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IEEE International Symposium on Intelligent Signal Processing

作者： C. A. Teixeira W. C. A. Pereira A. E. Ruano M. Graca Ruano Centre for Intelligent Systems Faculty of Sciences and Technology University of Algarve Portugal Biomedical Engineering Program-COPPE Federal University of Rio de Janeiro Brazil

ISBN: (纸本)1424408296;97

The safe and effective application of thermal therapies are limited by the existence of precise non-invasive temperature estimators. Such estimators would enable a correct power deposition on the region of interest by means of a correct instrumentation control. In multi-layered media, the temperature should be estimated at each layer and especially at the interfaces, where significant temperature changes should occur during therapy. In this work, a non-linear autoregressive structure with exogenous inputs (NARX) was applied to non-invasively estimate temperature in a multi-layered (non-homogeneous) medium, while submitted to physiotherapeutic ultrasound. The NARX structure is composed by a static feed-forward radial basis functions neural network (RBFNN), with external dynamics induced by its inputs. The NARX structure parameters were optimized by means of a multi-objective genetic algorithm. The best attained models reached a maximum absolute error inferior to 0.5degC (proposed threshold in hyperthermia/diathermia) at both the interface and inner layer points, at four radiation intensities. These models present also a small computational complexity as desired for real-time applications. To the best of ours knowledge this is the first non-invasive estimation approach in multi-layered media using ultrasound for both heating and estimation.

关键词： Temperature Nonhomogeneous media Medical treatment Ultrasonic imaging Instruments Feedforward systems Radial basis function networks Genetic algorithms Hyperthermia Computational complexity

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Computational Strategies for Protein Quantitation in 2D Electrophoresis Gel Image Processor for Matlab

Computational Strategies for Protein Quantitation in 2D Elec...

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Frontiers in the Convergence of Bioscience and Information Technologies, FBIT

作者： Umer Zeeshan Ijaz Safee Ullah Chaudhary Moon Sang Don Kyung Youn Kim Department of Electronic Engineering Cheju National University Cheju South Korea Department of Bio-Analytical Science Korea University of Science and Technology Daejeon South Korea Postgraduate Interdisciplinary Program Biomedical Engineering Cheju National University Cheju South Korea

In this paper, computational strategies are defined for protein quantisation by considering the shapes of the protein spots. The technique uses the clustering techniques like K-mean and fuzzy C-mean to distinguish between different types of protein spots and unwanted artifacts. The resulting technique is used in 2D electrophoresis gel image processor for Matlab with other image manipulation techniquies on the experimental data to evaluate its performance.

关键词： Electrokinetics Silver Protein engineering Proteomics biomedical engineering Anodes Cathodes Pipelines Signal processing algorithms Information technology

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Unconstrained Heart Rate Estimation System in Bed

Unconstrained Heart Rate Estimation System in Bed

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International Conference on Convergence Information Technology

作者： Gih Sung Chung Byoung Hoon Choi Ko Keun Kim Yong Gyu Lim Jin Wook Choi Do-Un Jeong Kwang Suk Park Interdisciplinary Program in Medical & Biological Engineering Seoul National University South Korea Department of Oriental Biomedical Engineering Sangji University Wonju South Korea Department of Biomedical Engineering College of Medicine Seoul National University South Korea Department of Neuropsychiatry and Division of Sleep Studies and Clinical Research Institute College of Medicine and Hospital Seoul National University South Korea

ISBN: (纸本)9780769530383

It is widely known that autonomic nervous system (ANS) is one of the indices to indicate the wakefulness of person. Therefore measuring the biosignals relating with the ANS during sleep is required to evaluate sleep quality. There are many researches that heart rate derived from the electrocardiogram (ECG) is good index to show the sympathetic or parasympathetic activities. To assess the quality of sleep, polysomnagraphy is used as golden standard but subjects have to attach many of sensors to their body and it is not only complicate, but also influence their sleep. In this study, to measure the autonomic nervous activities, we introduce newly developed system using load-cell. The sensors installed bottom of the bed measure the ballistocardiogram, mechanical vibration of heart. Ballistocardiogram is one of the nonintrusive methods to measure the heart rates unconstrainedly. By comparing with reference signal, ECG using Ag-AgCl electrodes, we validated our system with the four subjects. The results show comparison of LF/HF ratio, one of the heart rate variability, measured from the load-cells and Ag-AgCl electrodes for the each sleep stage, deep sleep, light sleep and REM sleep. It shows the different pattern for the light and deep sleep but contrary to our expectation, REM sleep doesn't indicate the highest value. LF/HF ratio measured from both methods have no significant differences.

关键词： Heart rate Sleep Electrocardiography Mechanical sensors Vibration measurement Electrodes Hafnium Autonomic nervous system Mechanical variables measurement Heart rate variability

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Mechano-active cartilage tissue engineering: The effect of dynamic compressive stimulation

Mechano-active cartilage tissue engineering: The effect of d...

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作者： Jung, Youngmee Kim, Soo Hyun Kim, Sang-Heon Kim, Young Ha Xie, Jun Matsuda, Takehisa Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O.Box 131 Cheongryang Seoul 130-650 Korea Republic of Interdisciplinary Program Medical and Biological Engineering Major Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology 1 Oryang Buk Gwangju 500-712 Korea Republic of Department of Orthopaedic Surgery School of Medicine Fukuoka University 8-19-1 Nanakuma Jonan Fukuoka 814-0180 Japan Genome and Biomedical Engineering Laboratory Kanazawa Institute of Technology 7-1 Ohgigaoka Nonoichi Ishikawa 921 - 8501 Japan Department of Biomedical Engineering Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of

Mechano-active scaffolds were fabricated from very elastic poly(lactide-co-carprolactone) by a gel-pressing method. The scaffolds were seeded with bone marrow stromal cells and the continuous compressive deformation was applied to cell-polymer constructs in the chondrogenic media. Then, they were implanted in nude mice subcutaneously to evaluate for the effect of dynamic compression for regeneration of cartilage. From the biochemical analyses, chondrogenic differentiation was sustained and enhanced significantly and chondral extracellular matrix was increased through mechanical stimulation. Histological analyses showed that implants stimulated mechanically formed mature and well-developed cartilaginous tissue, as evidenced by bone marrow derived chondrocytes within lacunae. Consequently, the periodic application of dynamic compression can encourage bone marrow stromal cells to differentiation to chondrogenic lineage and to maintain their phenotypes.

关键词： Cartilage

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Cartilaginous tissue formation with an elastic PLCL scaffold and human adipose tissue-derived stromal cells

Cartilaginous tissue formation with an elastic PLCL scaffold...

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作者： Lee, So Eun Jung, Youngmee Kim, Soo Hyun Kim, Sang-Heon Rhie, Jong Won Kim, Young Ha Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O. Box 131 Cheonryang Seoul 130-650 Korea Republic of Interdisciplinary Program Medical and Biological Engineering Major Seoul National University 28 Yeongeon Jongro Seoul 110-744 Korea Republic of Department of Plastic Surgery Catholic University 505 Banpo Seocho Seoul 137-701 Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology 1 Oryong- Buk Gwangju 500-712 Korea Republic of Department of Biomedical Engineering Seoul National University 28 Yeongeon Jongro Seoul 110-744 Korea Republic of

In cartilage tissue engineering, as a cell source, adult stem cells are very attractive for clinical applications. Recent studies suggest that human adipose tissue-derived stromal cells (ASCs) have multilineage potential similar to bone marrow-derived stromal cells (BMSCs). ASCs are obtained from adipose tissue easily isolated by suction-assisted lipectomy in various body parts. Also, as one of major factors of cartilage tissue engineering, scaffolds have an important role in cartilage formation. Poly(L-lactide-co-Ε-carprolactone) scaffolds have physiological activity, biodegradability, high cell affinity, and mechano-activity. The object of this study is cartilaginous tissue formation using highly elastic PLCL scaffolds and ASCs in vitro and in vivo. Poly(L-lactide-co-Ε-carprolactone) copolymers were synthesized from lactide and Ε-carprolactone in the presence of stannous octoate as catalyst. The scaffolds with 85% porosity and 300-500μm pore size were fabricated by gel-pressing method. ASCs were seeded on scaffolds and cultured for 21days in vitro. Cell/polymer constructs were characterized by reverse transcriptase-polymerase chain reaction for confirming differentiation to chondrocytes onto PLCL scaffolds. Also, for examining cartilaginous tissue formation in vivo, ASCs seeded scaffolds which were induced chondrogenesis for 2 weeks were implanted in nude mice subcutaneously for up to 8weeks. Histological studies showed that implants partially developed cartilaginous tissue within lacunae. And there was an accumulation of sulfated glycoaminoglycans. Immunohistochemical analysis revealed that implants were positively stained for specific extracellular matrix. These results indicate that ASCs and PLCL scaffols could be used to cartilage tissue engineering.

关键词： Tissue engineering

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Estimation of the Blood Pressure using Arterial Pressure-Volume Model

Estimation of the Blood Pressure using Arterial Pressure-Vol...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： J. H. Jung S. H. Yoon J. H. Kim I. C. Kim A. Y. Jeon S. Y. Ye B. C. Kim B. J. Shin J. H. Ro K. G. Nam Y. J. Kim G. R. Jeon Department of Interdisciplinary program in Biomedical Engineering Pusan National University Busan Korea PhysioLab Corp. Busan Korea Department of Physics Inje University Kyungnam Korea BK21 Medical Science Education Center School of medicine Pusan National Universiry Busan Korea Department of BioSystems Engineering Pusan National University Kyungnam Korea Department of Biomedical Engineering College of Medicine Pusan National University Busan Korea Department Electronics Engineering Pusan National University Busan Korea Department of Family Medicine Pusan National University Busan Korea PhysioLab Corporation Busan South Korea

An analysis of the conventional blood pressure estimation method of the oscillometric sphygmomanometer was performed through a computer simulation using an arterial pressure-volume(APV) model. A more accurate blood pressure estimation method was proposed from the analysis. Traditionally, the maximum amplitude algorithm was applied on the oscillation waveforms of the APV model to get the mean arterial pressure and the characteristic ratio. In doing so, the shape of pressure waveforms and the cutoff frequency of high-pass filter circuitry strongly affected the estimation of mean arterial pressure and characteristic ratio. This resulted in errors when estimating blood pressure. To find an algorithm independent from the influence of waveform shapes and filter parameters, the volume oscillation of the APV model and the phase shift of the oscillation with FFT were identified by increasing the cuff pressure from 1 mmHg to 200 mmHg (1 mmHg per second). The phase shift between the ranges of volume oscillation was then only observed between the systolic and diastolic blood pressures. The same results were obtained from simulations performed on two different arterial blood pressure waveforms and one hyperthermia waveform.

关键词： Blood pressure Shape Filters Performance analysis Computer simulation Cutoff frequency Circuits Frequency estimation Arterial blood pressure Hyperthermia

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Abstracts for the 6th Congress of Asian Sleep Research Society

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Sleep and Biological Rhythms 2009年第4期7卷 A1-A49页

作者： Seog Ju Kim In Kyoon Lyoo Yu-Jin Lee Do-Un Jeong Hirohiko Kanai Masanori Ookubo Atsushi Yoshimura Masako Okawa Noto Yamada Takeshi Munezawa Yoshitaka Kaneita Yoneatsu Osaki Hideyuki Kanda Tadahiro Ohtsu Masumi Minowa Kenji Suzuki Susumu Hijuchi Hiroyuki Suzuki Takashi Ohida Takashi Abe Yoko Komada Shoichi Asaoka Yuichi Inoue Jin-Seong Lee Sang-Yong Cho Deependra Kumar Hruda N. Mallick Velayudhan M. Kumar Mahesh K. Kaushik Akihiro Karashima Noiihiro Katayama Mitsuyuki Nakao Ravindra P. Nagendra Sathiamma Sulekha Sathyaprabha T. Narasappa Pradhan Nityanadan Bindu M. Kutty M. Nirmala P. N. Ravindra Basavaraj Ramappa Tubaki T. N. Sathyaprabha D. Sudhakar G. S. Lavekar C. R. Chandrashekar Kazuyoshi Kitaoka Mika Shimizu Sachiko Chikahisa Kazuo Yoshizaki Hiroyoshi Sei Jong-Won Kim Misa Takegami Shin Yamazaki Yasuaki Hayashino Rei Ono Koji Otani Miho Sekiguchi Shinichi Konno Shunichi Fukuhara Antonia J. Jakobson Paul Fitzgerald Russell Conduit Xin Shirley Li Siu Ping Joyce Lam Wai Man Mandy Yu Yun Kwok Wing Kazue Okamoto-Mizuno Koh Mizuno Mituaki Yamamoto Shuichiro Shirakawa Hirokazu Doi Mikako Kato Kazuyuki Shinohara Masako Tamaki Shiori Matsuda Katsuo Yamazaki Tadao Hori Keiko Ogawa Kazumi Takahashi Kunio Kitahama Katuo Yamazaki Yoshimasa Koyama Kohei Shioda Yugo Ueda Yukiko Nakamura Clara Inoue Kazushige Goto Sunao Uchida Yuko Morita Yoshiko Honda Tohru Kodama Mari Hagihara Toru Nakajima Masato Saito Yoshihiko Koga Shinichiro Tanaka Hiroshi Yamadera Madoka Takahara Sachiko Suwa Minoru Onozuka Sadao Sato Fumiharu Togo Taiki Komatsu Takeshi Mitani Jongbae Choi Bin Zhang Taeko Sasai Hiromi Mitsubayashi Mitsuhiro Ohtsu Isao Hasegawa Tatsuya Ishii Akira Komori Asami Suzuki Yue Nakahara Mitsuyasu Hiroki Mariko Nakauma Nobuo Someya Tomomasa Ochiai Shouhei Komori Rayleigh Ping-Ying Chiang Zai-Ting Yeh Seong T. Kim Seung H. Yoon Jeong S. Kwon Jong H. Choi Hyung J. Ahn Youngsoo Kim Bolortuya Yunren Lichao Chen Radhika Basheer Robert W. Mccarley Robert E. Strecker Makoto Honda Tetsuaki Arai Miyuki Fukazawa Yutaka Honda Kuniaki T Department of Psychiatry Gachon University of Medicine and Science Incheon Republic of Korea Department of Psychiatry Seoul National University Seoul Republic of Korea Department of Neuropsychiatry and Center for Sleep and Chronobiology Seoul National University Hospital Seoul Republic of Korea Department of Neuropsychiatry Seoul National University Hospital Seoul Republic of Korea Seoul National University Hospital Seoul Republic of Korea Department of Psychiatry Shiga University of Medical Science Otsu Japan Division of Public Health Department of Social Medicine Nihon University School of Medicine Tokyo Japan Department of Public Health Nihon University School of Medicine Tokyo Japan Division of Environmental and Preventive Medicine Department of Social Medicine Faculty of Medicine Tottori University Yonago Japan Department of Hygiene and Preventive Medicine Fukushima Medical University Fukushima Japan Department of Public Health Showa University School of Medicine Tokyo Japan Faculty of Humanities Seitoku University Matsudo Japan Section on Behavioral Science Division of Clinical Research National Hospital Organization Kurihama Alcoholism Center Yokosuka Japan Department of Otolaryngology Second Hospital Fujita Health University Nagoya Japan National Hospital Organization Kurihama Alcoholism Center Kanagawa Japan Metropolitan Police Department Criminal Investigation Laboratory Tokyo Japan Japan Somnology Center Neuropsychiatrie Research Institute Tokyo Japan Department of Somnology Tokyo Medical University Tokyo Japan Japan Somnology Center Neuropsychiatric Research Institute Tokyo Japan Department of Somnology Tokyo Medical and Dental University Tokyo Japan Center for Sleep and Chronobiology Department of Psychiatry and Behavioral Science Seoul National University College of Medicine Seoul Republic of Korea Department of Psychiatry and Behavioral Science Center for Sleep and Chronobiology Seoul Republic of Korea Department of Physiology Al

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Microfluidic cell culture chip employing polymeric nanofiber membrane

Microfluidic cell culture chip employing polymeric nanofiber...

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10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006

作者： Kim, Sung Rak Lee, Ki Hwa Lee, Kwang Ho Baek, Ju Yeoul Park, Yong Doo Sun, Kyung Lee, Sang Hoon Dept. of Biomedical Engineering Korea Univ. Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Korea Republic of Korea Republic of

In this paper, we have developed cell chip employing polymeric nanofiber membrane which was used for the better diffusion of nutrition or other materials suchas growth factor and for the scaffold of cell culture, and we evaluated the function of this chip by culturing the human mesenchymal stem cells (hMSCs) which have large potential applications in the tissue engineering. © 2006 Society for Chemistry and Micro-Nano Systems.

关键词： Cell culture

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A novel artificial renal microchip employing polymeric nanofibers membrane

A novel artificial renal microchip employing polymeric nanof...

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10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006

作者： Lee, Kwang Ho Kim, Jae Gwan Kim, Duck Joong Lee, Sang Hoon Min, Byoung Goo Interdisciplinary Program in Biomedical Engineering Major Seoul National University Korea Republic of School of Mechanical and Aerospace Engineering Seoul National University Korea Republic of Dept. Biomedical Engineering College of Medicine Korea University Korea Republic of Dept. Biomedical Engineering College of Medicine Seoul National University Korea Republic of

In this study, a novel artificial renal replacement system is presented using a biocompatible polymeric nanofibers and MEMS technology. Usually, a classical artificial renal replacement system employs a semi-permeable membrane based hemodialyzer that replaces an ability of the kidney by removing metabolic toxins through diffusion and hydraulic pressure gradients. But, it has some limits in efficient filtration of metabolic byproducts (e.g.: urea, creatinine, and so on). We have developed PDMS based artificial renal microchips (AR chip) integrating biocompatible polymeric nanofibers which are utilized for the filtration of blood. Here, we demonstrate a novel artificial renal chip by integrating a high efficient biocompatible polymeric nanofibers membrane with the PDMS based micro-fluidic platform. Via the optimization of PDMS micro fluidic channel network and the multiple packaging of nanofibers membrane, we will realize the portable and wearable artificial kidney system. © 2006 Society for Chemistry and Micro-Nano Systems.

关键词： Nanofibers

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An automated measurement system of ultrasonic properties of tofu and acorn curd (Dotori Muk)

An automated measurement system of ultrasonic properties of ...

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作者： Li, Ying Anjaneya Reddy Guntur, S.R. Choi, Min Joo Paeng, Dong-Guk Marine Industrial Engineering Cheju National University Jeju 690-756 Korea Republic of Department of Medicine Cheju National University Jeju 690-756 Korea Republic of Interdisciplinary Postgraduate Program in Biomedical Engineering Cheju National University Jeju 690-756 Korea Republic of

Tofu was suggested as Tissue Mimicking Materials (TMMs) due to its low cost, availability, gelatinous nature, and shape flexibility. However, the similarity in acoustic properties of the different packets of Tofu and acorn curd (Muk) is critical for TMMs but not fully investigated yet. In order to improve the accuracy for time-consuming and multi-stepped measurements of acoustic properties, an automated measurement system was developed. Using the automated system, the acoustic properties Tofu and Muk were measured to know whether they are similar among the different samples. In conclusion, the acoustic properties were measured to be similar among the different packets of Tofu and Muk, suggesting them as potential TMMs.

关键词： Biomaterials

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