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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Ko Keun Kim Kwang Suk Park Interdisciplinary Program in Biomedical Engineering Seoul National University Seoul South Korea Department of Biomedical Engineering Seoul National University Seoul South Korea

In this paper, the power line noise characteristics between conventional ECG measurement system using Ag/AgCl electrodes and capacitive-coupled ECG system using capacitive electrodes are compared by the concept of the effective coupling impedance. For this comparison, it is considered that both two systems include the negative feedback circuit, which is called Driven-Right-Leg in typical ECG system, to reduce the common mode noise. As the result, the negative feedback gain plays an important role in decreasing the effective coupling impedances and increasing the signal-to-noise ratios for the ECG signal and power line interferences to both two systems.

关键词： Interference Electrocardiography Impedance measurement Power measurement Circuit noise Electrodes Coupling circuits Negative feedback Noise measurement Feedback circuits

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System for unconstrained ECG measurement on a toilet seat using capacitive coupled electrodes : The efficacy and practicality

System for unconstrained ECG measurement on a toilet seat us...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Hyun Jae Baek Jung Soo Kim Ko Keun Kim Kwang Suk Park Interdisciplinary Program of Bioengineering Seoul National University Graduate School Republic of Korea Interdisciplinary Program in Medical and Biological Engineering Seoul National University Graduate School Republic of Korea Department of Biomedical Engineering Seoul National University Republic of Korea

Home healthcare is a common matter of concern to modern people. For the successful home healthcare, unconstrained bio-signal monitoring is important. Previously, unconstrained lavatory typed ECG measurement system was developed. It is enough to measure subject's ECG signal non-intrusively, but not practical because of moist environment of toilet. In this study, capacitive coupled electrode was employed for overcome above disadvantages. ECG was obtained by capacitive coupled electrode and compared with ECGs obtained from conventional Ag/AgCl electrode. Possible motion artifacts were investigated. Experimental results showed that toilet based capacitive coupled ECG signal was measured successfully.

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Application of an elastic biodegradable poly(L-lactide-co-Ε- caprolactone) scaffold for cartilage tissue regeneration

Application of an elastic biodegradable poly(L-lactide-co-Ε...

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作者： Jung, Youngmee Kim, Soo Hyun You, Hee Jin Kim, Sang-Heon Ha Kim, Young Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O. Box 131 Cheongryang Seoul 136-650 Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology Gwangju Korea Republic of Department of Biomedical Engineering Seoul National University Seoul Korea Republic of

In cartilage tissue regeneration, it is important that an implant inserted into a defect site can maintain its mechanical integrity and endure stress loads from the body, in addition to being biocompatible and able to induce tissue growth. These factors are crucial in the design of scaffolds for cartilage tissue engineering. We developed an elastic biodegradable scaffold from poly(L-lactideco-Ε-caprolactone) (PLCL) for application in cartilage treatment. Biodegradable PLCL co-polymer was synthesized from L-lactide and Ε-caprolactone in the presence of stannous octoate as a catalyst. A highly elastic PLCL scaffold was fabricated by a gel-pressing method with 80% porosity and 300-500 μm pore size. The tensile mechanical and recovery tests were performed in order to examine mechanical and elastic properties of the PLCL scaffold. They could be easily twisted and bent and exhibited almost complete (over 94%) recoverable extension up to breaking point. For examining cartilaginous tissue formation, rabbit chondrocytes were seeded on scaffolds. They were then cultured in vitro for 5 weeks or implanted in nude mice subcutaneously. From in vitro and in vivo tests, the accumulation of extracellular matrix on the constructs showed that chondrogenic differentiation was sustained onto PLCL scaffolds. Histological analysis showed that cells onto PLCL scaffolds formed mature and well-developed cartilaginous tissue, as evidenced by chondrocytes within lacunae. From these results, we are confident that elastic PLCL scaffolds exhibit biocompatibility and as such would provide an environment where cartilage tissue growth is enhanced and facilitated. © 2008 VSP.

关键词： Tissue regeneration

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Cartilaginous tissue formation using human adipose tissue derived stromal cells and TGF-β1 loaded functional nanoparticle-hydrogel-PLCL complex

Cartilaginous tissue formation using human adipose tissue de...

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8th World Biomaterials Congress 2008, WBC 2008

作者： Jung, Youngmee Kim, Soo Hyun Chung, Yong-Il Tae, Giyoong Kim, Sang-Heon Kim, Young Ha Lee, Jong Won Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology Seoul Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology Gwangju Korea Republic of Department of Plastic Surgery Catholic University of Korea Seoul Korea Republic of Department of Biomedical Engineering Seoul National University Seoul Korea Republic of

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Association between periodontitis and anti-cardiolipin antibodies in Buerger disease

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Journal of Clinical Periodontology 2009年第10期36卷 830-835页

作者： Chen, Yi-Wen Nagasawa, Toshiyuki Wara-Aswapati, Nawarat Ushida, Yuka Wang, Dongqing Takeuchi, Yasuo Kobayashi, Hiroaki Umeda, Makoto Inoue, Yoshinori Iwai, Takehisa Ishikawa, Isao Izumi, Yuichi Department of Hard Tissue Engineering Graduate School Tokyo Medical and Dental University Tokyo Japan National Taiwan University Hospital National Taiwan University Taipei Taiwan Department of Periodontology Faculty of Dentistry Khon Kaen University Khon Kaen Thailand Department of Periodontics and Oral Medicine Beijing Stomatological Hospital Capital Medical University Beijing China Department of Vascular and Applied Surgery Graduate School Tokyo Medical and Dental University Tokyo Japan Tsukuba Vascular Center Buerger Disease Research Institute Ibaragi Japan Institute of Advanced Biomedical Engineering and Science Tokyo Women's Medical University Tokyo Japan Global Center of Excellence Program International Research Center for Molecular Science in Tooth and Bone Diseases Tokyo Medical and Dental University Tokyo Japan Department of Periodontology and Endodontology Health Science University of Hokkaido Ishikari-gun Hokkaido 061-0293 1757 Kanazawa Tobetsu-cho Japan

Aim: Anti-cardiolipin (CL) antibodies can be induced in Buerger disease (BD), an inflammatory occlusive disorder affecting peripheral blood vessels, in response to bacteria bearing homology to the TLRVYK peptide of a phospholipid-binding plasma protein β-2-glycoprotein I. TLRVYK homologies are present in Porphyromonas gingivalis (TLRIYT) and Treponema denticola (TLALYK). This study investigated the association between periodontal infection and anti-CL antibodies in BD patients. Material and Methods: Periodontal conditions were examined in 19 BD patients and 25 systemically healthy control subjects. All subjects were heavy smokers. Serum anti-CL, anti-TLRVYK, anti-TLRIYT, and anti-TLALYK antibodies were assessed using the enzyme-linked immunosorbent assay. Results: BD patients had a significantly higher prevalence of periodontitis, more severe periodontal destruction and increased titres of serum anti-CL, anti-TLRVYK, anti-TLRIYT, and anti-TLALYK antibodies compared with healthy subjects. The levels of anti-CL antibodies positively correlated with those of the three anti-peptide antibodies. Anti-CL antibody titres were significantly associated with the percentage of sites with clinical attachment level ≥4 mm in BD patients. Conclusion: Elevated anti-CL antibody levels were associated with periodontal destruction in BD patients. Periodontopathic bacteria may serve as exogenous antigens that stimulate the anti-CL antibody production through molecular mimicry between the bacterial peptides and a host plasma protein. © 2009 John Wiley & Sons A/S.

关键词： β-2-glycoprotein I Anti-cardiolipin antibody Buerger disease Molecular mimicry Periodontitis

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Comparable parameter related to arterial stiffness in blood pressure estimation method

Comparable parameter related to arterial stiffness in blood ...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Jung Soo Kim Ko Keun Kim Hyun Jae Baek Kwang Suk Park Medical Research Center Seoul National University South Korea Interdisciplinary Program in Biomedical Engineering Seoul National University South Korea Bio-engineering Department Seoul National University South Korea Department of Biomedical Engineering College of Medicine Seoul National University South Korea

Diastolic blood pressure estimation using only pulse arrival time was not sufficient. To overcome it, arterial stiffness was considered. Several parameters related to information, time, slop information in photoplethysmography signal were chosen and investigated. Five subjects executed Valsalva Maneuver which caused the blood pressure variation. Time from maximum point of first derivative wave to dicrotic notch point in photoplethysmography signal (TDB) was selected as the robust and correlated parameter with blood pressure. Especially, the parameter had correlated with diastolic blood pressure more than systolic blood pressure (R= -0.666 for SBP, R= -0.712 for DBP). It could be useful for blood pressure estimation method which was valid for only systolic blood pressure.

关键词： Blood pressure biomedical monitoring biomedical engineering Robustness Arteries Information technology Amplitude estimation Delay effects Electrocardiography Timing

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Parallel multi-time point cell stimulus and lysis in a microfluidic device using chaotic mixing and pressure resistance

Parallel multi-time point cell stimulus and lysis in a micro...

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2008 AIChE Annual Meeting, AIChE 100

作者： Hirsch, Alison Rivet, Catherine Zhang, Boyang Kemp, Melissa Lu, Hang Georgia Institute of Technology School of Chemical and Biomolecular Engineering 311 Ferst Dr. NW Atlanta GA 30332 United States Interdisciplinary Bioengineering Program Georgia Institute of Technology 311 Ferst Dr. NW Atlanta GA 30332 United States Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology 311 Ferst Dr. NW Atlanta GA 30332 United States

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Classification of Parkinson gait and normal gait using Spatial-Temporal Image of Plantar pressure

Classification of Parkinson gait and normal gait using Spati...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Hyo-Seon Jeon Jonghee Han Won-Jin Yi BeomSeok Jeon Kwang Suk Park Interdisciplinary Program in Medical and Biological Engineering Graduate School Seoul National University South Korea Department of Oral and Maxillofacial Radiology College College of Dentistry Seoul National University South Korea Department of Neurology Seoul National University South Korea Department of Biomedical Engineering College of Medicine Seoul National University South Korea

The purpose of this paper is the classification of Spatial-Temporal Image of Plantar pressure (STIP) among normal step and the patients step of Parkinson disease. For this, we created a new image data, STIP, that have information of the change of plantar pressure during heel to toe motion (i.e., contain spatial and temporal information for plantar pressure). To get STIP, the walking of 21 patients with Parkinson disease and 17 age-matched healthy subjects were recorded and analyzed using in-shoe dynamic pressure measuring system with comfort walking. For feature extraction of gait, we applied Principal component analysis (PCA) to STIP and calculated weights of STIP on each principal components. Then, we build hard margin Support Vector Machine (SVM) classifier for gait recognition and test of generalization performance using normalized weights on PCs of STIP. SVM result indicated an overall accuracy of 91.73% by the RBF(Radial Basis Function) kernel function. These results demonstrate considerable potential in applying SVMs in gait classification for many applications.

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Towards a framework for analysis of biophotonic images of mouse models of cancer

Towards a framework for analysis of biophotonic images of mo...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Vidya Kamath Dmitry Goldgof Raul Argilagos Lori Hazlehurst Steven Eschrich Biomedical Engineering program University of South Florida USA Department of Computer Science University of South Florida USA Department of Interdisciplinary Oncology Moffitt Cancer Center and College of Medicine University of South Florida USA Dep. of Interdisciplinary Oncology H. Lee Moffitt Cancer Center and College of Medicine University of South Florida USA

Biophotonic imaging can be used to characterize tumor growth in animal models. Estimation of the numbers and location of target cells is dependent on accurate segmentation of a target region from the background luminescence of the animal body. Existing software systems extract general regions of interest in complex images but can fail to detect details or faint regions of interest in the presence of higher luminescent activity. Limited work has been published in the analysis of these images. We explore the use of popular medical image segmentation techniques in segmentation of bioluminescence images. The ability of each algorithm in detecting regions of interest is tested using established performance measures. Based on the characteristics of bioluminescence images of animal tumor models, and the performance of the algorithms, we formulate a framework for segmentation techniques best suited for this application.

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Fuzzy Optimization with Robust Logistic Membership Function: A Case Study In For Home Textile Industry

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IFAC Proceedings Volumes 2008年第2期41卷 5262-5266页

作者： Atanu Sengupta Pandian Vasant Cvetko J. Andeeski Institute of Interdisciplinary Scientific Research 17B Ramchandra Maitra Lane Kolkata-700005 India Electrical & Electronic Engineering Program University Technology Petronas 31750 Tronoh BSI Perak DR Malaysia Faculty of Tourism and Hospitality St. Clement Ohridski University of Bitola 6000 Ohrid Republic of Macedonia

Many engineering optimization problems can be considered as linear programming problems where the all or sum of the parameters involved are linguistic in nature. These can only be quantified using fuzzy sets. The aim of this paper is to solve fuzzy linear programming problem where the parameters involved are fuzzy numbers with logistic membership functions. To explore the applicability of the present study a numerical example is considered determine monthly production planning and profit of home-textile group. To solve this problem LINGO Software is used.

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