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IEEE EMBS Asian-Pacific Conference on biomedical engineering 2003, APBME 2003

作者： Seo, Jin Woo Ryu, Myung Suk Park, Kwang Suk Jeong, Do-Un Interdisciplinary Program-Biomedical Engineering Major Graduate School Seoul National University Korea Republic of Advanced Biometric Research Center Seoul National University Korea Republic of Department of Biomedical Engineering Seoul National University College of Medicine Korea Republic of Dept. of Psychiatry Div. of Sleep Studies Seoul Nat'l Univ. College of Medicine and Hospital Korea Republic of

ISBN: (纸本)0780379438

Despite that ECG(electrocardiogram) provides substantial amount of information about a monitored patient, it has limitations when monitored remotely. In order to overcome long wire and channel interference problems of monitoring, wc used a certified Bluetooth Protocol and developed a home-based bedside ECG monitoring system. Bluetooth Protocol enabled the real-time transfer of ECG data via wireless communication with display and storage on PC(pcrsonal computer). We wore also able to retransmit the stored data to other site via TCP/IP. This system has clinical utility for unconstrained monitoring of ECG at bedside not only at home but also in hospital settings. © 2003 IEEE.

关键词： Electrocardiograms

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In vivo observation of blood echogenicity variation during a cardiac cycle on human carotid arteries

In vivo observation of blood echogenicity variation during a...

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IEEE Symposium (IUS) Ultrasonics

作者： Dong-Guk Paeng B.S. Kim MinJoo Choi R.Y. Chiao K.K. Shung Interdisciplinary Program of Biomedical Engineering Cheju National University Jeju South Korea Department of Biomedical Engineering University of Southern California Los Angeles CA USA GE Medical Systems Milwaukee WI USA

A cyclic variation of blood echogenicity from human iliac arteries in vivo was first observed using an intravascular 30 MHz ultrasound imaging device. Several studies have confirmed the temporal variation of the backscattered power during a flow cycle but they were all from in vitro experiments. In this paper, cyclic variation of echogenicity in vivo on human carotid arteries (7 males and 3 females) was observed from harmonic images of a GE LOGIQ 700 expert system with an M12L probe. Blood echogenicity increased at early systole, reaching a maximum at peak systole, and then decreased to be weak during diastole. Echogenicity during systole was about 40 to 60 % higher than that during diastole for all radial positions. The ratio of the maximum echogenicity during systole to the mean echogenicity during diastole was small at the center and near the vessel wall, and became large between them. The cyclic variation of blood echogenicity is thought to be due to erythrocyte aggregation enhancement by the combined effects of flow acceleration and shear rate during systole.

关键词： In vivo Blood Humans Carotid arteries In vitro Expert systems biomedical engineering biomedical imaging Ultrasonic imaging Acceleration

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Development of an integrated home telemedicine system

Development of an integrated home telemedicine system

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IEEE EMBS Asian-Pacific Conference on biomedical engineering

作者： Honggu Chun Ki-jung Kim Jae Min Kang Hee Chan Kim Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul South Korea Department of Biomedical Engineering College of medicine Seoul National University Seoul South Korea

ISBN: (纸本)0780379438

We developed an integrated home telemedicine system equipped with automatic diagnosis and consultation function for patients with chronic disease such as cardiac disease, respiratory disease, diabetes and hypertension. The system measures standard 12ch ECG, respiratory function, blood glucose level and non-invasive blood pressure (NIBP). The measured data were stored on the system and transmitted to the central server everyday through the Internet. The system performed automatic diagnosis at every measurement and offered medical consultation to the patient. If there was any abnormality in the diagnostic result, the system gave a real-time alarm to the healthcare center for adequate teleconsultation or medical service. We have installed the developed system on an apartment for the performance evaluation and confirmed the possibility of the system as an effective tool for the telemedicine.

关键词： Telemedicine Cardiac disease Cardiovascular diseases Medical services Diabetes Hypertension Pressure measurement Measurement standards Electrocardiography Blood

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Application of non-intrusive physiological data monitoring in normal apartment style house

Application of non-intrusive physiological data monitoring i...

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IEEE EMBS Asian-Pacific Conference on biomedical engineering

作者： K.S. Park W.J. Yi J.W. Seo J.M. Choi J.H. Han K.H. Hong Department of Biomedical Engineering College of Medicine Seoul National University Seoul South Korea Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul South Korea

We have installed and applied the developed nonintrusive type physiological data monitoring methods in already existing normal apartment style house. Physiological data are collected from beds, toilet seat and sensors installed throughout rooms. Collected data are transmitted by wireless communication to the home server, which collects, processes and finally transmits data to central server. Home server communicate with central server through installed high-speed Internet line. By the monitoring windows, doctors and caring staffs can access collected data on central server.

关键词： biomedical monitoring Patient monitoring Electrocardiography Web server Medical services biomedical measurements Weight measurement Textiles Electrodes Electrical resistance measurement

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Gait analysis for freezing detection in patients with movement disorder using three dimensional acceleration system

Gait analysis for freezing detection in patients with moveme...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Jong Hee Han Won Jin Lee Tae Beom Ahn Beom Suk Jeon Kwang Suk Park Interdisciplinary program in Medical and Biological Engineering Major Seoul National University South Korea Department of Biomedical Engineering College of medicine Seoul National University South Korea Department of Neurology Seoul National University South Korea

ISBN: (纸本)0780377893

Due to the aging process, the aftereffect of an accident or the problems in brain, some people can experience difficulties in walking. It could be helpful in the treatment of these individuals suffering walking difficulties to monitor their movement. The unconstrained activity monitoring system (U-AMS) was developed to monitor the body's acceleration. It can be attached easily and doesn't interfere with daily activity. The hardware consists of 3-axis accelerometer, which records data for long periods of time. The movement image was simultaneously recorded by a camcorder. To collect data from U-AMS and analyze them, several programs were developed. The data were transferred to a computer by RS-232 module and displayed through viewing program made by MFC (Microsoft, USA). The analyzing program, which links viewing program to MATLAB (Mathworks, USA), analyzes the data to detect movement disorder. In this paper, freezing, which is characterized as start hesitation., was the target disorder. Using the different characteristics in frequency domain between freezing and normal gait, freezing appearances were detected. By comparing with movement image, the accuracy of the freezing detection was verified to have a good performance.

关键词： Acceleration Legged locomotion Aging Accidents Patient monitoring Hardware Accelerometers Video equipment Computer displays MATLAB

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Time scale and other invariants of integrative mechanical behavior in living cells

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Physical Review E 2003年第4期68卷 041914-041914页

作者： Ben Fabry Geoffrey N. Maksym James P. Butler Michael Glogauer Daniel Navajas Nathan A. Taback Emil J. Millet Jeffrey J. Fredberg Physiology Program Harvard School of Public Health 665 Huntington Avenue Boston Massachusetts 02115 USA School of Biomedical Engineering Dalhousie University 5981 University Avenue Halifax Nova Scotia Canada B3H 3J5 Faculty of Dentistry University of Toronto 150 College Street Toronto Ontario Canada M5S 3E2 Unitat Biofísica i Bioenginyeria Universitat de Barcelona–IDIBAPS Casanova 143 08036 Barcelona Spain Department of Biostatistics Harvard School of Public Health 665 Huntington Avenue Boston Massachusetts 02115 USA

In dealing with systems as complex as the cytoskeleton, we need organizing principles or, short of that, an empirical framework into which these systems fit. We report here unexpected invariants of cytoskeletal behavior that comprise such an empirical framework. We measured elastic and frictional moduli of a variety of cell types over a wide range of time scales and using a variety of biological interventions. In all instances elastic stresses dominated at frequencies below 300 Hz, increased only weakly with frequency, and followed a power law; no characteristic time scale was evident. Frictional stresses paralleled the elastic behavior at frequencies below 10 Hz but approached a Newtonian viscous behavior at higher frequencies. Surprisingly, all data could be collapsed onto master curves, the existence of which implies that elastic and frictional stresses share a common underlying mechanism. Taken together, these findings define an unanticipated integrative framework for studying protein interactions within the complex microenvironment of the cell body, and appear to set limits on what can be predicted about integrated mechanical behavior of the matrix based solely on cytoskeletal constituents considered in isolation. Moreover, these observations are consistent with the hypothesis that the cytoskeleton of the living cell behaves as a soft glassy material, wherein cytoskeletal proteins modulate cell mechanical properties mainly by changing an effective temperature of the cytoskeletal matrix. If so, then the effective temperature becomes an easily quantified determinant of the ability of the cytoskeleton to deform, flow, and reorganize.

关键词： Musculoskeletal system

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New method in acoustic analysis for the diagnosis of the laryngeal functions

New method in acoustic analysis for the diagnosis of the lar...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Jong Min Choi Myung-Whun Sung Kwang Suk Park Medical and Biological Engineering Major Interdisciplinary Program Department of Otorhinolaryngology Head and Neck Surgery College of Medicine Department of Biomedical Engineering College of Medicine Seoul National University Seoul South Korea

Speech has been widely used for the diagnosis of the laryngeal function, and many methods have been developed in voice analysis. But, some methods cannot be applied in clinical cases. So, we present a scheme for the diagnosis of the voice using some parametric methods. We expect this scheme to be useful for the diagnosis of patients' voices.

关键词： Frequency Speech analysis Jitter Medical diagnostic imaging Pathology biomedical engineering Educational institutions Sampling methods Databases biomedical acoustics

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New method in acoustic analysis for the diagnosis of the laryngeal functions

New method in acoustic analysis for the diagnosis of the lar...

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Proceedings of the 2002 IEEE engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the biomedical engineering Society (BMES / EMBS)

作者： Choi, Jong Min Sung, Myung-Whun Park, Kwang Suk Interdisciplinary Program Medical and Biological Eng. Major Seoul National University Seoul Korea Republic of Dept. of Otorhinol. Head Neck Surg. College of Medicine Seoul National University Seoul Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

Speech has been widely used for the diagnosis of the laryngeal function, and many methods have been developed in voice analysis. But, some methods cannot be applied in clinical case. So, we intend to present the new schemes for the diagnosis of the voice using some parametric methods. We expect this scheme to be useful for the diagnosis of the patients' voices.

关键词： Speech analysis

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Expert system for early diagnosis of eye diseases infecting the Malaysian population

Expert system for early diagnosis of eye diseases infecting ...

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IEEE Region 10 International Conference on Electrical and Electronic Technology

作者： Ibrahim, Fatimah Basheer Ali, Juliana Jaais, Fathilah Nasir Taib, Mohd Biomedical Engineering Program Faculty of Engineering University of Malaya 50603 Kuala Lumpur Malaysia Ophthalmology Department Faculty of Medicine University of Malaya 50603 Kuala Lumpur Malaysia Faculty of Electrical Engineering Universiti Teknologi Mara 40450 Shah Alam Selangor Malaysia

ISBN: (纸本)0780371011

This paper describes a knowledge based system employing certain expert system rules to detect different kind of eye diseases found in Malaysia. The types of eye diseases that can be detected with this system are allergic or infectious conjunctivitis, secondary and senile cataract, open angle glaucoma and acute glaucoma, keratitis and dry eyes syndrome. These are the most frequent eye diseases infecting the Malaysian population. The project was designed and programmed via the object-oriented expert system shell software, EXSYS. Expert rules were developed based on the symptoms of each type of the eye diseases, and they were presented using a tree graph forward chaining with depth search first method. In order to enhance user interaction with the system, graphical user interfaces were employed. Previously, several similar works have been published, but they are limited to detecting a single disease and also required expert medical officer to operate. The expert system described in this paper is able to detect and gives early diagnosis of five types of eye diseases;inclusive of senile, secondary, open angle, acute, allergic and infections.

关键词： Expert systems

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Quantitative analysis of cell detachment by shear stress

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Materials Science and engineering C 2001年第1-2期17卷 55-58页

作者： Furukawa, Katsuko Sakai Ushida, Takashi Nagase, Takayuki Nakamigawa, Hideki Noguchi, Takuya Tamaki, Tamotsu Tanaka, Junzo Tateishi, Tetsuya Biomedical Engineering Laboratory Department of Mechanical Engineering University of Tokyo Tokyo 113-8656 Japan CREST Japan Science and Technology Corporation Japan 3 Dimensional Cell and Tissue-Engineering Group National Institute for Interdisciplinary Research Ministry of International Trade and Industry Tsukuba Ibaraki Japan Department of Mechanical Engineering Faculty of Engineering Nippon Institute of Technology Gakuenndai 4-1 Miyashiro Minamisaitama Saitama Japan National Institute for Research in Inorganic Materials Japan Laboratory Department of Mechanical Engineering University of Tokyo Hongo 7-3-1 Bunkyo Tokyo 113-8656 Japan

It is important to enhance adhesive force of cells to scaffolds in a field of tissue engineering. In this study, we developed a new system that can evaluate detachment force of cells with ease. A cone and plate-type viscometer provides a well-defined homogeneous laminar flow and consists of simple structure. Therefore, the system was based on a modified cone and plate-type viscometer equipped with an upright epifluorescence microscope. The fixation of diverse biomaterials, i.e. plate-, membranous- and porous-shaped materials to the system was enabled possible. In addition, small volume of medium, small number of cells, and small piece of material were enough to evaluate cell detachment by shear stress. By using the newly developed apparatus, the phenomena of cell detachment were quantitatively analyzed with ease. Therefore, our apparatus should be a useful instrument to develop and evaluate the materials that are expected to enhance endothelialization. © 2001 Elsevier Science B.V. All rights reserved.

关键词： Materials science

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