O. Box 2455 Riyadh11451 Saudi Arabia Department of Pharmaceutical Biology Faculty of Pharmaceutical Sciences UCSI University Cheras Taman Connaught Kuala Lumpur56000 Malaysia Faculty of Science and Technology Madhyanchal Professional University Ratibad Bhopal462044 India Environmental and Atmospheric Sciences Research Group Scientific Research Center Al-Ayen University Thi-Qar Nasiriyah 64001 Iraq Department of Environmental Energy and Engineering Kyonggi University Yeongtong-Gu Gyeonggi-Do Suwon16227 Korea Republic of Department of Medical Biotechnology and Integrative Physiology Institute of Biotechnology Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences Thandalam Tamil Nadu Chennai602105 India Molecular Biology and Immunobiology Division Interdisciplinary Institute of Indian System of Medicine SRM-IST Tamil Nadu Kattankulathur603203 India

The dehydration of ethanol into diethyl ether over a SO4/SiO2 catalyst was investigated. The SO4/SiO2 catalysts were prepared by the sulfation method using 1, 2, and 3 M of sulfuric acid (SS1, SS2, and SS3) via hydrothermal treatment. This study is focused on the synthesis of a SO4/SiO2 catalyst with high total acidity that can be subsequently utilized to convert ethanol into diethyl ether. The total acidity test revealed that the sulfation process increased the total acidity of SiO2. The SS2 catalyst (with 2 M sulfuric acid) displayed the highest total acidity of 7.77 mmol/g, whereas the SiO2 total acidity was only 0.11 mmol/g. Meanwhile, the SS3 catalyst (with 3 M sulfuric acid) has a lower total acidity of 7.09 mmol/g due to the distribution of sulfate groups on the surface having reached its optimum condition. The crystallinity and structure of the SS2 catalyst were not affected by the hydrothermal treatment or the sulfate process on silica. Furthermore, The SS2 catalyst characteristics in the presence of sulfate lead to a flaky surface in the morphology and non-uniform particle size. In addition, the surface area and pore volume of the SS2 catalyst decreased (482.56–172.26 m2/g) and (0.297–0.253 cc/g), respectively, because of the presence of sulfate on the silica surface. The SS2 catalyst's pore shape information explains the formation of non-uniform pore sizes and shapes. Finally, the activity and selectivity of SO4/SiO2 catalysts in the conversion of ethanol to diethyl ether yielded the highest ethanol conversion of 70.01% and diethyl ether product of 9.05% from the SS2 catalyst (the catalyst with the highest total acidity). Variations in temperature reaction conditions (175–225 °C) show an optimum reaction temperature to produce diethyl ether at 200 °C (11.36%). © 2023 Elsevier Ltd

关键词： Silica

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Accurate de novo design of membrane-traversing macrocycles

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四川生理科学杂志 2022年第8期44卷 1474-1474页

作者： Gaurav Bhardwaj Institute for Protein Design University of Washington Seattle WA 98195 USA Department of Medicinal Chemistry University of Washington Seattle WA 98195 USA Biological Physics Structure and Design program University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Molecular Cell and Biology program University of Washington Seattle WA 98195 USA Institute for Molecular Bioscience Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science The University of Queensland Brisbane QLD 4072 Australia Department of Chemistry and Chemical Biology and Center for Biotechnology and Interdisciplinary Sciences Rensselaer Polytechnic Institute Troy NY 12180 USA Molecular Engineering and Sciences Program University of Washington Seattle WA 98195 USA Departamento de Quίmica Fίsica Universidad de Valencia Avenida Dr. Moliner 50 Burjassot 46100 Valencia Spain Department of Medicine Division of Allergy and Infectious Disease University of Washington Seattle WA USA Department of Chemistry and Biochemistry University of California-Los Angeles Los Angeles CA USA Takeda Pharmaceuticals Inc. Cambridge MA USA Howard Hughes Medical Institute University of Washington Seattle WA 98195 USA

We use computational design coupled with experimental characterization to systematically investigate the design principles for macrocycle membrane permeability and oral *** designed 1846-12 residue macrocycles with a wide range of predicted structures containing noncanonical backbone modifications and experimentally determined structures of 35;29 are very close to the computational *** such control,we show that membrane permeability can be systematically achieved by ensuring all amide(NH)groups are engaged in internal hydrogen bonding interactions.84 designs over the 6-12 residue size range cross membranes with an apparent permeability greater than 1×10^(-6)cm/s.

关键词： residue cycles backbone

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