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The processed C-terminus of AvrRps4 effector suppresses plant immunity via targeting multiple WRKYs

Journal of Integrative Plant Biology 2024年第8期66卷 1769-1787页

作者： Quang-Minh Nguyen Arya Bagus Boedi Iswanto Hobin Kang Jiyun Moon Kieu Anh Thi Phan Geon Hui Son Mi Chung Suh Eui-Hwan Chung Walter Gassmann Sang Hee Kim Division of Applied Life Science(BK21 Four Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea Department of Life Science Sogang UniversitySeoul 04107Korea Department of Plant Biotechnology Korea UniversitySeoul 02841Korea Division of Plant Science and Technology Christopher S.Bond Life Sciences Center and Interdisciplinary Plant GroupUniversity of MissouriColumbiaMissouri 65211USA Division of Life Science and Research Institute of Molecular Alchemy Gyeongsang National UniversityJinju 52828Korea

Pathogens generate and secrete effector proteins to the host plant cells during pathogenesis to promote virulence and *** the plant carries resistance(R)proteins that recognize pathogen effectors,effector-triggered immunity(ETI)is activated,resulting in a robust immune response and hypersensitive response(HR).The bipartite effector AvrRps4 from Pseudomonas syringae *** has been well studied in terms of avirulence *** planta,AvrRps4 is processed into two *** Cterminal fragment of AvrRps4(AvrRps4^(C))induces HR in turnip and is recognized by the paired resistance proteins AtRRS1/AtRPS4 in ***,we show that AvrRps4^(C)targets a group of Arabidopsis WRKY,including WRKY46,WRKY53,WRKY54,and WRKY70,to induce its virulence ***,AvrRps4^(C)suppresses the general binding and transcriptional activities of immune-positive regulator WRKY54 and WRKY54-mediated ***4^(C)interferes with WRKY54's binding activity to target gene SARD1 in vitro,suggesting WRKY54 is sequestered from the SARD1 promoter by AvrRps4^(C).Through the interaction of Avr Rps4^(C)with four WRKYs,AvrRps4 enhances the formation of homo-/heterotypic complexes of four WRKYs and sequesters them in the cytoplasm,thus inhibiting their function in plant ***,our results provide a detailed virulence mechanism of AvrRps4 through its C-terminus.

关键词： AvrRps4 bacterial effector effector-triggered immunity immune response suppression transcription factor WRKY

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The core morning clock component CCA1 enhances UPR target gene expression to facilitate ER stress recovery

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Plant Communications 2025年第4期6卷 234-247页

作者： Gyeongik Ahn In Jung Jung Gyeong-Im Shin Song Yi Jeong Myung Geun Ji Jin-Sung Huh Ji-Won Hwang Jeongsik Kim Joon-Yung Cha Sang Yeol Lee Min Gab Kim Woe-Yeon Kim Division of Applied Life Science(BK21 Four) PBRRCPMBBRCRILS&IALSGyeongsang National UniversityJinju 52828Republic of Korea National Institute of Wildlife Disease Control and Prevention(NIWDC) Ministry of EnvironmentGwangju 62407Republic of Korea Faculty of Science Education and Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National UniversityJeju 63243Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Science PMBBRCGyeongsang National UniversityJinju 52828Republic of Korea

The endoplasmic reticulum(ER)is a cellular organelle responsible for protein synthesis and *** its protein folding capacity is exceeded,unfolded or misfolded proteins accumulate,causing ER stress and triggering the unfolded protein response(UPR)to restore ER *** UPR gene expression in plants follows a diel cycle,the mechanisms by which the circadian clock regulates these genes remain ***,we demonstrate that sensitivity to ER stress in root growth exhibits time-of-day phases and that the circadian clock regulates UPR target gene expression during ER ***,mutations in the core morning clock component CIRCADIAN CLOCK ASSOCIATED 1(CCA1)impair ER stress ***1 forms a complex with the UPR modulator basic leucine zipper 28(bZIP28)and acts as an upstream regulator of ER stress *** ER stress,CCA1 is stabilized and associates with bZIP28 at the ER stress response element within the BiP3 promoter,enhancing the ER stress ***,CCA1 and bZIP28 coordinate a time-dependent adaptive response to ER stress to maintain ER *** re-sults suggest that the circadian clock primes the timing and levels of ER chaperone expression to enhance ER stress tolerance.

关键词： circadian clock ER stress ER chaperone CCA1 bZIP28

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HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis

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Plant Communications 2023年第4期4卷 225-239页

作者： Gyeongik Ahn Hee Jin Park Song Yi Jeong Gyeong-Im Shin Myung Geun Ji Joon-Yung Cha Jeongsik Kim Min Gab Kim Dae-Jin Yun Woe-Yeon Kim Research Institute of Life Science Institute of Agricultural and Life ScienceGyeongsang National UniversityJinju 52828Republic of Korea Division of Applied Life Science(BK21 Four) Plant Biological Rhythm Research CenterPlant Molecular Biology and Biotechnology Research CenterGraduate School of Gyeongsang National UniversityJinju 52828Republic of Korea Department of Biological Sciences College of Natural SciencesChonnam National UniversityGwangju 61186Republic of Korea Faculty of Science Education and Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National UniversityJeju 63243Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Science PMBBRCGyeongsang National UniversityJinju 52828Republic of Korea Institute of Glocal Disease Control Konkuk UniversitySeoul 05029Republic of Korea Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE) Northeast Normal UniversityChangchun 130024China

Flowering is the primary stage of the plant developmental transition and is tightly regulated by environmental factors such as light and ***,the mechanisms by which temperature signals are integrated into the photoperiodic flowering pathway are still poorly ***,we demonstrate that HOS15,which is known as a GI transcriptional repressor in the photoperiodic flowering pathway,controls flowering time in response to low ambient *** 16℃,the hos15 mutant exhibits an early flowering phenotype,and HOS15 acts upstream of photoperiodic flowering genes(GI,CO,and FT).GI protein abundance is increased in the hos15 mutant and is insensitive to the proteasome inhibitor ***,the hos15 mutant has a defect in low ambient temperature-mediated GI degradation,and HOS15 interacts with COP1,an E3 ubiquitin ligase for GI *** analyses of the hos15 cop1 double mutant revealed that repression of flowering by HOS15 is dependent on COP1 at 16℃.However,the HOS15-COP1 interaction was attenuated at 16℃,and GI protein abundance was additively increased in the hos15 cop1 double mutant,indicating that HOS15 acts independently of COP1 in GI turnover at low ambient *** study proposes that HOS15 controls GI abundance through multiple modes as an E3 ubiquitin ligase and transcriptional repressor to coordinate appropriate flowering time in response to ambient environmental conditions such as temperature and day length.

关键词： Arabidopsis flowering response low ambient temperature HOS15 GIGANTEA

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Taxonomic study on Sinopoda Jäger, 1999 (Araneae, Sparassidae, Heteropodinae), with three new species from Korea

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ZooKeys 2022年第1114期2022卷 77-104页

作者： Chae, Junho Lee, Jun-Gi Kim, Sam-Kyu Department of Biological Sciences Kangwon National University Chuncheon 24341 South Korea Applied Biology Program Division of Bio-Resource Science College of Agriculture & Life Sciences Kangwon National University Chuncheon 24341 South Korea Interdisciplinary Program in Smart Agriculture College of Agriculture & Life Sciences Kangwon National University Chuncheon 24341 South Korea

The genus Sinopoda Jäger, 1999 is a group of huntsman spiders (Araneae: Sparassidae: Heteropodinae), and currently seven species have been reported in Korea. In this study, three new species are described from Ko-rea, Sinopoda bigibba sp. nov., Sinopoda bogil sp. nov., and Sinopoda pantherina sp. nov.;Sinopoda jirisanen-sis Kim & Chae, 2013 is revalidated with neotype designation, and had been formerly synonymized with Si-nopoda forcipata (Karsch, 1881). Additionally, all previous records of Sinopoda stellatops Jäger & Ono, 2002 and S. forcipata from Korea are deemed misidentifications of S. jirisanensis and S. bogil sp. nov., respectively. © Junho Chae et al.

关键词： Biodiversity huntsman spiders Northeast Asia revalidation taxonomy

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Multi-class Segmentation of Anatomical Structures Using Deep Learning in CBCT Images Containing Metal Artifacts

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Transactions of the Korean Institute of Electrical Engineers 2022年第1期71卷 253-260页

作者： Yang, Su Chun, Soyoung Kim, Dael Jeoun, Bo Soung Yoo, Jiyong Kang, Se-Ryong Choi, Min-Hyuk Kim, Jo-Eun Huh, Kyung-Hoe Lee, Sam-Sun Heo, Min-Suk Yi, Won-Jin Dept. of Applied Bioengineering Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Republic of Interdisciplinary Program of Bioengineering Seoul National University Seoul Korea Republic of Dept. of Biomedical Radiation Sciences Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Republic of Dept. of Oral and Maxillofacial Radiology Seoul National University Dental Hospital Seoul Korea Republic of Dept. of Oral and Maxillofacial Radiology School of Dentistry and Dental Research Institute Seoul National University Seoul Korea Republic of

In order to perform preoperative surgical planning, accurate segmentation of anatomical structures in cone-beam computed tomography (CBCT) images is required. However, this image segmentation is often impeded by metal artifacts, and it takes a lot of time due to morphological variability in patients. In this paper, we proposed a deep learning based automatic multi-calss segmentation method for anatomical structures in CBCT images containing metal artifacts. Four U-Net based deep learning models were used for anatomical structure segmentation. Each deep learning model was constructed by changing the encoder of U-Net architecture to the backbones (DenseNet121, VGGNet16, ResNet101, and EfficienNetB4). For training and testing our method, we used 20744 CBCT images containing metal artifacts from 30 patient datasets. Experimental results show that the segmentation performances of the mandible, midfacial bone, mandibular canal, and maxillary sinus were achieved F1 scores of , , , and using DenseNet121 with Tversky loss, respectively. Furthermore, our method was able to perform robust and accurate segmentation of anatomical structures in CBCT images containing metal artifacts. © 2022 Korean Institute of Electrical Engineers. All rights reserved.

关键词： Image segmentation

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Structural and functional imaging of brains

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science China Chemistry 2023年第2期66卷 324-366页

作者： Zhichao Liu Ying Zhu Liming Zhang Weiping Jiang Yawei Liu Qiaowei Tang Xiaoqing Cai Jiang Li Lihua Wang Changlu Tao Xianzhen Yin Xiaowei Li Shangguo Hou Dawei Jiang Kai Liu Xin Zhou Hongjie Zhang Maili Liu Chunhai Fan Yang Tian Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200241China Interdisciplinary Research Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai201210China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Chinese Academy of SciencesWuhan National Laboratory for OptoelectronicsWuhan430071China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China Department of Chemistry Tsinghua UniversityBeijing100084China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Translational MedicineShanghai Jiao Tong UniversityShanghai200240China Interdisciplinary Center for Brain Information Brain Cognition and Brain Disease InstituteShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Lingang Laboratory Shanghai201602China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai200240China Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen518055China Department of Nuclear Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Analyzing the complex structures and functions of brain is the key issue to understanding the physiological and pathological *** neuronal morphology and local distribution of neurons/blood vessels in the brain have been known,the subcellular structures of cells remain challenging,especially in the live *** addition,the complicated brain functions involve numerous functional molecules,but the concentrations,distributions and interactions of these molecules in the brain are still poorly *** this review,frontier techniques available for multiscale structure imaging from organelles to the whole brain are first overviewed,including magnetic resonance imaging(MRI),computed tomography(CT),positron emission tomography(PET),serial-section electron microscopy(ss EM),light microscopy(LM)and synchrotron-based X-ray microscopy(XRM).Specially,XRM for three-dimensional(3D)imaging of large-scale brain tissue with high resolution and fast imaging speed is ***,the development of elegant methods for acquisition of brain functions from electrical/chemical signals in the brain is *** particular,the new electrophysiology technologies for neural recordings at the single-neuron level and in the brain are also *** also focus on the construction of electrochemical probes based on dual-recognition strategy and surface/interface chemistry for determination of chemical species in the brain with high selectivity and long-term stability,as well as electrochemophysiological microarray for simultaneously recording of electrochemical and electrophysiological signals in the ***,the recent development of brain MRI probes with high contrast-to-noise ratio(CNR)and sensitivity based on hyperpolarized techniques and multi-nuclear chemistry is ***,multiple optical probes and instruments,especially the optophysiological Raman probes and fiber Raman photometry,for imaging and biosensing in live brain are emphas

关键词： brain structure brain function brain chemistry chemical signal biosensing and bioimaging

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Label-Free and Liquid State Sers Detection of Multi-Scaled Bioanalytes Via Light-Induced Pinpoint Colloidal Assembly

SSRN

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SSRN 2024年

作者： Han, Seungyeon Park, Junhee Moon, Sunghyun Eom, Seonghyeon Jin, Chang Min Kim, Seungmin Ryu, Yong-Sang Choi, Yeonho Lee, Jong Bum Choi, Inhee Department of Life Science University of Seoul Seoul02504 Korea Republic of Department of Chemical Engineering University of Seoul Seoul02504 Korea Republic of Department of Biomedical Engineering Korea University Seoul02481 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02481 Korea Republic of Exopert Corporation Seoul02580 Korea Republic of Department of Applied Chemistry University of Seoul Seoul02504 Korea Republic of

Surface-enhanced Raman scattering (SERS) has been extensively applied to detect complex analytes due to its ability to enhance the fingerprint signals of molecules around nanostructured metallic surfaces. Thus, it is essential to design SERS-active nanostructures with abundant electromagnetic hotspots in a probed volume according to the dimensions of the analytes, as the analytes must be located in their hotspots for maximum signal enhancement. Herein, we demonstrate a simple method for detecting robust SERS signals from multi-scaled bioanalytes, regardless of their dimensions in the liquid state, through a photothermally driven co-assembly with colloidal plasmonic nanoparticles as signal enhancers. Under resonant light illumination, plasmonic nanoparticles and analytes in the solution quickly assemble at the focused surface area by convective movements induced by the photothermal heating of the plasmonic nanoparticles without any surface modification. Such collective assemblies of plasmonic nanoparticles and analytes were optimized by varying the optical density and surface charge of the nanoparticles, the viscosity of the solvent, and the light illumination time to maximize the SERS signals. Using these light-induced co-assemblies, the intrinsic SERS signals of small biomolecules can be detected down to nanomolar concentrations based on their fingerprint spectra. Furthermore, large-sized biomarkers, such as viruses and exosomes, were successfully detected without labels, and the complexity of the collected spectra was statistically analyzed using t-distributed stochastic neighbor embedding combined with support vector machine (t-SNE+SVM). The proposed method is expected to provide a robust and convenient method to sensitively detect biologically and environmentally relevant analytes at multiple scales in liquid samples. © 2024, The Authors. All rights reserved.

关键词： Viruses

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Cultivation of Chlorella sp. HS2 using wastewater from soy sauce factory

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Chemosphere 2023年 342卷 140162页

作者： Kim, Minsik Lee, Sang-Ah Yun, Jin-Ho Ko, So-Ra Cho, Dae-Hyun Kim, Hee Su Oh, Hee-Mock Kim, Hee-Sik Ahn, Chi-Yong Daejeon34141 Korea Republic of Dept. of Biological Engineering Inha University Incheon22212 Korea Republic of Faculty of Biotechnology College of Applied Life Sciences Jeju National University Jeju63243 Korea Republic of Interdisciplinary Graduate Program in Advance Convergence Technology and Science Jeju National University Jeju63243 Korea Republic of Department of Integrative Biotechnology Sungkyunkwan University Gyeonggi-do Suwon16419 Korea Republic of FarmHannong Chungcheongnam-do Nonsan33010 Korea Republic of

Incorporation of wastewater from industrial sectors into the design of microalgal biorefineries has significant potential for advancing the practical application of this emerging industry. This study tested various food industrial wastewaters to assess their suitability for microalgal cultivation. Among these wastewaters, defective soy sauce (DSS) and soy sauce wastewater (SWW) were chosen but DSS exhibited the highest nutrient content with 13,500 ppm total nitrogen and 3051 ppm total phosphorus. After diluting DSS by a factor of 50, small-scale cultivation of microalgae was conducted to optimize culture conditions. SWW exhibited optimal growth at 25–30 °C and 300–500 μE m−2 s−1, while DSS showed optimal growth at 30–35 °C. Based on a 100-mL lab-scale and 3-L outdoor cultivation with an extended cultivation period, DSS outperformed SWW, exhibiting higher final biomass productivity. Additionally, nutrient-concentrated nature of DSS is advantageous for transportation at an industrial scale, leading us to select it as the most promising feedstock for microalgal cultivation. With further optimization, DSS has the potential to serve as an effective microalgal cultivation feedstock for large-scale biomass production. © 2023 The Authors

关键词： Microalgae

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EXCESSIVE SUCROSE EXACERBATES HIGH FAT DIET-INDUCED HEPATIC INFLAMMATION AND FIBROSIS PROMOTING OSTEOARTHRITIS IN MICE MODEL

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Osteoarthritis and Cartilage 2025年 33卷 S139-S140页

作者： Yunhui Min Yunji Heo Dinesh Suminda Godagama Gamaarachchige minhye Kim myeongyeon shin Md. M. Ansari Young-Ok Son Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University Jeju Korea (the Republic of) Department of Animal Biotechnology Faculty of Biotechnology College of Applied Life Sciences Jeju National University Jeju-si Jeju-do Korea (the Republic of) Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju national University Jeju-si Jeju-do Korea (the Republic of)

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Manipulation of the nanoscale heliconical structure of a twist-bend nematic material with polarized light

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Physical Review Research 2020年第3期2卷 032004(R)-032004(R)页

作者： C. Feng J. Feng R. Saha Y. Arakawa J. Gleeson S. Sprunt C. Zhu A. Jákli Chemical Physics Interdisciplinary Program Advanced Materials and Liquid Crystal Institute Kent State University Kent Ohio 44242 USA Advanced Light Source Lawrence Berkeley National Lab Berkeley California 94720 USA Department of Physics Kent State University Kent Ohio 44242 USA Department of Applied Chemistry and Life Science Graduate School of Engineering Toyohashi University of Technology Toyohashi 441-8580 Japan

The effect of polarized violet light on the alignment and the heliconical pitch of a liquid crystal dimer containing both sulfur atoms and an azo linkage has been studied by tender resonant x-ray scattering. The results provide evidence of the manipulation of the nanoscale heliconical structure by polarized light. In addition to the bulk alignment of the heliconical nanostructure, the value of the heliconical pitch can be varied as well. After turning the light on, an increase of the pitch is observed in two steps. The increase with a subsecond timescale is attributed to the reduced heliconical order related to trans-cis photoisomerization. This is followed by a smaller increase over a 10-s timescale, which is likely related to the annihilation of defects. After turning the light off, the pitch first decreases within a few seconds to a value larger than the original (before illumination), and then relaxes further on a much longer (hours) timescale.

关键词： Chiral symmetry Dynamical phase transitions Twist deformation

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