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Science China Life Sciences 2025年第5期68卷 1536-1540页

作者： Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I

The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integrating biological knowledge into models and even accelerating the development of new AI based on biological discoveries, the boundaries of both are constantly expanding, and their connections are becoming closer.

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Display of coregistered cross-modality images using time-weighted alternation method

Display of coregistered cross-modality images using time-wei...

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作者： Sung Lee, Jae Chee, Youngjoon Kim, Boyeon Lee, Jong Min Park, Kwang Suk Kwark, Cheoleun Lee, Myung Chul Interdisciplinary Program in Medical and Biological Engineering Major Department of Biomedical Engineering Seoul National University Korea Republic of

Cross-modality coregistration of functional and anatomical images has rapidly grown as the aid for the interpretation of functional images. Various methods have been previously investigated so that the coregistered images can be easily interpreted and realistically visualized. We used the time/intensityweighted alternation method to display the coregistered images simultaneously. Stereotactic registration was done with two methods. We realized the automated method of alignment using the boundary of head scalp extracted from the sinogram of a PET emission scan and surface-matching algorithm in brain, and the semi-automated method using a paired point-matching algorithm in the chest and abdomen. For the simultaneous display of the stereotactically registered images, rapid switching of the screens were applied on which both images were written with independent color scales. Rapid alternate display of two images, that is synchronized using the monitor scanning process, could induce the fusion of images in the human visual perception system. Also, intensification of an interesting image is possible by weighting the displaying time or global intensities of images with the degree of interest. These techniques could be useful for the interpretation and visualization of the coregistered images. © 1997 The authors.

关键词： Display devices

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A preliminary study for unconstrained Pulse Arrival Time (PAT) measurement on a chair

A preliminary study for unconstrained Pulse Arrival Time (PA...

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2005 27th Annual International Conference of the engineering in Medicine and Biology Society, IEEE-EMBS 2005

作者： Ko, Keun Kim Youngjoon, Chee Juwan, Park Jungsoo, Kim Yong, Kyu Lim Kwang, Suk Park Interdisciplinary Program in Medical and Biological Engineering Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)0780387406

A method of measuring the pulse arrival time (PAT) non-consciously on a chair is proposed. In this method, the electrically non-contact ECG measurement system and the air cushion with balancing tubes are used. In this paper, the correlation between the typical PAT and the unconstrained PATs (A-PATs) are compared. The typical PAT is measured as the difference of R-peak of ECG and the steepest descent point of the PPG in toe. The three different A-PATs were measured from the pressure pulse of the air cushion (APP). The correlation between the typical PAT and the A-PAT from the steepest descent point of the APP was the highest (R=0.9663). ©2005 IEEE.

关键词： Electrocardiography

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Unconstrained pulse transit time measurement system for computer users

Unconstrained pulse transit time measurement system for comp...

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2005 27th Annual International Conference of the engineering in Medicine and Biology Society, IEEE-EMBS 2005

作者： Park, Juwan Lim, Yongkyu Chee, Youngjoon Kim, Jungsoo Kim, Kokeun Park, Kwang Suk Interdisciplinary Program in Medical and Biological Engineering Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)0780387406

Pulse Transit Time (PTT) is a simple non-invasive method to evaluate vascular function using photoplethysmography(PPG) and electrocardiography(ECG). This study introduces unconstrained PTT measurement method for computer users and evaluates that. The proposed system consists of chair and mouse those can measure ECG and PPG respectability. PTT was defined as time delay between ECG R peak and PPG steepest point. The correlation coefficient between PTT that measured from this system and conventional PTT was 0.93. This work will provide many opportunities for ubiquitous health monitoring. ©2005 IEEE.

关键词： Cardiovascular system

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Common mode noise cancellation for electrically non-contact ECG measurement system on a chair

Common mode noise cancellation for electrically non-contact ...

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2005 27th Annual International Conference of the engineering in Medicine and Biology Society, IEEE-EMBS 2005

作者： Ko, Keum Kim Yong, Kyu Lim Kwang, Suk Park Interdisciplinary Program in Medical and Biological Engineering Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)0780387406

Electrically non-contact ECG measurement system on a chair can be applied to a number of various fields for continuous health monitoring in daily life. However, the body is floated electrically for this system due to the capacitive electrodes and the floated body is very sensitive to the external noises or motion artifacts which affect the measurement system as the common mode noise. In this paper, the Driven-Seat-Ground circuit similar to the Driven-Right-Leg circuit is proposed to reduce the common mode noise. The analysis of this equivalent circuit is performed and the output signal waveforms are compared between with Driven-Seat-Ground and with capacitive ground. As the results, the Driven-Seat-Ground circuit improves significantly the properties of the fully capacitive ECG measurement system as the negative feedback. © 2005 IEEE.

关键词： Electrocardiography

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Cell chip to monitor the influence of electric field on the human mesendhymal stem cells 11

Cell chip to monitor the influence of electric field on the ...

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11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

作者： Kwon, Gu-Han Lee, Kwang Ho Lee, Eun-Joong Lee, Sang-Hoon Department of Biomedical Engineering College of Medicine Korea University Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Korea Republic of

ISBN: (纸本)9780979806407

A new micro cell chip which can induce stem cells to differentiate into specific body cell types has been designed and fabricated for tissue engineering. This paper presents the fabrication and preliminary test results of a MEMS cell electric stimulator. It provides a new tool of cell electric stimulation, culture and analysis for stem cell research. This study provides the controlling proliferation as well as morphology of human mesenchymal stem cell on the microchip. DC 1V, 5V, 12V, AC 5V, 1 Hz, 1K Hz, 1M Hz were compared with electric stimulation for their impact on the expansion and morphology of mesenchymal stem cells (MSCs). It provides a new generation of cell culture, stimulation and analysis devices for stem cell research and tissue engineering. © 2007 CBMS.

关键词： Stem cells

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The mitochondrial genome data of the Capsicum annuum cv. Dempsey (Solanaceae)

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Data in Brief 2025年

作者： Seona Yun Junseong Bae Jeongbin Park Hyeran Kim Institute of Life Sciences Kangwon National University Chuncheon Republic of Korea Interdisciplinary Program of Genomic Data Science Pusan National University Yangsan Republic of Korea Graduate School of Medical AI Pusan National University Yangsan Republic of Korea School of Biomedical Convergence Engineering Pusan National University Yangsan Republic of Korea Department of Biological Sciences Kangwon National University Chuncheon Republic of Korea Interdisciplinary Graduate Program in BIT Medical Convergence Kangwon National University Chuncheon Republic of Korea

Capsicum annuum L. (1753), commonly known as pepper, holds significant economic value as one of the globally cultivated horticultural crops. This study presents the mitochondrial genome of the sweet pepper C. annuum cv. Dempsey, assembled using Illumina NovaSeq data. The circular mitogenome is 577,453 base pairs (bp) in length and includes 36 protein-coding genes, three ribosomal RNA genes, and 43 transfer RNA genes. Phylogenetic analysis reveals that C. annuum is not monophyletic, with C. annuum cv. Dempsey identified as a sister to the hot pepper C. annuum cv. Jeju. This study provides as a valuable resource for comparative analyses of pepper mitogenomes, enhancing our understanding of the evolution and adaptive mechanisms of pepper species.

关键词： Capsicum annuum Sweet pepper cultivar Dempsey Mitogenome Phylogeny

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Personal dialysis using a web-based, portable system - C-PAK (Carry-on Pulse Artificial Kidney)

Personal dialysis using a web-based, portable system - C-PAK...

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BIODEVICES 2008 - 1st International Conference on Biomedical Electronics and Devices

作者： Lee, Jung Chan Kim, Wook Eun Lim, Ki Moo Kim, Jeong Chul Min, Byoung Goo Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Biomedical Engineering Seoul National University Seoul Korea Republic of

ISBN: (纸本)9789898111173

While the number of patients suffering from acute and chronic renal failure has been steadily increasing every year, the mortality rate is not improving. For the purpose of improvement on the quality of life and mortality of renal disease patients, we employ the hemofiltration principle to treat the end-stage renal disease patients. Hemofiltration equipment can be installed without additional plumbing and electrical power construction;operated only with several pre-packaged fluid bags without a huge water treatment facility. This paper describes the development of portable renal treatment equipment based on hemofiltration treatment, Carry-on Pulse Artificial Kidney (C-PAK), and reports the results of animal test using the equipment. The web-based remote monitor/control system for C-PAK is introduced also. We expect that our portable hemofiltration device for chronic renal failure patient would be an alternative for conventional hemodialysis machine and a solution to home renal treatment.

关键词： Diseases

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Second derivative of photoplethysmography for estimating vascular aging

Second derivative of photoplethysmography for estimating vas...

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6th International Special Topic Conference on ITAB, 2007

作者： Hyun, Jae Baek Jung, Soo Kim Yun, Sung Kim Haet, Bit Lee Kwang, Suk Park Interdisciplinary Program of Bioengineering Seoul National University Seoul Korea Republic of Interdisciplinary Program on Medical and Biological Engineering Seoul National University Seoul Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)9781424418688

Coronary artery disease (CAD) is one of the major causes of death. Therefore recurrent monitoring of arterial condition is important. The photoplethysmography (PPG) is simple and cost effective technique to measure blood volume change. As an application of PPG technique, the second derivative of photoplethysmography(SDPTG) was introduced for monitoring arterial condition. SDPTG consists of an a, b, c and d wave in systole and an e wave in diastole. The SDPTG wave pattern is determined by the proportions of the b, c, d, and e waves to the a wave. In the present study, it is confirmed that the b/a ratio and SDPTG-AI increased with age, and the c/a, d/a, and e/a ratios decreased with age. The informal method which substitutes formal SDPTG-AI was suggested. © 2008 IEEE.

关键词： Cost effectiveness

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Wavelet approach to artifact noise removal from Capacitive coupled Electrocardiograph

Wavelet approach to artifact noise removal from Capacitive c...

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30th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBS'08

作者： Seung, Min Lee Ko, Keun Kim Kwang, Suk Park Interdisciplinary Program of Bioengineering Seoul National University Graduate School Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Seoul National University Graduate School Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)9781424418152

Capacitive coupled Electrocardiography (ECG) is introduced as non-invasive measurement technology for ubiquitous health care and appliance are spread out widely. Although it has many merits, however, capacitive coupled ECG is very weak for motion artifacts for its non-skin-contact property. There are many studies for artifact problems which treats all artifact signals below 0.8Hz. In our capacitive coupled ECG measurement system, artifacts exist not only below 0.8Hz but also over than 10Hz. Therefore, artifact noise removal algorithm using wavelet method is tested to reject artifact-wandered signal from measured signals. It is observed that using power calculation each decimation step, artifact-wandered signal is removed as low frequency artifacts as high frequency artifacts. Although some original ECG signal is removed with artifact signal, we could level the signal quality for long term measure which shows the best quality ECG signals as we can get. © 2008 IEEE.

关键词： Electrocardiography

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