检索结果-内蒙古大学图书馆

science China Life sciences 2025年第5期68卷 1536-1540页

作者： Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I

The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integrating biological knowledge into models and even accelerating the development of new AI based on biological discoveries, the boundaries of both are constantly expanding, and their connections are becoming closer.

关键词：

来源：评论

学校读者我要写书评

暂无评论

VEGF family in cortical development

引用

Discover Neuroscience 2025年第1期20卷 1-20页

作者： Halim, Alexander Kuo, Hung-Chih Hou, Pei-Shan Taiwan International Graduate Program in Interdisciplinary Neuroscience College of Life Sciences National Yang Ming Chiao Tung University and Academia Sinica Taipei Taiwan Institute of Cellular and Organismic Biology Academia Sinica Taipei Taiwan Institute of Anatomy and Cell Biology College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Graduate Institute of Medical Genomics and Proteomics College of Medicine National Taiwan University Taipei Taiwan Institute of Brain Science College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Brain Research Center National Yang Ming Chiao Tung University Taipei Taiwan

Vascular endothelial growth factor (VEGF) has been extensively recognized as a crucial angiogenic factor that regulates both physiological and pathological blood vessel development in vascular endothelial cells (ECs). Emerging evidence indicates that VEGF and its receptors are also expressed in various non-EC types. Studies have shown that VEGF is secreted by neuroepithelial cells during neural tube formation in mouse embryonic day 8.5. This suggests that VEGF may have functions beyond angiogenesis, particularly in brain development. Additionally, the disruption of VEGF signaling has been linked to the development of cerebral cortical malformations, further supporting the potential role of VEGF in brain development. In this review, we summarize studies that elucidate the roles of VEGF signaling in regulating embryonic cortical neural progenitor expansion during early embryogenesis. We then explore the VEGF functions in promoting cortical neurogenesis and discuss the impact of the VEGF family on the regulation of the cerebrovascular system and cortical gliogenesis. Finally, we elaborate on the significance of the VEGF family in cortical-related disorders, noting that both deficiency and excessive expression of VEGF can adversely affect cortical development, resulting in cortical malformations. Overall, this review presents an updated and comprehensive understanding of the multifaceted regulatory roles of the VEGF family in the embryonic brain, offering insights into the underlying mechanisms of brain development.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Neuroprotective roles of SGLT2 and DPP4 inhibitors: Modulating ketone metabolism and suppressing NLRP3 inflammasome in T2D induced Alzheimer's disease

引用

Experimental Neurology 2025年 390卷 115271页

作者： Sim, A Young Kim, Jong Youl Lee, Yong-ho Lee, Jong Eun Department of Anatomy Yonsei University College of Medicine Seoul South Korea Department of Anatomy Catholic Kwandong University College of Medicine Gangneung South Korea Department of Internal Medicine Yonsei University College of Medicine Seoul South Korea Department of Systems Biology Glycosylation Network Research Center Yonsei University Seoul South Korea Interdisciplinary Program of Integrated OMICS for Biomedical Science Yonsei University Seoul South Korea of Medical Science Brain Korea 21 Project Yonsei University College of Medicine Seoul South Korea Brain Research Institute Yonsei University College of Medicine Seoul South Korea

Sodium-glucose cotransporter 2 inhibitor (SGLT2-i) and dipeptidyl peptidase-4 inhibitor (DPP4-i) are known to ameliorate Alzheimer's disease (AD)-like pathology and cognitive decline through distinct mechanisms. In this study, we investigated how these antidiabetic drugs elevate ketone levels and subsequently reduce amyloid-β (Aβ) and tau pathology via the NLR family pyrin domain containing 3 (NLRP3) inflammasome pathway in microglia, using a type 2 diabetes (T2D)-AD mouse model. Male C57BL/6 mice were fed a high-fat diet and injected with low doses of streptozotocin to establish a T2D-AD model. The mice were then treated with either SGLT2-i or DPP4-i. Our results revealed that both the inhibitors markedly enhanced brain ketone metabolism by upregulating key metabolic enzymes and transporters. They also reduced neuroinflammation by suppressing the expression of pro-inflammatory cytokines, such as IL-1β, and increasing the expression of the anti-inflammatory cytokine IL-4. A critical mechanism for this anti-inflammatory effect involved the inhibition of the expression of the NLRP3 inflammasome, a key driver of neuroinflammation. Notably, SGLT2-i appeared to inhibit NLRP3 inflammasome expression by disrupting the pTau-CX3C1 interaction, whereas DPP4-i exerted its effects through the Aβ-TLR4-NF-κB pathway. Moreover, our results showed that both the inhibitors promoted a shift in microglial activation from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, as indicated by the changes in CD206 and CD86 expression. These findings suggest that SGLT2-i and DPP4-i provide neuroprotective benefits through multiple mechanisms, including enhanced ketone metabolism, reduced neuroinflammation, and modulation of microglial activity in T2D-AD mouse model. This research offers a scientific basis for considering these inhibitors as potential therapeutic agents for neurodegenerative diseases, particularly in cognitive impairment patients with metabolic dysfunctio

关键词： Alzheimer's disease Neuroinflammation NLRP3 inflammasome Type 2 diabetes

来源：评论

学校读者我要写书评

暂无评论

Meter-scale heterostructure printing for high-toughness fiber electrodes in intelligent digital apparel

引用

Nature Communications 2025年第1期16卷 1-10页

作者： Lee, Gun-Hee Lee, Yunheum Seo, Hyeonyeob Jo, Kyunghyun Yeo, Jinwook Kim, Semin Bae, Jae-Young Kim, Chul Majidi, Carmel Kang, Jiheong Kang, Seung-Kyun Ryu, Seunghwa Park, Seongjun Medical Research Center Seoul National University Seoul South Korea Departments of Cogno-Mechatronics Engineering and Optics & Mechatronics Engineering Pusan National University Busan South Korea Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon South Korea Program of Brain and Cognitive Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon South Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon South Korea Graduate School of Semiconductor Technology Korea Advanced Institute of Science and Technology (KAIST) Daejeon South Korea Department of Materials Science and Engineering Seoul National University Seoul South Korea Department of Mechanical Engineering Carnegie Mellon University Pittsburgh PA United States Department of Chemistry Seoul National University Seoul Seoul South Korea School of Transdisciplinary Innovations Seoul National University Seoul South Korea Department of Biomedical Science College of Medicine Seoul National University Seoul South Korea Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul South Korea Department of Transdisciplinary Medicine Seoul National University Hospital Seoul South Korea

Intelligent digital apparel, which integrates electronic functionalities into clothing, represents the future of healthcare and ubiquitous control in wearable devices. Realizing such apparel necessitates developing meter-scale conductive fibers with high toughness, conductivity, stable conductance under deformation, and mechanical durability. In this study, we present a heterostructure printing method capable of producing meter-scale (~50 m) biphasic conductive fibers that meet these criteria. Our approach involves encapsulating deformable liquid metal particles (LMPs) within a functionalized thermoplastic polyurethane matrix. This encapsulation induces in situ assembly of LMPs during fiber formation, creating a heterostructure that seamlessly integrates the matrix’s durability with the LMPs’ superior electrical performance. Unlike rigid conductive materials, deformable LMPs offer stretchability and toughness with a low gauge factor. Through precise twisting using an engineered annealing machine, multiple fiber strands are transformed into robust, electrically stable meter-scale electrodes. This advancement enhances their practicality in various intelligent digital apparel applications, such as stretchable displays, wearable healthcare systems, and digital controls. © The Author(s) 2025.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Dopamine and acetylcholine correlations in the nucleus accumbens depend on behavioral task states

引用

Current Biology 2025年第6期35卷 1400-1407.e3页

作者： Costa, Kauê Machado Zhang, Zhewei Deutsch, Douglas Zhuo, Yizhou Li, Guochuan Li, Yulong Schoenbaum, Geoffrey National Institute on Drug Abuse Intramural Research Program National Institutes of Health Baltimore 21224 MD United States Department of Psychology University of Alabama at Birmingham Birmingham 35223 AL United States State Key Laboratory of Membrane Biology School of Life Sciences Peking University Beijing 100871 China PKU-IDG/McGovern Institute for Brain Research Beijing 100871 China Peking-Tsinghua Center for Life Sciences New Cornerstone Science Laboratory Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China Chinese Institute for Brain Research Beijing 102206 China Institute of Molecular Physiology Shenzhen Bay Laboratory Guangdong Shenzhen 518055 China National Biomedical Imaging Center Peking University Beijing 100871 China

Dopamine release in the nucleus accumbens (NAcc) changes quickly in response to errors in predicting events like reward delivery1,2,3 but also slowly ramps up when animals are moving toward a goal.4,5,6,7,8,9,10 This ... 详细信息

Dopamine release in the nucleus accumbens (NAcc) changes quickly in response to errors in predicting events like reward delivery¹^,²^,³ but also slowly ramps up when animals are moving toward a goal.⁴^,⁵^,⁶^,⁷^,⁸^,⁹^,¹⁰ This ramping has attracted much recent attention, as there is controversy regarding its computational role⁵^,⁷^,⁹^,¹¹ and whether they are driven by dopamine neuron firing⁷^,⁸^,⁹ or local circuit mechanisms.⁵^,⁶ If the latter is true, cholinergic transmission would be a prime candidate mechanism,¹²^,¹³^,¹⁴ and acetylcholine and dopamine signals should be positively correlated during behavior, particularly during motivated approach. However, in the dorsal striatum, striatal cholinergic interneurons typically “dip” their activity when reward or associated cues are presented, in opposition to dopamine,¹⁵^,¹⁶^,¹⁷^,¹⁸ and acetylcholine and dopamine release is generally anti-correlated in vivo.¹⁹^,²⁰ Furthermore, acetylcholine and dopamine have opposing effects on downstream striatal projection neurons (SPNs),²¹^,²² which suggests that cholinergic dips create a permissive window for dopamine to drive plasticity.²³ These studies therefore suggest that dopamine and acetylcholine should be anti-correlated during behavior. We tested between these hypotheses by simultaneously recording accumbal dopamine and acetylcholine signals in rats executing a task involving motivated approach. We found that dopamine ramps were not

关键词： acetylcholine approach dopamine fiber photometry instrumental motivation ramps rat reward prediction error salience

来源：评论

学校读者我要写书评

暂无评论

Self-packaged stretchable printed circuits with ligand-bound liquid metal particles in elastomer

引用

Nature Communications 2025年第1期16卷 1-11页

作者： Hyeonyeob Seo Gun-Hee Lee Dong-Yeong Kim Kum Seok Nam Jiwoo Park Yeonzu Son Semin Kim Congqi Yang Seongjun Park Joonhee Won Hyunjun Kim Steve Park Jae-Young Bae Seung-Kyun Kang Jiheong Kang Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Departments of Cogno-Mechatronics Engineering Pusan National University Busan Republic of Korea Departments of Optics and Mechatronics Engineering Pusan National University Busan Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Program of Brain and Cognitive Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon South Korea Graduate School of Semiconductor Technology Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Medical Research Center Seoul National University Seoul Republic of Korea Department of Biomedical Sciences College of Medicine Seoul National University Seoul Republic of Korea School of Transdisciplinary Innovations Seoul National University Seoul Republic of Korea Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul Republic of Korea Department of Transdisciplinary Medicine Seoul National University Hospital Seoul South Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea KAIST Institute for NanoCentury Daejeon Republic of Korea Department of Materials Science and Engineering Seoul National University Seoul Republic of Korea Department of Chemistry Seoul National University Seoul Republic of Korea

Packaging in stretchable electronics is crucial to protect components from environmental damage while preserving mechanical flexibility and providing electrical insulation. The conventional packaging process involves multiple steps that increase in complexity as the number of circuit layers multiply. In this study, we introduce a self-packaged stretchable printed circuit board enabled by the in situ phase separation of liquid metal particles (LMPs) within various polymer matrices during solution-based printing processes. The ligand-bound LMPs (LB-LMPs), engineered to inhibit oxide growth, undergo in situ sintering, prompting vertical phase separation. This synthesis strategy not only achieves high initial conductivity of the LMPs but also encapsulates them within the polymer matrix, preventing leakage and providing electrical insulation. Our method enables multi-layer circuit printing, eliminating the need for additional activation and packaging processes. Furthermore, by integrating conductive materials into packaging layers for selective electrical conductivity, vertical interconnect accesses and conductive pads can be formed, enabling large-scale, stretchable, and leakage-free multi-layer electrical circuits and bio-interfaces.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Spatiotemporal Learning of brain Dynamics from fMRI Using Frequency-Specific Multi-Band Attention for Cognitive and Psychiatric Applications

arXiv

引用

arXiv 2025年

作者： Bae, Sangyoon Kwon, Junbeom Yoo, Shinjae Cha, Jiook Interdisciplinary Program in Artificial Intelligence Seoul National University Gwanak-ro 1 Seoul Seoul08826 Korea Republic of Department of Psychology University of Texas at Austin Dean Keeton Street AustinTX78712 United States Computational Science Initiative Brookhaven National Laboratory Brookhaven Avenue Shirley New York11967 United States Department of Psychology Seoul National University Gwanak-ro 1 Seoul Seoul08826 Korea Republic of Department of Brain and Cognitive Sciences Seoul National University Gwanak-ro 1 Seoul Seoul08826 Korea Republic of

A central challenge in neuroscience is understanding how the brain’s complex nonlinear dynamics give rise to emergent properties underlying adaptive cognition and behavior across spatial and temporal scales. These dynamics exhibit scale-free and multifractal properties, shaping the adaptive reconfiguration of neural networks. However, conventional neuroimaging models remain constrained by assumptions of linearity and stationarity, limiting their capacity to fully characterize these intricate processes. Transformer-based architectures, known for capturing long-range dependencies in sequential data, naturally align with the brain’s intrinsically hierarchical and temporal organization. Here, we introduce Multi-Band brain Net (MBBN), a transformer-based deep learning framework that explicitly models frequency-specific spatiotemporal brain dynamics from fMRI by integrating scale-free network principles with frequency-resolved multi-band self-attention mechanisms. Trained on three large-scale neuroimaging cohorts (UK Biobank, ABCD, ABIDE) totaling 45,951 individuals, MBBN reveals previously undetectable frequency-dependent intrinsic network interactions, shedding new light on distinct connectivity disruptions across psychiatric conditions (ADHD, ASD, depression). This extensive validation demonstrates robust generalizability and highlights core neural principles conserved across populations and developmental stages. Specifically, MBBN achieves up to 30.59% higher predictive accuracy than state-of-the-art deep learning and conventional connectome-based methods, demonstrating the advantage of frequency-informed spatiotemporal modeling in capturing latent neural computations. Furthermore, MBBN’s attention-based interpretability reveals novel frequency-specific biomarkers for neurodevelopmental disorders, offering mechanistic insights into the hierarchical organization of brain function. By providing a principled, interpretable framework for dissecting spatiotemporal learning

关键词： brain mapping

来源：评论

学校读者我要写书评

暂无评论

Detection of Femtomolar Amyloid-β Peptides for Early-Stage Identification of Alzheimer’s Amyloid-β Aggregation with Functionalized Gold Nanoparticles

引用

ACS Applied Materials and Interfaces 2024年第3期16卷 3819-3828页

作者： Chang, Yu-Jen Chien, Yi-Hsin Chang, Chieh-Chun Wang, Pei-Ning Chen, Yun-Ru Chang, Yun-Chorng Genomics Research Center Academia Sinica Taipei115 Taiwan Taiwan International Graduate Program in Interdisciplinary Neuroscience National Taiwan University and Academia Sinica Taipei115 Taiwan Research Center for Applied Sciences Academia Sinica Taipei115 Taiwan Department of Physics National Taiwan University Taipei106 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Taiwan University Taipei115 Taiwan Brain Research Center National Yang Ming Chiao Tung University Taipei112 Taiwan Division of General Neurology Department of Neurological Institute Taipei Veterans General Hospital Taipei112 Taiwan

Progressive amyloid-β (Aβ) fibrillar aggregates have long been considered as the pathogenesis of Alzheimer’s disease (AD). Biocompatible and stable cysteine-Aβ peptide-conjugated gold nanoparticles (Cys-Aβ@AuNP) are demonstrated as suitable materials for detecting subfemtomolar Aβ peptides in human plasma. Incubation with Aβ peptides causes the Cys-Aβ@AuNP to aggregate and changes its absorption spectra. The spectral change is especially apparent and noticeable when detecting subfemtomolar Aβ peptides, and the aggregates contain only two or three AuNPs. Cys-Aβ@AuNP can also be used to identify early-stage Aβ oligomerization, which is not possible using the conventional method, in which the fluorescence of thioflavin-T is measured. The ability to detect Aβ oligomerization can facilitate therapeutics for AD. In addition, the binding of Aβ peptides by Cys-Aβ@AuNP in combination with centrifugation redirects the conventional Aβ aggregation pathway and can effectively inhibit the formation of toxic Aβ oligomers or fibrils. Therefore, the proposed Cys-Aβ@AuNP can also be used to develop effective therapeutic agents to inhibit Aβ aggregation. The results obtained in this study are expected to open revolutionary ways to both detect and inhibit Aβ aggregation at an early stage. © 2024 American Chemical Society

关键词： Oligomers

来源：评论

学校读者我要写书评

暂无评论

Post-COVID-19 Effects on Chronic Gastritis and Gastric Cellular and Molecular Characteristics in Male Mice

引用

Cellular and Molecular Gastroenterology and Hepatology 2025年第8期19卷 101511-101511页

作者： Jeong, Haengdueng Kim, Sung-Hee Kim, Jiseon Jeon, Donghun Uhm, Chanyang Oh, Heeju Cho, Kyungrae Park, In Ho Oh, Jooyeon Kim, Jeong Jin Jeong, Sang-Ho Park, Ji-Ho Park, Jun Won Yun, Jun-Won Seo, Jun-Young Shin, Jeon-Soo Goldenring, James R. Seong, Je Kyung Nam, Ki Taek Department of Biomedical Sciences Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul South Korea Epithelial Biology Center and Department of Surgery Vanderbilt University School of Medicine Nashville TN United States Institute of Immunology and Immunological Diseases Yonsei University College of Medicine Seoul South Korea Department of Microbiology Yonsei University College of Medicine Seoul South Korea Department of Surgery Gyongsang National University Hospital Jinju South Korea Korea Mouse Phenotyping Center Seoul National University Seoul South Korea Laboratory of Developmental Biology and Genomics Research Institute for Veterinary Science Brain Korea 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul South Korea Laboratory Animal Medicine College of Veterinary Medicine Seoul National University Seoul South Korea Laboratory of Veterinary Toxicology College of Veterinary Medicine Seoul National University Seoul South Korea BIO-MAX Institute Seoul National University Seoul South Korea Interdisciplinary Program for Bioinformatics Seoul National University Seoul South Korea

Backgrounds & Aims: Since the Omicron variant emerged as a major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, COVID-19-associated mortality has decreased remarkably. Nevertheless, patients with a history of SARS-CoV-2 infection have been suffering from an aftereffect commonly known as ‘long COVID,’ affecting diverse organs. However, the effect of SARS-CoV-2 on gastric cells and disease progression was not previously known. We aimed to investigate whether SARS-CoV-2 infection affects stomach cells and if post-COVID-19 conditions can lead to severe gastric disease. Methods: Stomach specimens obtained from male K18-hACE2 mice 7 days after SARS-CoV-2 infection were subjected to a transcriptomic analysis for molecular profiling. To investigate the putative role of SARS-CoV-2 in gastric carcinogenesis, K18-hACE2 mice affected by nonlethal COVID-19 were also inoculated with Helicobacter pylori SS1. Results: Despite the lack of viral dissemination and pathologic traits in the stomach, SARS-CoV-2 infection caused dramatic changes to the molecular profile and some immune subsets in this organ. Notably, the gene sets related to metaplasia and gastric cancer were significantly enriched after viral infection. As a result, chronic inflammatory responses and preneoplastic transitions were promoted in these mice. Conclusion: SARS-CoV-2 infection indirectly leads to profound and post-acute COVID-19 alterations in the stomach at the cellular and molecular levels, resulting in adverse outcomes following co-infection with SARS-CoV-2 and H pylori. Our results show that 2 prevalent pathogens of humans elicit a negative synergistic effect and provide evidence of the risk of severe chronic gastritis in the post-COVID-19 era. © 2025 The Authors

关键词： Chronic Gastritis Helicobacter pylori Post-acute COVID-19 Syndrome Virus and Diseases

来源：评论

学校读者我要写书评

暂无评论

Equilibrative nucleoside transporter 3 supports microglial functions and protects against the progression of Huntington's disease in the mouse model

引用

brain, Behavior, and Immunity 2024年 120卷 413-429页

作者： Lu, Ying-Sui Hung, Wei-Chien Hsieh, Yu-Ting Tsai, Pei-Yuan Tsai, Tsai-Hsien Fan, Hsiu-Han Chang, Ya-Gin Cheng, Hui-Kuei Huang, Shen-Yan Lin, Hsin-Chuan Lee, Yan-Hua Shen, Tzu-Hsiang Hung, Bing-Yu Tsai, Jin-Wu Dzhagalov, Ivan Cheng, Irene Han-Juo Lin, Chun-Jung Chern, Yijuang Hsu, Chia-Lin Institute of Microbiology and Immunology National Yang Ming Chiao Tung University Taipei Taiwan Taiwan International Graduate Program in Molecular Medicine National Yang Ming Chiao Tung University and Academia Sinica Taipei Taiwan Institute of Brain Science National Yang Ming Chiao Tung University Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Taiwan International Graduate Program in Interdisciplinary Neuroscience National Yang Ming Chiao Tung University and Academia Sinica Taipei Taiwan Biomedical Industry Ph.D. Program National Yang Ming Chiao Tung University Taipei Taiwan Brain Research Center National Yang Ming Chiao Tung University Taipei Taiwan School of Pharmacy College of Medicine National Taiwan University Taipei Taiwan

Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by involuntary movements, cognitive deficits, and psychiatric symptoms. Currently, there is no cure, and only limited treatments are available to manage the symptoms and to slow down the disease's progression. The molecular and cellular mechanisms of HD's pathogenesis are complex, involving immune cell activation, altered protein turnover, and disturbance in brain energy homeostasis. Microglia have been known to play a dual role in HD, contributing to neurodegeneration through inflammation but also enacting neuroprotective effects by clearing mHTT aggregates. However, little is known about the contribution of microglial metabolism to HD progression. This study explores the impact of a microglial metabolite transporter, equilibrative nucleoside transporter 3 (ENT3), in HD. Known as a lysosomal membrane transporter protein, ENT3 is highly enriched in microglia, with its expression correlated with HD severity. Using the R6/2 ENT3^−/− mouse model, we found that the deletion of ENT3 increases microglia numbers yet worsens HD progression, leading to mHTT accumulation, cell death, and disturbed energy metabolism. These results suggest that the delicate balance between microglial metabolism and function is crucial for maintaining brain homeostasis and that ENT3 has a protective role in ameliorating neurodegenerative processes. © 2024 The Authors

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：