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11th International Japan-Africa Conference on Electronics, Communications, and Computations, JAC-ECC 2023

作者： Bakr, Hend A. Salama, Ahmed M. Fares, Ahmed Zaky, Ahmed B. Cairo University Biomedical Engineering Program Faculty of Engineering Giza Egypt Benha University Computer Systems Engineering Program Faculty of Engineering at Shoubra Banha Egypt Computer science and information technology Programs Alexandria Egypt Benha University On leave from Computer Systems Engineering Program Faculty of Engineering at Shoubra Egypt

ISBN: (纸本)9798350369328

Physician scheduling is a critical task that impacts the quality of patient care, staff satisfaction, and operational efficiency in healthcare institutions. The traditional approach to physician scheduling is manual and time-consuming, which can result in errors, staff burnout, and suboptimal schedules. To address these challenges, researchers have turned to optimization techniques like CSP, which has shown promise in solving physician scheduling problems. This paper reviews the existing literature on CSP for physician scheduling and highlights the benefits and limitations of this approach. CSP's benefits include generating schedules quickly and efficiently, incorporating complex constraints and preferences, and handling changes and disruptions in real time. However, CSP also has some limitations, such as the need for a formalized model and the fact that it may not always generate the most intuitive schedules. Overall, the findings suggest that CSP is a promising approach to physician scheduling that can produce high-quality schedules while minimizing staff burnout and improving operational efficiency. © 2023 IEEE.

关键词： Constraint satisfaction problems

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The Development of Wound Healing Patch Containing Silk Sericin and Cinnamon Extract for the Treatment of Infected Wound 16

The Development of Wound Healing Patch Containing Silk Seric...

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16th biomedical engineering International Conference, BMEiCON 2024

作者： Piyapan, Siriporn Aramwit, Pornanong Chulalongkorn University Biomedical Engineering Program Faculty of Engineering Bangkok Thailand Chulalongkorn University Bioactive Resourse for Innovative Clinical Applications Research Unit Faculty of Pharmaceutical Sciences Bangkok Thailand

ISBN: (纸本)9798331505431

Sericin is a natural protein from silkworm cocoons. It is used in many biomedical applications as scaffolds, films, hydrogels, and micro/nanoparticles. This study was interested in fabricating a scaffold from sericin as a wound healing patch. The scaffold was fabricated, but sericin had poor properties, so it needed to be solved using another polymer. Poly(vinyl alcohol) (PV A) was chosen to improve their properties in conjunction with chemical (adding glutaraldehyde) and physical (freezing-thawing) crosslink. The cross-section of SEM showed high porous and good interconnectivity all around the sheet of both scaffolds. The chemical crosslink scaffold (CC scaffold) was smaller porous than the physical crosslink scaffold (PC scaffold). The result of FTIR showed that the specific absorption peaks of sericin were amide I at 1618-1640 cm-1 ( C=O stretching), amide II at 1518-1638 cm-1 (N-H bending and C-N stretching) and amide III at 1238 cm-1 (C-N and C=O stretching). Adding glutaraldehyde gave the two small peaks at 2830 -3000 cm-1, indicating the C-H bond of the aldehyde and alkyl functional group. The mechanical testing, crosslinking can resist deformation observed from Young's modulus. Young's modulus of non-crosslink, physical and chemical crosslink scaffolds were 1.4± 0.001,34.4± 0.004 and 7.5± 0.004 kPa, respectively. Elongation at break of scaffolds were 116.4 ± 11.1 %, 140.3 ± 13.2% and 22.7 ± 17%, respectively. These results suggested that the addition of glutaraldehyde had an impact on the brittleness of the scaffold. The swelling property indicated the wound healing patch's efficiency in absorbing liquids or exudate. There were two folds of swelling of the CC scaffold compared with the PC scaffold at intervals time after immersion. At the same time, sericin released more than 450 μ g mL from both scaffolds after 48 h. MTT assay showed that they were non-toxic at 2 4 and 4 8 h. Cell viability has been measured more than 70.0%. Moreover, our study wants to dev

关键词： Thawing

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Gelatin/carboxymethyl carrageenan/halloysites nanocomposite bone tissue engineering scaffolds with enhanced biomimetic mineralization 31

Gelatin/carboxymethyl carrageenan/halloysites nanocomposite ...

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31st National and 9th International Iranian Conference on biomedical engineering, ICBME 2024

作者： Andam, Samira Nourmohammadi, Jhamak Mashhadi, Raheleh Mohammadi, Vahideh University of Tehran Schools of Life Science Engineering College of Interdisciplinary Science and Technology Tehran Iran Islamic Azad University Central Tehran Branch Faculty of Technology and Engineering Biomedical Engineering Department Tehran Iran

ISBN: (纸本)9798331529710

Combining protein-polysaccharide-halloysite scaffolds to promote bone-like apatite formation has emerged as a promising strategy for replicating the extracellular matrix. This study aimed to design and evaluate a novel bioactive nanocomposite scaffold composed of carboxymethyl carrageenan, gelatin, and halloysites for bone regeneration applications. Various techniques were employed to characterize the scaffolds, assessing their morphology, compressive strength, apatite mineralization, and biological performance in comparison to halloysite-free scaffolds. The results showed a very porous structure with interconnecting pores. The inclusion of halloysite reduced pore size and overall porosity while enhancing compressive strength, cellular attachment, viability, and ALP production. The scaffold formed an apatite layer after 2 weeks of Immersion in simulated body fluid. © 2024 IEEE.

关键词： Apatite

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The Design and Optimisation of W-Angular Plate on Quadrilateral Surface 1

The Design and Optimisation of W-Angular Plate on Quadrilate...

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1st IEEE International Conference on Communication engineering and Emerging Technologies, ICoCET 2024

作者： Rajan, Riya Letchumi Bin Mohd Nasir, Nashrul Fazli Mamat, Normahira Binti Yahaya, Sahran Bin Tan, Eugene Chin, Lim Chee Meng, Cheng Ee Sharifah Robiah, Che Wan Bin Abdul Kadir, Mohd Rafiq Universiti Malaysia Perlis Biomedical Electronic Engineering Program Faculty of Electronic Engineering and Technology Perlis Malaysia Universiti Sains Malaysia Department of Orthopaedics Kubang Kerian Malaysia Leonix Sdn. Bhd. Batu Maung Malaysia Universiti Malaya Faculty of Engineering Biomedical Engineering Department Kuala Lumpur Malaysia

ISBN: (纸本)9798331504144

This study focuses on the design, optimization, and biomechanical evaluation of a W-angular hip plate intended for the quadrilateral surface of the human pelvis. The W angular configuration is chosen for its potential to enhance stability and load distribution across the complex pelvic anatomy. The primary objective is to investigate and refine the screw insertion technique that maximizes the plate's stability on the quadrilateral surface. This involves evaluating various parameters such as screw placement angles and depths to achieve optimal fixation. Mechanical behavior of the W-angular hip plate is comprehensively assessed under diverse loading conditions simulating activities essential to daily living, including walking, standing, and sitting. The evaluation encompasses the analysis of stress distribution, strain patterns, and deformation characteristics within the implant structure. Both male and female anatomical variations are considered to ensure a thorough assessment of performance across different patient demographics. The outcomes of this study aim to deepen the understanding of how the W-angular hip plate interacts with the pelvic bone and surrounding tissues under realistic conditions. © 2024 IEEE.

关键词： Titanium alloys

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A generalized adder for cell size homeostasis: Effects on stochastic clonal proliferation

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Biophysical Journal 2025年第9期124卷 1376-1386页

作者： Nieto, César Vargas-García, César Augusto Singh, Abhyudai Department of Electrical and Computer Engineering University of Delaware Newark DE United States AGROSAVIA - Corporacion Colombiana de Investigacion Agropecuaria Cundinamarca Mosquera Colombia Department of Electrical and Computer Engineering Biomedical Engineering Mathematical Sciences Interdisciplinary Neuroscience Program University of Delaware Newark DE United States

Measurements of cell size dynamics have revealed phenomenological principles by which individual cells control their size across diverse organisms. One of the emerging paradigms of cell size homeostasis is the adder, where the cell cycle duration is established such that the cell size increase from birth to division is independent of the newborn cell size. We provide a mechanistic formulation of the adder, considering that cell size follows any arbitrary nonexponential growth law. Our results show that the main requirement to obtain an adder regardless of the growth law (the time derivative of cell size) is that cell cycle regulators are produced at a rate proportional to the growth law, and cell division is triggered when these molecules reach a prescribed threshold level. Among the implications of this generalized adder, we investigate fluctuations in the proliferation of single-cell-derived colonies. Considering exponential cell size growth, random fluctuations in clonal size show a transient increase and then eventually decay to zero over time (i.e., clonal populations become asymptotically more similar). In contrast, several forms of nonexponential cell size dynamics (with adder-based cell size control) yield qualitatively different results: clonal size fluctuations monotonically increase over time, reaching a nonzero value. These results characterize the interplay between cell size homeostasis at the single-cell level and clonal proliferation at the population level, explaining the broad fluctuations in clonal sizes seen in barcoded human cell lines. © 2025 Biophysical Society

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Modelling the development of biological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,growth factor-coupled polycaprolactone fibres

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Engineered Regeneration 2024年第1期5卷 124-138页

作者： Badwi B.Boumelhem Stuart T.Fraser Syamak Farajikhah Rachel A.Shparberg Michael B.Morris Marcela M.M.Bilek Anyu Zhang Behnam Akhavan Simon Fleming Maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia School of Chemical and Biomolecular Engineering University of SydneyAustralia School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of Biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute(HMRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

Many biological structures such as nerves,blood and lymphatic vessels,and muscle fibres exhibit longitudinal ge-ometries with distinct cell types extending along both the length and width of internal linear *** these three-dimensional structures in vitro is challenging:the best-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on the signals received,holding great promise for regenerative ***,the integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can bridge this gap if the appropriate signalling systems are incorporated into the ***,we have taken a biomimicry approach to generate longitudinal structures in *** this approach,mouse embryonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone(PCL)fibres treated by plasma-immersion ion implantation and to which with lineage-specifying molecules have been covalently *** demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells:neurons,vascular endothelial cells,osteoclasts,adipocytes,and cells of the erythroid,myeloid,and lymphoid *** arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Growth factors Biomaterial engineering Plasma-immersion ion implantation Covalent biomolecule attachment Polycaprolactone

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Synthesis, characterization, and interfacial adhesion of titania iodine-doped nanotubes architectures on additively manufactured Ti-6Al-4 V implant

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Materialwissenschaft und Werkstofftechnik 2025年第3期56卷 438-454页

作者： Taweekitikul, P. Aliyu, A.A. Decha-Umphai, D. Tantavisut, S. Khamwannah, J. Puncreobutr, C. Lohwongwatana, B. Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand Trauma Unit Department of Orthopaedic Queen Savang Vadhana Memorial Hospital Chonburi20110 Thailand Biomedical Engineering Research Center Chulalongkorn University Bangkok10330 Thailand M3D Laboratory Advanced Materials Analysis Research Unit Department of Metallurgical Engineering Faculty of Engineering Chulalongkorn University Phayathai Road Wangmai Pathumwan District Bangkok10330 Thailand Biomechanics Research Center Meticuly Co. Ltd. Chulalongkorn University Bangkok10330 Thailand Hip Fracture Research Unit Department of Orthopaedic Faculty of Medicine Chulalongkorn University Bangkok10330 Thailand Department of Metallurgical Engineering Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand CambridgeMA02139 United States

This study aimed to synthesize, characterize, and evaluate the adhesion strength of titania nanotubes (titania nanotubes) and iodine-doped titania nanotubes (I-titania nanotubes) architectures on the additively manufactured Ti-6Al-4 V (Ti64) implant surface. The titania nanotubes and I-titania nanotubes were synthesized through two stages of electrochemical anodization, whereby titania nanotubes are anodically fabricated through a conventional approach and then modified by replacing the ethylene glycol electrolyte with potassium iodide solution. The characterization results revealed the formation of α-Ti, β-Ti, and titanium iodide (TiI2) phases on the titania nanotubes and I-titania nanotubes surfaces. The morphology of titania nanotubes exhibits a consistent diameter, evenly distributed, well-ordered array, and densely packed nanotubular structures. Formation of a water-soluble fluoride-rich [TiF6]2 complexes in the inner titania nanotubes surface and incessant nanotube′s sidewall etching resulted in poor interfacial titania nanotubes adhesion to the titanium-substrate surface. Iodine doping on the titania nanotubes is believed to reduce the [TiF6]2 complexes accumulation and the titania nanotubes sidewall etching. This facilitates the adhesion and interfacial mechanical anchorage between the titania nanotubes and the surface of the Ti64 implant. The hardness and adhesion strength of the titania nanotubes increased by more than 50 %, due to the formation of a hard titanium iodide film at the titania nanotubes/I-titania nanotubes surfaces and interfaces. © 2025 The Author(s). Materialwissenschaft und Werkstofftechnik published by Wiley-VCH GmbH.

关键词： Potassium iodide

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Key fuel characteristics and techno-economic aspects of torrefied rubberwood biomass pellets produced by incorporating various cassava-based binders at varied doses

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Environmental Science and Pollution Research 2024年第25期31卷 37663-37680页

作者： Kongto, Pumin Palamanit, Arkom Chaiprapat, Sumate Tippayawong, Nakorn Khempila, Jarunee Ruangim, Panatda Energy Technology Program Department of Interdisciplinary Engineering Faculty of Engineering Prince of Songkla University 15 Kanjanavanich Rd. Songkhla Hat Yai90110 Thailand Research Center Faculty of Engineering Prince of Songkla University 15 Kanjanavanich Rd. Songkhla Hat Yai90110 Thailand Department of Civil and Environmental Engineering Faculty of Engineering Prince of Songkla University 15 Kanjanavanich Rd. Songkhla Hat Yai90110 Thailand Department of Mechanical Engineering Chiang Mai University 239 Huay Kaew Rd. Chiang Mai Muang District 50200 Thailand Physics Program Faculty of Science and Technology Rajabhat Maha Sarakham University 80 Nakhon Sawan Rd. Maha Sarakham Mueang District 44000 Thailand

Improving energy content and hydrophobic nature of woody biomass can be pursued through torrefaction. This gives torrefied biomass with a low bulk density, potentially increasing storage and transport costs. To overcome this issue, densifying the torrefied biomass is necessary. However, poor binding of particles makes densification challenging without using a binder. Therefore, the aim of this study was to investigate the physicochemical characteristics and techno-economic aspects of torrefied rubberwood biomass (TRWB) when pelletized using various cassava-based binders at different blending ratios. The selected binders included cassava starch (CS), cassava pulp (CP), and cassava chip (CC). Each binder at 5%, 10%, or 15% (wt.) was mixed with TRWB and water before pelletizing using a flat die machine. The results revealed that pelletizing TRWB with different cassava-based binders at various blending ratios influenced the physicochemical characteristics of the TRWB pellets, particularly dimensions, bulk density, fuel and atomic ratios, and energy content. The TRWB pellets demonstrated energy densities in the range of 7.95–11.39 GJ/m3, and their mechanical durability and fine content fell within acceptable ranges. The TRWB pellets maintained their shape during 120 min of water soaking, with water absorption levels varying by binder dose. The pelletizing ability, material, and energy costs of TRWB pellets depend on binder type and dose. CP can be applied as a binder for pelletizing torrefied rubberwood biomass. However, the mechanical durability of the product needs to be above the user requirement or standard. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Pelletizing

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Effect of High-Flow Nasal Cannula on Capnogram Waveform for Studying Non-Invasive Human Ventilation 2

Effect of High-Flow Nasal Cannula on Capnogram Waveform for ...

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2nd IEEE National biomedical engineering Conference, NBEC 2023

作者： Tirta Nindhia, Tjokorda Gde Aqila Mohammed, Nursyasa Jamaludin, Julia Jais Devandran, Pagupathi Angel Bhaswara, Nabiel Rafa Hutajulu, Thalitakum Malarvili, M.B. Udayana University Jimbaran Study Program of Mechanical Engineering Engineering Faculty Bali Indonesia Universiti Teknologi Malaysia School of Biomedical and Health Science Engineering Johor Malaysia

ISBN: (纸本)9798350338546

This study is conducted to compare three different cannulas;all purpose nasal cannula with 2 prongs, nasal pressure cannula with 2 prongs and single port nasal cannula which are commonly used for capnography device. These cannulas or sometimes called as nasal prong is connected to the device via nose of subjects studied. This procedure is a part of respiratory study to monitor lungs condition and breathing pattern. This study involves 47 subject where the exhaled breath was recorded to make comparison and choose the most suitable and effective for capnography waveform analysis. Utilizing Statistical Package for the Social Sciences (SPSS) to find the normality of all the nasal cannula data based on capnogram waveform. The result from the analysis shows that the frequency distribution for type 1 nasal cannula which is also known as all-purpose nasal cannula had the feature values closer to the standard value. Our study proofs that all purpose nasal cannula sampling is the most suitable to capture exhaled breath for monitoring respiratory conditions. © 2023 IEEE.

关键词： capnography CO2 monitoring, feature extraction nasal cannula

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Molecular Imprinted Polymer Based Optical Sensor for Methanol Vapor Detection

Molecular Imprinted Polymer Based Optical Sensor for Methano...

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Optica Sensing Congress 2023, AIS, FTS, HISE, Sensors, ES 2023 - Part of Optical Sensors and Sensing Congress 2023

作者： Leelasirinuwong, Mintra Denkasineecharoen, Phebe Yungyuentrrakoon, Pin Jitpratak, Pannathorn Kongsawang, Nuntaporn Pathak, Akhilesh Kumar Viphavakit, Charusluk Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand Intelligent Control Automation of Process Systems Research Unit Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand

A molecular imprinted polymer-based optical sensor is proposed to detect methanol. The sensor is tested with different concentrations of methanal vapour for sensitivity and ethanol for selectivity. The result shows a ... 详细信息

ISBN: (纸本)9781957171241

关键词： Optical sensors

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