To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 1...
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.
O1 Regulation of genes by telomere length over long distances Jerry W. Shay O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell ...
O1 Regulation of genes by telomere length over long distances Jerry W. Shay O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa O3 Integration of metagenomics and metabolomics in gut microbiome research Maryam Goudarzi, Albert J. Fornace Jr. O4 A unique integrated system to discern pathogenesis of central nervous system tumors Saleh Baeesa, Deema Hussain, Mohammed Bangash, Fahad Alghamdi, Hans-Juergen Schulten, Angel Carracedo, Ishaq Khan, Hanadi Qashqari, Nawal Madkhali, Mohamad Saka, Kulvinder S. Saini, Awatif Jamal, Jaudah Al-Maghrabi, Adel Abuzenadah, Adeel Chaudhary, Mohammed Al Qahtani, Ghazi Damanhouri O5 RPL27A is a target of miR-595 and deficiency contributes to ribosomal dysgenesis Heba Alkhatabi O6 Next generation DNA sequencing panels for haemostatic and platelet disorders and for Fanconi anaemia in routine diagnostic service Anne Goodeve, Laura Crookes, Nikolas Niksic, Nicholas Beauchamp O7 Targeted sequencing panels and their utilization in personalized medicine Adel M. Abuzenadah O8 International biobanking in the era of precision medicine Jim Vaught O9 Biobank and biodata for clinical and forensic applications Bruce Budowle, Mourad Assidi, Abdelbaset Buhmeida O10 Tissue microarray technique: a powerful adjunct tool for molecular profiling of solid tumors Jaudah Al-Maghrabi O11 The CEGMR biobanking unit: achievements, challenges and future plans Abdelbaset Buhmeida, Mourad Assidi, Leena Merdad O12 Phylomedicine of tumors Sudhir Kumar, Sayaka Miura, Karen Gomez O13 Clinical implementation of pharmacogenomics for colorectal cancer treatment Angel Carracedo, Mahmood Rasool O14 From association to causality: translation of GWAS findings for genomic me
This paper investigates the unsteady aerodynamic features of wing-wing, wing-body and vortex-vortex interactions in insects' flapping motions under forward flight condition. A realistic wing trajectory, called the...
详细信息
We predict a quantum phase transition from normal to topological insulators in the 5d transition metal oxide Na2IrO3, where the transition can be driven by the change of the long-range hopping and trigonal crystal fie...
详细信息
We predict a quantum phase transition from normal to topological insulators in the 5d transition metal oxide Na2IrO3, where the transition can be driven by the change of the long-range hopping and trigonal crystal field terms. From the first-principles-derived tight-binding Hamiltonian, we determine the phase boundary through the parity analysis. In addition, our first-principles calculations for Na2IrO3 model structures show that the interlayer distance can be an important parameter for the existence of a three-dimensional strong topological insulator phase. Na2IrO3 is suggested to be a candidate material which can have both a nontrivial topology of bands and strong electron correlations.
This paper presents numerical investigations on the buzz characteristics of a supersonic inlet. By applying dynamic throttling conditions and using FSI (Fluid-Structure Interaction) technique, we were able to match op...
详细信息
A numerical simulation program for Resin Transfer Molding (RTM) manufacturing process is developed using eXtended Finite Element Method (XFEM) combined with the level set method. The level set method is used to track ...
详细信息
A numerical simulation program for Resin Transfer Molding (RTM) manufacturing process is developed using eXtended Finite Element Method (XFEM) combined with the level set method. The level set method is used to track the resin flow front at each time step. XFEM allows to obtaining better accuracy of the resin pressure field in the flow front region than the classical FEM. The enriched shape functions of XFEM are derived by using the level set values of the front region. Finally, the level set values are calculated by an implicit characteristic Galerkin method. The numerical fill time is compared with the analytical solution to validate this program.
作者：
Douglas, C.Kim, I.Lee, H.Sheen, D.School of Energy Resources
Department of Mathematics University of Wyoming Laramie WY 82072-3036 United States Bell Labs Seoul
Alcatel-Lucent 7fl DMC RandD Center Digital Media City E3-2 Sangam-Dong Mapo-Gu Seoul 120-270 Korea Republic of Department of Mathematics
Interdisciplinary Program in Computational Science and Technology Seoul National University Seoul 151-747 Korea Republic of
In this paper we solve linear parabolic problems using the three stage noble algorithms. First, the time discretization is approximated using the Laplace transformation method, which is both parallel in time (and can ...
详细信息
＜正＞According to the report,about 50%of helicopters in Korea are manufactured more than 30 years *** this reason,the large project on the development of the helicopter is *** this research,relationship between the a...
详细信息
＜正＞According to the report,about 50%of helicopters in Korea are manufactured more than 30 years *** this reason,the large project on the development of the helicopter is *** this research,relationship between the atomization properties and the characteristics of the reacting flow field in a small gas turbine engine are *** general,researches on the development of an injector need a lot of *** those experiments always have the risks of explosion and an emission of toxic *** computational studies on a chemical reacting flow are widely used as the speed of CPU becomes faster. A spray structure can be expressed in terms of droplet size distribution,break-up length,spray angle,and penetration distance. Among those,the characteristics of the reacting flow field in the gas turbine engine according to various droplet sizes are investigated. Combustion chamber is modeled with 1.3 million hybrid grid and n-pentane is used for the *** those setting,spray droplet trajectory and temperature distribution are compared. For the cases with three different droplet’s mean diameter,as the parcel size of the fuel decreases,reaction occurs faster in smaller *** those small parcels cannot penetrate deeper,fuels is not equally *** heat transfer and diffusion occur,this inequality increases the pattern factor,important parameter on the combustor *** on the outlet temperature with two different sizes show that to get lower pattern factor,mean diameter of the spray parcels should be at least *** means that injection of smaller parcels than the specific value reduces overall performance of the engine. In this work,only the droplet size distribution and spray angle are *** are lots of variables to affect the injection properties,more researches are planed and we work on some of these.
According to the report, about 50% of helicopters in Korea are manufactured more than 30 years ago. For this reason, the large project on the development of the helicopter is proposed. In this research, relationship b...
详细信息
ISBN:
(纸本)9787561228999
According to the report, about 50% of helicopters in Korea are manufactured more than 30 years ago. For this reason, the large project on the development of the helicopter is proposed. In this research, relationship between the atomization properties and the characteristics of the reacting flow field in a small gas turbine engine are studied. In general, researches on the development of an injector need a lot of experiments. But those experiments always have the risks of explosion and an emission of toxic gases. Recently computational studies on a chemical reacting flow are widely used as the speed of CPU becomes faster. A spray structure can be expressed in terms of droplet size distribution, break-up length, spray angle, and penetration distance. Among those, the characteristics of the reacting flow field in the gas turbine engine according to various droplet sizes are investigated. Combustion chamber is modeled with 1. 3 million hybrid grid and n-pentane is used for the fuel. With those setting, spray droplet trajectory and temperature distribution are compared. For the cases with three different droplet's mean diameter, as the parcel size of the fuel decreases, reaction occurs faster in smaller area. But those small parcels cannot penetrate deeper, fuels is not equally distributed. Although heat transfer and diffusion occur, this inequality increases the pattern factor, important parameter on the combustor performance. Comparisons on the outlet temperature with two different sizes show that to get lower pattern factor, mean diameter of the spray parcels should be at least 80. This means that injection of smaller parcels than the specific value reduces overall performance of the engine. In this work, only the droplet size distribution and spray angle are considered. There are lots of variables to affect the injection properties, more researches are planed and we work on some of these.
暂无评论