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Journal of Biosciences 1999年第1期24卷 33-198页

作者： N. Manoj V. R. Srinivas A. Surolia M. Vijayan K. Suguna R. Ravishankar R. Schwarzenbacher K. Zeth Diederichs G. M. Kostner A. Gries P. Laggner R. Prassl Madhusudan Pearl Akamine Nguyen-huu Xuong Susan S. Taylor M. Bidva Sagar K. Saikrishnan S. Roy K. Purnapatre P. Handa U. Varshney B. K. Biswal N. Sukumar J. K. Mohana Rao A. Johnson Vasantha Pattabhi S. Sri Krishna Mira Sastri H. S. Savithri M. R. N. Murthy Bindu Pillai Kannan M. V. Hosur Mukesh Kumar Swati Patwardhan K. K. Kannan B. Padmanabhaa S. Sasaki-Sugio M. Nukaga T. Matsuzaki S. Karthikevan S. Sharma A. K. Sharma M. Paramasivam P. Kumar J. A. Khan S. Yadav A. Srinivasan T. P. Singh S. Gourinath Neelima Alam A. Srintvasan Vikas Chandra Punit Kaur Ch. Betzel S. Ghosh A. K. Bera S. Bhattacharya S. Chakraborty A. K. Pal B. P. Mukhopadhyay I. Dey U. Haldar Asok Baneriee Jozef Sevcik Adriana Solovicova K. Sekar M. Sundaralingam N. Genov Dong-cai Liang Tao Jiang Ji-ping Zhang Wen-rui Chang Wolfgang Jahnke Marcel Blommers S. C. Panchal R. V. Hosur Bindu Pillay Puniti Mathur S. Srivatsun Ratan Mani Joshi N. R. Jaganathan V. S. Chauhan H. S. Atreya S. C. Sahu K. V. R. Chary Girjesh Govil Elisabeth Adjadj Éric Quinjou Nadia Izadi-Pruneyre Yves Blouquit Joël Mispelter Bernadette Heyd Guilhem Lerat Philippe Milnard Michel Desmadreil Y. Lin B. D. Nageswara Rao Vidva Raghunathan Mei H. Chau Prashant Pesais Sudha Srivastava Evans Coutinho Anil Saran Leizl F. Sapico Jayson Gesme Herbert Lijima Raymond Paxton Thamarapu Srikrishnan C. R. Grace G. Nagenagowda A. M. Lynn Sudha M. Cowsik Sarata C. Sahu S. Chauhan A. Bhattacharya G. Govil Anil Kumar Maurizio Pellecchia Erik R. P. Zuiderweg Keiichi Kawano Tomoyasu Aizawa Naoki Fujitani Yoichi Hayakawa Atsushi Ohnishi Tadayasu Ohkubo Yasuhiro Kumaki Kunio Hikichi Katsutoshi Nitta V. Rani Parvathy R. M. Kini Takumi Koshiba Yoshihiro Kobashigawa Min Yao Makoto Demura Astushi Nakagawa Isao Tanaka Kunihiro Kuwajima Jens Linge Seán O. Donoghue Michael Nilges G. Chakshusmathi Girish S. Ratnaparkhi P. K. Madhu R. Varadarajan C. Tetreau Molecular Biophysics Unit Indian Institute of Science Bangalore India Austrian Academy of Sciences Institute of Biophysics and X-ray Structure Research Graz Austria Faculty of Biology University of Konstanz Germany Institute of Medical Biochemistry University of Graz Austria Howard Huges Medical Institute Department of Chemistry & Biochemistry University of California La Jolla USA Department of Chemistry & Biochemistry University of California San Diego La Jolla USA Molecular Biophysics Unit India Department of Microbiology &Cell Biology Indian Institute of Science Bangalore India Macromolecular Structure Laboratory NCI - Frederick Cancer Research and Development Center ABL - Basic Research Program Frederick USA Department of Crystallography and Biophysics University of Madras Chennai Biochemistry Department Indian Institute of Science Bangalore India Condensed Matter Physics Division B.A.R.C. Trombay Mumbai Condensed Matter Physics Division Bhabha Atomic Research Centre Trombay Mumbai IMCB The University of Tokyo Tokyo Japan Mitsubishi Chemical Corporation Yokohama Research Center Yokohama Japan Faculty of Pharmaceutical Sciences Chiba University Chiba Japan Department of Biophysics All India Institute of Medical Sciences New Delhi India Department of Biophysics All India Institute of Medical sciences New Delhi India Institüt Physiologische Chemie Hamburg Germany Biophysics Department Bose Institute Calcutta India Slovak Academy of Sciences Institute of Molecular Biology Bratislava Slovakia Indian Institute of Science Bioinformatics Centre Bangalore Departments of Chemistry and Biochemistry Biological Macromolecular Structure Center USA Bulgarian Academy of Sciences Institute of Organic Chemistry Sofia Bulgaria Chinese Academy of Sciences Institute of Biophysics Beijing China Novartis Pharma AG Preclinical Research Basel Switzerland Department of Chemical Sciences Tata Institute of Fundamental Research Mumbai India Solid State Physics Div

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Display of coregistered cross-modality images using time-weighted alternation method

Display of coregistered cross-modality images using time-wei...

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作者： Sung Lee, Jae Chee, Youngjoon Kim, Boyeon Lee, Jong Min Park, Kwang Suk Kwark, Cheoleun Lee, Myung Chul Interdisciplinary Program in Medical and Biological Engineering Major Department of Biomedical Engineering Seoul National University Korea Republic of

Cross-modality coregistration of functional and anatomical images has rapidly grown as the aid for the interpretation of functional images. Various methods have been previously investigated so that the coregistered images can be easily interpreted and realistically visualized. We used the time/intensityweighted alternation method to display the coregistered images simultaneously. Stereotactic registration was done with two methods. We realized the automated method of alignment using the boundary of head scalp extracted from the sinogram of a PET emission scan and surface-matching algorithm in brain, and the semi-automated method using a paired point-matching algorithm in the chest and abdomen. For the simultaneous display of the stereotactically registered images, rapid switching of the screens were applied on which both images were written with independent color scales. Rapid alternate display of two images, that is synchronized using the monitor scanning process, could induce the fusion of images in the human visual perception system. Also, intensification of an interesting image is possible by weighting the displaying time or global intensities of images with the degree of interest. These techniques could be useful for the interpretation and visualization of the coregistered images. © 1997 The authors.

关键词： Display devices

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Optimal consumer subsidies and income transfers for minimum nutritional requirements: a basic model

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Food and Nutrition Bulletin 1997年第4期18卷 344-351页

作者： Chernichovsky, Dov Spiegel, Uri Zion, Uri Ben Gradstein, Mark Department of Health Policy and Management Program for Health Policy in Economies Under Stress Ben-Gurion University of the Negev Beer-Sheva Israel Interdisciplinary Department of Social Sciences Bar-Ilan University Israel Department of Economics University of Pennsylvania Philadelphia PA United States Faculty of Industrial Engineering and Management Technion Haifa Israel Department of Economics Ben-Gurion University of the Negev

The supply of food is no longer a major determinant of malnutrition in the developing world. Rather, a lack of purchasing power, ignorance about nutrition, and subjective tastes of preferences prevent some households and individuals from securing adequate diets. Some households spend more on food and other consumer items than would be needed for a minimum balanced diet. Yet they remain malnourished or have nutritionally undesirable diets. Food subsides and income transfers have been major policy options available to governments to augment household purchasing power and change consumer preferences in order to alleviate malnutrition. Those options have traditionally addressed the problem by considering one critical nutrient and one common staple. The model discussed here provides and demonstrates a solution to the question: What is the combined optimal income-transfer and subsidy programme that would meet particular nutritional requirements with the least budget expense to the government? It is argued and shown, with the aid of an initial model, that a combination of income transfers and food subsidies that consider a range of foods, rather than a single staple, and a range of nutrients, rather than a particular nutrient, may lead to cost-beneficial policies that meet wider nutritional objectives for less cost.

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A study on the modeling of nonlinear system using genetic programming

A study on the modeling of nonlinear system using genetic pr...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Boyeon Kim Kwangsuk Park Interdisciplinary Program of Biomedical Engineering Major Seoul National University South Korea Department of Biomedical Engineering College of Medicine Seoul National University South Korea

Even though there are several deterministic methods for the modeling of linear systems, there is no standard method for the modeling of nonlinear systems. Most biological systems can be thought of as nonlinear systems. For the modeling of biological systems the authors have studied nonlinear systems using genetic programming. Time series were generated from the simple known nonlinear dynamics. Then nonlinear dynamics was estimated from these time series using genetic programming. For the tested nonlinear systems this suggested method estimated the nonlinear dynamics correctly. This method also has been applied for the modeling of the dynamics of the 24-hour electrocardiogram.

关键词： Nonlinear systems Genetic programming Nonlinear equations Dynamic programming Time measurement Biological system modeling Nonlinear dynamical systems Biological systems Genetic mutations Biological cells

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A method for predicting the utilization of medical technology in neonatal care

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Technology and Health Care 1996年第4期3卷 273-278页

作者： Scalon, João D. Vidai Melo, Marcos F. Panerai, Ronney B. Department of Biomedical Engineering Federal University of São João del-Rey Campus Dom Bosco Sao Joao del Rey-MG CEP 36300-000 Brazil Biomedical Engineering Program-COPPE Federal University of Rio de Janeiro Rio de Janeiro RJ CEP 21945-970 PO Box 68510 Brazil Division of Medical Physics Faculty of Medicine University of Leicester Leicester LE2 7LX United Kingdom

The utilization of 12 neonatal intensive care technologies was recorded in 193 patients. An index of utilization (P(u)) was adopted to classify these technologies into three sub-groups corresponding to low (P(u) < 15%), medium (15% ≤ P(u) ≤ 85%), and high (P(u) > 85%) intensity of use. No models were developed for technologies with high intensity of use (intravenous hydration, warming, micro-haematocrit, heart rate monitoring). Multiple linear regression was used to predict the utilization of technologies with medium intensity of use (gasometry, oxygen hood, CPAP, mechanical ventilation), and multiple logistic regression was used with the same purpose for technologies with low intensity of use (exchange transfusion, bicarbonate, adrenaline, echocardiography). Both methods yielded significant models (P < 0.05) which can be used to improve planning and management of technology in neonatal intensive care units.

关键词： Clinical engineering Forecasting Health planning NICU Resource allocation Technology management Utilization review

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A study on the nonlinear dynamics of PR interval variability using surrogate data

A study on the nonlinear dynamics of PR interval variability...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Jongmin Lee Kwangsuk Park Insun Shin Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University in Korea South Korea Department of Biomedical Engineering Seoul National University Seoul South Korea Department of Mathematics Education Korea National University of Education South Korea

PR interval variability (PRV) has been proposed as a noninvasive tool for investigating the autonomic nervous system (ANS) as well as heart rate variability (HRV). The goal of this study is to determine whether PRV has nonlinear dynamics or not. The authors developed an automatic PR interval measurement algorithm, and tested it using MIT ECG databases. 24-hour Holter ECGs were acquired from 30 healthy adults. Surrogate data was generated from a simpler linear model to have similar statistical characteristics with the original data. To detect nonlinear dynamics of the time series, correlation dimension, Lyapunov exponent, and phase space reconstruction were evaluated in both data. The results showed that PRV was significantly different from the surrogate data in the tests. It was concluded that PR interval variability shows nonlinear behavior.

关键词： Heart rate variability Electrocardiography Nonlinear dynamical systems biomedical engineering Educational programs Systems engineering education Autonomic nervous system Databases Character generation Phase detection

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A new method of measuring ciliary beat frequency using image processing

A new method of measuring ciliary beat frequency using image...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Wonjin Yi Kwangsuk Park Yanggi Min Meonghun Sung Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University South Korea Department of Biomedical Engineering College of Medicine Seoul National University South Korea Department of Otolaryngology Head and Neck Surgery College of Med Seoul National University South Korea

Mucociliary clearance of the respiratory tract is one of the important defensive functions of the airway mucous. In this study, the authors developed a new method of measuring ciliary beat frequency (CBF) with high spatial resolution based on the image processing method. Microscopic ciliary images were digitized through an image grabbing board inside a PC, and data necessary for the power spectrum (FFT) analyses were extracted from these gray images by an image subtraction method. By means of FFT analyses, the maximum peak frequencies were found in each divided block of a whole acquired image. Finally using these frequencies, the authors composed frequency maps of various sizes showing the spatial distribution of CBF's in user specified resolution. The smaller the authors made the size of divided blocks included in analysis, the more detailed regional ciliary beat distributions they could evaluate.

关键词： Frequency measurement Image processing Image analysis Spatial resolution Pixel biomedical measurements Data mining biomedical imaging Optical sensors Optical microscopy

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Abstract

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Pflügers Archiv 1996年第6期431卷 R322-R356页

作者： L. J. Andries S. U. Sys A. L. Meulemans J. A. J. Schuurkes B. Vanheel J. Van de Voorde P. De Smet J. Li W. Van Driessche B. Flamion S. Foulon M. Abramow P. Calders W. Eechaute E. Lacroix I. Weyne D. Hoeben C. Burvenich P. Fransen D. Van Bedaf M. Demolder R. Ouedraogo P. Lebrun A. Herchuelz M. -H. Antoine S. Vandenput D. Votion N. Anciaux D. H. Duvivier T. Art P. Lekeux Y. Ghafir M. Geurts E. Hermans J. -M. Maloteaux B. Perrad B. Noel F. Lagache J. L. Bister R. Paquay G. Derycke M. A. Vandermeir S. de Brouwer C. -A. Porret N. Stergiopulos J. -J. Meister M. Verbeke N. Lameire N. M. De Clerck J. De Schuytter J. Tytgato G. Buyse J. Eggermont G. Droogmans B. Nilius P. Daenens S. Salomone O. Feron C. Dessy N. Morel T. Godfraind A. M. Aloisi P. Sacerdote L. Lodi G. Carli C. Carobi G. Garinei U. C. Miniaci P. Scotto M. Sabatino P. Sardo L. Iurato V. La Grutta M. A. Bagni G. Cecchi E. Cecchini F. Colomo P. Garzella R. Bottinelli S. D. H. Harridge M. Canepari C. Reggiani Saltin Reggiani D. Bambagioni G. Fanò G, Menchetti P. Danieli-Betto A. Esposito R. Betto A. Megighian M. Midrio D. Danieli Betto C. Orizio D. Liberati C. Locatelli D. De Grandis A. Veicsteinas D. Angoli D. Delia E. Wanke M. Bramucci A. Miano L. Quassinti E. Maccari O. Murri D. Amici G. Cibelli S. Jüngling S. Schoch H. H. Gerdest G. Thiel I. Demori C. Bottazzi A. Voci E. Fugassa A. Barreca F. Minuto G. Gallo S. Fulle S. Belia G. Menchetti M. Cacchio G. Gastaldi U. Laforenza G. Ferrari G. Rindi M. G. Doni E. Padoin O. Residori M. Cesaro L. Toma A. Rubini F Mutinelli L. Paulesu R. Romagnolie M. Cintorino P. Pippia M. A. Meloni L. Sciola A. Spano M. Cogoli-Greuter A. Cogoli A. Sardini G. M. Mintenig M. A. Valverde F. V. Sepùlveda D. R. Gill S. C. Hyde C. F. Higgins P. A. McNaughton A. Spena M. T. Arcuri S. Bonofiglio R. Chimenti C. Covello T. De Cicco S. Mazzulla G. Martino A. Tottene A. Moretti D. Pietrobon M. C. Baccari F. Calamai G. Staderini E. Cova R. Marelli P. Sommi U. Ventura A. M. Lombardi R. Fabris C. Pagano G. Federspil R. Vettor R. Mancinelli P. To Laboratory of Physiology RUCA University of Antwerp Belgium Dept. of Gastroint. Pharmacol. Janssen Research Foundation Beerse Belgium Department of Physiology and Physipathology University of Gent De Pintelaan 185 Gent Belgium Laboratory of Physiology K. U. Leuven Leuven Belgium Laboratory of Pathophysiology University of Bruxelles (ULB) Brussels Belgium Laboratory of Normal and Pathological Physiology University of Gent Belgium Department of Physiology Biochemistry and Biometrics Faculty of Veterinary Medicine University of Ghent Merelbeke Belgium Laboratory of Physiology University of Antwerp (RUCA) Antwerp Belgium Lab. de Pharmacodynamie et de Thérapeutique Université Libre de Bruxelles Bruxelles Belgique Laboratory for Functional Investigation Faculty of Veterinary Medicine University of Liége Liège Belgium Laboratory for Functional Investigation Faculty of Veterinary Medicine University of Liège Liège Belgium Laboratory of Pharmacology Catholic University of Louvain Brussels Laboratoire de Physiologie Animale FUNDP Namur Laboratory of animal Physiology Facultés universitaires Notre-Dame de la Paix Namur Belgium Biomedical Engineering Laboratory Swiss Federal Institute of Technology Lausanne Switzerland RUCA University of Antwerp Antwerp Belgium Laboratory of Physiology Laboratory of Toxicology University of Leuven Leuven Belgium Laboratoire de Pharmacologie Université Catholique de Louvain Bruxelles Belgium Istituto di Fisiologia Umana Università degli Studi Siena Dipartimento di Farmacologia Università degli Studi di Milano Milano Istituto di Fisiologia Umana Università di Perugia Perugia Dipartimento di Medicina Sperimentale Università di Reggio Calabria Laboratorio di Fisiologia Umana Catanzaro Istituto di Fisiologia umana Palermo Dipartimento di Scienze Fisiologiche Università di Firenze Firenze Dipartimento Biologia Cellulare e Molecolare (sez. Fisiologia e Biofisica) Università di Perugia Perugia Istituto di Fisiologia Umana Univer

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HIGH-FREQUENCY ELECTROCARDIOGRAM ANALYSIS OF THE ENTIRE QRS IN THE DIAGNOSIS AND ASSESSMENT OF CORONARY-ARTERY DISEASE

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PROGRESS IN CARDIOVASCULAR DISEASES 1993年第5期35卷 311-328页

作者： ABBOUD, S Biomedical Engineering Program Faculty of Engineering Tel Aviv University Israel

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A BLOOD-VESSEL MODEL-BASED ON VELOCITY PROFILES

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COMPUTERS IN BIOLOGY AND MEDICINE 1993年第4期23卷 295-300页

作者： BARNEA, O Biomedical Engineering Program Faculty of Engineering Tel Aviv University Tel Aviv 69978 Israel

A simple model of pressure-flow relationship in blood vessels was developed. The calculation of the model components was based on velocity profiles in the vessels. The flat velocity profile in the entrance of the vessel was considered. By using mean pressure over the cross-section and assuming a polynomial approximation of the velocity profile, it is shown that the resistance of a vessel segment increases with increased flatness of the velocity profile. Moreover, the analysis provides a means to calculate the resistance of a vessel segment based on the shape of the velocity profiles in that segment. The analysis shows that the inertance element of the segment is not affected by the shape of the velocity profile.

关键词： CARDIOVASCULAR MODEL COMPUTER MODEL BLOOD FLOW ARTERIAL RESISTANCE

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