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SSRN 2023年

作者： Kim, Jungah Kang, Sunah Choi, Min-Ha Park, Sohyun Nam, So Hee Park, Ji-Ung Lee, Yan Department of Chemistry College of Natural Sciences Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of Department of Plastic and Reconstructive Surgery Seoul National University Boramae Medical Center Seoul National University College of Medicine 5 Gil 20 Boramae-ro Dongjak-gu Seoul07061 Korea Republic of Institute of Medical and Biological Engineering Seoul National University College of Medicine 103 Daehak-ro Jongno-gu Seoul03080 Korea Republic of Interdisciplinary Program in Bioengineering Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of College of Pharmacy Dongduk Women’s University 60 Hwarang-ro 13-gil Seongbuk-gu Seoul02748 Korea Republic of

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) occurs in the capsule surrounding breast implants. Malignant transformation of T cells by bacteria-driven chronic inflammation may be underlying BIA-ALCL mechanism. Here, we covalently grafted 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymers on a silicone surface and examined its effects against BIA-ALCL pathogenesis. MPC grafting strongly inhibited the adhesion of bacteria and bacteria-causing inflammation. Additionally, cancer T cell proliferation and capsule-derived fibroblast-cancer cell communication were effectively inhibited by MPC grafting. We further demonstrated the effect of MPC against the immune responses causing BIA-ALCL around human silicone implants in micro-pigs. Finally, we generated a xenograft anaplastic T cell lymphoma mouse model around the silicone implants and demonstrated that MPC grafting could effectively inhibit the lymphoma progression. This study is the first to show that bacteria-driven induction and progression of BIA-ALCL can be effectively inhibited by surface modification of implants. © 2023, The Authors. All rights reserved.

关键词： Bacteria

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Time synchronization between parietal–frontocentral connectivity with MRCP and gait in post-stroke bipedal tasks

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Journal of Neuroengineering and Rehabilitation 2024年第1期21卷 101页

作者： Phang, Chun-Ren Su, Kai-Hsiang Cheng, Yuan-Yang Chen, Chia-Hsin Ko, Li-Wei International Ph.D. Program in Interdisciplinary Neuroscience (UST) College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biological Science and Technology College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Physical Medicine and Rehabilitation Taichung Veterans General Hospital Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Department of Physical Medicine and Rehabilitation Kaohsiung Medical University Hospital Kaohsiung Taiwan School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan Institute of Electrical and Control Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biomedical Science and Environment Biology Kaohsiung Medical University Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung Taiwan

Background: In post-stroke rehabilitation, functional connectivity (FC), motor-related cortical potential (MRCP), and gait activities are common measures related to recovery outcomes. However, the interrelationship between FC, MRCP, gait activities, and bipedal distinguishability have yet to be investigated. Methods: Ten participants were equipped with EEG devices and inertial measurement units (IMUs) while performing lower limb motor preparation (MP) and motor execution (ME) tasks. MRCP, FCs, and bipedal distinguishability were extracted from the EEG signals, while the change in knee degree during the ME phase was calculated from the gait data. FCs were analyzed with pairwise Pearson’s correlation, and the brain-wide FC was fed into support vector machine (SVM) for bipedal classification. Results: Parietal–frontocentral connectivity (PFCC) dysconnection and MRCP desynchronization were related to the MP and ME phases, respectively. Hemiplegic limb movement exhibited higher PFCC strength than nonhemiplegic limb movement. Bipedal classification had a short-lived peak of 75.1% in the pre-movement phase. These results contribute to a better understanding of the neurophysiological functions during motor tasks, with respect to localized MRCP and nonlocalized FC activities. The difference in PFCCs between both limbs could be a marker to understand the motor function of the brain of post-stroke patients. Conclusions: In this study, we discovered that PFCCs are temporally dependent on lower limb gait movement and MRCP. The PFCCs are also related to the lower limb motor performance of post-stroke patients. The detection of motor intentions allows the development of bipedal brain-controlled exoskeletons for lower limb active rehabilitation. © The Author(s) 2024.

关键词： Brain–computer interface Functional connectivity Motor execution Motor preparation Post-stroke

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Ionic Circuits Based on Polyelectrolyte Diodes on a Microchip†

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Angewandte Chemie 2009年第21期121卷

作者： Ji‐Hyung Han Kwang Bok Kim Hee Chan Kim Taek Dong Chung Department of Chemistry Seoul National University Seoul 151‐747 (Korea) Fax: (+82) 887‐4354 http://www.niel.or.kr/ Interdisciplinary Program Bioengineering Major Seoul National University Seoul 110‐744 (Korea) Department of Biomedical Engineering College of Medicine and Institute of Medical and Biological Engineering Medical Research Center Seoul National University Seoul 110‐744 (Korea)

Bei Grün gehen : Eine Polyelektrolytdiode auf einem Mikrochip zeigt ein eindeutiges nichtlineares Gleichrichterverhalten. Mit diesem System lässt sich in Echtzeit die dynamische Verteilung von Ionen in einer geladenen Polymerphase im elektrischen Feld mithilfe von Fluoreszenzbildern visualisieren. Mehrere Polyelektrolytdioden wurden auf einem Mikrochip integriert, um vielfältige Logikgatter auf Basis ionischer Schaltkreise herzustellen (siehe Bild).

关键词： Fluoreszenz Gleichrichter Ionische Schaltkreise Mikrochips Polyelektrolyte

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Corrigendum to "Metal-organic frameworks, NH2-MIL-88(Fe), as carriers for ophthalmic delivery of brimonidine" [Acta Biomater. 79 (2018) 344-353]

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Acta biomaterialia 2019年 85卷 321页

作者： Se-Na Kim Chun Gwon Park Beom Kang Huh Seung Ho Lee Chang Hee Min Yun Young Lee Young Kook Kim Ki Ho Park Young Bin Choy Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul 08826 Republic of Korea. Department of Biomedical Engineering SKKU Institute for Convergence Sungkyunkwan University (SKKU) Suwon 16419 Republic of Korea. Institute of Medical & Biological Engineering Medical Research Center Seoul National University Seoul 03080 Republic of Korea. Department of Biomedical Engineering Seoul National University College of Medicine Seoul 03080 Republic of Korea. Department of Ophthalmology Seoul National University Hospital Seoul 03080 Republic of Korea Department of Ophthalmology Seoul National University College of Medicine Seoul 03080 Republic of Korea. Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul 08826 Republic of Korea Institute of Medical & Biological Engineering Medical Research Center Seoul National University Seoul 03080 Republic of Korea Department of Biomedical Engineering Seoul National University College of Medicine Seoul 03080 Republic of Korea. Electronic address: ybchoy@snu.ac.kr.

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Corrigendum to "Mathematical model of modified hybrid pump mechanism for cardiopulmonary resuscitation" [Computer methods and programs in biomedicine 206 (2021) 106106]

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Computer methods and programs in biomedicine 2022年 218卷 106711页

作者： Dong Ah Shin Jung Chan Lee Interdisciplinary Program in Bioengineering Graduate School Seoul National University Seoul 08826 Republic of Korea. Department of Biomedical Engineering College of Medicine and Institute of Medical and Biological Engineering Medical Research Center Seoul National University Seoul 03080 Republic of Korea Institute of BioEngineering Bio-MAX Institute Seoul National University Seoul 08826 Republic of Korea. Electronic address: ljch@snu.ac.kr.

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Integration of MRI and somatosensory evoked potentials facilitate diagnosis of spinal cord compression

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Scientific Reports 2023年第1期13卷 1-12页

作者： Sun, Shu-Pin Phang, Chun-Ren Tzou, Shey-Cherng Chen, Chang-Mu Ko, Li-Wei International Ph.D. Program in Interdisciplinary Neuroscience (UST) College of Biological Science and Technology National Yang Ming Chiao Tung University 734 Engineering Bldg. 5 1001 Daxue Road Hsinchu 30010 Taiwan Department of Medical Research National Taiwan University Hospital Hsin-Chu Branch Hsinchu 300 Taiwan Institute of Molecular Medicine and Bioengineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Department of Surgery College of Medicine and Hospital National Taiwan University No. 7 Zhongshan South Road Taipei 10002 Taiwan Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Institute of Electrical and Control Engineering Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Department of Biomedical Science and Environment Biology and the Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung 807 Taiwan

This study aimed to integrate magnetic resonance imaging (MRI) and related somatosensory evoked potential (SSEP) features to assist in the diagnosis of spinal cord compression (SCC). MRI scans were graded from 0 to 3 according to the changes in the subarachnoid space and scan signals to confirm differences in SCC levels. The amplitude, latency, and time–frequency analysis (TFA) power of preoperative SSEP features were extracted and the changes were used as standard judgments to detect neurological function changes. Then the patient distribution was quantified according to the SSEP feature changes under the same and different MRI compression grades. Significant differences were found in the amplitude and TFA power between MRI grades. We estimated three degrees of amplitude anomalies and power loss under each MRI grade and found the presence or absence of power loss occurs after abnormal changes in amplitude only. For SCC, few integrated approach combines the advantages of both MRI and evoked potentials. However, integrating the amplitude and TFA power changes of SSEP features with MRI grading can help in the diagnosis and speculate progression of SCC. © 2023, The Author(s).

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Accurate de novo design of membrane-traversing macrocycles

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四川生理科学杂志 2022年第8期44卷 1474-1474页

作者： Gaurav Bhardwaj Institute for Protein Design University of Washington Seattle WA 98195 USA Department of Medicinal Chemistry University of Washington Seattle WA 98195 USA Biological Physics Structure and Design program University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Molecular Cell and Biology program University of Washington Seattle WA 98195 USA Institute for Molecular Bioscience Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science The University of Queensland Brisbane QLD 4072 Australia Department of Chemistry and Chemical Biology and Center for Biotechnology and Interdisciplinary Sciences Rensselaer Polytechnic Institute Troy NY 12180 USA Molecular Engineering and Sciences Program University of Washington Seattle WA 98195 USA Departamento de Quίmica Fίsica Universidad de Valencia Avenida Dr. Moliner 50 Burjassot 46100 Valencia Spain Department of Medicine Division of Allergy and Infectious Disease University of Washington Seattle WA USA Department of Chemistry and Biochemistry University of California-Los Angeles Los Angeles CA USA Takeda Pharmaceuticals Inc. Cambridge MA USA Howard Hughes Medical Institute University of Washington Seattle WA 98195 USA

We use computational design coupled with experimental characterization to systematically investigate the design principles for macrocycle membrane permeability and oral *** designed 1846-12 residue macrocycles with a wide range of predicted structures containing noncanonical backbone modifications and experimentally determined structures of 35;29 are very close to the computational *** such control,we show that membrane permeability can be systematically achieved by ensuring all amide(NH)groups are engaged in internal hydrogen bonding interactions.84 designs over the 6-12 residue size range cross membranes with an apparent permeability greater than 1×10^(-6)cm/s.

关键词： residue cycles backbone

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Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease

arXiv

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arXiv 2017年

作者： Kim, Donghoon Yoo, Je Min Hwang, Heehong Lee, Junghee Lee, Su Hyun Yun, Seung Pil Park, Myung Jin Lee, Minjun Choi, Seulah Kwon, Sang Ho Lee, Saebom Kwon, Seung-Hwan Kim, Sangjune Park, Yong Joo Kinoshita, Misaki Lee, Young-Ho Shin, Seokmin Paik, Seung R. Lee, Sung Joong Lee, Seulki Hong, Byung Hee Ko, Han Seok Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine BaltimoreMD United States Department of Neurology Johns Hopkins University School of Medicine BaltimoreMD United States Russell H. Morgan Department of Radiology and Radiological Sciences Johns Hopkins University School of Medicine BaltimoreMD United States Centre for Nanomedicine at the Wilmer Eye Institute Johns Hopkins University School of Medicine BaltimoreMD United States Diana Helis Henry Medical Research Foundation New OrleansLA United States Adrienne Helis Malvin Medical Research Foundation New OrleansLA United States Department of Neuroscience and Physiology Interdisciplinary Program in Neuroscience Dental Research Institute Seoul National University Seoul08826 Korea Republic of Department of Chemistry College of Natural Science Seoul National University Seoul08826 Korea Republic of School of Chemical and Biological Engineering College of Engineering Seoul National University Seoul08826 Korea Republic of Inter University Semiconductor Research Centre Seoul National University Seoul08826 Korea Republic of Institute for Protein Research Osaka University Yamadaoka 3 2 Suita Japan

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Corrigendum to "Target-specific near-IR induced drug release and photothermal therapy with accumulated Au/Ag hollow nanoshells on pulmonary cancer cell membranes" [Biomaterials 45 (2015) 81-92]

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Biomaterials 2015年 65卷 124-125页

作者： Mi Suk Noh Somin Lee Homan Kang Jin-Kyoung Yang Hyunmi Lee Doyk Hwang Jong Woo Lee Sinyoung Jeong Yoonjeong Jang Bong-Hyun Jun Dae Hong Jeong Seong Keun Kim Yoon-Sik Lee Myung-Haing Cho Laboratory of Toxicology College of Veterinary Medicine Seoul National University Seoul 151-742 Republic of Korea Program in Nano Science and Technology Graduate School of Convergence Science and Technology Seoul National University Seoul 151-742 Republic of Korea Medical Supplies Evaluation Center Korea Testing Certification Gunpo 435-862 Republic of Korea. Graduate Group of Tumor Biology Seoul National University Seoul 151-742 Republic of Korea. Interdisciplinary Program in Nano-Science and Technology Seoul National University Seoul 151-742 Republic of Korea School of Electrical Engineering and Computer Science Seoul National University Seoul 151-742 Republic of Korea. School of Chemical and Biological Engineering Seoul National University Seoul 151-742 Republic of Korea. Department of Biophysics and Chemical Biology and Department of Chemistry Seoul National University Seoul 151-742 Republic of Korea. Department of Chemistry Education Seoul National University Seoul 151-742 Republic of Korea. Laboratory of Toxicology College of Veterinary Medicine Seoul National University Seoul 151-742 Republic of Korea. Department of Bioscience and Biotechnology Konkuk University Seoul 143-701 Republic of Korea. Department of Chemistry Education Seoul National University Seoul 151-742 Republic of Korea. School of Chemical and Biological Engineering Seoul National University Seoul 151-742 Republic of Korea. Electronic address: yslee@snu.ac.kr. Graduate Group of Tumor Biology Seoul National University Seoul 151-742 Republic of Korea Advanced Institute of Convergence Technology Seoul National University Suwon 443-270 Republic of Korea. Electronic address: mchotox@snu.ac.kr.

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Author Correction: SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs

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EXPERIMENTAL AND MOLECULAR MEDICINE 2023年第12期55卷 2609-2609页

作者： Kim, Junsoo Youn, Daehwa Choi, Seunghoon Lee, Youn Woo Sumberzul, Dulguun Yoon, Jeongeun Lee, Hanju Bae, Jong Woo Noh, Hyuna On, Dain Hong, Seung-Min An, Se-Hee Jang, Hui Jeong Kim, Seo Yeon Kim, Young Been Hwang, Ji-Yeon Lee, Hyo-Jung Kim, Hong Bin Park, Jun Won Yun, Jun-Won Shin, Jeon-Soo Seo, Jun-Young Nam, Ki Taek Choi, Kang-Seuk Lee, Ho-Young Chang, Hyeshik Seong, Je Kyung Cho, Jun Center for RNA Research Institute for Basic Science (IBS) Seoul National University Seoul Republic of Korea Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju Republic of Korea Korea Mouse Phenotyping Center (KMPC) Seoul National University Seoul Republic of Korea Laboratory of Developmental Biology and Genomics Research Institute for Veterinary Science and BK 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul Republic of Korea Department of Nuclear Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea School of Biological Sciences Seoul National University Seoul Republic of Korea Laboratory of Avian Diseases Research Institute for Veterinary Science and BK 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul Republic of Korea Preclinical Research Center Seoul National University Bundang Hospital Seongnam Republic of Korea Department of Periodontology Section of Dentistry Seoul National University Bundang Hospital Seongnam Republic of Korea Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Republic of Korea Division of Biomedical Convergence College of Biomedical Science Kangwon National University ChunCheon Republic of Korea Laboratory of Veterinary Toxicology College of Veterinary Medicine Seoul National University Seoul Republic of Korea Severance Biomedical Science Institute Graduate School of Medical Science Brain Korea 21 Project Yonsei University College of Medicine Seoul Republic of Korea Department of Nuclear Medicine Seoul National University College of Medicine Seoul Republic of Korea Interdisciplinary Program and BIO MAX Institute Seoul National University

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