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29th Annual International Conference of IEEE-EMBS, engineering in Medicine and Biology Society, EMBC'07

作者： Min, Yang Jung Jaemin, Kang Il, Hyung Shin Yoonseo, Koo Gil, Joon Suh Hee, Chan Kim Interdisciplinary Program Graduate School Seoul National University Seoul Korea Republic of Department of Emergency Medicine Seoul National University Seoul Korea Republic of Department of Biomedical Engineering Institute of Medical and Biological Engineering Seoul National University Seoul Korea Republic of

ISBN: (纸本)1424407885

When an emergent case occurs, to give proper and immediate emergency treatment to a patient is as important as to transfer him or her to the hospital as early as possible. For this circumstance where first aid usually happens in an ambulance, we developed the Ubiquitous Integrated Biotelemetry System for Emergency Care (UIBSEC) based on wireless 3.5G HSDPA module in order to provide more proper and active medical care to a patient. For this system we performed experimental tests on the HSDPA module to measure practical performance values with respect to throughput and RTT (round-trip-time) and compared the result with the theoretical specifications. In the course of developing this system we created the C#-based Network Solution Library (NSL) which helps drastically reducing the overhead. We applied this library to components of the UIBSEC - two kinds of clients and one central server - and confirmed that it works smoothly in wireless networks and it is useful in the future development process of network applications. © 2007 IEEE.

关键词： Servers

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Noninvasive heart rate variability analysis using loadcell-installed bed during sleep

Noninvasive heart rate variability analysis using loadcell-i...

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29th Annual International Conference of IEEE-EMBS, engineering in Medicine and Biology Society, EMBC'07

作者： Chung, Gih Sung Choi, Byoung Hoon Jeong, Do-Un Park, Kwang Suk Interdisciplinary Program in Medical and Biological Engineering Seoul National University Graduate School Korea Republic of Dept. of Neuropsychiatry College of Medicine and Hospital Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)1424407885

Polysomnography is the standard method to score the sleep stages or to determine the quality of sleep. During all night examination, subjects must attach complicate and numerous electrodes on their body to acquire the biosignals. They can influence participants' sleep stage transition or sleep pattern, and the method seems intricate. In many researches, it is reported that autonomic nervous system (ANS) is varying with sleep stage transition and heart rate variability (HRV) is one of the indices which reflects the changes of autonomic nervous system. In this point of view, we can estimate the sleep quality by observing the HRV variation. In this study, to analyze the heart rate variability, we introduce a new system that can detect the heart beats of subjects during sleep by using bed installed load-cell sensors. The pressure to the sensor changes with the pulsation of the heart and we consider it as ballistocardiogram, the physical heart beat signal. To validate our system, we adopted this system for the 4 subjects with the polysomnography. The results show the LF/HF ratio of the heart rate, one of the reflection parameters of ANS, acquired from the system for each sleep stage. To validate the results, the HRV from electrocardiogram using Ag-AgCl electrodes will be compared. © 2007 IEEE.

关键词： biomedical engineering

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Segmentation of solid nodules in ultrasonographic breast image based on wavelet transform

Segmentation of solid nodules in ultrasonographic breast ima...

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29th Annual International Conference of IEEE-EMBS, engineering in Medicine and Biology Society, EMBC'07

作者： Park, Sangyun Kong, Hyoun-Joong Moon, Woo Kyoung Kim, Hee Chan Interdisciplinary Program Graduate School Seoul National University Seoul Korea Republic of Department of Radiology Seoul National University Seoul 110-744 Korea Republic of Department of Biomedical Engineering College of Medicine and Institute of Medical and Biological Engineering Seoul National University Seoul Korea Republic of

ISBN: (纸本)1424407885

An accurate segmentation of solid nodules in ultrasonographic (US) breast image is presented. 1-level 2-dimensional Discrete Wavelet Transform (DWT) is used to create features reflecting the texture information of the original image. Using these features, the texture classification is achieved. Finally, solid nodule region is segmented from the classified texture region. Proper threshold for texture classification is automatically decided. Empirically acquired information about the relationship between the texture characteristic of the original image and the optimal threshold is examined and used. Presented algorithm is applied to 284 malignant solid nodules and 300 benign solid nodules and the resulting images are presented. © 2007 IEEE.

关键词： Ultrasonography

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Capacitive-Coupled ECG Measurement and Its Applications for Ubiquitous Healthcare

Capacitive-Coupled ECG Measurement and Its Applications for ...

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International Conference on Convergence Information Technology

作者： Ko Keun Kim Yong Gyu Lim Jung Soo Kim Kwang Suk Park Interdisciplinary Program in Biomedical Engineering Seoul National University Seoul South Korea Department of Oriental Biomedical Engineering Sangji University Wonju South Korea Department of Biomedical Engineering College of Medicine Seoul National University Seoul South Korea

Unconstrained ECG measurement is important for ubiquitous healthcare. The methods for this are being developed, and the capacitive-coupled ECG (CC- ECG) measurement is reported recently. In this paper, this measuremen... 详细信息

ISBN: (纸本)9781424431779

关键词： Electrocardiography Medical services biomedical measurements Electrodes biomedical engineering Surface impedance Rubber Textiles Skin Impedance measurement

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186 – Inefficient neural network during spatial working memory task in subjects at high genetic-risk for schizophrenia

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Schizophrenia Research 2008年 98卷 110-110页

作者： Han, J.Y. Park, J.Y. Kang, D.H. Choi, J.S. Jung, M.H. Choi, C.H. Jung, Y.S. Lee, J.M. Kwon, J.S. Interdisciplinary Program in Cognitive and Brain Science Seoul National University Seoul Republic of Korea Department of Psychiatry Seoul National University College of Medicine Seoul Republic of Korea Clinical Cognitive Neuroscience Center Neuroscience Institute SNU-MRC Seoul Republic of Korea Department of Radiology National Medical Center Seoul Republic of Korea Department of Biomedical Engineering Hanyang University School of Medicine Seoul Republic of Korea

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Activity energy expenditure assessment system based on activity classification using multi-site triaxial accelerometers

Activity energy expenditure assessment system based on activ...

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29th Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBS 2007), vol.6

作者： Kim Dongwoo Hee Chan Kim Interdisciplinary Program Seoul National University Seoul Korea Department of Biomedical Engineering Seoul National University Seoul Korea

Wireless networked multi-site triaxial accelerometry system was proposed to estimate activity energy expenditure during daily life. Proposed system used different estimation algorithms according to activity classification based on measured acceleration signals. The estimation results showed higher correlation (R{sup}2=0.98) and smaller standard errors of estimation (SEE=0.66 kcal) than any other system in preceding reports.

关键词： Accelerometers Acceleration biomedical engineering Legged locomotion Signal processing algorithms biomedical measurements Differential equations Wrist engineering in medicine and biology Energy measurement

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Multilayered non‐invasive temperature estimation from backscattered ultrasound

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The Journal of the Acoustical Society of America 2008年第5_SUPPLEMENT期123卷 3227-3227页

作者： Cesar A. Teixeira Maria Graça Ruano António Ruano Wagner C. Pereira University of Algarve Faculty of Sciences and Technology Campus de Gambelas 8005‐139 Faro Portugal cteixei@*** University of Algarve Faculty of Sciences and Technology Campus de Gambelas 8005‐139 Faro Portugal mruano@ualg.pt University of Algarve Faculty of Sciences and Technology Campus de Gambelas 8005‐139 Faro Portugal aruano@ualg.pt Biomedical Engineering Program ‐ COPPE Federal University of Rio de Janeiro CEP. 21.941‐972 Rio de Janeiro Brazil wagner@peb.ufrj.br

A major drawback on the application of thermal therapies is the lack of reliable knowledge about temperature in the region under treatment. The most attractive approach is non‐invasive temperature estimation (NITE) strategies and, among them, techniques based on backscattered ultrasound (BSU) are a convenient choice for its portability and simplicity. Using BSU some methods have been proposed for temperature estimation basically for homogeneous media, and simple operating situations. More complex scenarios can be explored by non‐linear approaches. In this work, a methodology based on neural networks is presented for temperature estimation in a multilayer phantom. A three‐layer gel‐based phantom was heated at eight intensities, between 0.30 and 2.0 W/cm2 (at 1MHz) for 15 minutes. Temperature and BSU signals were acquired from five spatial‐points at each 10 seconds. Temporal echo‐shifts, induced by temperature change, were computed from the BSU signals, and used as model's input information. Neural models were developed to estimate temperature at four intensities. Then models were validated in data including all the intensities. The best model presents a maximum absolute error of 0.43 °C for untrained situations. To the best of our knowledge this is the first NITE approach in multilayered media.

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Multivariate feature selection using random subspace classifiers for gene expression data

Multivariate feature selection using random subspace classif...

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7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE

作者： Kamath, Vidya P. Hall, Lawrence O. Yeatman, Timothy J. Eschrich, Steven A. Biomedical Engineering Program University of South Florida H. Lee Moffitt Cancer Center and Research Institute Tampa FL United States Dept. of Computer Science and Engineering University of South Florida Tampa FL United States Dept. Interdisciplinary Oncology H. Lee Moffitt Cancer Center and Research Institute Tampa FL United States

ISBN: (纸本)1424415098

Gene expression analysis techniques identify important genes that predict specified outcomes based on sample characteristics. Given the small sample sizes common to these studies and the large dimensionality of the data, feature selection methods are essential. In addition, cancer-related expression analysis often involves imbalanced datasets due to rare forms of disease. Popular methods of feature selection employ univariate techniques to identify the features most suitable for analysis. We propose a multivariate technique for selecting accurate subsets of features using an approach based on random subspaces. The random subspace method is used to explore random combinations of features and only subspaces that produce accurate classifiers are retained. The method is tested on two independent gene expression datasets and compared with a univariate approach. The multivariate feature selection method resulted in a 33% improvement in classification accuracy overall and 90% improvement in classification accuracy for the minority class. ©2007 IEEE.

关键词： Gene expression

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The relationship between HRV parameters and stressful driving situation in the real road

The relationship between HRV parameters and stressful drivin...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Haet Bit Lee Jung Soo Kim Yun Seong Kim Hyun Jae Baek Myung Suk Ryu Kwang Suk Park Seoul National University South Korea Interdisciplinary Program in Medical and Biological Engineering Graduate School Republic of Korea Advanced Biometric Research Center Republic of Korea Department of Biomedical Engineering Seoul National University Republic of Korea

The aim of this paper is to find a relation between HRV parameters of ECG and stressful driving situation in the real road through various tests. First, we gave a stress to the subject by increasing the driving speed using driving simulator in the laboratory. Second, the subject drove the vehicle on the real road. Through let him drove in the busy narrow street, we evoked stress. ECG and PPG signal was recorded from steering wheel and back cushion each unconsciously. The driving experiment with simulator was not suitable to reproduce actual traffic condition because the adaptation was occurred. On the other hand, in real driving test, the results show that the heart rate is increase, and SDNN, RMSSD, pNN50 were decreased. The heart rate is the strongest indicator and other parameters tend to be changed depend on a personal. The blood pressure had no significant changes. Our results show the good possibility of that the time parameters of the HRV could be used as an instantaneous stress indicator.

关键词： Heart rate variability Stress Electrocardiography Testing Heart rate Laboratories Road vehicles Wheels Traffic control Blood pressure

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Cartilage tissue engineering using a elastic poly (L-lactide-co-Ε- caprolactone) scaffold

Cartilage tissue engineering using a elastic poly (L-lactide...

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作者： Jung, Youngmee Kim, Soo Hyun Kim, Sang-Heon Kim, Young Ha Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O.Box 131 Cheongryang Seoul 130-650 Korea Republic of Interdisciplinary Program Medical and Biological Engineering Major Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology 1 Oryang Buk Gwangju 500-712 Korea Republic of Department of Biomedical Engineering Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of

Mechano-active scaffolds were fabricated from very elastic poly(L-lactide-co-Ε-carprolactone). The scaffolds with 80% porosity and 300-500 um pore size were prepared by a gel-pressing method. As a control group for elastic properties of polymer scaffolds, rigid poly L-lactide scaffolds were fabricated. The scaffolds were seeded with chondrocytes and cultured to evaluate the effect of elastic properties of polymer scaffolds for the differentiation and the ECM secretion of chondrocytes. Also, the chondrocytes-seeded constructs were implanted in nude mice subcutaneously to investigate their biocompatibility and cartilage formation. From the biochemical analyses, chondrogenic differentiation was sustained and enhanced significantly and chondral extracellular matrix was increased through mechanical stimulation of dynamic environment in the dynamic body systems. Histological analysis showed that implants of PLCL constructs formed mature and well-developed cartilaginous tissue, as evidenced by chondrocytes within lacunae. Consequently, the elastic PLCL scaffolds could be used to engineer cartilage in mechanically dynamic environments.

关键词： Cartilage

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