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15th biomedical engineering International Conference, BMEiCON 2023

作者： Rattana, Aksarapak Yamdech, Rungnapha Damrongsakkul, Siriporn Rattanavaraporn, Juthamas Thongnuek, Peerapat Kanokpanont, Sorada Mota, Antonella Nopprang, Phatcharaphon Sangkitporn, Siripakorn Dambua, Acharaporn Boonchu, Patcharaporn Suparak, Supaporn Dhepakson, Panadda Jamkratoke, Jutarat Center of Excellence in Biomaterial Engineering in Medical and Health Thailand Chulalongkorn University Department of Chemical Engineering Bangkok Thailand Chulalongkorn University Biomedical Engineering Program Faculty of Engineering Bangkok Thailand University of Trento BIOtech Research Center Department of Industrial Engineering TN Mattarello Italy Ministry of Public Health Advanced Therapy Medicinal Product Center Department of Medical Sciences Nonthaburi Thailand The Queen Sirikit Sericulture Center Nakhon Ratchasima Nakorn Ratchasima Thailand

ISBN: (纸本)9798350345247

This is the first report of sterile Thai silk fibroin (SF) solution (2-4% (w/v) in water) production at semi-commercial scale under the medical device management system conforming to standard ISO13485:2016. Thai silk cocoons (Bombyx mori, local strain, named Nangnoi Srisaket 1) was maintained, cultured and produced in controlled conditions at The Queen Sirikit Sericulture Center Nakhon Ratchasima, Thailand. The GMP (Medical Device) conformed protocol was optimized. The degummed silk fibers were dissolved in concentrated ionic liquid and purified in the clean room facility of the Department of Medical Sciences, Ministry of Public Health, Thailand. With minimal sterilization of the end product (4%w/w SF Solution), sterility and endotoxin test of the product indicated that the purified proteins were negative for bacteria, mycobacteria, yeast and fungi. The endotoxin levels of all inputs, intermediates and the product was © 2023 IEEE.

关键词： Purification

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Towards Mathematical Modeling of Tissue-Engineered Skeletal Muscle Considering Contraction-Induced Stiffness Changes*

Towards Mathematical Modeling of Tissue-Engineered Skeletal ...

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IEEE International Conference on Cyborg and Bionic Systems (CBS)

作者： Yoshitake Akiyama Mizuki Nakamura Noriyasu Iwamoto Ken Masuya Biomedical Engineering Department Shinshu University Ueda-shi Nagano JAPAN YKK Corporation Kurobe-shi Toyama JAPAN Mechanical Engineering Program Faculty of Engineering University of Miyazaki Miyazaki-shi Miyazaki JAPAN

ISBN: (数字)9798350388039

ISBN: (纸本)9798350388046

Recently, bio-hybrid devices using muscle tissue or muscle cells as a drive source have been actively studied. Although there have been many reports on the development of bioactuators, most of them are concerned with muscle tissue culture and assembly methods, and very few studies have been conducted from the control engineering perspective of tissue-engineered muscle actuators. It is known that the stiffness of muscle changes between relaxation and excitation, and in particular, empirically, tissue-engineered muscle is immature compared to biological muscle, so the change in stiffness during contraction is relatively very large. Therefore, we will first evaluate the change in stiffness of cultured muscle during relaxation and contraction by a push test and confirm that the stiffness increases significantly with TESM. In addition, it is difficult to represent this large change in stiffness using the conventional Hill’s four-element model. Therefore, this study proposes a model of TESM in which two active elements that are involved only during contraction are added to Hill’s four-element model. The force equations for these isometric tests are derived. As a next step, we plan to experimentally identify the parameters to confirm the validity of this model.

关键词： Actuators Control engineering Biological system modeling Human-machine systems Force Muscles Mathematical models Assembly

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Flood modeling in the Ba River basin using a coupled hydrodynamic model—MIKE FLOOD

River

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River 2024年第2期3卷 199-207页

作者： Luc Anh Tuan Can Thu Van Doan Van Binh Sameh AKantoush Tetsuya Sumi Le Van Quyen Ta Thi Huong Master Program in Water Technology Reuse&Management(with TU DarmstadtGermany)Faculty of EngineeringVietnamese–German UniversityBen Cat TownVietnam Ho Chi Minh City University of Natural Resources and Environment Ho Chi Minh CityVietnam Water Resources Research Center Disaster Prevention Research InstituteKyoto UniversityKyotoJapan VNU School of Interdisciplinary Study and Arts Cau GiayVietnam

The problem of flooding in Central Vietnam in general and the lower Ba River in particular is one of the natural disasters that frequently threatens people's lives and socioeconomic development in the ***,climate change is becoming ever more prominent and hotter,making extreme natural disasters more unusual and *** this research,MIKE-FLOOD—a model that connects a 1-dimensional(1-D)MIKE 11 Hydrodynamics(HD)model with a 2-dimensional(2-D)MIKE 21 HD model—was used to set *** model was calculated for three floods:(1)flood in October 1993,(2)flood in November 2003,and(3)flood in November 2007;these are floods with high frequency and relatively large *** results show that the 1993 flood rose and receded *** flood peak inundated an area of 22,600 ha,accounting for 52%of the natural *** flooded areas deeper than 1,2,3,4,and 5m were 16500,11,000,7000,4200,and 2200 ha,*** the center of Tuy Hoa city,the flooded area at the time of maximum water level was almost 100%.

关键词： Ba River basin coupled hydrodynamic model flooding MikeFlood model

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Effect of High-Flow Nasal Cannula on Capnogram Waveform for Studying Non-Invasive Human Ventilation

Effect of High-Flow Nasal Cannula on Capnogram Waveform for ...

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biomedical engineering Conference (NBEC), IEEE National

作者： Tjokorda Gde Tirta Nindhia Nursyasa Aqila Mohammed Julia Jais Jamaludin Pagupathi Devandran Nabiel Rafa Angel Bhaswara Thalitakum Hutajulu M.B. Malarvili Study Program of Mechanical Engineering Engineering Faculty Udayana University Jimbaran Bali Indonesia School of Biomedical and Health Science Engineering Universiti Teknologi Malaysia Johor Malaysia

This study is conducted to compare three different cannulas; all purpose nasal cannula with 2 prongs, nasal pressure cannula with 2 prongs and single port nasal cannula which are commonly used for capnography device. These cannulas or sometimes called as nasal prong is connected to the device via nose of subjects studied. This procedure is a part of respiratory study to monitor lungs condition and breathing pattern. This study involves 47 subject where the exhaled breath was recorded to make comparison and choose the most suitable and effective for capnography waveform analysis. Utilizing Statistical Package for the Social Sciences (SPSS) to find the normality of all the nasal cannula data based on capnogram waveform. The result from the analysis shows that the frequency distribution for type 1 nasal cannula which is also known as all-purpose nasal cannula had the feature values closer to the standard value. Our study proofs that all purpose nasal cannula sampling is the most suitable to capture exhaled breath for monitoring respiratory conditions.

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Predicting Potential Fires in Indonesia by Analyzing VIIRS Night Data during 2018 – 2022

Predicting Potential Fires in Indonesia by Analyzing VIIRS N...

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International Symposium on Grids and Clouds 2023 in conjunction with HEPiX Spring Workshop, ISGC and HEPiX 2023

作者： Suhardiman, Basuki Hermanto, Benni Rio Directorate of Information Technology Institut Teknologi Bandung Jl Ganesha 10 Bandung Indonesia Master’s Program in Computational Science Faculty of Mathematics and Natural Sciences Institut Teknologi Bandung Jl Ganesha 10 Bandung Indonesia Biomedical Engineering Department School of Electrical Engineering and Informatics Institut Teknologi Bandung Indonesia

Forest fires have been detected to occur in Indonesia since 1998. The forest fires mostly resulted from human activities in order to expand their land, especially oil palm lands. Once a land clearing is carried out, it covers areas of tens to hundreds of thousands of hectares. The peak of the forest fires occurred in 2015 when almost half of the world was affected especially by smoke from the fire. In 2011, VIIRS (Visible Infrared Imaging Radiometer Suite) was launched by NOAA (National Oceanic and Atmospheric Administration). In their collected data, there is data on Indonesia issued daily for areas in the islands of Java, Sumatra, Kalimantan, Sulawesi, and the general areas of Indonesia. The VIIRS night data shows the possibility of some burning at night. We need to identify burnings that potentially become fires, which are potentially producing smoke. It is important to observe areas where large-scale forest fires frequently occur, so the authority could do some prevention beforehand. Using existing data released per day per area, we utilize an ANN (Artificial Neural Network) to identify a potential fire. The processes start with data cleaning and processing, Neural Network creation, and finally ANN training and testing. By using the ANN prediction model with the MinMax Scaler, we choose variables Temperature, Radiant Heat Intensity, and Source Footprint. Simulations are made to show the ranges of these variables that predict the possibility of’flame’ status occurring. We conclude that the ANN method can give more accurate results than the existing classification. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Fires

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Correction: Recent progress in DNA data storage based on high-throughput DNA synthesis

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biomedical engineering letters 2024年第5期14卷 1147-1152页

作者： Seokwoo Jo Haewon Shin Sung-Yune Joe David Baek Chaewon Park Honggu Chun Department of Biomedical Engineering Korea University 466 Hana Science Hall Seoul 02841 Korea. Interdisciplinary Program in Precision Public Health Korea University 466 Hana Science Hall Seoul 02841 Korea.

[This corrects the article DOI: 10.1007/s13534-024-00386-z.].

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STABLE AND SCALABLE engineering OF HUMAN PRIMARY T CELLS VIA MICROFLUIDIC CELL STRETCHING 25

STABLE AND SCALABLE ENGINEERING OF HUMAN PRIMARY T CELLS VIA...

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25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Hur, Jeongsoo Chung, Aram School of Biomedical Engineering Korea University Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Korea Republic of

ISBN: (纸本)9781733419031

A novel microfluidic approach specifically designed to engineer human primary T-lymphocytes effectively with high scalability while maintaining cell functionality is reported. The system employs a unique cell elongation-restoration phenomenon called "cell stretching," which enables highly effective intracellular delivery of external cargos into cells. Vortical recirculation flows are exerted where cells are hydrodynamically elongated and restored, resulting in effective permeabilization of the cellular membrane. Using the platform, highly efficient (>90%), low-material-cost (6 cells/min) delivery of various cargos into human primary T-cells was achieved, demonstrating the practical utility for chimeric antigen receptor (CAR) T-cell-based cancer immunotherapy. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： T-cells

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Investigating malignancy-dependent mechanical properties of breast cancer cells

Investigating malignancy-dependent mechanical properties of ...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Zeina Habli Ahmad Zantout Marwan El-Sabban Massoud L. Khraiche Biomedical Engineering Program Maroun Semaan Faculty of Engineering and Architecture AUB Beirut Lebanon Department of Anatomy Cell Biology and Physiological Sciences Faculty of Medicine AUB Beirut Lebanon

Cancer invasiveness significantly impacts cellular mechanical properties which regulate cell motility and, subsequently, cell metastatic potential. Understanding the adhesion forces and stiffness/rigidity of cancer cells can provide better insights into their mechanical adaptability related to their degree of invasiveness. Here, we used single-cell force spectroscopy in conjunction with quartz crystal microbalance-with dissipation measurements to compare the mechanical properties of mammary epithelial cancer cells with different metastatic potentials, namely MCF-7 (non-invasive) and MDA-MB-231 (aggressive and highly invasive). Our results showed that MCF-7 exhibits larger adhesion forces, stronger intercellular forces, and a considerably stiff/rigid phenotype, contrary to MDA-MB-231. The biomechanical properties obtained are associated with the malignant potential of these cells such that the forces of adhesion and viscoelasticity are inversely proportional to cell invasiveness. This study integrates a new quantitative tool with real-time measurements to provide better insights into the mechanics of cancer cells across metastatic stages.

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Subject-Specific Pre-Processing Pipeline for EEG Artifact Removal Aimed at Enhancing SSVEP Detection

Subject-Specific Pre-Processing Pipeline for EEG Artifact Re...

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biomedical engineering and Bioengineering (CI-IB&BI), IEEE International Congress of

作者： Andres F. Ruiz-Olaya Emma V. Beltran Edith Pulido Faculty of Mechanical Electronics and Biomedical Engineering Antonio Nariño University Bogota Colombia Bioenginering Program Universidad El Bosque Bogota Colombia

ISBN: (数字)9798331532352

ISBN: (纸本)9798331532369

Steady-State Visually Evoked Potentials (SSVEP) based Brain-Computer Interfaces (BCIs) offer significant potential in assistive and rehabilitation technologies. However, the performance of SSVEP detection is often compromised by artifacts in Electroencephalography (EEG) signals and inter-subject variability, among other factors. This study introduces a subject-specific p reprocessing p ipeline a imed a t enhancing SSVEP signal detection accuracy. The proposed method involves a dual-stage approach, utilizing EEG signals recorded both during a baseline rest state and during tasks known to induce artifacts. By establishing a personalized reference for each subject, the pipeline enables more accurate artifact detection and removal. The pipeline's efficacy w as e valuated u sing Canonical Correlation Analysis (CCA) on an open EEG dataset, with performance assessed across varying time segments (1, 2, 3 y 4 s). Detection accuracy was calculated to quantify performance in SSVEP detection. The performance of the proposed method for the 4-second time segment was superior (96.44%) compared to the standard method (93.78%). The results demonstrate the pipeline's potential to improve the reliability of SSVEP-based BCIs, particularly in highly contaminated signals.

关键词： Electric potential Brain Visualization Accuracy Pipelines Electroencephalography Steady-state Standards Signal detection biomedical engineering

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Porous silicon on paper sensors: Factors affecting biosensing performance 17

Porous silicon on paper sensors: Factors affecting biosensin...

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Frontiers in Biological Detection: From Nanosensors to Systems XVII 2025

作者： An, Huijin Laibinis, Paul E. Locke, Andrea K. Weiss, Sharon M. Interdisciplinary Material Science Program Vanderbilt University NashvilleTN37235 United States Department of Electrical and Computer Engineering Vanderbilt University NashvilleTN37235 United States Department of Chemical and Biomolecular Engineering Vanderbilt University NashvilleTN37235 United States Department of Chemistry Vanderbilt University NashvilleTN37235 United States Department of Biomedical Engineering Vanderbilt University NashvilleTN37235 United States

ISBN: (纸本)9781510684249

A paper-based biosensor integrating a functionalized porous silicon (PSi) membrane as the active sensing element for quantifiable protein detection has been developed. For similar short-time exposures to an analyte, improved molecular transport in PSi membranes when on paper leads to larger signal changes compared to traditional PSi films that remain on a silicon substrate. In this work, we discuss controlling the incubation time of the analyte and the overall testing time of the sensor by incorporating different combinations of wicking and absorbent paper beneath the PSi membrane. With this control, the PSi-on-paper sensor platform has the potential to serve as an effective low-cost rapid diagnostic test with highly sensitive, quantitative readout for a wide range of analytes. © 2025 SPIE.

关键词： Porous silicon

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