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Fabrication of QCM sensor array and PDMS micro chamber for biosensor applications

Fabrication of QCM sensor array and PDMS micro chamber for b...

International Conference on Electrical engineering/Electronics, Computer, Telecommunications and Information Technology, ECTI-CON

作者： K. Jaruwongrungsee T. Maturos K. Wong-ek M. Sangworasil C. Pintavirooj A. Wisitsora-at A. Tuantranont Biomedical Signal and Image Processing Laboratory Department of Electronics Engineering Faculty of Engineering King Mongkut's Institute of Technology Ladkrabang Bangkok Thailand Nanoelectronics and MEMS Laboratory National Electronics and Computer Technology Center Pathum Thani Thailand Nanosceince and Technology Program Graduated College Chulalongkom University Bangkok Thailand

In this work, an array of quartz crystal microbalance (QCM) sensors is fabricated on a single quartz crystal substrate and attached with poly(dimethylsiloxane) (PDMS) micro chamber for using in flow-injection system. The Cr/Au electrode array is deposited on both side of quartz substrate by sputtering through electroplated microshadow mask. PDMS micro chamber was fabricated by mold casting technique with SU-8 mold. Fabricated PDMS micro chamber and QCM sensor array were attached together for using in flow-injection system. In our experiment, the QCM electrodes were coated with the carboxylic poly(vinyl chloride) (PVC-COOH) and then the carboxylic group was activated with carbodiimide hydrochloride (EDC) and N-hydroxylsuccinimide (NHS) for protein binding. The scanning electron micrograph shown the trapped protein on the modified sensing layer, it confirmed that our QCM sensor and PDMS micro chamber can be used as QCM biosensor array. This new QCM sensor array provide possibility of multiple detection in small amount of sample within a single quartz crystal substrate that avoid the error signal from the different properties of each sensor in an array.

关键词： Sensor arrays Biosensors Fabrication Sensor systems Electrodes Proteins Chromium Gold Sputtering Casting

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The Broad Institute-Six Years Later

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CHEMISTRY & BIOLOGY 2010年第4期17卷 311-312页

作者： McCarthy, Alice Main Text “In June 2003 the scientific and medical communities at MIT Harvard University and its affiliated hospitals and the Whitehead Institute banded together as collaborating partners to form the Eli and Edythe L. Broad Institute based in Cambridge MA. The Broad Institute established with initial funding from a $100 million philanthropic donation from the Los Angeles-based Broad family was primarily viewed as a marriage between the Whitehead Institute's Center for Genome Research (WICGR) and the Harvard Institute of Chemistry and Cell Biology (ICCB). Eli Broad founder and chairman of AIG SunAmerica Inc. explained “the purpose of the Broad Institute is to create a new type of research institute to build on the accomplishments of the human genome project and to move to clinical applications to both prevent and cure diseases.” Every Thursday morning we meet with perhaps 20 faculty members and 100 other researchers to discuss what we're all doing and should be doing next. -David Altschuler This paragraph was written five years ago when the Broad Institute was in its very earliest days as a life science research community (McCarthy 2005). Since that time “the Broad” as it's known has kept true to Eli Broad's vision having attracted a talented group of researchers faculty trainees and professional staff. This 1600 person research community known internally as “Broadies” includes faculty staff and students from throughout the MIT and Harvard biomedical research communities and beyond with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. “What is special about the Broad is that we have people from Harvard MIT and the Harvard hospitals come together and work on problems of shared interest that could not be solved in their own individuals labs” explains David Altshuler M.D. Ph.D. Deputy Director and one of the Broad's six core faculty members. “These problems require expertise beyond any one principal investigator and in

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Erratum to “Differences in cortical activity between methamphetamine-dependent and healthy individuals performing a facial affect matching task” [Drug and Alcohol Dependence 93 (2008) 93–102]

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Drug and Alcohol Dependence 2009年第3期101卷 213-214页

作者： Payer, Doris E. Lieberman, Matthew D. Monterosso, John R. Xu, Jiansong Fong, Timothy W. London, Edythe D. Neuroscience Interdepartmental Program University of California Los Angeles USA Department of Psychology University of California Los Angeles USA Department of Psychiatry and Biobehavioral Sciences University of California Los Angeles USA Department of Molecular and Medical Pharmacology University of California Los Angeles USA Brain Research Institute University of California Los Angeles USA Biomedical Engineering Interdepartmental Faculty University of California Los Angeles USA

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Personal dialysis using a web-based, portable system - C-PAK (Carry-on Pulse Artificial Kidney)

Personal dialysis using a web-based, portable system - C-PAK...

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BIODEVICES 2008 - 1st International Conference on biomedical Electronics and Devices

作者： Lee, Jung Chan Kim, Wook Eun Lim, Ki Moo Kim, Jeong Chul Min, Byoung Goo Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Biomedical Engineering Seoul National University Seoul Korea Republic of

ISBN: (纸本)9789898111173

While the number of patients suffering from acute and chronic renal failure has been steadily increasing every year, the mortality rate is not improving. For the purpose of improvement on the quality of life and mortality of renal disease patients, we employ the hemofiltration principle to treat the end-stage renal disease patients. Hemofiltration equipment can be installed without additional plumbing and electrical power construction;operated only with several pre-packaged fluid bags without a huge water treatment facility. This paper describes the development of portable renal treatment equipment based on hemofiltration treatment, Carry-on Pulse Artificial Kidney (C-PAK), and reports the results of animal test using the equipment. The web-based remote monitor/control system for C-PAK is introduced also. We expect that our portable hemofiltration device for chronic renal failure patient would be an alternative for conventional hemodialysis machine and a solution to home renal treatment.

关键词： Diseases

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Wavelet approach to artifact noise removal from Capacitive coupled Electrocardiograph

Wavelet approach to artifact noise removal from Capacitive c...

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30th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBS'08

作者： Seung, Min Lee Ko, Keun Kim Kwang, Suk Park Interdisciplinary Program of Bioengineering Seoul National University Graduate School Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Seoul National University Graduate School Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)9781424418152

Capacitive coupled Electrocardiography (ECG) is introduced as non-invasive measurement technology for ubiquitous health care and appliance are spread out widely. Although it has many merits, however, capacitive coupled ECG is very weak for motion artifacts for its non-skin-contact property. There are many studies for artifact problems which treats all artifact signals below 0.8Hz. In our capacitive coupled ECG measurement system, artifacts exist not only below 0.8Hz but also over than 10Hz. Therefore, artifact noise removal algorithm using wavelet method is tested to reject artifact-wandered signal from measured signals. It is observed that using power calculation each decimation step, artifact-wandered signal is removed as low frequency artifacts as high frequency artifacts. Although some original ECG signal is removed with artifact signal, we could level the signal quality for long term measure which shows the best quality ECG signals as we can get. © 2008 IEEE.

关键词： Electrocardiography

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Meeting Report from the Second "Minimum Information for Biological and biomedical Investigations" (MIBBI) workshop

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Standards in genomic sciences 2010年第3期3卷 259-66页

作者： Carsten Kettner Dawn Field Susanna-Assunta Sansone Chris Taylor Jan Aerts Nigel Binns Andrew Blake Cedrik M Britten Ario de Marco Jennifer Fostel Pascale Gaudet Alejandra González-Beltrán Nigel Hardy Jan Hellemans Henning Hermjakob Nick Juty Jim Leebens-Mack Eamonn Maguire Steffen Neumann Sandra Orchard Helen Parkinson William Piel Shoba Ranganathan Philippe Rocca-Serra Annapaola Santarsiero David Shotton Peter Sterk Andreas Untergasser Patricia L Whetzel Beilstein-Institut Frankfurt am Main Germany Centre for Ecology & Hydrology UK Oxford e-Research Centre University of Oxford UK The European Bioinformatics Institute (EBI) UK Faculty of Engineering - ESAT/SCD Leuven University Leuven-Heverlee Belgium Division of Pathway Medicine University of Edinburgh Medical School Edinburgh UK MRC Harwell UK Medical Department University Medical Center Johannes Gutenberg University-Mainz Mainz Germany Consortium for Genomic Technology Milano Italy University of Nova Gorica Nova Gorica Slovenia NIEHS NIH US National Toxicology Program USA Swiss Institute of Bioinformatics Geneva Switzerland Computational and Systems Medicine and Department of Computer Science University College London London UK Department of Computer Science Aberystwyth University Aberystwyth UK Center for Medical Genetics Ghent University Ghent Belgium Department of Plant Biology University of Georgia Athens USA Department of Stress- and Developmental Biology Institute for Plant Biochemistry Halle Germany Peabody Museum of Natural History Yale University New Haven USA Macquarie University Sydney Australia National University of Singapore Singapore Cancer Pharmacology The Mario Negri Institute for Pharmacological Research Milan Italy Image Bioinformatics Research Group Department of Zoology University of Oxford Oxford UK Wellcome Trust Sanger Institute UK Zentrum für Molekulare Biologie der Universität Heidelberg Heidelberg Germany The National Center for Biomedical Ontology / Stanford Center for Biomedical Informatics Research Stanford University Stanford USA

This report summarizes the proceedings of the second workshop of the 'Minimum Information for Biological and biomedical Investigations' (MIBBI) consortium held on Dec 1-2, 2010 in Rüdesheim, Germany through the sponsorship of the Beilstein-Institute. MIBBI is an umbrella organization uniting communities developing Minimum Information (MI) checklists to standardize the description of data sets, the workflows by which they were generated and the scientific context for the work. This workshop brought together representatives of more than twenty communities to present the status of their MI checklists and plans for future development. Shared challenges and solutions were identified and the role of MIBBI in MI checklist development was discussed. The meeting featured some thirty presentations, wide-ranging discussions and breakout groups. The top outcomes of the two-day workshop as defined by the participants were: 1) the chance to share best practices and to identify areas of synergy; 2) defining a series of tasks for updating the MIBBI Portal; 3) reemphasizing the need to maintain independent MI checklists for various communities while leveraging common terms and workflow elements contained in multiple checklists; and 4) revision of the concept of the MIBBI Foundry to focus on the creation of a core set of MIBBI modules intended for reuse by individual MI checklist projects while maintaining the integrity of each MI project. Further information about MIBBI and its range of activities can be found at http://***/.

关键词： Minimum Information European Bioinformatics Institute biomedical Ontology Stable Link Breakout Group

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Ionic Circuits Based on Polyelectrolyte Diodes on a Microchip†

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Angewandte Chemie 2009年第21期121卷

作者： Ji‐Hyung Han Kwang Bok Kim Hee Chan Kim Taek Dong Chung Department of Chemistry Seoul National University Seoul 151‐747 (Korea) Fax: (+82) 887‐4354 http://www.niel.or.kr/ Interdisciplinary Program Bioengineering Major Seoul National University Seoul 110‐744 (Korea) Department of Biomedical Engineering College of Medicine and Institute of Medical and Biological Engineering Medical Research Center Seoul National University Seoul 110‐744 (Korea)

Bei Grün gehen : Eine Polyelektrolytdiode auf einem Mikrochip zeigt ein eindeutiges nichtlineares Gleichrichterverhalten. Mit diesem System lässt sich in Echtzeit die dynamische Verteilung von Ionen in einer geladenen Polymerphase im elektrischen Feld mithilfe von Fluoreszenzbildern visualisieren. Mehrere Polyelektrolytdioden wurden auf einem Mikrochip integriert, um vielfältige Logikgatter auf Basis ionischer Schaltkreise herzustellen (siehe Bild).

关键词： Fluoreszenz Gleichrichter Ionische Schaltkreise Mikrochips Polyelektrolyte

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Effective coupling impedance for power line interference in capacitive-coupled ECG measurement system

Effective coupling impedance for power line interference in ...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Ko Keun Kim Kwang Suk Park Interdisciplinary Program in Biomedical Engineering Seoul National University Seoul South Korea Department of Biomedical Engineering Seoul National University Seoul South Korea

In this paper, the power line noise characteristics between conventional ECG measurement system using Ag/AgCl electrodes and capacitive-coupled ECG system using capacitive electrodes are compared by the concept of the effective coupling impedance. For this comparison, it is considered that both two systems include the negative feedback circuit, which is called Driven-Right-Leg in typical ECG system, to reduce the common mode noise. As the result, the negative feedback gain plays an important role in decreasing the effective coupling impedances and increasing the signal-to-noise ratios for the ECG signal and power line interferences to both two systems.

关键词： Interference Electrocardiography Impedance measurement Power measurement Circuit noise Electrodes Coupling circuits Negative feedback Noise measurement Feedback circuits

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System for unconstrained ECG measurement on a toilet seat using capacitive coupled electrodes : The efficacy and practicality

System for unconstrained ECG measurement on a toilet seat us...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Hyun Jae Baek Jung Soo Kim Ko Keun Kim Kwang Suk Park Interdisciplinary Program of Bioengineering Seoul National University Graduate School Republic of Korea Interdisciplinary Program in Medical and Biological Engineering Seoul National University Graduate School Republic of Korea Department of Biomedical Engineering Seoul National University Republic of Korea

Home healthcare is a common matter of concern to modern people. For the successful home healthcare, unconstrained bio-signal monitoring is important. Previously, unconstrained lavatory typed ECG measurement system was developed. It is enough to measure subject's ECG signal non-intrusively, but not practical because of moist environment of toilet. In this study, capacitive coupled electrode was employed for overcome above disadvantages. ECG was obtained by capacitive coupled electrode and compared with ECGs obtained from conventional Ag/AgCl electrode. Possible motion artifacts were investigated. Experimental results showed that toilet based capacitive coupled ECG signal was measured successfully.

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Application of an elastic biodegradable poly(L-lactide-co-Ε- caprolactone) scaffold for cartilage tissue regeneration

Application of an elastic biodegradable poly(L-lactide-co-Ε...

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作者： Jung, Youngmee Kim, Soo Hyun You, Hee Jin Kim, Sang-Heon Ha Kim, Young Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O. Box 131 Cheongryang Seoul 136-650 Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology Gwangju Korea Republic of Department of Biomedical Engineering Seoul National University Seoul Korea Republic of

In cartilage tissue regeneration, it is important that an implant inserted into a defect site can maintain its mechanical integrity and endure stress loads from the body, in addition to being biocompatible and able to induce tissue growth. These factors are crucial in the design of scaffolds for cartilage tissue engineering. We developed an elastic biodegradable scaffold from poly(L-lactideco-Ε-caprolactone) (PLCL) for application in cartilage treatment. Biodegradable PLCL co-polymer was synthesized from L-lactide and Ε-caprolactone in the presence of stannous octoate as a catalyst. A highly elastic PLCL scaffold was fabricated by a gel-pressing method with 80% porosity and 300-500 μm pore size. The tensile mechanical and recovery tests were performed in order to examine mechanical and elastic properties of the PLCL scaffold. They could be easily twisted and bent and exhibited almost complete (over 94%) recoverable extension up to breaking point. For examining cartilaginous tissue formation, rabbit chondrocytes were seeded on scaffolds. They were then cultured in vitro for 5 weeks or implanted in nude mice subcutaneously. From in vitro and in vivo tests, the accumulation of extracellular matrix on the constructs showed that chondrogenic differentiation was sustained onto PLCL scaffolds. Histological analysis showed that cells onto PLCL scaffolds formed mature and well-developed cartilaginous tissue, as evidenced by chondrocytes within lacunae. From these results, we are confident that elastic PLCL scaffolds exhibit biocompatibility and as such would provide an environment where cartilage tissue growth is enhanced and facilitated. © 2008 VSP.

关键词： Tissue regeneration

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